Interleukin-4 and Interleukin-13 signaling

No Pathway Network information available for Interleukin-4 and Interleukin-13 signaling

Pathways in the Interleukin-4 and Interleukin-13 signaling SuperPath

#	Name	Source	Genes
1	Interleukin-4 and Interleukin-13 signaling	Reactome	AKT1 ALOX15 ALOX5 ANXA1 BATF BCL2 BCL2L1 BCL6 BIRC5 CCL11 CCL2 CCL22 CCND1 CD36 CDKN1A CEBPD COL1A2 CXCL8 F13A1 FCER2 FGF2 FN1 FOS FOXO1 FOXO3 FSCN1 GATA3 HGF HIF1A HMOX1 HSP90AA1 HSP90B1 HSPA8 ICAM1 IL10 IL12A IL12B IL13 IL13RA1 IL13RA2 IL17A IL17F IL18 IL1A IL1B IL23A IL23R IL2RG IL4 IL4R IL6 IL6R IRF4 ITGAM ITGAX ITGB1 ITGB2 JAK1 JAK2 JAK3 JUNB LAMA5 LBP LCN2 LIF MAOA MCL1 MMP1 MMP2 MMP3 MMP9 MUC1 MYC NANOG NDN NOS2 OPRD1 OPRM1 OSM PIK3R1 PIM1 POMC POU2F1 PTGS2 RHOU RORA RORC S1PR1 SAA1 SOCS1 SOCS3 SOCS5 SOX2 STAT1 STAT3 STAT6 TGFB1 TIMP1 TNFRSF1B TP53 TWIST1 TYK2 VCAM1 VEGFA VIM ZEB1 (see all 106) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
2	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	1
3	BATF	Basic Leucine Zipper ATF-Like Transcription Factor	Protein Coding	1
4	IL17F	Interleukin 17F	Protein Coding	1
5	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
6	IL23R	Interleukin 23 Receptor	Protein Coding	1
7	S1PR1	Sphingosine-1-Phosphate Receptor 1	Protein Coding	1
8	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
9	F13A1	Coagulation Factor XIII A Chain	Protein Coding	1
10	FCER2	Fc Epsilon Receptor II	Protein Coding	1
11	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
12	FOXO1	Forkhead Box O1	Protein Coding	1
13	FOXO3	Forkhead Box O3	Protein Coding	1
14	FN1	Fibronectin 1	Protein Coding	1
15	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
16	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	1
17	ALOX15	Arachidonate 15-Lipoxygenase	Protein Coding	1
18	GATA3	GATA Binding Protein 3	Protein Coding	1
19	ANXA1	Annexin A1	Protein Coding	1
20	HGF	Hepatocyte Growth Factor	Protein Coding	1
21	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
22	HMOX1	Heme Oxygenase 1	Protein Coding	1
23	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	1
24	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
25	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
26	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
27	IL1A	Interleukin 1 Alpha	Protein Coding	1
28	IL1B	Interleukin 1 Beta	Protein Coding	1
29	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
30	IL4	Interleukin 4	Protein Coding	1
31	IL4R	Interleukin 4 Receptor	Protein Coding	1
32	IL6	Interleukin 6	Protein Coding	1
33	IL6R	Interleukin 6 Receptor	Protein Coding	1
34	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
35	IL10	Interleukin 10	Protein Coding	1
36	IL12A	Interleukin 12A	Protein Coding	1
37	IL12B	Interleukin 12B	Protein Coding	1
38	IL13	Interleukin 13	Protein Coding	1
39	IL13RA1	Interleukin 13 Receptor Subunit Alpha 1	Protein Coding	1
40	IL13RA2	Interleukin 13 Receptor Subunit Alpha 2	Protein Coding	1
41	IL17A	Interleukin 17A	Protein Coding	1
42	IL18	Interleukin 18	Protein Coding	1
43	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
44	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
45	ITGAX	Integrin Subunit Alpha X	Protein Coding	1
46	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
47	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
48	JAK1	Janus Kinase 1	Protein Coding	1
49	JAK2	Janus Kinase 2	Protein Coding	1
50	JAK3	Janus Kinase 3	Protein Coding	1
51	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
52	LAMA5	Laminin Subunit Alpha 5	Protein Coding	1
53	LBP	Lipopolysaccharide Binding Protein	Protein Coding	1
54	LCN2	Lipocalin 2	Protein Coding	1
55	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	1
56	MAOA	Monoamine Oxidase A	Protein Coding	1
57	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	1
58	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
59	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
60	MMP3	Matrix Metallopeptidase 3	Protein Coding	1
61	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
62	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	1
63	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
64	NDN	Necdin, MAGE Family Member	Protein Coding	1
65	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
66	OPRD1	Opioid Receptor Delta 1	Protein Coding	1
67	OPRM1	Opioid Receptor Mu 1	Protein Coding	1
68	OSM	Oncostatin M	Protein Coding	1
69	IL23A	Interleukin 23 Subunit Alpha	Protein Coding	1
70	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
71	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
72	POMC	Proopiomelanocortin	Protein Coding	1
73	POU2F1	POU Class 2 Homeobox 1	Protein Coding	1
74	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
75	RHOU	Ras Homolog Family Member U	Protein Coding	1
76	CCND1	Cyclin D1	Protein Coding	1
77	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
78	BCL2L1	BCL2 Like 1	Protein Coding	1
79	BCL6	BCL6 Transcription Repressor	Protein Coding	1
80	RORA	RAR Related Orphan Receptor A	Protein Coding	1
81	RORC	RAR Related Orphan Receptor C	Protein Coding	1
82	SAA1	Serum Amyloid A1	Protein Coding	1
83	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
84	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
85	CCL22	C-C Motif Chemokine Ligand 22	Protein Coding	1
86	FSCN1	Fascin Actin-Bundling Protein 1	Protein Coding	1
87	SOX2	SRY-Box Transcription Factor 2	Protein Coding	1
88	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
89	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
90	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
91	ZEB1	Zinc Finger E-Box Binding Homeobox 1	Protein Coding	1
92	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
93	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	1
94	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
95	TP53	Tumor Protein P53	Protein Coding	1
96	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
97	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	1
98	TYK2	Tyrosine Kinase 2	Protein Coding	1
99	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
100	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
101	VIM	Vimentin	Protein Coding	1
102	NANOG	Nanog Homeobox	Protein Coding	1
103	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
104	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
105	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	1
106	SOCS5	Suppressor Of Cytokine Signaling 5	Protein Coding	1

