Interleukin-1 family signaling

Pathway network for the Interleukin-1 family signaling SuperPath

Sources:

Reactome

Pathways in the Interleukin-1 family signaling SuperPath

#	Name	Source	Genes
1	Interleukin-1 family signaling	Reactome	ADRM1 AGER ALOX5 ALPK1 APP BTRC CASP1 CASP8 CHUK CTSG CUL1 FBXW11 GSDMD HMGB1 IKBIP IKBKB IKBKG IL13 IL18 IL18BP IL18R1 IL18RAP IL1A IL1B IL1F10 IL1R1 IL1R2 IL1RAP IL1RAPL1 IL1RL1 IL1RL2 IL1RN IL33 IL36A IL36B IL36G IL36RN IL37 IL4 IRAK1 IRAK2 IRAK3 IRAK4 LRRC14 MAP2K1 MAP2K4 MAP2K6 MAP3K3 MAP3K7 MAP3K8 MAPK8 MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTPN11 PTPN12 PTPN13 PTPN14 PTPN18 PTPN2 PTPN20 PTPN23 PTPN4 PTPN5 PTPN6 PTPN7 PTPN9 RBX1 RELA RIPK2 RPS27A S100A12 S100B SAA1 SEM1 SIGIRR SKP1 SMAD3 SQSTM1 STAT3 TAB1 TAB2 TAB3 TBK1 TIFA TNIP2 TOLLIP TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 (see all 139) (see less)
2	Interleukin-1 signaling	Reactome	ADRM1 AGER ALPK1 APP BTRC CASP8 CHUK CUL1 FBXW11 HMGB1 IKBIP IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 IL1RAP IL1RN IRAK1 IRAK2 IRAK3 IRAK4 LRRC14 MAP2K1 MAP2K4 MAP2K6 MAP3K3 MAP3K7 MAP3K8 MYD88 N4BP1 NFKB1 NFKB2 NFKBIA NFKBIB NKIRAS1 NKIRAS2 NLRC5 NLRX1 NOD1 NOD2 PELI1 PELI2 PELI3 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RBX1 RELA RIPK2 RPS27A S100A12 S100B SAA1 SEM1 SKP1 SQSTM1 TAB1 TAB2 TAB3 TIFA TNIP2 TOLLIP TP53 TRAF2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 USP14 USP18 (see all 101) (see less)
3	Interleukin-18 signaling	Reactome	ALOX5 IL13 IL18 IL18BP IL18R1 IL18RAP IL37 IL4 (see all 8) (see less)
4	Interleukin-38 signaling	Reactome	IL1F10 IL1RAPL1 IL1RL2 MAPK8

