Integrins in angiogenesis

No Pathway Network information available for Integrins in angiogenesis

Pathways in the Integrins in angiogenesis SuperPath

#	Name	Source	Genes
1	Integrins in angiogenesis	PubChem	ADGRA2 AKT1 ANGPTL3 BCAR1 CASP8 CBL CDKN1B COL11A1 COL11A2 COL1A1 COL1A2 COL2A1 COL3A1 COL4A3 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL7A1 CSF1 CSF1R EDIL3 F11R FGF2 FN1 HSP90AA1 IGF1R ILK IRS1 ITGAV ITGB3 KDR MAPK3 MFGE8 PI4KA PI4KB PIK3C2A PIK3CA PIK3R1 PTK2 PTK2B PTPN11 PXN RAC1 RHOA ROCK1 RPS6KB1 SDC1 SPP1 SRC TGFBR2 TLN1 VAV3 VCL VEGFA VTN (see all 57) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADGRA2	Adhesion G Protein-Coupled Receptor A2	Protein Coding	1
2	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	1
3	MFGE8	Milk Fat Globule EGF And Factor V/VIII Domain Containing	Protein Coding	1
4	COL6A2	Collagen Type VI Alpha 2 Chain	Protein Coding	1
5	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	1
6	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	1
7	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	1
8	COL11A2	Collagen Type XI Alpha 2 Chain	Protein Coding	1
9	COL6A1	Collagen Type VI Alpha 1 Chain	Protein Coding	1
10	COL11A1	Collagen Type XI Alpha 1 Chain	Protein Coding	1
11	COL7A1	Collagen Type VII Alpha 1 Chain	Protein Coding	1
12	COL6A3	Collagen Type VI Alpha 3 Chain	Protein Coding	1
13	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	1
14	PI4KA	Phosphatidylinositol 4-Kinase Alpha	Protein Coding	1
15	EDIL3	EGF Like And Discoidin Domains 3	Protein Coding	1
16	CSF1	Colony Stimulating Factor 1	Protein Coding	1
17	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
18	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
19	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
20	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
21	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
22	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
23	CASP8	Caspase 8	Protein Coding	1
24	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
25	PI4KB	Phosphatidylinositol 4-Kinase Beta	Protein Coding	1
26	SDC1	Syndecan 1	Protein Coding	1
27	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
28	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
29	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
30	VTN	Vitronectin	Protein Coding	1
31	FN1	Fibronectin 1	Protein Coding	1
32	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
33	ILK	Integrin Linked Kinase	Protein Coding	1
34	PXN	Paxillin	Protein Coding	1
35	F11R	F11 Receptor	Protein Coding	1
36	VCL	Vinculin	Protein Coding	1
37	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
38	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
39	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
40	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
41	TLN1	Talin 1	Protein Coding	1
42	RHOA	Ras Homolog Family Member A	Protein Coding	1
43	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
44	RAC1	Rac Family Small GTPase 1	Protein Coding	1
45	ANGPTL3	Angiopoietin Like 3	Protein Coding	1
46	CBL	Cbl Proto-Oncogene	Protein Coding	1
47	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
48	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
49	KDR	Kinase Insert Domain Receptor	Protein Coding	1
50	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
51	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
52	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
53	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
54	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
55	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
56	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
57	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with Integrins in angiogenesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, TGFBR2	9.88