Disorders associated with Interleukin-4 and Interleukin-13 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	6.33
2	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, BCL6, MYC	6.33
3	Diffuse large b-cell lymphoma	Enrichment	FOXO1, SOCS1, STAT3, TP53	4.90
4	Intravascular large b-cell lymphoma	Enrichment	BCL2, BCL6	4.22
5	Asthma	Enrichment	ALOX5, CCL11, IL13	4.14
6	Human immunodeficiency virus type 1	Enrichment	CCL11, CCL2, IL10	3.46
7	Cerebral malaria	Enrichment	CD36, ICAM1	3.44
8	Behcet syndrome	Enrichment	IL10, IL12A, IL23R	3.39
9	Rhabdomyosarcoma 2	Enrichment	FOXO1, TP53	3.22
10	Follicular lymphoma	Enrichment	BCL2, BCL6	3.22
11	Histiocytoid hemangioma	Enrichment	FOS, VIM	3.22
12	Malaria	Enrichment	CD36, ICAM1, NOS2	3.13
13	Chronic mucocutaneous candidiasis	Enrichment	IL17F, STAT1	3.05
14	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, TGFB1	3.05
15	Breast adenocarcinoma	Enrichment	AKT1, TP53	3.05
16	Essential thrombocythemia	Enrichment	JAK2, TP53	2.91
17	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	2.58
18	Systemic lupus erythematosus	Enrichment	IL10, ITGAM, SOCS1	2.46
19	Colorectal cancer	Enrichment	AKT1, CCND1, PIK3R1, TP53	2.32
20	Proteus syndrome	Enrichment	AKT1	2.11
21	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.11
22	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.11
23	Immunodeficiency 35	Enrichment	TYK2	2.11
24	Coronary heart disease 7	Enrichment	CD36	2.11
25	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.11
26	Deafness, autosomal recessive 39	Enrichment	HGF	2.11
27	Tubulointerstitial kidney disease, autosomal dominant 2	Enrichment	MUC1	2.11
28	Dermatitis, atopic, 4	Enrichment	SOCS3	2.11
29	Candidiasis, familial, 6	Enrichment	IL17F	2.11
30	Nephrotic syndrome, type 26	Enrichment	LAMA5	2.11
31	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.11
32	Immunodeficiency 131	Enrichment	IRF4	2.11
33	Short syndrome	Enrichment	PIK3R1	2.11
34	Bone marrow failure syndrome 5	Enrichment	TP53	2.11
35	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.11
36	Graft-versus-host disease	Enrichment	IL10	2.11
37	Papilloma of choroid plexus	Enrichment	TP53	2.11
38	Basal cell carcinoma 7	Enrichment	TP53	2.11
39	Brunner syndrome	Enrichment	MAOA	2.11
40	Anaplastic thyroid carcinoma	Enrichment	TP53	2.11
41	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.11
42	Allergic rhinitis	Enrichment	IL13	2.11
43	Immunodeficiency 42	Enrichment	RORC	2.11
44	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.11
45	Psoriasis 7	Enrichment	IL23R	2.11
46	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.11
47	Coronary heart disease 6	Enrichment	MMP3	2.11
48	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.11
49	Immunodeficiency 31a	Enrichment	STAT1	2.11
50	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.11
51	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.11
52	Immunodeficiency 29	Enrichment	IL12B	2.11
53	Cowden syndrome 6	Enrichment	AKT1	2.11
54	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.11
55	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.11
56	Inflammatory bowel disease 17	Enrichment	IL23R	2.11
57	Immunodeficiency 31b	Enrichment	STAT1	2.11
58	Factor xiii, a subunit, deficiency of	Enrichment	F13A1	2.11
59	Ductal carcinoma in situ	Enrichment	TP53	2.11
60	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.11
61	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.11
62	Bent bone dysplasia syndrome 2	Enrichment	LAMA5	2.11
63	Serum amyloid a amyloidosis	Enrichment	SAA1	2.11
64	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.11
65	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.11
66	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.11
67	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.11
68	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.11