Gene overlap in member pathways for Interleukin-1 family signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL18BP	Interleukin 18 Binding Protein	Protein Coding	2
2	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	2
3	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	2
4	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	2
5	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	2
6	IL1RAPL1	Interleukin 1 Receptor Accessory Protein Like 1	Protein Coding	2
7	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	2
8	USP18	Ubiquitin Specific Peptidase 18	Protein Coding	2
9	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
10	IKBIP	IKBKB Interacting Protein	Protein Coding	2
11	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	2
12	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	2
13	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	2
14	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	2
15	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	2
16	PELI3	Pellino E3 Ubiquitin Protein Ligase Family Member 3	Protein Coding	2
17	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	2
18	IL37	Interleukin 37	Protein Coding	2
19	NKIRAS2	NFKB Inhibitor Interacting Ras Like 2	Protein Coding	2
20	NKIRAS1	NFKB Inhibitor Interacting Ras Like 1	Protein Coding	2
21	HMGB1	High Mobility Group Box 1	Protein Coding	2
22	APP	Amyloid Beta Precursor Protein	Protein Coding	2
23	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
24	IL1A	Interleukin 1 Alpha	Protein Coding	2
25	IL1B	Interleukin 1 Beta	Protein Coding	2
26	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	2
27	IL1RAP	Interleukin 1 Receptor Accessory Protein	Protein Coding	2
28	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	2
29	IL4	Interleukin 4	Protein Coding	2
30	IL13	Interleukin 13	Protein Coding	2
31	IL18	Interleukin 18	Protein Coding	2
32	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	2
33	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	2
34	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	2
35	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	2
36	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
37	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
38	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
39	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
40	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	2
41	TOLLIP	Toll Interacting Protein	Protein Coding	2
42	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
43	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
44	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
45	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
46	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
47	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
48	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
49	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
50	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
51	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
52	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
53	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
54	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
55	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
56	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
57	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
58	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
59	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	2
60	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	2
61	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	2
62	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	2
63	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	2
64	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	2
65	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	2
66	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	2
67	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	2
68	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	2
69	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	2
70	PELI2	Pellino E3 Ubiquitin Protein Ligase Family Member 2	Protein Coding	2
71	PELI1	Pellino E3 Ubiquitin Protein Ligase 1	Protein Coding	2
72	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	2
73	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	2
74	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	2
75	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
76	RPS27A	Ribosomal Protein S27a	Protein Coding	2
77	S100A12	S100 Calcium Binding Protein A12	Protein Coding	2
78	S100B	S100 Calcium Binding Protein B	Protein Coding	2
79	SAA1	Serum Amyloid A1	Protein Coding	2
80	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	2
81	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
82	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	2
83	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
84	TP53	Tumor Protein P53	Protein Coding	2
85	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	2
86	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
87	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
88	UBB	Ubiquitin B	Protein Coding	2
89	UBC	Ubiquitin C	Protein Coding	2
90	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	2
91	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	2
92	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	2
93	TNIP2	TNFAIP3 Interacting Protein 2	Protein Coding	2
94	NLRX1	NLR Family Member X1	Protein Coding	2
95	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	2
96	ALPK1	Alpha Kinase 1	Protein Coding	2
97	CASP8	Caspase 8	Protein Coding	2
98	NLRC5	NLR Family CARD Domain Containing 5	Protein Coding	2
99	CUL1	Cullin 1	Protein Coding	2
100	IL1F10	Interleukin 1 Family Member 10	Protein Coding	2
101	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
102	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	2
103	IL18RAP	Interleukin 18 Receptor Accessory Protein	Protein Coding	2
104	IL1RL2	Interleukin 1 Receptor Like 2	Protein Coding	2
105	IL18R1	Interleukin 18 Receptor 1	Protein Coding	2
106	SQSTM1	Sequestosome 1	Protein Coding	2
107	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	2
108	USP14	Ubiquitin Specific Peptidase 14	Protein Coding	2
109	TIFA	TRAF Interacting Protein With Forkhead Associated Domain	Protein Coding	2
110	N4BP1	NEDD4 Binding Protein 1	Protein Coding	2
111	LRRC14	Leucine Rich Repeat Containing 14	Protein Coding	2
112	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	2
113	RBX1	Ring-Box 1	Protein Coding	2
114	CTSG	Cathepsin G	Protein Coding	1
115	PTPN23	Protein Tyrosine Phosphatase Non-Receptor Type 23	Protein Coding	1
116	PTPN20	Protein Tyrosine Phosphatase Non-Receptor Type 20	Protein Coding	1
117	PTPN18	Protein Tyrosine Phosphatase Non-Receptor Type 18	Protein Coding	1
118	IL36RN	Interleukin 36 Receptor Antagonist	Protein Coding	1
119	IL36B	Interleukin 36 Beta	Protein Coding	1
120	IL36A	Interleukin 36 Alpha	Protein Coding	1
121	TBK1	TANK Binding Kinase 1	Protein Coding	1
122	SMAD3	SMAD Family Member 3	Protein Coding	1
123	IL36G	Interleukin 36 Gamma	Protein Coding	1
124	PTPN2	Protein Tyrosine Phosphatase Non-Receptor Type 2	Protein Coding	1
125	PTPN4	Protein Tyrosine Phosphatase Non-Receptor Type 4	Protein Coding	1
126	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
127	PTPN7	Protein Tyrosine Phosphatase Non-Receptor Type 7	Protein Coding	1
128	PTPN9	Protein Tyrosine Phosphatase Non-Receptor Type 9	Protein Coding	1
129	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
130	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	1
131	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	1
132	PTPN14	Protein Tyrosine Phosphatase Non-Receptor Type 14	Protein Coding	1
133	SIGIRR	Single Ig And TIR Domain Containing	Protein Coding	1
134	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
135	GSDMD	Gasdermin D	Protein Coding	1
136	CASP1	Caspase 1	Protein Coding	1
137	PTPN5	Protein Tyrosine Phosphatase Non-Receptor Type 5	Protein Coding	1
138	IL33	Interleukin 33	Protein Coding	1
139	IL1RL1	Interleukin 1 Receptor Like 1	Protein Coding	1

