Interleukin-7 signaling

No Pathway Network information available for Interleukin-7 signaling

Pathways in the Interleukin-7 signaling SuperPath

#	Name	Source	Genes
1	Interleukin-7 signaling	Reactome	BRWD1 CISH CRLF2 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 HGF IL2RG IL7 IL7R IRS1 IRS2 JAK1 JAK3 PIK3R1 PIK3R2 PIK3R3 RAG1 RAG2 SMARCA4 SOCS1 SOCS2 STAT3 STAT5A STAT5B TSLP (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	1
2	H3C14	H3 Clustered Histone 14	Protein Coding	1
3	HGF	Hepatocyte Growth Factor	Protein Coding	1
4	H3C15	H3 Clustered Histone 15	Protein Coding	1
5	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
6	IL7	Interleukin 7	Protein Coding	1
7	IL7R	Interleukin 7 Receptor	Protein Coding	1
8	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
9	JAK1	Janus Kinase 1	Protein Coding	1
10	JAK3	Janus Kinase 3	Protein Coding	1
11	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
12	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
13	BRWD1	Bromodomain And WD Repeat Domain Containing 1	Protein Coding	1
14	RAG1	Recombination Activating 1	Protein Coding	1
15	RAG2	Recombination Activating 2	Protein Coding	1
16	CRLF2	Cytokine Receptor Like Factor 2	Protein Coding	1
17	H3C13	H3 Clustered Histone 13	Protein Coding	1
18	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
19	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
20	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
21	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
22	H3C1	H3 Clustered Histone 1	Protein Coding	1
23	H3C4	H3 Clustered Histone 4	Protein Coding	1
24	H3C3	H3 Clustered Histone 3	Protein Coding	1
25	H3C6	H3 Clustered Histone 6	Protein Coding	1
26	H3C11	H3 Clustered Histone 11	Protein Coding	1
27	H3C8	H3 Clustered Histone 8	Protein Coding	1
28	H3C12	H3 Clustered Histone 12	Protein Coding	1
29	H3C10	H3 Clustered Histone 10	Protein Coding	1
30	H3C2	H3 Clustered Histone 2	Protein Coding	1
31	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
32	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	1
33	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
34	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
35	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	1
36	H3C7	H3 Clustered Histone 7	Protein Coding	1

Disorders associated with Interleukin-7 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Omenn syndrome	Enrichment	IL2RG, IL7R, RAG1, RAG2	8.06
2	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3, RAG1, RAG2	6.77
3	Severe combined immunodeficiency	Enrichment	IL7R, JAK3, RAG1, RAG2	5.79
4	Combined cellular and humoral immune defects with granulomas	Enrichment	RAG1, RAG2	4.69
5	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	4.69
6	Myeloma, multiple	Enrichment	H3C1, IL7R, PIK3R2	3.36
7	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.28
8	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	2.94
9	Deafness, autosomal recessive 39	Enrichment	HGF	2.58
10	Alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	Enrichment	RAG1	2.58
11	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.58
12	Immunodeficiency 130 with hpv-related verrucosis	Enrichment	IL7	2.58
13	Ciliary dyskinesia, primary, 51	Enrichment	BRWD1	2.58
14	Short syndrome	Enrichment	PIK3R1	2.58
15	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.58
16	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.58
17	Recombinase activating gene 1 deficiency	Enrichment	RAG1	2.58
18	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.58
19	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.58
20	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.58
21	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.58
22	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.58
23	Recombinase activating gene 2 deficiency	Enrichment	RAG2	2.58
24	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.58
25	T-b+ severe combined immunodeficiency due to il-7ralpha deficiency	Enrichment	IL7R	2.58
26	Combined immunodeficiency due to partial rag1 deficiency	Enrichment	RAG1	2.58
27	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.58
28	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.58
29	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.28
30	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	2.28
31	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4	2.28
32	Immunodeficiency 104, severe combined	Enrichment	IL7R	2.28
33	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.28
34	Multiple sclerosis 3	Enrichment	IL7R	2.28
35	Otosclerosis 12	Enrichment	SMARCA4	2.28
36	Coffin-siris syndrome 4	Enrichment	SMARCA4	2.28
37	Bronchiectasis	Enrichment	BRWD1	2.28
38	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.28
39	Type 2 diabetes mellitus	Enrichment	IRS1, IRS2	2.26
40	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.10
41	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.10
42	Immune thrombocytopenia	Enrichment	SOCS1	2.10
43	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	2.10
44	Combined immunodeficiency, x-linked	Enrichment	IL2RG	2.10
45	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.10
46	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.10
47	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.10
48	Bacteremia 2	Enrichment	CISH	2.10
49	Hyper ige syndrome	Enrichment	STAT3	2.10
50	Immunodeficiency 14	Enrichment	PIK3R1	2.10
51	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.98
52	Infantile sialic acid storage disease	Enrichment	RAG2	1.98
53	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.98
54	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.98
55	Salla disease	Enrichment	RAG2	1.98
56	Tuberculosis	Enrichment	CISH	1.98
57	Adenosine deaminase deficiency	Enrichment	JAK3	1.98
58	Inherited epidermodysplasia verruciformis	Enrichment	IL7	1.98
59	Free sialic acid storage disorder	Enrichment	RAG2	1.88
60	Common variable immunodeficiency	Enrichment	RAG2	1.73
61	Overgrowth syndrome	Enrichment	PIK3R1	1.73
62	Glioma susceptibility 1	Enrichment	H3C1	1.68
63	Neuroblastoma	Enrichment	SMARCA4	1.68
64	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.68
65	Ventricular septal defect	Enrichment	SMARCA4	1.63
66	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.58
67	Immune deficiency disease	Enrichment	RAG2	1.54
68	Combined immunodeficiency	Enrichment	IL2RG	1.54
69	Atrial heart septal defect	Enrichment	SMARCA4	1.54
70	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.54
71	Interatrial communication	Enrichment	SMARCA4	1.54
72	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.54
73	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.47
74	Nk-cell enteropathy	Enrichment	JAK3	1.47
75	Coffin-siris syndrome 1	Enrichment	SMARCA4	1.41
76	Familial hypercholesterolemia	Enrichment	SMARCA4	1.41
77	Cleft palate, isolated	Enrichment	SMARCA4	1.35
78	Malaria	Enrichment	CISH	1.23
79	Severe covid-19	Enrichment	JAK3	1.13
80	Visceral heterotaxy 5	Enrichment	BRWD1	1.10
81	Male infertility	Enrichment	BRWD1	1.06
82	Systemic lupus erythematosus	Enrichment	SOCS1	1.01
83	Cerebral palsy	Enrichment	SMARCA4	1.01
84	Sensorineural hearing loss	Enrichment	HGF	0.92
85	Primary ovarian insufficiency	Enrichment	BRWD1	0.84
86	Breast cancer	Enrichment	IL7R	0.74
87	Colorectal cancer	Enrichment	PIK3R1	0.68
88	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF	0.68
89	Inherited cancer-predisposing syndrome	Enrichment	SMARCA4	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Interleukin-7 signaling

Pathway Network for Interleukin-7 signaling

Member Pathways for Interleukin-7 signaling

Pathways in the Interleukin-7 signaling SuperPath

Associated Genes for Interleukin-7 signaling

Associated Disorders for Interleukin-7 signaling

Disorders associated with Interleukin-7 signaling SuperPath

STRING Interaction Network for Interleukin-7 signaling

Sources for Interleukin-7 signaling