69	Choroid plexus cancer	Enrichment	TP53	2.11
70	Atherosclerosis	Enrichment	ALOX5	2.11
71	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.11
72	Whipple disease	Enrichment	IRF4	2.11
73	Premature aging	Enrichment	VIM	2.11
74	Lama5-related multisystemic syndrome	Enrichment	LAMA5	2.11
75	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.11
76	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.11
77	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.81
78	Burkitt lymphoma	Enrichment	MYC	1.81
79	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	1.81
80	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.81
81	Camurati-engelmann disease 1	Enrichment	TGFB1	1.81
82	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.81
83	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.81
84	Hemangiopericytoma, malignant	Enrichment	STAT6	1.81
85	Bruck syndrome 1	Enrichment	COL1A2	1.81
86	Robinow-sorauf syndrome	Enrichment	TWIST1	1.81
87	Cervical cancer	Enrichment	TP53	1.81
88	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.81
89	Lymphoma, hodgkin, classic	Enrichment	TP53	1.81
90	Thrombocythemia 3	Enrichment	JAK2	1.81
91	Immunodeficiency 31c	Enrichment	STAT1	1.81
92	Sweeney-cox syndrome	Enrichment	TWIST1	1.81
93	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A2	1.81
94	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.81
95	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	1.81
96	Cataract 30	Enrichment	VIM	1.81
97	Camurati-engelmann disease	Enrichment	TGFB1	1.81
98	Congenital fibrosarcoma	Enrichment	TP53	1.81
99	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.81
100	Li-fraumeni syndrome 1	Enrichment	TP53	1.81
101	Sarcoma	Enrichment	TP53	1.81
102	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.81
103	Cervix carcinoma	Enrichment	TP53	1.81
104	Hodgkin's lymphoma	Enrichment	TP53	1.81
105	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	1.81
106	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	1.81
107	Intellectual developmental disorder with or without epilepsy or cerebellar ataxia	Enrichment	RORA	1.81
108	Polycythemia	Enrichment	JAK2	1.81
109	Metaphyseal anadysplasia	Enrichment	MMP9	1.81
110	Lymphomatoid papulosis	Enrichment	TYK2	1.81
111	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A2	1.81
112	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	1.81
113	Hypereosinophilic syndrome	Enrichment	JAK2	1.81
114	Dentinogenesis imperfecta	Enrichment	COL1A2	1.81
115	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.81
116	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	1.81
117	Factor xiii deficiency	Enrichment	F13A1	1.81
118	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.81
119	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	1.81
120	Bladder cancer	Enrichment	CDKN1A, TP53	1.67
121	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.63
122	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.63
123	Craniosynostosis 1	Enrichment	TWIST1	1.63
124	Immune thrombocytopenia	Enrichment	SOCS1	1.63
125	Takayasu arteritis	Enrichment	IL12B	1.63
126	Polycythemia vera	Enrichment	JAK2	1.63
127	Mycosis fungoides	Enrichment	TNFRSF1B	1.63
128	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.63
129	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.63
130	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	1.63
131	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.63
132	Osteogenic sarcoma	Enrichment	TP53	1.63
133	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.63
134	Corneal dystrophy, posterior polymorphous, 3	Enrichment	ZEB1	1.63
135	Corneal dystrophy, fuchs endothelial, 6	Enrichment	ZEB1	1.63
136	Nasopharyngeal carcinoma	Enrichment	TP53	1.63
137	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.63
