Interaction between L1 and Ankyrins

No Pathway Network information available for Interaction between L1 and Ankyrins

Pathways in the Interaction between L1 and Ankyrins SuperPath

#	Name	Source	Genes
1	Interaction between L1 and Ankyrins	Reactome	ACTB ACTG1 ANK1 ANK2 ANK3 KCNQ2 KCNQ3 L1CAM NFASC NRCAM SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SCN11A	Sodium Voltage-Gated Channel Alpha Subunit 11	Protein Coding	1
2	NFASC	Neurofascin	Protein Coding	1
3	ANK1	Ankyrin 1	Protein Coding	1
4	ANK2	Ankyrin 2	Protein Coding	1
5	ANK3	Ankyrin 3	Protein Coding	1
6	KCNQ2	Potassium Voltage-Gated Channel Subfamily Q Member 2	Protein Coding	1
7	KCNQ3	Potassium Voltage-Gated Channel Subfamily Q Member 3	Protein Coding	1
8	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	1
9	NRCAM	Neuronal Cell Adhesion Molecule	Protein Coding	1
10	SPTBN5	Spectrin Beta, Non-Erythrocytic 5	Protein Coding	1
11	SCN3B	Sodium Voltage-Gated Channel Beta Subunit 3	Protein Coding	1
12	SPTBN4	Spectrin Beta, Non-Erythrocytic 4	Protein Coding	1
13	ACTB	Actin Beta	Protein Coding	1
14	SCN1A	Sodium Voltage-Gated Channel Alpha Subunit 1	Protein Coding	1
15	SCN1B	Sodium Voltage-Gated Channel Beta Subunit 1	Protein Coding	1
16	SCN2A	Sodium Voltage-Gated Channel Alpha Subunit 2	Protein Coding	1
17	SCN2B	Sodium Voltage-Gated Channel Beta Subunit 2	Protein Coding	1
18	SCN3A	Sodium Voltage-Gated Channel Alpha Subunit 3	Protein Coding	1
19	SCN4A	Sodium Voltage-Gated Channel Alpha Subunit 4	Protein Coding	1
20	SCN4B	Sodium Voltage-Gated Channel Beta Subunit 4	Protein Coding	1
21	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	1
22	SCN7A	Sodium Voltage-Gated Channel Alpha Subunit 7	Protein Coding	1
23	SCN8A	Sodium Voltage-Gated Channel Alpha Subunit 8	Protein Coding	1
24	SCN9A	Sodium Voltage-Gated Channel Alpha Subunit 9	Protein Coding	1
25	SCN10A	Sodium Voltage-Gated Channel Alpha Subunit 10	Protein Coding	1
26	SPTA1	Spectrin Alpha, Erythrocytic 1	Protein Coding	1
27	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	1
28	SPTB	Spectrin Beta, Erythrocytic	Protein Coding	1
29	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	1
30	SPTBN2	Spectrin Beta, Non-Erythrocytic 2	Protein Coding	1
31	ACTG1	Actin Gamma 1	Protein Coding	1

