Internalization of ErbB1

No Pathway Network information available for Internalization of ErbB1

Pathways in the Internalization of ErbB1 SuperPath

#	Name	Source	Genes
1	Internalization of ErbB1	PubChem	AMPH ARHGEF7 CBL CBLB CDC42 CHMP3 DNM1 EGF EGFR EPN1 EPS15 GRB2 HGS ITSN1 LRIG1 PIK3CA PIK3CB PIK3R1 PTK2 RAB5A RAF1 RNF103-CHMP3 SH3GL2 SH3KBP1 SHC1 SOS1 SPRY2 SRC STAMBP SYNJ1 TSG101 USP8 ZFYVE28 (see all 33) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ZFYVE28	Zinc Finger FYVE-Type Containing 28	Protein Coding	1
2	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
3	SYNJ1	Synaptojanin 1	Protein Coding	1
4	STAMBP	STAM Binding Protein	Protein Coding	1
5	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	1
6	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	1
7	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	1
8	EGF	Epidermal Growth Factor	Protein Coding	1
9	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
10	SH3KBP1	SH3 Domain Containing Kinase Binding Protein 1	Protein Coding	1
11	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
12	DNM1	Dynamin 1	Protein Coding	1
13	ITSN1	Intersectin 1	Protein Coding	1
14	CDC42	Cell Division Cycle 42	Protein Coding	1
15	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
16	CHMP3	Charged Multivesicular Body Protein 3	Protein Coding	1
17	RNF103-CHMP3	RNF103-CHMP3 Readthrough	Protein Coding	1
18	TSG101	Tumor Susceptibility 101	Protein Coding	1
19	AMPH	Amphiphysin	Protein Coding	1
20	EPS15	Epidermal Growth Factor Receptor Pathway Substrate 15	Protein Coding	1
21	EPN1	Epsin 1	Protein Coding	1
22	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	1
23	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	1
24	CBL	Cbl Proto-Oncogene	Protein Coding	1
25	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
26	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
27	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
28	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
29	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
30	SHC1	SHC Adaptor Protein 1	Protein Coding	1
31	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
32	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
33	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1