2	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2, COL5A1, COL5A2	8.38
3	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL5A1, COL5A2	8.38
4	Collagen vi-related dystrophies	Enrichment	COL6A1, COL6A2, COL6A3	7.15
5	Intermediate collagen vi-related muscular dystrophy	Enrichment	COL6A1, COL6A2, COL6A3	7.15
6	Bethlem muscular dystrophy	Enrichment	COL6A1, COL6A2, COL6A3	6.55
7	Ullrich congenital muscular dystrophy 1a	Enrichment	COL6A1, COL6A2, COL6A3	6.16
8	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, COL3A1, COL5A1, COL5A2, TGFBR2	5.98
9	Bethlem myopathy 1a	Enrichment	COL6A1, COL6A2, COL6A3	5.61
10	Connective tissue disease	Enrichment	COL11A1, COL2A1, COL5A1, TGFBR2	5.03
11	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	COL2A1, FN1	4.76
12	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	COL2A1, FN1	4.76
13	Otospondylomegaepiphyseal dysplasia, autosomal recessive	Enrichment	COL11A2, COL2A1	4.76
14	Otospondylomegaepiphyseal dysplasia, autosomal dominant	Enrichment	COL11A2, COL2A1	4.76
15	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	4.76
16	Fibrochondrogenesis	Enrichment	COL11A1, COL11A2	4.76
17	Stickler syndrome, type ii	Enrichment	COL11A1, COL1A1	4.76
18	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	4.76
19	Osteoporosis	Enrichment	COL1A1, COL1A2, SRC	4.61
20	Telecanthus	Enrichment	COL11A1, COL5A2	4.28
21	Ehlers-danlos syndrome, classic type, 2	Enrichment	COL5A1, COL5A2	4.28
22	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.28
23	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.28
24	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	3.98
25	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.98
26	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	3.98
27	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	3.59
28	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.59
29	Keratoconus	Enrichment	COL1A1, COL5A2	3.59
30	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.59
31	Nevus, epidermal	Enrichment	COL7A1, PIK3CA	3.44
32	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	3.44
33	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SRC	3.32
34	Adult hepatocellular carcinoma	Enrichment	CASP8, PIK3CA	3.21
35	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.21
36	Myopathy	Enrichment	COL6A1, COL6A2, COL6A3	3.21
37	Marfan syndrome	Enrichment	COL2A1, TGFBR2	3.12
38	Stickler syndrome	Enrichment	COL11A1, COL2A1	3.12
39	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.12
40	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.03
41	Thrombocytopenia	Enrichment	ITGB3, PTPN11, SRC	2.97
42	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	2.95
43	Meningioma	Enrichment	AKT1, PIK3CA	2.95
44	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	2.88
45	Hypertelorism	Enrichment	COL11A1, COL1A1, PIK3CA	2.87
46	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	2.75
47	Myopia	Enrichment	COL11A1, COL2A1	2.75
48	Lynch syndrome	Enrichment	PIK3CA, TGFBR2	2.75
49	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, PTPN11	2.75
50	Beckwith-wiedemann syndrome	Enrichment	COL6A1, COL7A1	2.59
51	Heart, malformation of	Enrichment	COL11A2, COL2A1	2.59
52	Hepatocellular carcinoma	Enrichment	CASP8, PIK3CA	2.42
53	Breast cancer	Enrichment	AKT1, CASP8, PIK3CA	2.42
54	Noonan syndrome 1	Enrichment	CBL, PTPN11	2.38
55	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.38
56	Stickler syndrome, type i	Enrichment	COL2A1	2.38
57	Macrodactyly	Enrichment	PIK3CA	2.38
58	Proteus syndrome	Enrichment	AKT1	2.38
59	Epidermolysis bullosa dystrophica, pretibial	Enrichment	COL7A1	2.38
60	Epidermolysis bullosa dystrophica, autosomal dominant	Enrichment	COL7A1	2.38
61	Metachondromatosis	Enrichment	PTPN11	2.38
62	Epiphyseal dysplasia, multiple, with myopia and conductive deafness	Enrichment	COL2A1	2.38
63	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.38