138	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.63
139	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.63
140	Hyper ige syndrome	Enrichment	STAT3	1.63
141	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.63
142	Anaplastic astrocytoma	Enrichment	TP53	1.63
143	Immunodeficiency 14	Enrichment	PIK3R1	1.63
144	Squamous cell carcinoma	Enrichment	TP53	1.63
145	Adenocarcinoma	Enrichment	TP53	1.63
146	Intraocular pressure quantitative trait locus	Enrichment	ZEB1	1.63
147	End stage renal disease	Enrichment	GATA3	1.63
148	Bone osteosarcoma	Enrichment	TP53	1.63
149	High bone mass osteogenesis imperfecta	Enrichment	COL1A2	1.63
150	Enchondromatosis	Enrichment	HIF1A	1.63
151	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	1.63
152	Saczary syndrome	Enrichment	TNFRSF1B	1.63
153	Cystic fibrosis	Enrichment	HMOX1, TGFB1	1.59
154	Kaposi sarcoma	Enrichment	IL6	1.51
155	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A2	1.51
156	Erythrocytosis, familial, 1	Enrichment	JAK2	1.51
157	Small cell cancer of the lung	Enrichment	TP53	1.51
158	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.51
159	Microphthalmia, syndromic 3	Enrichment	SOX2	1.51
160	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.51
161	Budd-chiari syndrome	Enrichment	JAK2	1.51
162	Saethre-chotzen syndrome	Enrichment	TWIST1	1.51
163	Schaaf-yang syndrome	Enrichment	NDN	1.51
164	Congenital generalized lipodystrophy	Enrichment	FOS	1.51
165	Mantle cell lymphoma	Enrichment	CCND1	1.51
166	Lung sarcomatoid carcinoma	Enrichment	TP53	1.51
167	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.51
168	Blood platelet disease	Enrichment	CD36	1.51
169	Corneal dystrophy	Enrichment	ZEB1	1.51
170	Adenosine deaminase deficiency	Enrichment	JAK3	1.51
171	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A2	1.51
172	Non-syndromic bicoronal craniosynostosis	Enrichment	TWIST1	1.51
173	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.51
174	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.41
175	Von hippel-lindau syndrome	Enrichment	CCND1	1.41
176	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.41
177	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.41
178	Fuchs' endothelial dystrophy	Enrichment	ZEB1	1.41
179	Lymphoma	Enrichment	TP53	1.41
180	Myeloproliferative neoplasm	Enrichment	JAK2	1.41
181	Acute megakaryocytic leukemia	Enrichment	TP53	1.41
182	Leukemia, acute myeloid	Enrichment	JAK2, TP53	1.41
183	Gastric cancer	Enrichment	IL1B, TP53	1.35
184	Nephrotic syndrome	Enrichment	FN1, LAMA5	1.35
185	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A2	1.34
186	Li-fraumeni syndrome	Enrichment	TP53	1.34
187	Osteogenesis imperfecta, type i	Enrichment	COL1A2	1.34
188	Corneal dystrophy, posterior polymorphous, 1	Enrichment	ZEB1	1.34
189	Type 1 diabetes mellitus	Enrichment	IL6	1.34
190	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.34
191	Adrenocortical carcinoma	Enrichment	TP53	1.34
192	Classic ehlers-danlos syndrome	Enrichment	COL1A2	1.34
193	Hereditary breast carcinoma	Enrichment	AKT1, TP53	1.33
194	Esophageal cancer	Enrichment	TP53	1.27
195	Prader-willi syndrome	Enrichment	NDN	1.27
196	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.27
197	Osteogenesis imperfecta, type ii	Enrichment	COL1A2	1.27
198	Thrombophilia due to thrombin defect	Enrichment	F13A1	1.27
199	Myelofibrosis	Enrichment	JAK2	1.27
200	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.27
201	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.27
202	Gallbladder cancer	Enrichment	TP53	1.27
203	Overgrowth syndrome	Enrichment	PIK3R1	1.27
204	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.27
205	Glioma susceptibility 1	Enrichment	TP53	1.22
206	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.22
207	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.22
