Interleukin-12 family signaling

Pathway network for the Interleukin-12 family signaling SuperPath

Sources:

Reactome

Pathways in the Interleukin-12 family signaling SuperPath

#	Name	Source	Genes
1	Interleukin-12 family signaling	Reactome	AIP ANXA2 ARF1 BOLA2 BOLA2B CA1 CANX CAPZA1 CDC42 CFL1 CNN2 CRLF1 EBI3 GSTA2 GSTO1 HNRNPA2B1 HNRNPDL HNRNPF HSPA9 IFNG IL10 IL12A IL12B IL12RB1 IL12RB2 IL23A IL23R IL27 IL27RA IL6ST JAK1 JAK2 LCP1 LMNB1 MIF MSN MTAP P4HB PAK2 PDCD4 PITPNA PPIA PSME2 RALA RAP1B RPLP0 SERPINB2 SNRPA1 SOD1 SOD2 STAT1 STAT3 STAT4 TALDO1 TCP1 TYK2 VAMP7 (see all 57) (see less)
2	Interleukin-12 signaling	Reactome	AIP ANXA2 ARF1 BOLA2 BOLA2B CA1 CAPZA1 CDC42 CFL1 CNN2 GSTA2 GSTO1 HNRNPA2B1 HNRNPDL HNRNPF HSPA9 IFNG IL10 IL12A IL12B IL12RB1 IL12RB2 JAK1 JAK2 LCP1 LMNB1 MIF MSN MTAP P4HB PAK2 PDCD4 PITPNA PPIA PSME2 RALA RAP1B RPLP0 SERPINB2 SNRPA1 SOD1 SOD2 STAT4 TALDO1 TCP1 TYK2 VAMP7 (see all 47) (see less)
3	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Reactome	AIP ANXA2 ARF1 BOLA2 BOLA2B CA1 CAPZA1 CDC42 CFL1 CNN2 GSTA2 GSTO1 HNRNPA2B1 HNRNPDL HNRNPF HSPA9 IFNG IL10 LCP1 LMNB1 MIF MSN MTAP PAK2 PDCD4 PITPNA PPIA PSME2 RALA RAP1B RPLP0 SERPINB2 SNRPA1 SOD1 SOD2 STAT4 TALDO1 TCP1 (see all 38) (see less)
4	Interleukin-35 Signalling	Reactome	CANX EBI3 IL12A IL12RB2 IL27RA IL6ST JAK1 JAK2 STAT1 STAT3 STAT4 TYK2 (see all 12) (see less)
5	Interleukin-27 signaling	Reactome	CANX CRLF1 EBI3 IL27 IL27RA IL6ST JAK1 JAK2 STAT1 STAT3 TYK2 (see all 11) (see less)
6	Interleukin-23 signaling	Reactome	IL12B IL12RB1 IL23A IL23R JAK2 P4HB STAT3 STAT4 TYK2 (see all 9) (see less)

Gene overlap in member pathways for Interleukin-12 family signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	JAK2	Janus Kinase 2	Protein Coding	5
2	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	5
3	TYK2	Tyrosine Kinase 2	Protein Coding	5
4	JAK1	Janus Kinase 1	Protein Coding	4
5	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	4
6	EBI3	Epstein-Barr Virus Induced 3	Protein Coding	3
7	CFL1	Cofilin 1	Protein Coding	3
8	CNN2	Calponin 2	Protein Coding	3
9	PDCD4	Programmed Cell Death 4	Protein Coding	3
10	GSTA2	Glutathione S-Transferase Alpha 2	Protein Coding	3
11	ANXA2	Annexin A2	Protein Coding	3
12	HNRNPA2B1	Heterogeneous Nuclear Ribonucleoprotein A2/B1	Protein Coding	3
13	HNRNPF	Heterogeneous Nuclear Ribonucleoprotein F	Protein Coding	3
14	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	3
15	IFNG	Interferon Gamma	Protein Coding	3
16	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	3
17	IL10	Interleukin 10	Protein Coding	3
18	IL12A	Interleukin 12A	Protein Coding	3
19	IL12B	Interleukin 12B	Protein Coding	3
20	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	3
21	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	3
22	ARF1	ARF GTPase 1	Protein Coding	3
23	LCP1	Lymphocyte Cytosolic Protein 1	Protein Coding	3
24	LMNB1	Lamin B1	Protein Coding	3
25	MIF	Macrophage Migration Inhibitory Factor	Protein Coding	3
26	MSN	Moesin	Protein Coding	3
27	MTAP	Methylthioadenosine Phosphorylase	Protein Coding	3
28	P4HB	Prolyl 4-Hydroxylase Subunit Beta	Protein Coding	3
29	SERPINB2	Serpin Family B Member 2	Protein Coding	3
30	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	3
31	PITPNA	Phosphatidylinositol Transfer Protein Alpha	Protein Coding	3
32	PPIA	Peptidylprolyl Isomerase A	Protein Coding	3
33	BOLA2	BolA Family Member 2	Protein Coding	3
34	PSME2	Proteasome Activator Subunit 2	Protein Coding	3
35	RALA	RAS Like Proto-Oncogene A	Protein Coding	3
36	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	3
37	RPLP0	Ribosomal Protein Lateral Stalk Subunit P0	Protein Coding	3
38	BOLA2B	BolA Family Member 2B	Protein Coding	3
39	SNRPA1	Small Nuclear Ribonucleoprotein Polypeptide A''	Protein Coding	3
40	SOD1	Superoxide Dismutase 1	Protein Coding	3
41	SOD2	Superoxide Dismutase 2	Protein Coding	3
42	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	3
43	TALDO1	Transaldolase 1	Protein Coding	3
44	TCP1	T-Complex 1	Protein Coding	3
45	CA1	Carbonic Anhydrase 1	Protein Coding	3
46	CANX	Calnexin	Protein Coding	3
47	CAPZA1	Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1	Protein Coding	3
48	AIP	AHR Interacting HSP90 Co-Chaperone	Protein Coding	3
49	GSTO1	Glutathione S-Transferase Omega 1	Protein Coding	3
50	IL27RA	Interleukin 27 Receptor Subunit Alpha	Protein Coding	3
51	CDC42	Cell Division Cycle 42	Protein Coding	3
52	HNRNPDL	Heterogeneous Nuclear Ribonucleoprotein D Like	Protein Coding	3
53	IL23R	Interleukin 23 Receptor	Protein Coding	2
54	IL27	Interleukin 27	Protein Coding	2
55	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	2
56	VAMP7	Vesicle Associated Membrane Protein 7	Protein Coding	2
57	CRLF1	Cytokine Receptor Like Factor 1	Protein Coding	2