64	Epidermolysis bullosa dystrophica, autosomal recessive	Enrichment	COL7A1	2.38
65	Spondylometaphyseal dysplasia, algerian type	Enrichment	COL2A1	2.38
66	Deafness, autosomal recessive 53	Enrichment	COL11A2	2.38
67	Osteoarthritis with mild chondrodysplasia	Enrichment	COL2A1	2.38
68	Avascular necrosis of femoral head, primary, 1	Enrichment	COL2A1	2.38
69	Czech dysplasia	Enrichment	COL2A1	2.38
70	Caspase 8 deficiency	Enrichment	CASP8	2.38
71	Nail disorder, nonsyndromic congenital, 8	Enrichment	COL7A1	2.38
72	Marshall syndrome	Enrichment	COL11A1	2.38
73	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.38
74	Kniest dysplasia	Enrichment	COL2A1	2.38
75	Transient bullous dermolysis of the newborn	Enrichment	COL7A1	2.38
76	Leopard syndrome 1	Enrichment	PTPN11	2.38
77	Platyspondylic lethal skeletal dysplasia, torrance type	Enrichment	COL2A1	2.38
78	Epidermolysis bullosa with congenital localized absence of skin and deformity of nails	Enrichment	COL7A1	2.38
79	Cowden syndrome 5	Enrichment	PIK3CA	2.38
80	Fibrochondrogenesis 1	Enrichment	COL11A1	2.38
81	Spondyloepiphyseal dysplasia, stanescu type	Enrichment	COL2A1	2.38
82	Acrogeria, gottron type	Enrichment	COL3A1	2.38
83	Achondrogenesis, type ii	Enrichment	COL2A1	2.38
84	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.38
85	Ullrich congenital muscular dystrophy 1b	Enrichment	COL6A2	2.38
86	Short syndrome	Enrichment	PIK3R1	2.38
87	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.38
88	Spondyloperipheral dysplasia	Enrichment	COL2A1	2.38
89	Myosclerosis, autosomal recessive	Enrichment	COL6A2	2.38
90	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.38
91	Ullrich congenital muscular dystrophy 1c	Enrichment	COL6A3	2.38
92	Deafness, autosomal dominant 37	Enrichment	COL11A1	2.38
93	Deafness, autosomal dominant 13	Enrichment	COL11A2	2.38
94	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.38
95	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.38
96	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.38
97	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.38
98	Epidermolysis bullosa pruriginosa	Enrichment	COL7A1	2.38
99	Neuroendocrine tumor	Enrichment	CDKN1B	2.38
100	Stickler syndrome, type i, nonsyndromic ocular	Enrichment	COL2A1	2.38
101	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.38
102	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.38
103	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.38
104	Cowden syndrome 6	Enrichment	AKT1	2.38
105	Fibrochondrogenesis 2	Enrichment	COL11A2	2.38
106	Dystonia 27	Enrichment	COL6A3	2.38
107	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.38
108	Thyroid gland disease	Enrichment	COL7A1	2.38
109	Thrombocytopenia 6	Enrichment	SRC	2.38
110	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.38
111	Qualitative or quantitative defects of collagen 6	Enrichment	COL6A2	2.38
112	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.38
113	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.38
114	Spastic paraplegia 84, autosomal recessive	Enrichment	PI4KA	2.38
115	Vitreoretinopathy with phalangeal epiphyseal dysplasia	Enrichment	COL2A1	2.38
116	Recessive dystrophic epidermolysis bullosa-generalized other	Enrichment	COL7A1	2.38
117	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.38
118	Tufted angioma of skin	Enrichment	KDR	2.38
119	Asphyxia neonatorum	Enrichment	COL1A1	2.38
120	Bethlem myopathy 1b	Enrichment	COL6A2	2.38
121	Csf1r-related disorder	Enrichment	CSF1R	2.38
122	Deafness, autosomal dominant 87	Enrichment	PI4KB	2.38
123	Hypospadias	Enrichment	PIK3CA	2.38
124	Bethlem myopathy 1c	Enrichment	COL6A3	2.38
125	Autosomal dominant rhegmatogenous retinal detachment	Enrichment	COL2A1	2.38
126	Rare venous malformation	Enrichment	PIK3CA	2.38
127	Multiple epiphyseal dysplasia with myopia and deafness	Enrichment	COL2A1	2.38
