Interleukin-1 induced activation of NF-kB

No Pathway Network information available for Interleukin-1 induced activation of NF-kB

#	Name	Source	Genes
1	Interleukin-1 induced activation of NF-kB	WikiPathways	AJUBA IL1A IRAK1 PRKCZ SQSTM1 TIFA TRAF6 UBE2N UBE2V1 (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SQSTM1	Sequestosome 1	Protein Coding	1
2	AJUBA	Ajuba LIM Protein	Protein Coding	1
3	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
4	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
5	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
6	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
7	IL1A	Interleukin 1 Alpha	Protein Coding	1
8	TIFA	TRAF Interacting Protein With Forkhead Associated Domain	Protein Coding	1
9	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Paget disease of bone 3	Enrichment	SQSTM1	3.18
2	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	3.18
3	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	3.18
4	Welander distal myopathy	Enrichment	SQSTM1	2.88
5	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.88
6	Paget's disease of bone	Enrichment	SQSTM1	2.88
7	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.88
8	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	2.58
9	Paget's disease of bone 2	Enrichment	SQSTM1	2.58
10	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.58
11	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.48
12	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	2.22
13	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	2.18
14	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	2.07
15	Systemic lupus erythematosus	Enrichment	IRAK1	1.59
16	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	1.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Interleukin-1 induced activation of NF-kB