Interleukin-2 family signaling

Pathway network for the Interleukin-2 family signaling SuperPath

Sources:

Reactome

Pathways in the Interleukin-2 family signaling SuperPath

#	Name	Source	Genes
1	Interleukin-2 family signaling	Reactome	CSF2 CSF2RA CSF2RB GAB2 GRB2 HAVCR2 IL15 IL15RA IL2 IL21 IL21R IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IL9 IL9R INPP5D INPPL1 JAK1 JAK2 JAK3 LCK LGALS9 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTK2B PTPN6 SHC1 SOS1 SOS2 STAT1 STAT3 STAT4 STAT5A STAT5B SYK (see all 44) (see less)
2	Interleukin-3, Interleukin-5 and GM-CSF signaling	Reactome	BLNK CBL CRK CRKL CSF2 CSF2RA CSF2RB FYN GAB2 GRB2 HCK IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INPP5D INPPL1 JAK1 JAK2 JAK3 LYN PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKACA PTPN11 PTPN6 RAPGEF1 RPS27A SHC1 SOS1 STAT5A STAT5B SYK UBA52 UBB UBC VAV1 YES1 YWHAZ (see all 47) (see less)
3	Signaling by CSF1 (M-CSF) in myeloid cells	Reactome	CBL CSF1 CSF1R FYN GAB2 GAB3 GRAP2 GRB2 HCK IL34 INPP5D INPPL1 KRAS LYN PIK3CA PIK3CB PIK3CD PIK3R1 PLCG2 PTPN11 RPS27A SHC1 SOS1 SRC STAT1 STAT3 THOC5 UBA52 UBB UBC YES1 (see all 31) (see less)
4	Interleukin receptor SHC signaling	Reactome	CSF2 CSF2RA CSF2RB GAB2 GRB2 IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA INPP5D INPPL1 JAK1 JAK2 JAK3 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTPN6 SHC1 SOS1 (see all 27) (see less)
5	Regulation of signaling by CBL	Reactome	BLNK CBL CRK CRKL FYN GRB2 HCK LYN PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 RAPGEF1 RPS27A SYK UBA52 UBB UBC VAV1 YES1 (see all 22) (see less)
6	Interleukin-15 signaling	Reactome	GAB2 GRB2 IL15 IL15RA IL2RB IL2RG JAK1 JAK3 SHC1 SOS1 SOS2 STAT3 STAT5A STAT5B (see all 14) (see less)
7	Interleukin-21 signaling	Reactome	IL21 IL21R IL2RG JAK1 JAK3 STAT1 STAT3 STAT4 STAT5A STAT5B (see all 10) (see less)

Gene overlap in member pathways for Interleukin-2 family signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	6
2	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	5
3	JAK1	Janus Kinase 1	Protein Coding	5
4	JAK3	Janus Kinase 3	Protein Coding	5
5	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	5
6	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	5
7	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	5
8	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	5
9	SHC1	SHC Adaptor Protein 1	Protein Coding	5
10	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	5
11	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	5
12	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	4
13	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	4
14	INPPL1	Inositol Polyphosphate Phosphatase Like 1	Protein Coding	4
15	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	4
16	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	4
17	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	4
18	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	4
19	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	4
20	CSF2	Colony Stimulating Factor 2	Protein Coding	3
21	CSF2RA	Colony Stimulating Factor 2 Receptor Subunit Alpha	Protein Coding	3
22	CSF2RB	Colony Stimulating Factor 2 Receptor Subunit Beta	Protein Coding	3
23	IL2	Interleukin 2	Protein Coding	3
24	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	3
25	IL3	Interleukin 3	Protein Coding	3
26	IL3RA	Interleukin 3 Receptor Subunit Alpha	Protein Coding	3
27	IL5	Interleukin 5	Protein Coding	3
28	IL5RA	Interleukin 5 Receptor Subunit Alpha	Protein Coding	3
29	JAK2	Janus Kinase 2	Protein Coding	3
30	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	3
31	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	3
32	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	3
33	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
34	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
35	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
36	RPS27A	Ribosomal Protein S27a	Protein Coding	3
37	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
38	UBB	Ubiquitin B	Protein Coding	3
39	UBC	Ubiquitin C	Protein Coding	3
40	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	3
41	CBL	Cbl Proto-Oncogene	Protein Coding	3
42	IL15	Interleukin 15	Protein Coding	2
43	IL15RA	Interleukin 15 Receptor Subunit Alpha	Protein Coding	2
44	IL21R	Interleukin 21 Receptor	Protein Coding	2
45	IL21	Interleukin 21	Protein Coding	2
46	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
47	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	2
48	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
49	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	2
50	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	2
51	BLNK	B Cell Linker	Protein Coding	2
52	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
53	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
54	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
55	IL9	Interleukin 9	Protein Coding	1
56	IL9R	Interleukin 9 Receptor	Protein Coding	1
57	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
58	LGALS9	Galectin 9	Protein Coding	1
59	HAVCR2	Hepatitis A Virus Cellular Receptor 2	Protein Coding	1
60	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
61	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
62	GAB3	GRB2 Associated Binding Protein 3	Protein Coding	1
63	CSF1	Colony Stimulating Factor 1	Protein Coding	1
64	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
65	IL34	Interleukin 34	Protein Coding	1
66	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
67	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
68	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
69	THOC5	THO Complex Subunit 5	Protein Coding	1
70	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	1

