Interleukin-11 signaling pathway

No Pathway Network information available for Interleukin-11 signaling pathway

Pathways in the Interleukin-11 signaling pathway SuperPath

#	Name	Source	Genes
1	Interleukin-11 signaling pathway	WikiPathways	AKT1 ATF1 BCL2 BGLAP BIRC5 CHUK CREB1 FES FYN GRB2 HRAS IBSP ICAM1 IKBKB IL11 IL11RA IL6ST ITGA2 JAK1 JAK2 MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIAS1 PIAS3 PIK3R1 PIK3R2 PTPA PTPN11 RAF1 RELA RPS6 RPS6KA1 RPS6KB1 RUNX2 SOCS3 SRC STAT1 STAT3 TGFB1 TYK2 YES1 (see all 44) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
2	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
3	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
4	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
5	TYK2	Tyrosine Kinase 2	Protein Coding	1
6	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
7	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
8	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
9	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
10	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	1
11	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
12	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
13	RPS6	Ribosomal Protein S6	Protein Coding	1
14	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
15	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
16	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
17	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
18	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
19	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
20	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
21	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
22	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
23	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
24	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
25	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
26	ATF1	Activating Transcription Factor 1	Protein Coding	1
27	JAK2	Janus Kinase 2	Protein Coding	1
28	JAK1	Janus Kinase 1	Protein Coding	1
29	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
30	IL11RA	Interleukin 11 Receptor Subunit Alpha	Protein Coding	1
31	IL11	Interleukin 11	Protein Coding	1
32	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
33	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
34	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
35	IBSP	Integrin Binding Sialoprotein	Protein Coding	1
36	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
37	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
38	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
39	FES	FES Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
40	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
41	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
42	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
43	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
44	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1

