Interleukin-6 family signaling

Pathway network for the Interleukin-6 family signaling SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)

Pathways in the Interleukin-6 family signaling SuperPath

#	Name	Source	Genes
1	Interleukin-6 family signaling	Reactome	CBL CLCF1 CNTF CNTFR CRLF1 CTF1 IL11 IL11RA IL31 IL31RA IL6 IL6R IL6ST JAK1 JAK2 LIF LIFR OSM OSMR PTPN11 SOCS3 STAT1 STAT3 TYK2 (see all 24) (see less)
2	Immune response Oncostatin M signaling via JAK-Stat in human cells	GeneGo (Thomson Reuters)	CCL11 CCL2 CCND1 IL6ST JAK1 JAK2 LIFR MMP1 OSM OSMR SERPINA3 SOCS3 STAT1 STAT3 STAT5A STAT5B TIMP1 TYK2 VEGFA (see all 19) (see less)
3	IL-6-type cytokine receptor ligand interactions	Reactome	CLCF1 CNTF CNTFR CRLF1 CTF1 IL11 IL11RA IL31 IL31RA IL6ST JAK1 JAK2 LIF LIFR OSM OSMR TYK2 (see all 17) (see less)
4	Interleukin-6 signaling	Reactome	CBL IL6 IL6R IL6ST JAK1 JAK2 PTPN11 SOCS3 STAT1 STAT3 TYK2 (see all 11) (see less)