Disorders associated with Interleukin-2 family signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, KRAS, PTPN11, SOS1	7.52
2	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.50
3	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11, YWHAZ	6.81
4	Noonan syndrome 1	Enrichment	CBL, KRAS, PTPN11, SOS1	6.72
5	Rasopathy	Enrichment	CBL, KRAS, PTPN11, SOS1	6.49
6	Noonan syndrome 3	Enrichment	KRAS, PTPN11, SOS1	6.42
7	Autosomal non-syndromic agammaglobulinemia	Enrichment	BLNK, PIK3CD, PIK3R1	6.36
8	Immunodeficiency 31c	Enrichment	IL21R, STAT1	6.31
9	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.96
10	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.96
11	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, PTPN11	5.63
12	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.12
13	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	5.12
14	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	5.12
15	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.82
16	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	4.42
17	Hereditary pulmonary alveolar proteinosis	Enrichment	CSF2RA, CSF2RB	4.42
18	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.12
19	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.12
20	Nevus, epidermal	Enrichment	KRAS, PIK3CA	3.98
21	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.98
22	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.98
23	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	3.93
24	Lung non-small cell carcinoma	Enrichment	KRAS, PIK3CA	3.56
25	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	3.53
26	Breast cancer	Enrichment	IL2, PIK3CA, SHC1	3.36
27	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.28
28	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	3.13
29	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	3.13
30	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.13
31	Systemic lupus erythematosus 11	Enrichment	STAT4	3.13
32	Immunodeficiency 31a	Enrichment	STAT1	3.13
33	Immunodeficiency 31b	Enrichment	STAT1	3.13
34	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.13
35	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	3.13
36	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.13
37	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.13
38	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.13
39	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, SRC	3.00
40	Noonan syndrome 4	Enrichment	SOS1	2.99
41	Noonan syndrome 9	Enrichment	SOS2	2.99
42	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.99
43	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.83
44	Immunodeficiency 56	Enrichment	IL21R	2.83
45	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.83
46	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.83
47	Macrodactyly	Enrichment	PIK3CA	2.79
48	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.79
49	Cowden syndrome 5	Enrichment	PIK3CA	2.79
50	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.79
51	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.79
52	Short syndrome	Enrichment	PIK3R1	2.79
53	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.79
54	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.79
55	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.79
56	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.79
57	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.79
58	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.79
59	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.79
60	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.79
61	Hypospadias	Enrichment	PIK3CA	2.79
62	Colitis	Enrichment	SYK	2.79
63	Rare venous malformation	Enrichment	PIK3CA	2.79
64	Diaphragmatic eventration	Enrichment	PIK3CA	2.79
65	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.79
66	Rare combined vascular malformation	Enrichment	PIK3CA	2.79
67	Cavernous lymphangioma	Enrichment	PIK3CA	2.79
68	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.79
69	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.79
70	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.79
71	Macrodactyly of toe	Enrichment	PIK3CA	2.79
72	Bladder cancer	Enrichment	KRAS, PIK3CA	2.70
73	Surfactant metabolism dysfunction, pulmonary, 4	Enrichment	CSF2RA	2.70
74	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.70
75	Surfactant metabolism dysfunction, pulmonary, 5	Enrichment	CSF2RB	2.70