Disorders associated with Interleukin-1 family signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Asthma	Enrichment	ALOX5, IL13	4.78
2	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	4.26
3	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.26
4	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	4.26
5	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	3.79
6	Intellectual developmental disorder, x-linked 21	Enrichment	IL1RAPL1	3.53
7	Allergic rhinitis	Enrichment	IL13	3.23
8	Hepatitis, fulminant viral	Enrichment	IL18BP	3.23
9	Inflammatory bowel disease 31, autosomal recessive	Enrichment	IL37	3.23
10	Atherosclerosis	Enrichment	ALOX5	3.23
11	Inflammatory bowel disease	Enrichment	IL37	3.23
12	Patent foramen ovale	Enrichment	PSMC3, PTPN11, TAB2	3.11
13	Diffuse large b-cell lymphoma	Enrichment	MYD88, STAT3, TP53	3.04
14	Lymphoma	Enrichment	PTPN11, TP53	2.99
15	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.95
16	Isolated split hand-split foot malformation	Enrichment	BTRC, SEM1	2.83
17	Patent ductus arteriosus	Enrichment	PSMC3, PTPN11	2.82
18	Autoinflammatory disease	Enrichment	IL1RN, IL36RN, NOD2	2.74
19	Adult hepatocellular carcinoma	Enrichment	CASP8, TP53	2.72
20	Gastric cancer	Enrichment	IL1B, IL1RN, TP53	2.40
21	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1, TBK1	2.35
22	Gliosarcoma	Enrichment	NFKBIA, TP53	2.21
23	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	2.16
24	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.13
25	Paget disease of bone 3	Enrichment	SQSTM1	2.13
26	Incontinentia pigmenti	Enrichment	IKBKG	2.13
27	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.13
28	Immunodeficiency 68	Enrichment	MYD88	2.13
29	Caspase 8 deficiency	Enrichment	CASP8	2.13
30	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.13
31	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.13
32	Melorheostosis, isolated	Enrichment	MAP2K1	2.13
33	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.13
34	Fetal encasement syndrome	Enrichment	CHUK	2.13
35	Blau syndrome	Enrichment	NOD2	2.13
36	Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis	Enrichment	IL1RN	2.13
37	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.13
38	Immunodeficiency 15b	Enrichment	IKBKB	2.13
39	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.13
40	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.13
41	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.13
42	Immunodeficiency 15a	Enrichment	IKBKB	2.13
43	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.13
44	Bone marrow failure syndrome 5	Enrichment	TP53	2.13
45	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.13
46	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.13
47	Papilloma of choroid plexus	Enrichment	TP53	2.13
48	Basal cell carcinoma 7	Enrichment	TP53	2.13
49	Anaplastic thyroid carcinoma	Enrichment	TP53	2.13
50	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.13
51	Asthma-related traits 5	Enrichment	IRAK3	2.13
52	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.13
53	Microvascular complications of diabetes 4	Enrichment	IL1RN	2.13
54	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.13
55	Melorheostosis	Enrichment	MAP2K1	2.13
56	Immunodeficiency 67	Enrichment	IRAK4	2.13
57	Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome	Enrichment	ALPK1	2.13
58	Ductal carcinoma in situ	Enrichment	TP53	2.13
59	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.13
60	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.13
61	Pseudo-torch syndrome 2	Enrichment	USP18	2.13
62	Serum amyloid a amyloidosis	Enrichment	SAA1	2.13
63	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.13
64	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.13
65	Alpk1-related autoinflammatory disease	Enrichment	ALPK1	2.13
66	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.13
67	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.13
68	Choroid plexus cancer	Enrichment	TP53	2.13
69	Waldenstram macroglobulinemia	Enrichment	MYD88	2.13
70	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.13
71	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.13
72	Verrucous hemangioma	Enrichment	MAP3K3	2.13
73	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.13
74	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, PTPN11	2.00
75	Metachondromatosis	Enrichment	PTPN11	1.99
76	Leopard syndrome 1	Enrichment	PTPN11	1.99
77	Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity	Enrichment	PTPN23	1.99
78	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	1.99
79	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	1.99
80	Choanal atresia and lymphedema	Enrichment	PTPN14	1.99
81	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	1.99
82	Corticobasal syndrome	Enrichment	TBK1	1.99
83	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	1.99
84	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	1.99
