Interferon Pathway

No Pathway Network information available for Interferon Pathway

Pathways in the Interferon Pathway SuperPath

#	Name	Source	Genes
1	Interferon Pathway	QIAGEN	ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 ATF4 CREB1 CREB3 CREB3L4 EIF4E EIF4EBP1 H3-3A H3-3B H3-4 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 IFNA1 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA2 IFNA21 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNAR1 IFNAR2 IFNB1 IFNG IFNGR1 IFNGR2 IFNK IFNW1 IL6 IRF9 IRS1 IRS2 JAK1 JAK2 MAP2K3 MAP2K6 MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAPK11 MAPK12 MAPK13 MAPK14 MCF2L MTOR NET1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PRKCD RAC1 RPS6 RPS6KA4 RPS6KA5 RPS6KB1 STAT1 STAT2 TYK2 VAV1 VAV2 VAV3 (see all 91) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
2	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	1
3	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	1
4	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1
5	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	1
6	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	1
7	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
8	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	1
9	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	1
10	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	1
11	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
12	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
13	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	1
14	ATF4	Activating Transcription Factor 4	Protein Coding	1
15	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
16	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
17	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
18	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
19	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
20	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
21	H3-3A	H3.3 Histone A	Protein Coding	1
22	H3-3B	H3.3 Histone B	Protein Coding	1
23	H3C1	H3 Clustered Histone 1	Protein Coding	1
24	H3C2	H3 Clustered Histone 2	Protein Coding	1
25	H3C3	H3 Clustered Histone 3	Protein Coding	1
26	H3C4	H3 Clustered Histone 4	Protein Coding	1
27	H3C6	H3 Clustered Histone 6	Protein Coding	1
28	H3C7	H3 Clustered Histone 7	Protein Coding	1
29	H3C8	H3 Clustered Histone 8	Protein Coding	1
30	H3C10	H3 Clustered Histone 10	Protein Coding	1
31	H3C11	H3 Clustered Histone 11	Protein Coding	1
32	H3C12	H3 Clustered Histone 12	Protein Coding	1
33	H3-4	H3.4 Histone, Cluster Member	Protein Coding	1
34	IFNA1	Interferon Alpha 1	Protein Coding	1
35	IFNA10	Interferon Alpha 10	Protein Coding	1
36	IFNA13	Interferon Alpha 13	Protein Coding	1
37	IFNA14	Interferon Alpha 14	Protein Coding	1
38	IFNA16	Interferon Alpha 16	Protein Coding	1
39	IFNA17	Interferon Alpha 17	Protein Coding	1
40	IFNA2	Interferon Alpha 2	Protein Coding	1
41	IFNA21	Interferon Alpha 21	Protein Coding	1
42	IFNA4	Interferon Alpha 4	Protein Coding	1
43	IFNA5	Interferon Alpha 5	Protein Coding	1
44	IFNA6	Interferon Alpha 6	Protein Coding	1
45	IFNA7	Interferon Alpha 7	Protein Coding	1
46	IFNA8	Interferon Alpha 8	Protein Coding	1
47	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	1
48	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	1
49	IFNB1	Interferon Beta 1	Protein Coding	1
50	IFNG	Interferon Gamma	Protein Coding	1
51	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
52	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
53	IFNK	Interferon Kappa	Protein Coding	1
54	IFNW1	Interferon Omega 1	Protein Coding	1
55	IL6	Interleukin 6	Protein Coding	1
56	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
57	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
58	IRF9	Interferon Regulatory Factor 9	Protein Coding	1
59	JAK1	Janus Kinase 1	Protein Coding	1
60	JAK2	Janus Kinase 2	Protein Coding	1
61	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
62	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
63	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
64	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
65	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
66	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
67	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
68	MAP3K6	Mitogen-Activated Protein Kinase Kinase Kinase 6	Protein Coding	1
69	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
70	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
71	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
72	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
73	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
74	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	1
75	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
76	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
77	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
78	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
79	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
80	PRKCD	Protein Kinase C Delta	Protein Coding	1
81	RAC1	Rac Family Small GTPase 1	Protein Coding	1
82	RPS6	Ribosomal Protein S6	Protein Coding	1
83	RPS6KA4	Ribosomal Protein S6 Kinase A4	Protein Coding	1
84	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
85	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
86	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
87	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
88	TYK2	Tyrosine Kinase 2	Protein Coding	1
89	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
90	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
91	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1

