Interleukin-20 family signaling

No Pathway Network information available for Interleukin-20 family signaling

Pathways in the Interleukin-20 family signaling SuperPath

#	Name	Source	Genes
1	Interleukin-20 family signaling	Reactome	IFNL1 IFNL2 IFNL3 IFNLR1 IL10RB IL19 IL20 IL20RA IL20RB IL22 IL22RA1 IL22RA2 IL24 IL26 JAK1 JAK2 JAK3 PTPN11 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B TYK2 (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL24	Interleukin 24	Protein Coding	1
2	IL22RA2	Interleukin 22 Receptor Subunit Alpha 2	Protein Coding	1
3	IFNLR1	Interferon Lambda Receptor 1	Protein Coding	1
4	IFNL2	Interferon Lambda 2	Protein Coding	1
5	IFNL3	Interferon Lambda 3	Protein Coding	1
6	IFNL1	Interferon Lambda 1	Protein Coding	1
7	IL19	Interleukin 19	Protein Coding	1
8	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	1
9	JAK1	Janus Kinase 1	Protein Coding	1
10	JAK2	Janus Kinase 2	Protein Coding	1
11	JAK3	Janus Kinase 3	Protein Coding	1
12	IL20	Interleukin 20	Protein Coding	1
13	IL22	Interleukin 22	Protein Coding	1
14	IL20RA	Interleukin 20 Receptor Subunit Alpha	Protein Coding	1
15	IL20RB	Interleukin 20 Receptor Subunit Beta	Protein Coding	1
16	IL26	Interleukin 26	Protein Coding	1
17	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
18	IL22RA1	Interleukin 22 Receptor Subunit Alpha 1	Protein Coding	1
19	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
20	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
21	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
22	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
23	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
24	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
25	TYK2	Tyrosine Kinase 2	Protein Coding	1

Disorders associated with Interleukin-20 family signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	8.26
2	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.60
3	Severe covid-19	Enrichment	IL10RB, JAK3	2.89
4	Metachondromatosis	Enrichment	PTPN11	2.73
5	Immunodeficiency 35	Enrichment	TYK2	2.73
6	Leopard syndrome 1	Enrichment	PTPN11	2.73
7	Pseudo-torch syndrome 3	Enrichment	STAT2	2.73
8	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.73
9	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.73
10	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.73
11	Systemic lupus erythematosus 11	Enrichment	STAT4	2.73
12	Immunodeficiency 31a	Enrichment	STAT1	2.73
13	Immunodeficiency 31b	Enrichment	STAT1	2.73
14	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.73
15	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.73
16	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.73
17	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.73
18	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.73
19	Malignant astrocytoma	Enrichment	PTPN11	2.73
20	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.43
21	Thrombocythemia 3	Enrichment	JAK2	2.43
22	Immunodeficiency 31c	Enrichment	STAT1	2.43
23	Werner syndrome	Enrichment	PTPN11	2.43
24	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.43
25	Polycythemia	Enrichment	JAK2	2.43
26	Lymphomatoid papulosis	Enrichment	TYK2	2.43
27	Hypereosinophilic syndrome	Enrichment	JAK2	2.43
28	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.43
29	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.43
30	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.26
31	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.26
32	Polycythemia vera	Enrichment	JAK2	2.26
33	Hepatitis c virus	Enrichment	IFNL3	2.26
34	Hyper ige syndrome	Enrichment	STAT3	2.26
35	Inflammatory bowel disease 25	Enrichment	IL10RB	2.26
36	Immunodeficiency 44	Enrichment	STAT2	2.26
37	Tricuspid valve insufficiency	Enrichment	PTPN11	2.26
38	Erythrocytosis, familial, 1	Enrichment	JAK2	2.13
39	Budd-chiari syndrome	Enrichment	JAK2	2.13
40	Hepatitis b	Enrichment	IL10RB	2.13
41	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.13
42	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.13
43	Adenosine deaminase deficiency	Enrichment	JAK3	2.13
44	Pediatric systemic lupus erythematosus	Enrichment	STAT4	2.13
45	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	2.04
46	Lymphoma	Enrichment	PTPN11	2.04
47	Myeloproliferative neoplasm	Enrichment	JAK2	2.04
48	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	1.96
49	Patent ductus arteriosus	Enrichment	PTPN11	1.96
50	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.96
51	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10RB	1.96
52	Myelofibrosis	Enrichment	JAK2	1.89
53	Noonan syndrome 3	Enrichment	PTPN11	1.89
54	Essential thrombocythemia	Enrichment	JAK2	1.89
55	Oligoarticular juvenile idiopathic arthritis	Enrichment	STAT4	1.89
56	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	STAT4	1.89
57	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.83
58	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.78
59	Pectus excavatum	Enrichment	PTPN11	1.70
60	Specific learning disability	Enrichment	PTPN11	1.70
61	Epicanthus	Enrichment	PTPN11	1.66
62	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.66
63	Congenital long qt syndrome	Enrichment	PTPN11	1.66
64	Nk-cell enteropathy	Enrichment	JAK3	1.63
65	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.56
66	Human immunodeficiency virus type 1	Enrichment	IL19	1.49
67	Patent foramen ovale	Enrichment	PTPN11	1.49
68	Behcet syndrome	Enrichment	STAT4	1.46
69	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.46
70	Multisystem inflammatory syndrome in children	Enrichment	IL22RA2	1.40
71	Noonan syndrome 1	Enrichment	PTPN11	1.38
72	Scoliosis	Enrichment	PTPN11	1.36
73	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.33
74	Rasopathy	Enrichment	PTPN11	1.33
75	Strabismus	Enrichment	PTPN11	1.31
76	Long qt syndrome 1	Enrichment	PTPN11	1.27
77	Non-immune hydrops fetalis	Enrichment	PTPN11	1.25
78	Severe combined immunodeficiency	Enrichment	JAK3	1.23
79	Systemic lupus erythematosus	Enrichment	STAT4	1.16
80	Leukemia, acute myeloid	Enrichment	JAK2	1.15
81	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.12
82	Thrombocytopenia	Enrichment	PTPN11	1.07
83	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.01
84	Primary ovarian insufficiency	Enrichment	JAK2	0.99
85	Autism spectrum disorder	Enrichment	PTPN11	0.74
86	Microcephaly	Enrichment	PTPN11	0.69
87	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-20 family signaling

Pathway Network for Interleukin-20 family signaling

Member Pathways for Interleukin-20 family signaling

Pathways in the Interleukin-20 family signaling SuperPath

Associated Genes for Interleukin-20 family signaling

Associated Disorders for Interleukin-20 family signaling

Disorders associated with Interleukin-20 family signaling SuperPath

STRING Interaction Network for Interleukin-20 family signaling

Sources for Interleukin-20 family signaling