Disorders associated with Interaction between L1 and Ankyrins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Self-limited infantile epilepsy	Enrichment	KCNQ2, KCNQ3, SCN2A, SCN8A	9.89
2	Developmental and epileptic encephalopathy	Enrichment	KCNQ2, SCN1A, SCN2A, SCN3A, SCN8A, SPTAN1	9.82
3	Benign epilepsy with centrotemporal spikes	Enrichment	KCNQ3, SCN1A, SCN1B, SCN2A, SCN9A, SPTAN1	9.46
4	Centralopathic epilepsy	Enrichment	KCNQ3, SCN1A, SCN1B, SCN2A, SCN9A, SPTAN1	9.31
5	Familial atrial fibrillation	Enrichment	SCN1B, SCN2B, SCN3B, SCN4B, SCN5A	8.73
6	Brugada syndrome	Enrichment	SCN10A, SCN1B, SCN2B, SCN3B, SCN5A	8.55
7	Dravet syndrome	Enrichment	SCN1A, SCN1B, SCN2A, SCN9A	8.33
8	Hereditary sodium channelopathy-related small fibers neuropathy	Enrichment	SCN10A, SCN11A, SCN9A	7.97
9	Generalized epilepsy with febrile seizures plus	Enrichment	SCN1A, SCN1B, SCN2A, SCN9A	7.66
10	Erythermalgia, primary	Enrichment	SCN10A, SCN11A, SCN9A	7.36
11	West syndrome	Enrichment	KCNQ2, SCN1A, SCN2A, SCN8A, SPTAN1	7.34
12	Paroxysmal extreme pain disorder	Enrichment	SCN10A, SCN11A, SCN9A	6.97
13	Hereditary spherocytosis	Enrichment	ANK1, SPTA1, SPTB	6.67
14	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	SCN10A, SCN11A, SCN9A	6.42
15	Focal epilepsy	Enrichment	SCN2A, SCN8A, SPTAN1	6.42
16	Long qt syndrome 1	Enrichment	ANK2, SCN10A, SCN4B, SCN5A	6.23
17	Developmental and epileptic encephalopathy 14	Enrichment	KCNQ2, SCN1A, SCN2A	6.05
18	Epilepsy	Enrichment	SCN1A, SCN2A, SCN3A, SCN8A	5.72
19	Seizures, benign familial neonatal, 2	Enrichment	KCNQ2, KCNQ3	5.30
20	Pyropoikilocytosis, hereditary	Enrichment	SPTA1, SPTB	5.30
21	Seizures, benign familial infantile, 3	Enrichment	KCNQ2, SCN2A	5.30
22	Benign familial neonatal epilepsy	Enrichment	KCNQ3, SCN2A	5.30
23	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.30
24	Seizures, benign familial infantile, 5	Enrichment	KCNQ3, SCN8A	5.30
25	Self-limited neonatal epilepsy	Enrichment	KCNQ2, KCNQ3	5.30
26	Benign neonatal seizures	Enrichment	KCNQ3, SCN2A	5.30
27	Undetermined early-onset epileptic encephalopathy	Enrichment	SCN1A, SCN1B, SCN3A, SCN8A	5.12
28	Complex neurodevelopmental disorder	Enrichment	ANK2, NRCAM, SCN2A, SCN8A, SPTBN1	5.08
29	Generalized epilepsy with febrile seizures plus, type 1	Enrichment	SCN1A, SCN1B	4.82
30	Developmental and epileptic encephalopathy 1	Enrichment	KCNQ2, SCN1A, SCN8A	4.62
31	Hereditary elliptocytosis	Enrichment	SPTA1, SPTB	4.52
32	Hereditary progressive cardiac conduction defect	Enrichment	SCN1B, SCN5A	4.52
33	Fetal akinesia deformation sequence 1	Enrichment	SCN4A, SCN5A, SCN8A	4.10
34	Brugada syndrome 1	Enrichment	SCN10A, SCN5A	3.98
35	Hemolytic anemia	Enrichment	SPTA1, SPTB	3.98
36	Distal arthrogryposis	Enrichment	SCN4A, SCN5A, SCN8A	3.93
37	Cardiac conduction defect	Enrichment	SCN1B, SCN5A	3.48
38	Protein-deficiency anemia	Enrichment	SPTA1, SPTB	3.41
39	Autism	Enrichment	SCN1A, SCN2A, SCN8A	3.24
40	Sudden infant death syndrome	Enrichment	SCN1A, SCN5A	3.17
41	Early infantile developmental and epileptic encephalopathy	Enrichment	SCN1B, SCN2A	3.12
42	Long qt syndrome	Enrichment	ANK2, SCN5A	2.65
43	Elliptocytosis 2	Enrichment	SPTA1	2.64
44	Hydrocephalus due to congenital stenosis of aqueduct of sylvius	Enrichment	L1CAM	2.64
45	Baraitser-winter syndrome 1	Enrichment	ACTB	2.64