Disorders associated with Interleukin-12 family signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	9.39
2	Behcet syndrome	Enrichment	IL10, IL12A, IL23R, STAT4	5.98
3	Primary biliary cholangitis	Enrichment	IL12A, IL12RB1	3.38
4	Cole-carpenter syndrome 1	Enrichment	P4HB	3.18
5	Immunodeficiency 35	Enrichment	TYK2	3.18
6	Immunodeficiency 30	Enrichment	IL12RB1	3.18
7	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	3.18
8	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.18
9	Systemic lupus erythematosus 11	Enrichment	STAT4	3.18
10	Psoriasis 7	Enrichment	IL23R	3.18
11	Immunodeficiency 29	Enrichment	IL12B	3.18
12	Inflammatory bowel disease 17	Enrichment	IL23R	3.18
13	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.18
14	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.18
15	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.18
16	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	3.09
17	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	3.09
18	Immunodeficiency 31a	Enrichment	STAT1	3.09
19	Immunodeficiency 31b	Enrichment	STAT1	3.09
20	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	3.09
21	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	3.09
22	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.09
23	Human immunodeficiency virus type 1	Enrichment	IFNG, IL10	2.94
24	Thrombocythemia 3	Enrichment	JAK2	2.88
25	Polycythemia	Enrichment	JAK2	2.88
26	Lymphomatoid papulosis	Enrichment	TYK2	2.88
27	Hypereosinophilic syndrome	Enrichment	JAK2	2.88
28	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.88
29	Immunodeficiency 31c	Enrichment	STAT1	2.79
30	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.79
31	Cold-induced sweating syndrome including crisponi syndrome	Enrichment	CRLF1	2.79
32	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.70
33	Takayasu arteritis	Enrichment	IL12B	2.70
34	Polycythemia vera	Enrichment	JAK2	2.70
35	Hyper ige syndrome	Enrichment	STAT3	2.70
36	Cole-carpenter syndrome	Enrichment	P4HB	2.70
37	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.61
38	Cone-rod dystrophy 12	Enrichment	CRLF1	2.61
39	Cold-induced sweating syndrome	Enrichment	CRLF1	2.61
40	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.61
41	Erythrocytosis, familial, 1	Enrichment	JAK2	2.58
42	Budd-chiari syndrome	Enrichment	JAK2	2.58
43	Pediatric systemic lupus erythematosus	Enrichment	STAT4	2.58
44	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.55
45	Immunodeficiency 50	Enrichment	MSN	2.55
46	Muscular dystrophy, limb-girdle, autosomal dominant 3	Enrichment	HNRNPDL	2.55
47	Microvascular complications of diabetes 6	Enrichment	SOD2	2.55
48	Even-plus syndrome	Enrichment	HSPA9	2.55
49	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.55
50	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	2.55
51	Immunodeficiency 69	Enrichment	IFNG	2.55
52	Knobloch syndrome 2	Enrichment	PAK2	2.55
53	Intellectual developmental disorder with polymicrogyria and seizures	Enrichment	TCP1	2.55
54	Graft-versus-host disease	Enrichment	IL10	2.55
55	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.55
56	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.55
57	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	Enrichment	HNRNPA2B1	2.55
58	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.55
59	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.55
60	Oculopharyngeal muscular dystrophy 2	Enrichment	HNRNPA2B1	2.55
61	Nocarh syndrome	Enrichment	CDC42	2.55
62	Cold-induced sweating syndrome 1	Enrichment	CRLF1	2.49
63	Idiopathic achalasia	Enrichment	CRLF1	2.49
64	Myeloproliferative neoplasm	Enrichment	JAK2	2.48
65	Osteogenesis imperfecta, type i	Enrichment	P4HB	2.40
66	Crisponi/cold-induced sweating syndrome 1	Enrichment	CRLF1	2.39