128	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.38
129	Diaphragmatic eventration	Enrichment	PIK3CA	2.38
130	Hypochondrogenesis	Enrichment	COL2A1	2.38
131	Capillary leak syndrome	Enrichment	TLN1	2.38
132	Pneumothorax	Enrichment	COL5A1	2.38
133	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.38
134	Localized dystrophic epidermolysis bullosa, acral form	Enrichment	COL7A1	2.38
135	Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome	Enrichment	COL11A1	2.38
136	Dysspondyloenchondromatosis	Enrichment	COL2A1	2.38
137	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.38
138	Cystic lymphangioma	Enrichment	COL11A2	2.38
139	Rare combined vascular malformation	Enrichment	PIK3CA	2.38
140	Gastrointestinal defects and immunodeficiency syndrome 2	Enrichment	PI4KA	2.38
141	Abdominal aortic aneurysm	Enrichment	COL3A1	2.38
142	Cavernous lymphangioma	Enrichment	PIK3CA	2.38
143	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.38
144	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.38
145	Recessive dystrophic epidermolysis bullosa inversa	Enrichment	COL7A1	2.38
146	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.38
147	Type 2 collagen-related bone disorder	Enrichment	COL2A1	2.38
148	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.38
149	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.38
150	Macrodactyly of toe	Enrichment	PIK3CA	2.38
151	Generalized dominant dystrophic epidermolysis bullosa	Enrichment	COL7A1	2.38
152	Pi4ka-related disorder	Enrichment	PI4KA	2.38
153	Malignant astrocytoma	Enrichment	PTPN11	2.38
154	Scoliosis	Enrichment	COL2A1, PTPN11	2.35
155	Rasopathy	Enrichment	CBL, PTPN11	2.28
156	Lung cancer	Enrichment	CASP8, PIK3CA	2.10
157	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.08
158	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.08
159	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.08
160	Bruck syndrome 1	Enrichment	COL1A2	2.08
161	Ovarian germ cell cancer	Enrichment	CBL	2.08
162	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.08
163	Loeys-dietz syndrome 2	Enrichment	TGFBR2	2.08
164	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.08
165	Legg-calve-perthes disease	Enrichment	COL2A1	2.08
166	Keratosis, seborrheic	Enrichment	PIK3CA	2.08
167	Neurodevelopmental disorder with spasticity, hypomyelinating leukodystrophy, and brain abnormalities	Enrichment	PI4KA	2.08
168	Angioma, tufted	Enrichment	KDR	2.08
169	Noonan syndrome 8	Enrichment	PIK3CA	2.08
170	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.08
171	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.08
172	Fibromuscular dysplasia, multifocal	Enrichment	COL5A1	2.08
173	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.08
174	Werner syndrome	Enrichment	PTPN11	2.08
175	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.08
176	Aortic dissection	Enrichment	COL3A1	2.08
177	Recessive dystrophic epidermolysis bullosa	Enrichment	COL7A1	2.08
178	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.08
179	Hypobetalipoproteinemia, familial, 2	Enrichment	ANGPTL3	2.08
180	Familial avascular necrosis of the femoral head	Enrichment	COL2A1	2.08
181	Developmental and epileptic encephalopathy 23	Enrichment	ANGPTL3	2.08
182	Combined immunodeficiency-multiple intestinal atresia	Enrichment	PI4KA	2.08
183	Malignant germ cell tumor of ovary	Enrichment	CBL	2.08
184	Dentinogenesis imperfecta	Enrichment	COL1A2	2.08
185	Epidermolysis bullosa dystrophica	Enrichment	COL7A1	2.08
186	Ovarian cancer	Enrichment	AKT1, CDKN1B, PIK3CA	2.06
187	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.90
188	Mccune-albright syndrome	Enrichment	COL2A1	1.90
189	Hematuria, benign familial, 1	Enrichment	COL4A3	1.90
190	Spondyloepiphyseal dysplasia congenita	Enrichment	COL2A1	1.90
191	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.90
192	Megalocornea	Enrichment	COL11A1	1.90