46	Cardiac arrhythmia, ankyrin-b-related	Enrichment	ANK2	2.64
47	Spinocerebellar ataxia 5	Enrichment	SPTBN2	2.64
48	Brugada syndrome 5	Enrichment	SCN1B	2.64
49	Long qt syndrome 10	Enrichment	SCN4B	2.64
50	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	2.64
51	Intellectual developmental disorder, autosomal recessive 37	Enrichment	ANK3	2.64
52	Episodic pain syndrome, familial, 3	Enrichment	SCN11A	2.64
53	Developmental and epileptic encephalopathy 7	Enrichment	KCNQ2	2.64
54	Developmental and epileptic encephalopathy 11	Enrichment	SCN2A	2.64
55	Neuropathy, hereditary sensory and autonomic, type vii	Enrichment	SCN11A	2.64
56	Atrial fibrillation, familial, 14	Enrichment	SCN2B	2.64
57	Corpus callosum, partial agenesis of, x-linked	Enrichment	L1CAM	2.64
58	Hydrocephalus, congenital, x-linked	Enrichment	L1CAM	2.64
59	Spherocytosis, type 3	Enrichment	SPTA1	2.64
60	Myoclonus, familial, 2	Enrichment	SCN8A	2.64
61	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.64
62	Developmental and epileptic encephalopathy 62	Enrichment	SCN3A	2.64
63	Long qt syndrome 4	Enrichment	ANK2	2.64
64	Masa syndrome	Enrichment	L1CAM	2.64
65	Atrial fibrillation, familial, 13	Enrichment	SCN1B	2.64
66	Spinocerebellar ataxia, autosomal recessive 14	Enrichment	SPTBN2	2.64
67	Developmental delay, impaired speech, and behavioral abnormalities	Enrichment	SPTBN1	2.64
68	Becker nevus syndrome	Enrichment	ACTB	2.64
69	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.64
70	Hyperpigmentation, familial progressive, 1	Enrichment	SPTA1	2.64
71	Episodic ataxia, type 9	Enrichment	SCN2A	2.64
72	Episodic pain syndrome, familial, 2	Enrichment	SCN10A	2.64
73	Benign familial infantile epilepsy	Enrichment	SCN2A	2.64
74	Brugada syndrome 7	Enrichment	SCN3B	2.64
75	Epilepsy, familial focal, with variable foci 4	Enrichment	SCN3A	2.64
76	8p11.2 deletion syndrome	Enrichment	ANK1	2.64
77	Spherocytosis, type 2	Enrichment	SPTB	2.64
78	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.64
79	Elliptocytosis 3	Enrichment	SPTB	2.64
80	Neurodevelopmental disorder with neuromuscular and skeletal abnormalities	Enrichment	NRCAM	2.64
81	Muscular channelopathy	Enrichment	SCN4A	2.64
82	Neurodevelopmental disorder with central and peripheral motor dysfunction	Enrichment	NFASC	2.64
83	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	2.64
84	Developmental delay with or without epilepsy	Enrichment	SPTAN1	2.64
85	Baraitser-winter syndrome	Enrichment	ACTB	2.64
86	Kcnq3-related disorders	Enrichment	KCNQ3	2.64
87	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	2.64
88	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.64
89	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.64
90	X-linked complicated spastic paraplegia type 1	Enrichment	L1CAM	2.64
91	Kcnq2-related disorders	Enrichment	KCNQ2	2.64
92	Microcephaly	Enrichment	ACTB, ACTG1, SCN1A	2.57
93	Seizures, benign familial neonatal, 1	Enrichment	KCNQ2	2.34
94	Atrial standstill 1	Enrichment	SCN5A	2.34
95	Progressive familial heart block, type ia	Enrichment	SCN5A	2.34
96	Paramyotonia congenita	Enrichment	SCN4A	2.34
97	Batten-turner congenital myopathy	Enrichment	SCN4A	2.34
98	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	2.34
99	Indifference to pain, congenital, autosomal recessive	Enrichment	SCN9A	2.34