Disorders associated with Interferon Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multisystem inflammatory syndrome in children	Enrichment	IFNA21, IFNA4, IFNA6, IFNAR2, IFNB1	6.53
2	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.35
3	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2	3.88
4	Immunodeficiency 44	Enrichment	IFNAR2, STAT2	3.88
5	Hepatitis b	Enrichment	IFNAR2, IFNGR1	3.58
6	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.04
7	Glioma susceptibility 1	Enrichment	H3-3A, H3C1	2.92
8	Type 2 diabetes mellitus	Enrichment	IL6, IRS1, IRS2	2.56
9	Helicobacter pylori infection	Enrichment	IFNGR1	2.17
10	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.17
11	Immunodeficiency 35	Enrichment	TYK2	2.17
12	46,xy sex reversal 6	Enrichment	MAP3K1	2.17
13	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.17
14	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.17
15	Immunodeficiency 27a	Enrichment	IFNGR1	2.17
16	Immunodeficiency 62	Enrichment	ARHGEF1	2.17
17	Immunodeficiency 69	Enrichment	IFNG	2.17
18	Pseudo-torch syndrome 3	Enrichment	STAT2	2.17
19	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.17
20	Immunodeficiency 106 viral infections	Enrichment	IFNAR1	2.17
21	Short syndrome	Enrichment	PIK3R1	2.17
22	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.17
23	Autism 19	Enrichment	EIF4E	2.17
24	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	2.17
25	Immunodeficiency 27b	Enrichment	IFNGR1	2.17
26	Immunodeficiency 31a	Enrichment	STAT1	2.17
27	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.17
28	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.17
29	Immunodeficiency 31b	Enrichment	STAT1	2.17
30	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	2.17
31	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.17
32	Immunodeficiency 65 viral infections	Enrichment	IRF9	2.17
33	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.17
34	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.17
35	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.17
36	Verrucous hemangioma	Enrichment	MAP3K3	2.17
37	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.17
38	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.87
39	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.87
40	Immunodeficiency 45	Enrichment	IFNAR2	1.87
41	Thrombocythemia 3	Enrichment	JAK2	1.87
42	Immunodeficiency 31c	Enrichment	STAT1	1.87
43	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.87
44	Cebalid syndrome	Enrichment	MTOR	1.87
45	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.87
46	Smith-kingsmore syndrome	Enrichment	MTOR	1.87
47	Polycythemia	Enrichment	JAK2	1.87
48	Lymphomatoid papulosis	Enrichment	TYK2	1.87
49	Hypereosinophilic syndrome	Enrichment	JAK2	1.87
50	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	1.87
51	Polycythemia vera	Enrichment	JAK2	1.70
52	Tuberous sclerosis 1	Enrichment	IFNG	1.70
53	Hepatitis c virus	Enrichment	IFNG	1.70
54	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.70
55	Tuberous sclerosis 2	Enrichment	IFNG	1.70
56	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.70
57	Immunodeficiency 28	Enrichment	IFNGR2	1.70
58	Immunodeficiency 14	Enrichment	PIK3R1	1.70
59	Melanoma of soft tissue	Enrichment	CREB1	1.70
60	Kaposi sarcoma	Enrichment	IL6	1.58
61	Erythrocytosis, familial, 1	Enrichment	JAK2	1.58
62	Diffuse gastric and lobular breast cancer syndrome	Enrichment	MAP3K6	1.58
63	Budd-chiari syndrome	Enrichment	JAK2	1.58
64	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.58
65	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.58
66	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.58
67	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.58
68	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.58
69	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.48
70	Myeloproliferative neoplasm	Enrichment	JAK2	1.48
71	Hemimegalencephaly	Enrichment	MTOR	1.48
72	Idiopathic aplastic anemia	Enrichment	IFNG	1.48
73	Type 1 diabetes mellitus	Enrichment	IL6	1.40
74	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.40
75	Myelofibrosis	Enrichment	JAK2	1.34
76	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.34
77	Essential thrombocythemia	Enrichment	JAK2	1.34
78	Myeloma, multiple	Enrichment	H3C1, PIK3R2	1.27
79	Inflammatory bowel disease 1	Enrichment	IL6	1.23
80	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.23
81	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.23
82	Aplastic anemia	Enrichment	IFNG	1.19
83	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.19
84	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.15
85	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.05
86	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.02
87	Rare genetic intellectual disability	Enrichment	MTOR	1.02
88	Human immunodeficiency virus type 1	Enrichment	IFNG	0.94
89	Arteriovenous malformations of the brain	Enrichment	IL6	0.92
90	Behcet syndrome	Enrichment	IFNGR1	0.92
91	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.67
92	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.67
93	Leukemia, acute myeloid	Enrichment	JAK2	0.63
94	Charcot-marie-tooth disease	Enrichment	ARHGEF10	0.62
95	Primary ovarian insufficiency	Enrichment	JAK2	0.48
96	Colorectal cancer	Enrichment	PIK3R1	0.35
97	Ovarian cancer	Enrichment	MAP3K1	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interferon Pathway

Pathway Network for Interferon Pathway

Member Pathways for Interferon Pathway

Pathways in the Interferon Pathway SuperPath

Associated Genes for Interferon Pathway

Associated Disorders for Interferon Pathway

Disorders associated with Interferon Pathway SuperPath

STRING Interaction Network for Interferon Pathway

Sources for Interferon Pathway