Interferon type I signaling pathways

No Pathway Network information available for Interferon type I signaling pathways

Pathways in the Interferon type I signaling pathways SuperPath

#	Name	Source	Genes
1	Interferon type I signaling pathways	WikiPathways	CRK FYN JAK1 LCK PIAS1 PIAS3 PTPN11 PTPN6 PTPRC ZAP70 (see all 10) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
2	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
3	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
4	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
5	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
6	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
7	JAK1	Janus Kinase 1	Protein Coding	1
8	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
9	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
10	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1

Disorders associated with Interferon type I signaling pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	LCK, PTPRC, ZAP70	5.81
2	Metachondromatosis	Enrichment	PTPN11	3.13
3	Leopard syndrome 1	Enrichment	PTPN11	3.13
4	Immunodeficiency 48	Enrichment	ZAP70	3.13
5	Immunodeficiency 105, severe combined	Enrichment	PTPRC	3.13
6	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	3.13
7	Immunodeficiency 22	Enrichment	LCK	3.13
8	Cd45 deficiency	Enrichment	PTPRC	3.13
9	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	3.13
10	Bullous pyoderma gangrenosum	Enrichment	PTPN6	3.13
11	Pustular pyoderma gangrenosum	Enrichment	PTPN6	3.13
12	Classic pyoderma gangrenosum	Enrichment	PTPN6	3.13
13	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.13
14	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	3.13
15	Malignant astrocytoma	Enrichment	PTPN11	3.13
16	Werner syndrome	Enrichment	PTPN11	2.83
17	Immunodeficiency 104, severe combined	Enrichment	PTPRC	2.83
18	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.83
19	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.66
20	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1	2.66
21	Tricuspid valve insufficiency	Enrichment	PTPN11	2.66
22	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.53
23	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.53
24	Lymphoma	Enrichment	PTPN11	2.43
25	Patent ductus arteriosus	Enrichment	PTPN11	2.35
26	Noonan syndrome 3	Enrichment	PTPN11	2.29
27	Pectus excavatum	Enrichment	PTPN11	2.09
28	Combined immunodeficiency	Enrichment	ZAP70	2.09
29	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	2.09
30	Specific learning disability	Enrichment	PTPN11	2.09
31	Combined t and b cell immunodeficiency	Enrichment	ZAP70	2.09
32	Epicanthus	Enrichment	PTPN11	2.05
33	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.05
34	Congenital long qt syndrome	Enrichment	PTPN11	2.05
35	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.96
36	Patent foramen ovale	Enrichment	PTPN11	1.88
37	Noonan syndrome 1	Enrichment	PTPN11	1.77
38	Scoliosis	Enrichment	PTPN11	1.76
39	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.72
40	Rasopathy	Enrichment	PTPN11	1.72
41	Strabismus	Enrichment	PTPN11	1.70
42	Long qt syndrome 1	Enrichment	PTPN11	1.66
43	Non-immune hydrops fetalis	Enrichment	PTPN11	1.65
44	Nephronophthisis	Enrichment	PIAS1	1.62
45	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.50
46	Thrombocytopenia	Enrichment	PTPN11	1.46
47	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.39
48	Autism spectrum disorder	Enrichment	PTPN11	1.11
49	Microcephaly	Enrichment	PTPN11	1.06
50	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	1.03

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interferon type I signaling pathways

Pathway Network for Interferon type I signaling pathways

Member Pathways for Interferon type I signaling pathways

Pathways in the Interferon type I signaling pathways SuperPath

Associated Genes for Interferon type I signaling pathways

Associated Disorders for Interferon type I signaling pathways

Disorders associated with Interferon type I signaling pathways SuperPath

STRING Interaction Network for Interferon type I signaling pathways

Sources for Interferon type I signaling pathways