100	Sick sinus syndrome 1	Enrichment	SCN5A	2.34
101	Myotonia, potassium-aggravated	Enrichment	SCN4A	2.34
102	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.34
103	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.34
104	Chudley-mccullough syndrome	Enrichment	SPTB	2.34
105	Atrial fibrillation, familial, 10	Enrichment	SCN5A	2.34
106	Migraine, familial hemiplegic, 3	Enrichment	SCN1A	2.34
107	Neurodevelopmental disorder with hypotonia, neuropathy, and deafness	Enrichment	SPTBN4	2.34
108	Cognitive impairment with or without cerebellar ataxia	Enrichment	SCN8A	2.34
109	Long qt syndrome 3	Enrichment	SCN5A	2.34
110	Developmental and epileptic encephalopathy 6b	Enrichment	SCN1A	2.34
111	Sinoatrial node disease	Enrichment	SCN5A	2.34
112	Congenital myopathy 22a, classic	Enrichment	SCN4A	2.34
113	Congenital myopathy 22b, severe fetal	Enrichment	SCN4A	2.34
114	Myasthenic syndrome, congenital, 16	Enrichment	SCN4A	2.34
115	Developmental and epileptic encephalopathy 30	Enrichment	SCN2A	2.34
116	Congenital hemolytic anemia	Enrichment	SPTA1	2.34
117	Ichthyosis, congenital, autosomal recessive 10	Enrichment	KCNQ2	2.34
118	Hypokalemic periodic paralysis, type 2	Enrichment	SCN4A	2.34
119	Scn1a seizure disorders	Enrichment	SCN1A	2.34
120	Malignant migrating partial seizures of infancy	Enrichment	SCN2A	2.34
121	Developmental and epileptic encephalopathy 76	Enrichment	SCN1A	2.34
122	Small fiber neuropathy	Enrichment	SCN9A	2.34
123	Isolated atrial standstill	Enrichment	SCN5A	2.34
124	Autosomal dominant non-syndromic intellectual disability	Enrichment	KCNQ2, SCN8A	2.24
125	Spastic ataxia	Enrichment	SCN2A, SPTAN1	2.19
126	Dystonia 12	Enrichment	SCN2A	2.16
127	Generalized epilepsy with febrile seizures plus, type 2	Enrichment	SCN1A	2.16
128	Developmental and epileptic encephalopathy 13	Enrichment	SCN8A	2.16
129	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	SPTBN1	2.16
130	Generalized epilepsy with febrile seizures plus, type 7	Enrichment	SCN9A	2.16
131	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	2.16
132	Tremor, hereditary essential, 6	Enrichment	SCN4A	2.16
133	Hereditary episodic ataxia	Enrichment	SCN2A	2.16
134	Neuropathy, hereditary sensory and autonomic, type iia	Enrichment	SCN9A	2.04
135	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	SCN5A	2.04
136	Long qt syndrome 2	Enrichment	SCN5A	2.04
137	Hyperkalemic periodic paralysis	Enrichment	SCN4A	2.04
138	Aminoacylase 1 deficiency	Enrichment	ACTB	2.04
139	Developmental and epileptic encephalopathy 12	Enrichment	SCN2A	2.04
140	Hereditary sensory and autonomic neuropathy type 2	Enrichment	SCN9A	2.04
141	Developmental and epileptic encephalopathy 52	Enrichment	SCN1B	2.04
142	Atrial fibrillation	Enrichment	SCN5A	2.04
143	Sotos syndrome 1	Enrichment	SCN4A	2.04
144	Episodic ataxia	Enrichment	SCN2A	2.04
145	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	2.04
146	Familial or sporadic hemiplegic migraine	Enrichment	SCN1A	2.04
147	Sick sinus syndrome	Enrichment	SCN5A	2.04
148	Paroxysmal familial ventricular fibrillation	Enrichment	SCN5A	2.04
149	Familial sick sinus syndrome	Enrichment	SCN5A	2.04
150	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	2.04
151	Sotos syndrome	Enrichment	SCN4A	1.94
152	Spherocytosis, type 1	Enrichment	ANK1	1.94
153	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	SCN8A	1.94