Disorders associated with Interleukin-11 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1	9.08
2	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1	8.04
3	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1	7.75
4	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.50
5	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1	5.96
6	Melanoma of soft tissue	Enrichment	ATF1, CREB1	4.51
7	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.21
8	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.21
9	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.21
10	Myelofibrosis	Enrichment	JAK2, SRC	3.67
11	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.55
12	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.44
13	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.34
14	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1	3.26
15	Specific learning disability	Enrichment	MAPK1, PTPN11	3.26
16	Colorectal cancer	Enrichment	AKT1, PIK3R1, SRC	2.55
17	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.50
18	Proteus syndrome	Enrichment	AKT1	2.49
19	Metachondromatosis	Enrichment	PTPN11	2.49
20	Immunodeficiency 35	Enrichment	TYK2	2.49
21	Noonan syndrome 5	Enrichment	RAF1	2.49
22	Melorheostosis, isolated	Enrichment	MAP2K1	2.49
23	Dermatitis, atopic, 4	Enrichment	SOCS3	2.49
24	Leopard syndrome 1	Enrichment	PTPN11	2.49
25	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.49
26	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.49
27	Fetal encasement syndrome	Enrichment	CHUK	2.49
28	Craniosynostosis and dental anomalies	Enrichment	IL11RA	2.49
29	Immunodeficiency 15b	Enrichment	IKBKB	2.49
30	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.49
31	Noonan syndrome 13	Enrichment	MAPK1	2.49
32	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.49
33	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.49
34	Immunodeficiency 15a	Enrichment	IKBKB	2.49
35	Short syndrome	Enrichment	PIK3R1	2.49
36	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.49
37	Melorheostosis	Enrichment	MAP2K1	2.49
38	Leopard syndrome 2	Enrichment	RAF1	2.49
39	Immunodeficiency 31a	Enrichment	STAT1	2.49
40	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.49
41	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.49
42	Cowden syndrome 6	Enrichment	AKT1	2.49
43	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.49
44	Immunodeficiency 31b	Enrichment	STAT1	2.49
45	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.49
46	Thrombocytopenia 6	Enrichment	SRC	2.49
47	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.49
48	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.49
49	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.49
50	Trigonitis	Enrichment	RAF1	2.49
51	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.49
52	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.49
53	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.49
54	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.49
55	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.49
56	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.49
57	Malignant astrocytoma	Enrichment	PTPN11	2.49
58	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.35
59	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.19
60	Camurati-engelmann disease 1	Enrichment	TGFB1	2.19
61	Costello syndrome	Enrichment	HRAS	2.19
62	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.19
63	Thrombocythemia 3	Enrichment	JAK2	2.19
64	Immunodeficiency 31c	Enrichment	STAT1	2.19
65	Werner syndrome	Enrichment	PTPN11	2.19
66	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.19
67	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.19
68	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.19
69	Rela fusion-positive ependymoma	Enrichment	RELA	2.19
70	Camurati-engelmann disease	Enrichment	TGFB1	2.19
71	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.19
72	Polycythemia	Enrichment	JAK2	2.19
73	Lymphomatoid papulosis	Enrichment	TYK2	2.19
74	Hypereosinophilic syndrome	Enrichment	JAK2	2.19
75	Tafro syndrome	Enrichment	MAP2K2	2.19
76	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.19
77	Wooly hair nevus	Enrichment	HRAS	2.19
78	Cleidocranial dysplasia 1	Enrichment	RUNX2	2.01
79	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.01
80	Polycythemia vera	Enrichment	JAK2	2.01
81	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.01
82	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.01
83	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.01
84	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.01
85	Large congenital melanocytic nevus	Enrichment	HRAS	2.01
86	Hyper ige syndrome	Enrichment	STAT3	2.01
87	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.01
88	Immunodeficiency 14	Enrichment	PIK3R1	2.01
89	Cleidocranial dysplasia	Enrichment	RUNX2	2.01
90	Spermatocytoma	Enrichment	HRAS	2.01
91	Tricuspid valve insufficiency	Enrichment	PTPN11	2.01
92	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.01
93	Thrombocytopenia	Enrichment	PTPN11, SRC	1.98
94	Erythrocytosis, familial, 1	Enrichment	JAK2	1.89
95	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.89
96	Budd-chiari syndrome	Enrichment	JAK2	1.89
97	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.89
98	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.89
99	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.89
100	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.89
101	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.89
102	Epidermolytic nevus	Enrichment	HRAS	1.89
103	Cerebral malaria	Enrichment	ICAM1	1.89
104	Follicular lymphoma	Enrichment	BCL2	1.79
105	Lymphoma	Enrichment	PTPN11	1.79
106	Myeloproliferative neoplasm	Enrichment	JAK2	1.79
107	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.71
108	Patent ductus arteriosus	Enrichment	PTPN11	1.71
109	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.71
110	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2	1.71
111	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.71
112	Breast adenocarcinoma	Enrichment	AKT1	1.71
113	Nevus, epidermal	Enrichment	HRAS	1.65
114	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.65
115	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.65
116	Essential thrombocythemia	Enrichment	JAK2	1.65
117	Pilomyxoid astrocytoma	Enrichment	RAF1	1.65
118	Follicular thyroid carcinoma	Enrichment	HRAS	1.65
119	Overgrowth syndrome	Enrichment	PIK3R1	1.65
120	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.59
121	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.54
122	Cowden syndrome	Enrichment	AKT1	1.54
123	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.50
124	Pectus excavatum	Enrichment	PTPN11	1.45
125	Epicanthus	Enrichment	PTPN11	1.42
126	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.42
127	Meningioma	Enrichment	AKT1	1.42
128	Lip and oral cavity carcinoma	Enrichment	HRAS	1.42
129	Congenital long qt syndrome	Enrichment	PTPN11	1.42
130	Acute promyelocytic leukemia	Enrichment	STAT3	1.38
131	Osteoporosis	Enrichment	SRC	1.35
132	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.31
133	Rhabdomyosarcoma	Enrichment	HRAS	1.30
134	Heart, malformation of	Enrichment	MAPK1	1.25
135	Patent foramen ovale	Enrichment	PTPN11	1.25
136	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.22
137	Microcephaly	Enrichment	MAPK1, PTPN11	1.22
138	Craniosynostosis	Enrichment	IL11RA	1.20
139	Malaria	Enrichment	ICAM1	1.14
140	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.12
141	Scoliosis	Enrichment	PTPN11	1.12
142	Strabismus	Enrichment	PTPN11	1.08
143	Bladder cancer	Enrichment	HRAS	1.05
144	Differentiated thyroid carcinoma	Enrichment	HRAS	1.05
145	Long qt syndrome 1	Enrichment	PTPN11	1.03
146	Cystic fibrosis	Enrichment	TGFB1	1.01
147	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.99
148	Nephronophthisis	Enrichment	PIAS1	0.99
149	Severe combined immunodeficiency	Enrichment	IKBKB	0.99
150	Left ventricular noncompaction	Enrichment	RAF1	0.97
151	Leukemia, acute myeloid	Enrichment	JAK2	0.91
152	Nephrotic syndrome	Enrichment	RUNX2	0.88
153	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.88
154	Hereditary breast carcinoma	Enrichment	AKT1	0.87
155	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.80
156	Myeloma, multiple	Enrichment	PIK3R2	0.78
157	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.78
158	Primary ovarian insufficiency	Enrichment	JAK2	0.76
159	Breast cancer	Enrichment	AKT1	0.66
160	Dilated cardiomyopathy	Enrichment	RAF1	0.64
161	Ovarian cancer	Enrichment	AKT1	0.55
162	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.46

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-11 signaling pathway

Pathway Network for Interleukin-11 signaling pathway

Member Pathways for Interleukin-11 signaling pathway

Pathways in the Interleukin-11 signaling pathway SuperPath

Associated Genes for Interleukin-11 signaling pathway

Associated Disorders for Interleukin-11 signaling pathway

Disorders associated with Interleukin-11 signaling pathway SuperPath

STRING Interaction Network for Interleukin-11 signaling pathway

Sources for Interleukin-11 signaling pathway