Disorders associated with Internalization of ErbB1 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, RAF1, SOS1	5.23
2	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.76
3	Noonan syndrome 1	Enrichment	CBL, RAF1, SOS1	4.65
4	Rasopathy	Enrichment	CBL, RAF1, SOS1	4.48
5	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, CDC42	4.46
6	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	4.07
7	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	4.07
8	Noonan syndrome 3	Enrichment	RAF1, SOS1	3.92
9	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	3.69
10	Lung non-small cell carcinoma	Enrichment	EGFR, PIK3CA	3.51
11	Lip and oral cavity carcinoma	Enrichment	EGFR, PIK3CA	3.43
12	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, SRC	2.92
13	Bladder cancer	Enrichment	EGFR, PIK3CA	2.65
14	Macrodactyly	Enrichment	PIK3CA	2.61
15	Noonan syndrome 5	Enrichment	RAF1	2.61
16	Immunodeficiency 61	Enrichment	SH3KBP1	2.61
17	Hypomagnesemia 4, renal	Enrichment	EGF	2.61
18	Noonan syndrome 4	Enrichment	SOS1	2.61
19	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.61
20	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.61
21	Cowden syndrome 5	Enrichment	PIK3CA	2.61
22	Iga nephropathy 3	Enrichment	SPRY2	2.61
23	Developmental and epileptic encephalopathy 53	Enrichment	SYNJ1	2.61
24	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.61
25	Short syndrome	Enrichment	PIK3R1	2.61
26	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.61
27	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.61
28	Leopard syndrome 2	Enrichment	RAF1	2.61
29	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.61
30	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.61
31	Thrombocytopenia 6	Enrichment	SRC	2.61
32	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.61
33	Trigonitis	Enrichment	RAF1	2.61
34	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.61
35	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	2.61
36	Hypospadias	Enrichment	PIK3CA	2.61
37	Rare venous malformation	Enrichment	PIK3CA	2.61
38	Diaphragmatic eventration	Enrichment	PIK3CA	2.61
39	Nocarh syndrome	Enrichment	CDC42	2.61
40	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.61
41	Rare combined vascular malformation	Enrichment	PIK3CA	2.61
42	Cavernous lymphangioma	Enrichment	PIK3CA	2.61
43	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.61
44	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.61
45	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.61
46	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.61
47	Macrodactyly of toe	Enrichment	PIK3CA	2.61
48	Lung cancer	Enrichment	EGFR, PIK3CA	2.57
49	Fibromatosis, gingival, 1	Enrichment	SOS1	2.31
50	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	2.31
51	Ovarian germ cell cancer	Enrichment	CBL	2.31
52	Pulmonic stenosis	Enrichment	SOS1	2.31
53	Keratosis, seborrheic	Enrichment	PIK3CA	2.31
54	Noonan syndrome 8	Enrichment	PIK3CA	2.31
55	Parkinson disease 20, early-onset	Enrichment	SYNJ1	2.31
56	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	2.31
57	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.31
58	Microcephaly-capillary malformation syndrome	Enrichment	STAMBP	2.31
59	Immune system disease	Enrichment	CDC42	2.31
60	Malignant germ cell tumor of ovary	Enrichment	CBL	2.31
61	West syndrome	Enrichment	DNM1, SYNJ1	2.29
62	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.14
63	Nuchal bleb, familial	Enrichment	SOS1	2.14
64	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.14
65	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.14
66	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	2.14
67	Immunodeficiency 14	Enrichment	PIK3R1	2.14
68	Atypical juvenile parkinsonism	Enrichment	SYNJ1	2.14
69	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.14
70	Keratoacanthoma	Enrichment	PIK3CA	2.14
71	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1, SYNJ1	2.09
72	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	2.01
73	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.01
74	Cerebrovascular disease	Enrichment	PIK3CA	2.01
75	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.01
76	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.01
77	Gingival fibromatosis	Enrichment	SOS1	2.01
78	Capillary malformations, congenital	Enrichment	PIK3CA	1.92
79	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.92
80	Myeloproliferative neoplasm	Enrichment	CBL	1.92
81	Hemimegalencephaly	Enrichment	PIK3CA	1.92
82	Aggressive systemic mastocytosis	Enrichment	CBL	1.92
83	Breast cancer	Enrichment	PIK3CA, SHC1	1.85
84	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.84
85	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.84
86	Breast adenocarcinoma	Enrichment	PIK3CA	1.84
87	Nevus, epidermal	Enrichment	PIK3CA	1.77
88	Myelofibrosis	Enrichment	SRC	1.77
89	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.77
90	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.77
91	Gallbladder cancer	Enrichment	PIK3CA	1.77
92	Pilomyxoid astrocytoma	Enrichment	RAF1	1.77
93	Overgrowth syndrome	Enrichment	PIK3R1	1.77
94	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.71
95	Lennox-gastaut syndrome	Enrichment	DNM1	1.71
96	Arteriovenous malformation	Enrichment	PIK3CA	1.66
97	Primary hyperaldosteronism	Enrichment	USP8	1.66
98	Cowden syndrome	Enrichment	PIK3CA	1.66
99	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.62
100	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.62
101	Ovarian cancer	Enrichment	EGFR, PIK3CA	1.60
102	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.54
103	Early-onset parkinson's disease	Enrichment	SYNJ1	1.54
104	Meningioma	Enrichment	PIK3CA	1.54
105	Aortic valve disease 1	Enrichment	SOS1	1.51
106	Stereotypic movement disorder	Enrichment	DNM1	1.51
107	Nk-cell enteropathy	Enrichment	PIK3CB	1.51
108	Osteoporosis	Enrichment	SRC	1.47
109	Lung cancer susceptibility 3	Enrichment	EGFR	1.47
110	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.47
111	Lynch syndrome	Enrichment	PIK3CA	1.44
112	Rhabdomyosarcoma	Enrichment	CBL	1.42
113	Gliosarcoma	Enrichment	EGFR	1.42
114	Giant cell glioblastoma	Enrichment	EGFR	1.39
115	Arteriovenous malformations of the brain	Enrichment	EGFR	1.34
116	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	1.34
117	Endometrial cancer	Enrichment	PIK3CA	1.30
118	Hepatocellular carcinoma	Enrichment	PIK3CA	1.28
119	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.25
120	Developmental and epileptic encephalopathy 1	Enrichment	SYNJ1	1.23
121	Prostate cancer	Enrichment	PIK3CA	1.17
122	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.11
123	Left ventricular noncompaction	Enrichment	RAF1	1.09
124	Gastric cancer	Enrichment	PIK3CA	1.00
125	Hereditary breast carcinoma	Enrichment	PIK3CA	0.99
126	Thrombocytopenia	Enrichment	SRC	0.96
127	Autosomal dominant non-syndromic intellectual disability	Enrichment	ITSN1	0.94
128	Hypertelorism	Enrichment	PIK3CA	0.92
129	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.92
130	Dilated cardiomyopathy	Enrichment	RAF1	0.75
131	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Internalization of ErbB1

Pathway Network for Internalization of ErbB1

Member Pathways for Internalization of ErbB1

Pathways in the Internalization of ErbB1 SuperPath

Associated Genes for Internalization of ErbB1

Associated Disorders for Internalization of ErbB1

Disorders associated with Internalization of ErbB1 SuperPath

STRING Interaction Network for Internalization of ErbB1

Sources for Internalization of ErbB1