154	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	L1CAM	1.94
155	Heart conduction disease	Enrichment	SCN5A	1.94
156	Pervasive developmental disorder	Enrichment	SPTBN1	1.94
157	Cardiac arrest	Enrichment	SCN5A	1.94
158	Coloboma of choroid and retina	Enrichment	ACTG1	1.94
159	Sensory peripheral neuropathy	Enrichment	SCN11A	1.94
160	Rare pervasive developmental disorder	Enrichment	SPTBN1	1.94
161	Hypokalemic periodic paralysis, type 1	Enrichment	SCN4A	1.87
162	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	ANK2	1.87
163	Pain disorder	Enrichment	SCN4A	1.87
164	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	SCN3A	1.80
165	Lennox-gastaut syndrome	Enrichment	SCN1A	1.74
166	Alternating hemiplegia of childhood	Enrichment	SCN2A	1.74
167	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	ANK2	1.74
168	Myoclonic-atonic epilepsy	Enrichment	SCN1A	1.69
169	Bilateral perisylvian polymicrogyria	Enrichment	SCN3A	1.69
170	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	SCN5A	1.69
171	Hydrops fetalis	Enrichment	L1CAM	1.69
172	Cat eye syndrome	Enrichment	ACTG1	1.65
173	Polymicrogyria	Enrichment	SCN3A	1.65
174	Epilepsy, myoclonic juvenile	Enrichment	KCNQ3	1.60
175	Movement disease	Enrichment	SCN2A	1.60
176	Autism spectrum disorder	Enrichment	ANK2, SCN2A	1.59
177	Epicanthus	Enrichment	KCNQ2	1.57
178	Congenital long qt syndrome	Enrichment	SCN5A	1.57
179	Postsynaptic congenital myasthenic syndromes	Enrichment	SCN4A	1.57
180	Medulloblastoma	Enrichment	ANK3	1.50
181	Wolff-parkinson-white syndrome	Enrichment	SCN5A	1.44
182	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	SCN5A	1.44
183	Cardiomyopathy, dilated, 1e	Enrichment	SCN5A	1.42
184	Neuromuscular disease	Enrichment	SPTAN1	1.39
185	Congenital myopathy	Enrichment	SCN4A	1.37
186	Lissencephaly	Enrichment	ACTG1	1.33
187	Malaria	Enrichment	SCN8A	1.29
188	Jeune thoracic dystrophy	Enrichment	SPTAN1	1.25
189	Asphyxiating thoracic dystrophy	Enrichment	SPTAN1	1.21
190	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	SPTAN1	1.14
191	Cakut	Enrichment	ACTG1	1.13
192	Left ventricular noncompaction	Enrichment	SCN5A	1.11
193	Non-syndromic genetic deafness	Enrichment	ACTG1	1.10
194	Myopathy	Enrichment	SCN4A	1.06
195	Hereditary spastic paraplegia	Enrichment	SPTAN1	1.04
196	Nonsyndromic hearing loss	Enrichment	ACTG1	1.04
197	Body mass index quantitative trait locus 11	Enrichment	SCN1A	0.97
198	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.95
199	Familial isolated dilated cardiomyopathy	Enrichment	SCN5A	0.94
200	Rare genetic deafness	Enrichment	ACTG1	0.78
201	Dilated cardiomyopathy	Enrichment	SCN5A	0.78
202	Congenital nervous system abnormality	Enrichment	ANK3	0.67
203	Nervous system disease	Enrichment	ANK3	0.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interaction between L1 and Ankyrins

Pathway Network for Interaction between L1 and Ankyrins

Member Pathways for Interaction between L1 and Ankyrins

Pathways in the Interaction between L1 and Ankyrins SuperPath

Associated Genes for Interaction between L1 and Ankyrins

Associated Disorders for Interaction between L1 and Ankyrins

Disorders associated with Interaction between L1 and Ankyrins SuperPath

STRING Interaction Network for Interaction between L1 and Ankyrins

Sources for Interaction between L1 and Ankyrins