208	Rheumatoid arthritis	Enrichment	IL10	1.17
209	Inflammatory bowel disease 1	Enrichment	IL6	1.17
210	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.17
211	Adult hepatocellular carcinoma	Enrichment	TP53	1.17
212	Primary hyperaldosteronism	Enrichment	TP53	1.17
213	Primary biliary cholangitis	Enrichment	IL12A	1.17
214	Cowden syndrome	Enrichment	AKT1	1.17
215	Myeloma, multiple	Enrichment	CCND1, TP53	1.15
216	Cataract 30, multiple types	Enrichment	VIM	1.12
217	Omenn syndrome	Enrichment	IL2RG	1.12
218	Familial colorectal cancer	Enrichment	TP53	1.12
219	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.12
220	Primary bone dysplasia	Enrichment	COL1A2	1.12
221	Myelodysplastic syndrome	Enrichment	TP53	1.08
222	Nanophthalmos	Enrichment	SOX2	1.08
223	Combined immunodeficiency	Enrichment	IL2RG	1.08
224	Osteochondrodysplasia	Enrichment	COL1A2	1.08
225	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.08
226	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.08
227	Presynaptic congenital myasthenic syndromes	Enrichment	LAMA5	1.08
228	Septooptic dysplasia	Enrichment	SOX2	1.05
229	Meningioma	Enrichment	AKT1	1.05
230	Lip and oral cavity carcinoma	Enrichment	TP53	1.05
231	Osteogenesis imperfecta, type iv	Enrichment	COL1A2	1.01
232	Neural tube defects	Enrichment	ITGB1	1.01
233	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.01
234	Acute promyelocytic leukemia	Enrichment	STAT3	1.01
235	Nk-cell enteropathy	Enrichment	JAK3	1.01
236	Multiple sclerosis	Enrichment	LAMA5	0.98
237	Osteoporosis	Enrichment	COL1A2	0.98
238	Lung cancer susceptibility 3	Enrichment	TP53	0.98
239	Osteogenesis imperfecta, type iii	Enrichment	COL1A2	0.95
240	Breast cancer	Enrichment	AKT1, TP53	0.93
241	Rhabdomyosarcoma	Enrichment	TP53	0.93
242	Gliosarcoma	Enrichment	TP53	0.93
243	Giant cell glioblastoma	Enrichment	TP53	0.90
244	Arteriovenous malformations of the brain	Enrichment	IL6	0.86
245	Ehlers-danlos syndrome	Enrichment	COL1A2	0.86
246	Macs syndrome	Enrichment	SOX2	0.84
247	Hepatoblastoma	Enrichment	TP53	0.82
248	Hepatocellular carcinoma	Enrichment	TP53	0.80
249	Myocardial infarction	Enrichment	F13A1	0.80
250	Microphthalmia	Enrichment	SOX2	0.80
251	Diamond-blackfan anemia 1	Enrichment	TP53	0.78
252	Brittle bone disorder	Enrichment	COL1A2	0.78
253	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.78
254	Pancreatic cancer	Enrichment	TP53	0.75
255	Ovarian cancer	Enrichment	AKT1, TP53	0.73
256	Prostate cancer	Enrichment	TP53	0.69
257	Severe covid-19	Enrichment	JAK3	0.69
258	Severe combined immunodeficiency	Enrichment	JAK3	0.64
259	Cakut	Enrichment	GATA3	0.63
260	Genetic steroid-resistant nephrotic syndrome	Enrichment	LAMA5	0.63
261	Diamond-blackfan anemia	Enrichment	TP53	0.61
262	Type 2 diabetes mellitus	Enrichment	IL6	0.55
263	Sensorineural hearing loss	Enrichment	HGF	0.50
264	Body mass index quantitative trait locus 11	Enrichment	POMC	0.49
265	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.45
266	Primary ovarian insufficiency	Enrichment	JAK2	0.43
267	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF	0.30
268	Complex neurodevelopmental disorder	Enrichment	RORA	0.21
269	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.19

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-4 and Interleukin-13 signaling

Pathway Network for Interleukin-4 and Interleukin-13 signaling

Member Pathways for Interleukin-4 and Interleukin-13 signaling

Pathways in the Interleukin-4 and Interleukin-13 signaling SuperPath

Associated Genes for Interleukin-4 and Interleukin-13 signaling

Associated Disorders for Interleukin-4 and Interleukin-13 signaling

Disorders associated with Interleukin-4 and Interleukin-13 signaling SuperPath

STRING Interaction Network for Interleukin-4 and Interleukin-13 signaling

Sources for Interleukin-4 and Interleukin-13 signaling