Interleukin-10 signaling

No Pathway Network information available for Interleukin-10 signaling

Pathways in the Interleukin-10 signaling SuperPath

#	Name	Source	Genes
1	Interleukin-10 signaling	Reactome	CCL19 CCL2 CCL20 CCL22 CCL3 CCL3L1 CCL3L3 CCL4 CCL4L1 CCL5 CCR1 CCR2 CCR5 CD80 CD86 CSF1 CSF2 CSF3 CXCL1 CXCL10 CXCL2 CXCL8 FCER2 FPR1 ICAM1 IL10 IL10RA IL10RB IL12A IL12B IL18 IL1A IL1B IL1R1 IL1R2 IL1RN IL6 JAK1 LIF PTAFR PTGS2 STAT3 TIMP1 TNFRSF1B TYK2 (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CCR1	C-C Motif Chemokine Receptor 1	Protein Coding	1
2	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	1
3	CSF1	Colony Stimulating Factor 1	Protein Coding	1
4	CSF2	Colony Stimulating Factor 2	Protein Coding	1
5	CSF3	Colony Stimulating Factor 3	Protein Coding	1
6	FCER2	Fc Epsilon Receptor II	Protein Coding	1
7	FPR1	Formyl Peptide Receptor 1	Protein Coding	1
8	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	1
9	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	1
10	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
11	IL1A	Interleukin 1 Alpha	Protein Coding	1
12	IL1B	Interleukin 1 Beta	Protein Coding	1
13	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
14	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	1
15	IL6	Interleukin 6	Protein Coding	1
16	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
17	IL10	Interleukin 10	Protein Coding	1
18	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	1
19	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	1
20	IL12A	Interleukin 12A	Protein Coding	1
21	IL12B	Interleukin 12B	Protein Coding	1
22	IL18	Interleukin 18	Protein Coding	1
23	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
24	JAK1	Janus Kinase 1	Protein Coding	1
25	CCL4L1	C-C Motif Chemokine Ligand 4 Like 1	Protein Coding	1
26	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	1
27	CCL3L3	C-C Motif Chemokine Ligand 3 Like 3	Protein Coding	1
28	PTAFR	Platelet Activating Factor Receptor	Protein Coding	1
29	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
30	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
31	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	1
32	CCL3L1	C-C Motif Chemokine Ligand 3 Like 1	Protein Coding	1
33	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	1
34	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	1
35	CCL19	C-C Motif Chemokine Ligand 19	Protein Coding	1
36	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	1
37	CCL22	C-C Motif Chemokine Ligand 22	Protein Coding	1
38	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
39	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	1
40	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
41	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	1
42	TYK2	Tyrosine Kinase 2	Protein Coding	1
43	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	1
44	CD80	CD80 Molecule	Protein Coding	1
45	CD86	CD86 Molecule	Protein Coding	1

Disorders associated with Interleukin-10 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Human immunodeficiency virus type 1	Enrichment	CCL2, CCL3, CCL3L1, CCL5, CCR2, CCR5, IL10	16.00
2	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, IL10RA, IL10RB	6.17
3	Behcet syndrome	Enrichment	CCR1, IL10, IL12A	4.50
4	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	4.49
5	Immunodeficiency 35	Enrichment	TYK2	2.48
6	Polycystic lung disease	Enrichment	CCR2	2.48
7	Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis	Enrichment	IL1RN	2.48
8	Graft-versus-host disease	Enrichment	IL10	2.48
9	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.48
10	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.48
11	Microvascular complications of diabetes 4	Enrichment	IL1RN	2.48
12	Immunodeficiency 29	Enrichment	IL12B	2.48
13	Type 1 diabetes mellitus 22	Enrichment	CCR5	2.48
14	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.48
15	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.48
16	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.48
17	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.48
18	West nile virus	Enrichment	CCR5	2.18
19	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	2.18
20	Inflammatory bowel disease 28	Enrichment	IL10RA	2.18
21	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.18
22	Lymphomatoid papulosis	Enrichment	TYK2	2.18
23	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.18
24	Gastric cancer	Enrichment	IL1B, IL1RN	2.05
25	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.00
26	Takayasu arteritis	Enrichment	IL12B	2.00
27	Mycosis fungoides	Enrichment	TNFRSF1B	2.00
28	Hepatitis c virus	Enrichment	CCR5	2.00
29	Hyper ige syndrome	Enrichment	STAT3	2.00
30	Inflammatory bowel disease 25	Enrichment	IL10RB	2.00
31	Aggressive periodontitis	Enrichment	FPR1	2.00
32	Saczary syndrome	Enrichment	TNFRSF1B	2.00
33	Kaposi sarcoma	Enrichment	IL6	1.88
34	Hepatitis b	Enrichment	IL10RB	1.88
35	Cerebral malaria	Enrichment	ICAM1	1.88
36	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.88
37	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.78
38	Type 1 diabetes mellitus	Enrichment	IL6	1.70
39	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	1.70
40	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.58
41	Rheumatoid arthritis	Enrichment	IL10	1.53
42	Inflammatory bowel disease 1	Enrichment	IL6	1.53
43	Primary biliary cholangitis	Enrichment	IL12A	1.53
44	Acute promyelocytic leukemia	Enrichment	STAT3	1.37
45	Arteriovenous malformations of the brain	Enrichment	IL6	1.21
46	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.21
47	Malaria	Enrichment	ICAM1	1.13
48	Autoinflammatory disease	Enrichment	IL1RN	1.12
49	Severe covid-19	Enrichment	IL10RB	1.04
50	Systemic lupus erythematosus	Enrichment	IL10	0.91
51	Type 2 diabetes mellitus	Enrichment	IL6	0.88

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-10 signaling

Pathway Network for Interleukin-10 signaling

Member Pathways for Interleukin-10 signaling

Pathways in the Interleukin-10 signaling SuperPath

Associated Genes for Interleukin-10 signaling

Associated Disorders for Interleukin-10 signaling

Disorders associated with Interleukin-10 signaling SuperPath

STRING Interaction Network for Interleukin-10 signaling

Sources for Interleukin-10 signaling