85	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	1.99
86	Bullous pyoderma gangrenosum	Enrichment	PTPN6	1.99
87	Pustular pyoderma gangrenosum	Enrichment	PTPN6	1.99
88	Lymphedema-posterior choanal atresia syndrome	Enrichment	PTPN14	1.99
89	Classic pyoderma gangrenosum	Enrichment	PTPN6	1.99
90	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	1.99
91	Malignant astrocytoma	Enrichment	PTPN11	1.99
92	Non-syndromic x-linked intellectual disability	Enrichment	IL1RAPL1	1.98
93	Hepatocellular carcinoma	Enrichment	CASP8, TP53	1.94
94	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	1.83
95	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.83
96	Cervical cancer	Enrichment	TP53	1.83
97	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.83
98	Welander distal myopathy	Enrichment	SQSTM1	1.83
99	Yao syndrome	Enrichment	NOD2	1.83
100	Lymphoma, hodgkin, classic	Enrichment	TP53	1.83
101	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.83
102	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.83
103	Diamond-blackfan anemia 12	Enrichment	NKIRAS1	1.83
104	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	1.83
105	Birk-aharoni syndrome	Enrichment	PSMC1	1.83
106	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.83
107	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.83
108	Rela fusion-positive ependymoma	Enrichment	RELA	1.83
109	Congenital fibrosarcoma	Enrichment	TP53	1.83
110	Li-fraumeni syndrome 1	Enrichment	TP53	1.83
111	Sarcoma	Enrichment	TP53	1.83
112	Congenital dyserythropoietic anemia	Enrichment	IRAK4	1.83
113	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.83
114	Cervix carcinoma	Enrichment	TP53	1.83
115	Hodgkin's lymphoma	Enrichment	TP53	1.83
116	Paget's disease of bone	Enrichment	SQSTM1	1.83
117	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.83
118	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.83
119	Crohn's disease	Enrichment	NOD2	1.83
120	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.83
121	Common variable immunodeficiency 12	Enrichment	NFKB1	1.83
122	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.83
123	Submucosal cleft palate	Enrichment	UBB	1.83
124	Cleft hard palate	Enrichment	UBB	1.83
125	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	1.83
126	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.69
127	Psoriasis 14, pustular	Enrichment	IL36RN	1.69
128	Werner syndrome	Enrichment	PTPN11	1.69
129	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	1.69
130	Pelvic organ prolapse	Enrichment	TAB2	1.65
131	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.65
132	Uvula, bifid	Enrichment	UBB	1.65
133	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.65
134	Osteogenic sarcoma	Enrichment	TP53	1.65
135	Cleft soft palate	Enrichment	UBB	1.65
136	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.65
137	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.65
138	Anaplastic astrocytoma	Enrichment	TP53	1.65
139	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.65
140	Squamous cell carcinoma	Enrichment	TP53	1.65
141	Adenocarcinoma	Enrichment	TP53	1.65
142	Bone osteosarcoma	Enrichment	TP53	1.65
143	Thyroid hemiagenesis	Enrichment	PSMD3	1.65
144	Noonan syndrome 1	Enrichment	MAP2K1, PTPN11	1.64
145	Lung cancer	Enrichment	CASP8, MAP3K8	1.63
146	Rasopathy	Enrichment	MAP2K1, PTPN11	1.54
147	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.53
148	Small cell cancer of the lung	Enrichment	TP53	1.53
149	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.53
150	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.53
151	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.53
152	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.53
153	Lung sarcomatoid carcinoma	Enrichment	TP53	1.53
154	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.53
155	Paget's disease of bone 2	Enrichment	SQSTM1	1.53
156	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.53
157	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.52
158	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.52
159	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.52
160	Hyper ige syndrome	Enrichment	STAT3	1.52
161	Tricuspid valve insufficiency	Enrichment	PTPN11	1.52
162	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.44
163	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.44
164	Rhabdomyosarcoma 2	Enrichment	TP53	1.44
165	Acute megakaryocytic leukemia	Enrichment	TP53	1.44
166	Aortic aneurysm	Enrichment	SMAD3	1.39
167	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.39
168	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.39
169	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.36
170	Li-fraumeni syndrome	Enrichment	TP53	1.36
171	Adrenocortical carcinoma	Enrichment	TP53	1.36
172	Breast adenocarcinoma	Enrichment	TP53	1.36
173	Herpes simplex virus encephalitis	Enrichment	TBK1	1.30
174	Esophageal cancer	Enrichment	TP53	1.29