Gene overlap in member pathways for Interleukin-6 family signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	4
2	JAK1	Janus Kinase 1	Protein Coding	4
3	JAK2	Janus Kinase 2	Protein Coding	4
4	TYK2	Tyrosine Kinase 2	Protein Coding	4
5	LIFR	LIF Receptor Subunit Alpha	Protein Coding	3
6	OSM	Oncostatin M	Protein Coding	3
7	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	3
8	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
9	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	3
10	OSMR	Oncostatin M Receptor	Protein Coding	3
11	CNTF	Ciliary Neurotrophic Factor	Protein Coding	2
12	CNTFR	Ciliary Neurotrophic Factor Receptor	Protein Coding	2
13	IL31RA	Interleukin 31 Receptor A	Protein Coding	2
14	CTF1	Cardiotrophin 1	Protein Coding	2
15	CLCF1	Cardiotrophin Like Cytokine Factor 1	Protein Coding	2
16	IL6	Interleukin 6	Protein Coding	2
17	IL6R	Interleukin 6 Receptor	Protein Coding	2
18	IL11	Interleukin 11	Protein Coding	2
19	IL11RA	Interleukin 11 Receptor Subunit Alpha	Protein Coding	2
20	IL31	Interleukin 31	Protein Coding	2
21	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	2
22	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
23	CBL	Cbl Proto-Oncogene	Protein Coding	2
24	CRLF1	Cytokine Receptor Like Factor 1	Protein Coding	2
25	SERPINA3	Serpin Family A Member 3	Protein Coding	1
26	CCND1	Cyclin D1	Protein Coding	1
27	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
28	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
29	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
30	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
31	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
32	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	1
33	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with Interleukin-6 family signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	9.39
2	Primary cutaneous amyloidosis	Enrichment	IL31RA, OSMR	5.83
3	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	5.45
4	Stuve-wiedemann syndrome 1	Enrichment	IL6ST, LIFR	5.35
5	Cold-induced sweating syndrome	Enrichment	CLCF1, CRLF1	5.35
6	Stüve-wiedemann syndrome	Enrichment	IL6ST, LIFR	5.35
7	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	5.22
8	Crisponi/cold-induced sweating syndrome 1	Enrichment	CLCF1, CRLF1	4.83
9	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	4.41
10	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, PTPN11	4.20
11	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.84
12	Noonan syndrome 1	Enrichment	CBL, PTPN11	3.82
13	Rasopathy	Enrichment	CBL, PTPN11	3.72
14	Human immunodeficiency virus type 1	Enrichment	CCL11, CCL2	3.55
15	Metachondromatosis	Enrichment	PTPN11	3.09
16	Immunodeficiency 35	Enrichment	TYK2	3.09
17	Dermatitis, atopic, 4	Enrichment	SOCS3	3.09
18	Leopard syndrome 1	Enrichment	PTPN11	3.09
19	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	3.09
20	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	3.09
21	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.09
22	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	3.09
23	Immunodeficiency 31a	Enrichment	STAT1	3.09
24	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	3.09
25	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	3.09
26	Immunodeficiency 31b	Enrichment	STAT1	3.09
27	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.09
28	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	3.09
29	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	3.09
30	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.09
31	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.09
32	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.09
33	Malignant astrocytoma	Enrichment	PTPN11	3.09
34	Amyloidosis, primary localized cutaneous, 1	Enrichment	OSMR	2.90
35	Craniosynostosis and dental anomalies	Enrichment	IL11RA	2.90
36	Amyloidosis, primary localized cutaneous, 2	Enrichment	IL31RA	2.90
37	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.85
38	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.85
39	Ovarian germ cell cancer	Enrichment	CBL	2.79
40	Thrombocythemia 3	Enrichment	JAK2	2.79
41	Immunodeficiency 31c	Enrichment	STAT1	2.79
42	Werner syndrome	Enrichment	PTPN11	2.79
43	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.79
44	Polycythemia	Enrichment	JAK2	2.79
45	Lymphomatoid papulosis	Enrichment	TYK2	2.79
46	Hypereosinophilic syndrome	Enrichment	JAK2	2.79
47	Malignant germ cell tumor of ovary	Enrichment	CBL	2.79
48	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.79
49	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.61
50	Polycythemia vera	Enrichment	JAK2	2.61
51	Hyper ige syndrome	Enrichment	STAT3	2.61
52	Tricuspid valve insufficiency	Enrichment	PTPN11	2.61
53	Crisponi/cold-induced sweating syndrome 2	Enrichment	CLCF1	2.60
54	Cold-induced sweating syndrome 2	Enrichment	CLCF1	2.60
55	Cold-induced sweating syndrome including crisponi syndrome	Enrichment	CRLF1	2.60
56	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.55
57	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	2.55
58	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.55
59	Kaposi sarcoma	Enrichment	IL6	2.49
60	Erythrocytosis, familial, 1	Enrichment	JAK2	2.49
61	Budd-chiari syndrome	Enrichment	JAK2	2.49
62	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.49
63	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.49
64	Cone-rod dystrophy 12	Enrichment	CRLF1	2.43
65	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.39
66	Lymphoma	Enrichment	PTPN11	2.39
67	Aggressive systemic mastocytosis	Enrichment	CBL	2.39
68	Type 1 diabetes mellitus	Enrichment	IL6	2.31
69	Patent ductus arteriosus	Enrichment	PTPN11	2.31
70	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.31
71	Cold-induced sweating syndrome 1	Enrichment	CRLF1	2.30
72	Idiopathic achalasia	Enrichment	CRLF1	2.30
73	Mantle cell lymphoma	Enrichment	CCND1	2.25
74	Myelofibrosis	Enrichment	JAK2	2.25
75	Noonan syndrome 3	Enrichment	PTPN11	2.25
76	Essential thrombocythemia	Enrichment	JAK2	2.25
77	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.19
78	Von hippel-lindau syndrome	Enrichment	CCND1	2.16
79	Inflammatory bowel disease 1	Enrichment	IL6	2.14
80	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	2.14
81	Pectus excavatum	Enrichment	PTPN11	2.05
82	Specific learning disability	Enrichment	PTPN11	2.05
83	Epicanthus	Enrichment	PTPN11	2.01
84	Congenital long qt syndrome	Enrichment	PTPN11	2.01
85	Rhabdomyosarcoma	Enrichment	CBL	1.89
86	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.86
87	Patent foramen ovale	Enrichment	PTPN11	1.84
88	Asthma	Enrichment	CCL11	1.82
89	Arteriovenous malformations of the brain	Enrichment	IL6	1.82
90	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.82
91	Scoliosis	Enrichment	PTPN11	1.71
92	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.68
93	Strabismus	Enrichment	PTPN11	1.66
94	Long qt syndrome 1	Enrichment	PTPN11	1.62
95	Craniosynostosis	Enrichment	IL11RA	1.61
96	Non-immune hydrops fetalis	Enrichment	PTPN11	1.60
97	Leukemia, acute myeloid	Enrichment	JAK2	1.50
98	Type 2 diabetes mellitus	Enrichment	IL6	1.47
99	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.46
100	Thrombocytopenia	Enrichment	PTPN11	1.42
101	Cakut	Enrichment	LIFR	1.38
102	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.35
103	Primary ovarian insufficiency	Enrichment	JAK2	1.33
104	Myeloma, multiple	Enrichment	CCND1	1.12
105	Autism spectrum disorder	Enrichment	PTPN11	1.07
106	Microcephaly	Enrichment	PTPN11	1.02
107	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.99
108	Colorectal cancer	Enrichment	CCND1	0.94

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-6 family signaling

Pathway Network for Interleukin-6 family signaling

Pathway network for the Interleukin-6 family signaling SuperPath

Member Pathways for Interleukin-6 family signaling

Pathways in the Interleukin-6 family signaling SuperPath

Gene overlap in member pathways for Interleukin-6 family signaling SuperPath

Associated Genes for Interleukin-6 family signaling

Associated Disorders for Interleukin-6 family signaling

Disorders associated with Interleukin-6 family signaling SuperPath

STRING Interaction Network for Interleukin-6 family signaling

Sources for Interleukin-6 family signaling