76	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.70
77	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.70
78	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.70
79	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.70
80	Fibromatosis, gingival, 1	Enrichment	SOS1	2.69
81	Pulmonic stenosis	Enrichment	SOS1	2.69
82	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.66
83	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.66
84	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	2.66
85	Combined immunodeficiency, x-linked	Enrichment	IL2RG	2.66
86	Hyper ige syndrome	Enrichment	STAT3	2.66
87	Immunodeficiency, common variable, 11	Enrichment	IL21	2.66
88	Non-immune hydrops fetalis	Enrichment	KRAS, PTPN11	2.65
89	Metachondromatosis	Enrichment	PTPN11	2.64
90	Oculoectodermal syndrome	Enrichment	KRAS	2.64
91	Leopard syndrome 1	Enrichment	PTPN11	2.64
92	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.64
93	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.64
94	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.64
95	Thrombocytopenia 6	Enrichment	SRC	2.64
96	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.64
97	Csf1r-related disorder	Enrichment	CSF1R	2.64
98	Congenital pulmonary airway malformation	Enrichment	KRAS	2.64
99	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.64
100	Malignant astrocytoma	Enrichment	PTPN11	2.64
101	Lung cancer	Enrichment	KRAS, PIK3CA	2.62
102	Adenosine deaminase deficiency	Enrichment	JAK3	2.53
103	Pediatric systemic lupus erythematosus	Enrichment	STAT4	2.53
104	Nuchal bleb, familial	Enrichment	SOS1	2.51
105	Ovarian germ cell cancer	Enrichment	CBL	2.49
106	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	2.49
107	Keratosis, seborrheic	Enrichment	PIK3CA	2.49
108	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.49
109	Noonan syndrome 8	Enrichment	PIK3CA	2.49
110	Agammaglobulinemia 4	Enrichment	BLNK	2.49
111	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.49
112	Immune system disease	Enrichment	PIK3CD	2.49
113	Arthritis	Enrichment	SYK	2.49
114	Malignant germ cell tumor of ovary	Enrichment	CBL	2.49
115	Submucosal cleft palate	Enrichment	UBB	2.49
116	Cleft hard palate	Enrichment	UBB	2.49
117	Immunodeficiency 22	Enrichment	LCK	2.49
118	T-cell lymphoma, subcutaneous panniculitis-like	Enrichment	HAVCR2	2.49
119	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.46
120	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.46
121	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	2.43
122	Schneckenbecken dysplasia	Enrichment	INPPL1	2.40
123	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.40
124	Thrombocythemia 3	Enrichment	JAK2	2.40
125	Polycythemia	Enrichment	JAK2	2.40
126	Hypereosinophilic syndrome	Enrichment	JAK2	2.40
127	Gingival fibromatosis	Enrichment	SOS1	2.38
128	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.38
129	Gastric cancer	Enrichment	KRAS, PIK3CA	2.37
130	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.35
131	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.35
132	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.34
133	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	2.34
134	Werner syndrome	Enrichment	PTPN11	2.34
135	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.31
136	Uvula, bifid	Enrichment	UBB	2.31
137	Cleft soft palate	Enrichment	UBB	2.31
138	Keratoacanthoma	Enrichment	PIK3CA	2.31
139	Severe combined immunodeficiency	Enrichment	JAK3, LCK	2.29
140	Thrombocytopenia	Enrichment	PTPN11, SRC	2.27
141	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.23
142	Opsismodysplasia	Enrichment	INPPL1	2.22
143	Polycythemia vera	Enrichment	JAK2	2.22
144	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.22
145	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	2.19
146	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.19
147	Cerebrovascular disease	Enrichment	PIK3CA	2.19
148	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.19
149	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	2.16
150	Tricuspid valve insufficiency	Enrichment	PTPN11	2.16
151	Fibrolamellar carcinoma	Enrichment	PRKACA	2.16
152	Omenn syndrome	Enrichment	IL2RG	2.13
153	Erythrocytosis, familial, 1	Enrichment	JAK2	2.10
154	Budd-chiari syndrome	Enrichment	JAK2	2.10
155	Combined immunodeficiency	Enrichment	IL2RG	2.09
156	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	2.09