193	Nail disorder, nonsyndromic congenital, 4	Enrichment	COL7A1	1.90
194	Hypophosphatasia, infantile	Enrichment	COL11A2	1.90
195	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.90
196	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.90
197	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.90
198	Heparin cofactor ii deficiency	Enrichment	PI4KA	1.90
199	Caffey disease	Enrichment	COL1A1	1.90
200	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.90
201	Pilarowski-bjornsson syndrome	Enrichment	COL4A3	1.90
202	Alport syndrome 3b, autosomal recessive	Enrichment	COL4A3	1.90
203	Loeys-dietz syndrome 1	Enrichment	TGFBR2	1.90
204	Immunodeficiency 14	Enrichment	PIK3R1	1.90
205	Hematuria, benign familial, 2	Enrichment	COL4A3	1.90
206	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.90
207	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.90
208	Tricuspid valve insufficiency	Enrichment	PTPN11	1.90
209	Multiple epiphyseal dysplasia	Enrichment	COL2A1	1.90
210	Keratoacanthoma	Enrichment	PIK3CA	1.90
211	Digenic alport syndrome	Enrichment	COL4A3	1.90
212	Hyperpigmentation of the skin	Enrichment	COL7A1	1.90
213	Nephrotic syndrome	Enrichment	COL4A3, FN1	1.85
214	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.83
215	Microcephaly	Enrichment	COL7A1, IGF1R, PTPN11	1.83
216	Alport syndrome 2, autosomal recessive	Enrichment	COL4A3	1.78
217	Phenylketonuria	Enrichment	COL1A1	1.78
218	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.78
219	Cerebrovascular disease	Enrichment	PIK3CA	1.78
220	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.78
221	Epidermolytic hyperkeratosis	Enrichment	COL7A1	1.78
222	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.78
223	Autosomal recessive alport syndrome	Enrichment	COL4A3	1.78
224	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.78
225	Primary hyperparathyroidism	Enrichment	CDKN1B	1.78
226	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	COL11A1, COL11A2	1.70
227	Alport syndrome 3a, autosomal dominant	Enrichment	COL4A3	1.68
228	Capillary malformations, congenital	Enrichment	PIK3CA	1.68
229	Epidermolytic hyperkeratosis 1	Enrichment	COL7A1	1.68
230	Retinal detachment	Enrichment	COL2A1	1.68
231	Insulin-like growth factor i	Enrichment	IGF1R	1.68
232	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.68
233	Lymphoma	Enrichment	PTPN11	1.68
234	Autosomal dominant alport syndrome	Enrichment	COL4A3	1.68
235	Myeloproliferative neoplasm	Enrichment	CBL	1.68
236	Epidermolysis bullosa	Enrichment	COL7A1	1.68
237	Hemimegalencephaly	Enrichment	PIK3CA	1.68
238	Alport syndrome	Enrichment	COL4A3	1.68
239	Aggressive systemic mastocytosis	Enrichment	CBL	1.68
240	Familial cerebral saccular aneurysm	Enrichment	COL3A1	1.68
241	Developmental dysplasia of the hip 1	Enrichment	COL2A1	1.60
242	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.60
243	Cowden syndrome 1	Enrichment	PIK3CA	1.60
244	Hemangioma, capillary infantile	Enrichment	KDR	1.60
245	Inguinal hernia	Enrichment	COL5A1	1.60
246	Pain disorder	Enrichment	COL5A1	1.60
247	Patent ductus arteriosus	Enrichment	PTPN11	1.60
248	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.60
249	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.60
250	Esophageal cancer	Enrichment	TGFBR2	1.54
251	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.54
252	Myelofibrosis	Enrichment	SRC	1.54
253	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.54
254	Intervertebral disc disease	Enrichment	COL11A1	1.54
255	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.54
256	Noonan syndrome 3	Enrichment	PTPN11	1.54
257	Multiple enchondromatosis, maffucci type	Enrichment	COL2A1	1.54
258	Gallbladder cancer	Enrichment	PIK3CA	1.54
259	Overgrowth syndrome	Enrichment	PIK3R1	1.54
260	Gastroesophageal reflux	Enrichment	COL5A1	1.48
261	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1	1.48