67	Myelofibrosis	Enrichment	JAK2	2.33
68	Essential thrombocythemia	Enrichment	JAK2	2.33
69	Oligoarticular juvenile idiopathic arthritis	Enrichment	STAT4	2.33
70	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	STAT4	2.33
71	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.31
72	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.28
73	Systemic lupus erythematosus	Enrichment	IL10, STAT4	2.28
74	Diaphyseal medullary stenosis with malignant fibrous histiocytoma	Enrichment	MTAP	2.25
75	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.25
76	Transaldolase deficiency	Enrichment	TALDO1	2.25
77	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.25
78	Immune system disease	Enrichment	CDC42	2.25
79	Autosomal dominant primary microcephaly	Enrichment	LMNB1	2.25
80	Acromegaly	Enrichment	AIP	2.25
81	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.25
82	Null pituitary adenoma	Enrichment	AIP	2.25
83	Diaphyseal medullary stenosis-bone malignancy syndrome	Enrichment	MTAP	2.25
84	Familial isolated pituitary adenoma	Enrichment	AIP	2.25
85	Silent pituitary adenoma	Enrichment	AIP	2.25
86	Gigantism	Enrichment	AIP	2.25
87	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	2.22
88	Tuberous sclerosis 1	Enrichment	IFNG	2.08
89	Hepatitis c virus	Enrichment	IFNG	2.08
90	Tuberous sclerosis 2	Enrichment	IFNG	2.08
91	Pituitary adenoma 1, multiple types	Enrichment	AIP	2.08
92	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	HNRNPA2B1	2.08
93	Growth hormone secreting pituitary adenoma	Enrichment	AIP	2.08
94	Aip familial isolated pituitary adenomas	Enrichment	AIP	2.08
95	Acute promyelocytic leukemia	Enrichment	STAT3	2.07
96	Myopathy, autophagic vacuolar, infantile-onset	Enrichment	HNRNPA2B1	1.95
97	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.95
98	Prolactinoma	Enrichment	AIP	1.95
99	Knobloch syndrome	Enrichment	PAK2	1.95
100	Systemic-onset juvenile idiopathic arthritis	Enrichment	MIF	1.95
101	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	HNRNPA2B1, SOD1	1.94
102	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.90
103	Rheumatoid arthritis, systemic juvenile	Enrichment	MIF	1.86
104	Knobloch syndrome 1	Enrichment	PAK2	1.86
105	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	1.86
106	Idiopathic aplastic anemia	Enrichment	IFNG	1.86
107	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	1.78
108	Motor neuron disease	Enrichment	SOD1	1.71
109	Rheumatoid arthritis	Enrichment	IL10	1.60
110	Leukemia, acute myeloid	Enrichment	JAK2	1.58
111	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.56
112	Aplastic anemia	Enrichment	IFNG	1.56
113	Primary ovarian insufficiency	Enrichment	JAK2	1.41
114	Periventricular nodular heterotopia	Enrichment	ARF1	1.41
115	46,xy partial gonadal dysgenesis	Enrichment	VAMP7	1.32
116	Cystic fibrosis	Enrichment	MIF	1.07
117	Hereditary breast ovarian cancer syndrome	Enrichment	LCP1	0.84
118	Complex neurodevelopmental disorder	Enrichment	RALA	0.53
119	Inherited cancer-predisposing syndrome	Enrichment	AIP	0.51

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-12 family signaling

Pathway Network for Interleukin-12 family signaling

Pathway network for the Interleukin-12 family signaling SuperPath

Member Pathways for Interleukin-12 family signaling

Pathways in the Interleukin-12 family signaling SuperPath

Gene overlap in member pathways for Interleukin-12 family signaling SuperPath

Associated Genes for Interleukin-12 family signaling

Associated Disorders for Interleukin-12 family signaling

Disorders associated with Interleukin-12 family signaling SuperPath

STRING Interaction Network for Interleukin-12 family signaling

Sources for Interleukin-12 family signaling