157	Combined t and b cell immunodeficiency	Enrichment	IL2RG	2.09
158	Capillary malformations, congenital	Enrichment	PIK3CA	2.09
159	Hemimegalencephaly	Enrichment	PIK3CA	2.09
160	Aggressive systemic mastocytosis	Enrichment	CBL	2.09
161	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS	2.04
162	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.04
163	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.04
164	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.04
165	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.04
166	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	2.04
167	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.04
168	Pilocytic astrocytoma	Enrichment	KRAS	2.04
169	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.01
170	Cowden syndrome 1	Enrichment	PIK3CA	2.01
171	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.01
172	Ichthyosis	Enrichment	IL2RB	1.95
173	Overgrowth syndrome	Enrichment	PIK3R1	1.95
174	Lymphoma	Enrichment	PTPN11	1.94
175	Aortic valve disease 1	Enrichment	SOS1	1.87
176	Patent ductus arteriosus	Enrichment	PTPN11	1.87
177	Myelofibrosis	Enrichment	JAK2	1.86
178	Essential thrombocythemia	Enrichment	JAK2	1.86
179	Behcet syndrome	Enrichment	STAT4	1.86
180	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.86
181	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.84
182	Arteriovenous malformation	Enrichment	PIK3CA	1.84
183	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.84
184	Cowden syndrome	Enrichment	PIK3CA	1.84
185	Leukemia, chronic myeloid	Enrichment	KRAS	1.80
186	Pilomyxoid astrocytoma	Enrichment	KRAS	1.80
187	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.79
188	Immune deficiency disease	Enrichment	SYK	1.75
189	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.75
190	Meningioma	Enrichment	PIK3CA	1.71
191	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.71
192	Severe covid-19	Enrichment	JAK3	1.67
193	Ovarian cancer	Enrichment	KRAS, PIK3CA	1.65
194	Pectus excavatum	Enrichment	PTPN11	1.60
195	Frontotemporal dementia 1	Enrichment	CSF1R	1.60
196	Specific learning disability	Enrichment	PTPN11	1.60
197	Rhabdomyosarcoma	Enrichment	CBL	1.59
198	Epicanthus	Enrichment	PTPN11	1.57
199	Congenital long qt syndrome	Enrichment	PTPN11	1.57
200	Systemic lupus erythematosus	Enrichment	STAT4	1.55
201	Alzheimer's disease	Enrichment	CSF1R	1.53
202	Ellis-van creveld syndrome	Enrichment	PRKACA	1.51
203	Osteoporosis	Enrichment	SRC	1.50
204	Lung cancer susceptibility 3	Enrichment	KRAS	1.50
205	Endometrial cancer	Enrichment	PIK3CA	1.47
206	Hepatocellular carcinoma	Enrichment	PIK3CA	1.45
207	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.42
208	Patent foramen ovale	Enrichment	PTPN11	1.39
209	Arteriovenous malformations of the brain	Enrichment	KRAS	1.37
210	Prostate cancer	Enrichment	PIK3CA	1.34
211	Scoliosis	Enrichment	PTPN11	1.27
212	Pancreatic cancer	Enrichment	KRAS	1.25
213	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.24
214	Strabismus	Enrichment	PTPN11	1.22
215	Differentiated thyroid carcinoma	Enrichment	KRAS	1.19
216	Long qt syndrome 1	Enrichment	PTPN11	1.18
217	Leukemia, acute myeloid	Enrichment	JAK2	1.12
218	Hypertelorism	Enrichment	PIK3CA	1.09
219	Myeloma, multiple	Enrichment	PIK3R2	1.06
220	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.03
221	Primary ovarian insufficiency	Enrichment	JAK2	0.95
222	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.93
223	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.92
224	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.90
225	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.80
226	Autism spectrum disorder	Enrichment	PTPN11	0.65
227	Microcephaly	Enrichment	PTPN11	0.61
228	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-2 family signaling

Pathway Network for Interleukin-2 family signaling

Pathway network for the Interleukin-2 family signaling SuperPath

Member Pathways for Interleukin-2 family signaling

Pathways in the Interleukin-2 family signaling SuperPath

Gene overlap in member pathways for Interleukin-2 family signaling SuperPath

Associated Genes for Interleukin-2 family signaling

Associated Disorders for Interleukin-2 family signaling

Disorders associated with Interleukin-2 family signaling SuperPath

STRING Interaction Network for Interleukin-2 family signaling

Sources for Interleukin-2 family signaling