Interleukin-37 signaling

No Pathway Network information available for Interleukin-37 signaling

Pathways in the Interleukin-37 signaling SuperPath

#	Name	Source	Genes
1	Interleukin-37 signaling	Reactome	CASP1 IL18BP IL18R1 IL37 PTPN11 PTPN12 PTPN13 PTPN14 PTPN18 PTPN2 PTPN20 PTPN23 PTPN4 PTPN5 PTPN6 PTPN7 PTPN9 SIGIRR SMAD3 STAT3 TBK1 (see all 21) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL18BP	Interleukin 18 Binding Protein	Protein Coding	1
2	PTPN23	Protein Tyrosine Phosphatase Non-Receptor Type 23	Protein Coding	1
3	PTPN20	Protein Tyrosine Phosphatase Non-Receptor Type 20	Protein Coding	1
4	PTPN18	Protein Tyrosine Phosphatase Non-Receptor Type 18	Protein Coding	1
5	IL37	Interleukin 37	Protein Coding	1
6	TBK1	TANK Binding Kinase 1	Protein Coding	1
7	SMAD3	SMAD Family Member 3	Protein Coding	1
8	PTPN2	Protein Tyrosine Phosphatase Non-Receptor Type 2	Protein Coding	1
9	PTPN4	Protein Tyrosine Phosphatase Non-Receptor Type 4	Protein Coding	1
10	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
11	PTPN7	Protein Tyrosine Phosphatase Non-Receptor Type 7	Protein Coding	1
12	PTPN9	Protein Tyrosine Phosphatase Non-Receptor Type 9	Protein Coding	1
13	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
14	PTPN12	Protein Tyrosine Phosphatase Non-Receptor Type 12	Protein Coding	1
15	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	1
16	PTPN14	Protein Tyrosine Phosphatase Non-Receptor Type 14	Protein Coding	1
17	SIGIRR	Single Ig And TIR Domain Containing	Protein Coding	1
18	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
19	CASP1	Caspase 1	Protein Coding	1
20	PTPN5	Protein Tyrosine Phosphatase Non-Receptor Type 5	Protein Coding	1
21	IL18R1	Interleukin 18 Receptor 1	Protein Coding	1

Disorders associated with Interleukin-37 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Metachondromatosis	Enrichment	PTPN11	2.81
2	Leopard syndrome 1	Enrichment	PTPN11	2.81
3	Neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity	Enrichment	PTPN23	2.81
4	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.81
5	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.81
6	Choanal atresia and lymphedema	Enrichment	PTPN14	2.81
7	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.81
8	Hepatitis, fulminant viral	Enrichment	IL18BP	2.81
9	Corticobasal syndrome	Enrichment	TBK1	2.81
10	Inflammatory bowel disease 31, autosomal recessive	Enrichment	IL37	2.81
11	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.81
12	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.81
13	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.81
14	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.81
15	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.81
16	Inflammatory bowel disease	Enrichment	IL37	2.81
17	Lymphedema-posterior choanal atresia syndrome	Enrichment	PTPN14	2.81
18	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.81
19	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.81
20	Malignant astrocytoma	Enrichment	PTPN11	2.81
21	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.51
22	Werner syndrome	Enrichment	PTPN11	2.51
23	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.51
24	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.33
25	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.33
26	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.33
27	Hyper ige syndrome	Enrichment	STAT3	2.33
28	Tricuspid valve insufficiency	Enrichment	PTPN11	2.33
29	Aortic aneurysm	Enrichment	SMAD3	2.21
30	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.21
31	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.21
32	Lymphoma	Enrichment	PTPN11	2.11
33	Herpes simplex virus encephalitis	Enrichment	TBK1	2.11
34	Patent ductus arteriosus	Enrichment	PTPN11	2.03
35	Noonan syndrome 3	Enrichment	PTPN11	1.97
36	Motor neuron disease	Enrichment	TBK1	1.97
37	Oligoarticular juvenile idiopathic arthritis	Enrichment	PTPN2	1.97
38	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	PTPN2	1.97
39	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.91
40	Loeys-dietz syndrome	Enrichment	SMAD3	1.86
41	Progressive non-fluent aphasia	Enrichment	TBK1	1.86
42	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.86
43	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.81
44	Pectus excavatum	Enrichment	PTPN11	1.77
45	Specific learning disability	Enrichment	PTPN11	1.77
46	Epicanthus	Enrichment	PTPN11	1.73
47	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.73
48	Congenital long qt syndrome	Enrichment	PTPN11	1.73
49	Acute promyelocytic leukemia	Enrichment	STAT3	1.70
50	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.67
51	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.64
52	Patent foramen ovale	Enrichment	PTPN11	1.56
53	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.54
54	Ehlers-danlos syndrome	Enrichment	SMAD3	1.54
55	Noonan syndrome 1	Enrichment	PTPN11	1.46
56	Scoliosis	Enrichment	PTPN11	1.44
57	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.40
58	Rasopathy	Enrichment	PTPN11	1.40
59	Strabismus	Enrichment	PTPN11	1.39
60	Long qt syndrome 1	Enrichment	PTPN11	1.34
61	Non-immune hydrops fetalis	Enrichment	PTPN11	1.33
62	Connective tissue disease	Enrichment	SMAD3	1.31
63	Hereditary spastic paraplegia	Enrichment	PTPN23	1.20
64	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.19
65	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3	1.18
66	Thrombocytopenia	Enrichment	PTPN11	1.14
67	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.08
68	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	1.06
69	Colorectal cancer	Enrichment	PTPN12	0.90
70	Autism spectrum disorder	Enrichment	PTPN11	0.81
71	Microcephaly	Enrichment	PTPN11	0.76
72	Complex neurodevelopmental disorder	Enrichment	PTPN23	0.76
73	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-37 signaling

Pathway Network for Interleukin-37 signaling

Member Pathways for Interleukin-37 signaling

Pathways in the Interleukin-37 signaling SuperPath

Associated Genes for Interleukin-37 signaling

Associated Disorders for Interleukin-37 signaling

Disorders associated with Interleukin-37 signaling SuperPath

STRING Interaction Network for Interleukin-37 signaling

Sources for Interleukin-37 signaling