262	Orthostatic intolerance	Enrichment	COL5A1	1.48
263	Loeys-dietz syndrome	Enrichment	TGFBR2	1.43
264	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.43
265	Arteriovenous malformation	Enrichment	PIK3CA	1.43
266	Bilateral perisylvian polymicrogyria	Enrichment	PI4KA	1.43
267	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1	1.43
268	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.38
269	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.38
270	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.38
271	Pectus excavatum	Enrichment	PTPN11	1.34
272	Frontotemporal dementia 1	Enrichment	CSF1R	1.34
273	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.34
274	Ichthyosis	Enrichment	COL7A1	1.34
275	Specific learning disability	Enrichment	PTPN11	1.34
276	Epicanthus	Enrichment	PTPN11	1.31
277	Cutis laxa	Enrichment	COL5A1	1.31
278	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.31
279	Congenital long qt syndrome	Enrichment	PTPN11	1.31
280	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	COL5A1	1.27
281	Alzheimer's disease	Enrichment	CSF1R	1.27
282	Clubfoot	Enrichment	COL5A1	1.27
283	Nk-cell enteropathy	Enrichment	IGF1R	1.27
284	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1	1.24
285	Cataract	Enrichment	COL5A1	1.24
286	Kidney disease	Enrichment	COL4A3	1.21
287	Rhabdomyosarcoma	Enrichment	CBL	1.19
288	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.16
289	Cleft palate, isolated	Enrichment	COL11A1	1.16
290	Patent foramen ovale	Enrichment	PTPN11	1.14
291	Endometrial cancer	Enrichment	PIK3CA	1.07
292	Hepatoblastoma	Enrichment	COL7A1	1.07
293	Myocardial infarction	Enrichment	ITGB3	1.05
294	Skin disease	Enrichment	COL7A1	1.05
295	Ear malformation	Enrichment	COL11A2	1.02
296	Muscular dystrophy	Enrichment	COL6A2	1.02
297	Tetralogy of fallot	Enrichment	KDR	0.98
298	Hydrops fetalis, nonimmune	Enrichment	PTPN11	0.98
299	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, PTPN11	0.97
300	Strabismus	Enrichment	PTPN11	0.97
301	Bladder cancer	Enrichment	PIK3CA	0.94
302	Prostate cancer	Enrichment	PIK3CA	0.94
303	Severe covid-19	Enrichment	ITGAV	0.94
304	Long qt syndrome 1	Enrichment	PTPN11	0.93
305	Stargardt disease 1	Enrichment	COL2A1	0.93
306	Non-immune hydrops fetalis	Enrichment	PTPN11	0.91
307	Genetic steroid-resistant nephrotic syndrome	Enrichment	COL4A3	0.87
308	Systemic lupus erythematosus	Enrichment	SPP1	0.82
309	Type 2 diabetes mellitus	Enrichment	IRS1	0.79
310	Nonsyndromic hearing loss	Enrichment	COL11A2	0.79
311	Gastric cancer	Enrichment	PIK3CA	0.78
312	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.78
313	Sensorineural hearing loss	Enrichment	COL11A2	0.74
314	Familial isolated dilated cardiomyopathy	Enrichment	VCL	0.70
315	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.68
316	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.68
317	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.66
318	Primary ovarian insufficiency	Enrichment	KDR	0.66
319	Autism	Enrichment	COL11A1	0.58
320	Rare genetic deafness	Enrichment	COL11A2	0.55
321	Dilated cardiomyopathy	Enrichment	VCL	0.54
322	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	COL11A2	0.50
323	Hereditary retinal dystrophy	Enrichment	COL11A2, COL2A1	0.46
324	Fundus dystrophy	Enrichment	COL11A2, COL2A1	0.46
325	Autism spectrum disorder	Enrichment	PTPN11	0.43

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Integrins in angiogenesis

Pathway Network for Integrins in angiogenesis

Member Pathways for Integrins in angiogenesis

Pathways in the Integrins in angiogenesis SuperPath

Associated Genes for Integrins in angiogenesis

Associated Disorders for Integrins in angiogenesis

Disorders associated with Integrins in angiogenesis SuperPath

STRING Interaction Network for Integrins in angiogenesis

Sources for Integrins in angiogenesis