175	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.29
176	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.29
177	Alzheimer's disease 1	Enrichment	APP	1.29
178	Essential thrombocythemia	Enrichment	TP53	1.29
179	Gallbladder cancer	Enrichment	TP53	1.29
180	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.29
181	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.29
182	Glioma susceptibility 1	Enrichment	TP53	1.24
183	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.24
184	Inflammatory bowel disease 1	Enrichment	NOD2	1.19
185	Coronary heart disease 5	Enrichment	IKBKG	1.19
186	Arteriovenous malformation	Enrichment	MAP2K1	1.19
187	Primary hyperaldosteronism	Enrichment	TP53	1.19
188	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.19
189	Noonan syndrome 3	Enrichment	PTPN11	1.16
190	Motor neuron disease	Enrichment	TBK1	1.16
191	Oligoarticular juvenile idiopathic arthritis	Enrichment	PTPN2	1.16
192	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	PTPN2	1.16
193	Leukemia, chronic lymphocytic	Enrichment	TP53	1.14
194	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.14
195	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.14
196	Polymicrogyria	Enrichment	PSMC3	1.14
197	Familial colorectal cancer	Enrichment	TP53	1.14
198	Migraine with or without aura 1	Enrichment	TAB2	1.10
199	Myelodysplastic syndrome	Enrichment	TP53	1.10
200	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.10
201	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.10
202	Lip and oral cavity carcinoma	Enrichment	TP53	1.07
203	Loeys-dietz syndrome	Enrichment	SMAD3	1.05
204	Progressive non-fluent aphasia	Enrichment	TBK1	1.05
205	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.05
206	Aortic valve disease 1	Enrichment	TAB2	1.03
207	Alzheimer's disease	Enrichment	APP	1.03
208	Lung cancer susceptibility 3	Enrichment	TP53	1.00
209	Pectus excavatum	Enrichment	PTPN11	0.97
210	Specific learning disability	Enrichment	PTPN11	0.97
211	Breast cancer	Enrichment	CASP8, TP53	0.97
212	Rhabdomyosarcoma	Enrichment	TP53	0.95
213	Epicanthus	Enrichment	PTPN11	0.93
214	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	0.93
215	Congenital long qt syndrome	Enrichment	PTPN11	0.93
216	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1, TBK1	0.92
217	Alzheimer disease, familial, 1	Enrichment	APP	0.92
218	Acute promyelocytic leukemia	Enrichment	STAT3	0.90
219	Behcet syndrome	Enrichment	NOD2	0.88
220	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.87
221	Complex neurodevelopmental disorder	Enrichment	FBXW11, PSMD12, PTPN23	0.87
222	Hepatoblastoma	Enrichment	TP53	0.84
223	Myocardial infarction	Enrichment	PSMA6	0.82
224	Multisystem inflammatory syndrome in children	Enrichment	IRAK3	0.82
225	Diamond-blackfan anemia 1	Enrichment	TP53	0.80
226	Malaria	Enrichment	IKBKG	0.80
227	Pancreatic cancer	Enrichment	TP53	0.77
228	Ehlers-danlos syndrome	Enrichment	SMAD3	0.75
229	Bladder cancer	Enrichment	TP53	0.71
230	Prostate cancer	Enrichment	TP53	0.71
231	Severe combined immunodeficiency	Enrichment	IKBKB	0.66
232	Scoliosis	Enrichment	PTPN11	0.66
233	Colorectal cancer	Enrichment	PTPN12, TP53	0.65
234	Hydrops fetalis, nonimmune	Enrichment	PTPN11	0.63
235	Diamond-blackfan anemia	Enrichment	TP53	0.63
236	Strabismus	Enrichment	PTPN11	0.61
237	Systemic lupus erythematosus	Enrichment	IRAK1	0.60
238	Leukemia, acute myeloid	Enrichment	TP53	0.59
239	Long qt syndrome 1	Enrichment	PTPN11	0.58
240	Non-immune hydrops fetalis	Enrichment	PTPN11	0.56
241	Hereditary breast carcinoma	Enrichment	TP53	0.55
242	Connective tissue disease	Enrichment	SMAD3	0.55
243	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	0.51
244	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.47
245	Myeloma, multiple	Enrichment	TP53	0.47
246	Hereditary spastic paraplegia	Enrichment	PTPN23	0.45
247	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.45
248	Microcephaly	Enrichment	PSMC3, PTPN11	0.44
249	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3	0.44
250	Thrombocytopenia	Enrichment	PTPN11	0.41
251	Inherited cancer-predisposing syndrome	Enrichment	PTPN11, TP53	0.41
252	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.36
253	Dilated cardiomyopathy	Enrichment	TAB2	0.35
254	Ovarian cancer	Enrichment	TP53	0.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-1 family signaling

Pathway Network for Interleukin-1 family signaling

Pathway network for the Interleukin-1 family signaling SuperPath

Member Pathways for Interleukin-1 family signaling

Pathways in the Interleukin-1 family signaling SuperPath

Gene overlap in member pathways for Interleukin-1 family signaling SuperPath

Associated Genes for Interleukin-1 family signaling

Associated Disorders for Interleukin-1 family signaling

Disorders associated with Interleukin-1 family signaling SuperPath

STRING Interaction Network for Interleukin-1 family signaling

Sources for Interleukin-1 family signaling