Intracellular trafficking proteins involved in CMT neuropathy

No Pathway Network information available for Intracellular trafficking proteins involved in CMT neuropathy

Pathways in the Intracellular trafficking proteins involved in CMT neuropathy SuperPath

#	Name	Source	Genes
1	Intracellular trafficking proteins involved in CMT neuropathy	WikiPathways	DNM2 EGR2 FGD4 FIG4 GDAP1 HSPB1 HSPB8 KIF1B LITAF LRSAM1 MFN2 MPZ MTMR2 NDRG1 NEFL PMP22 RAB11A RAB11B RAB25 RAB3A RAB3B RAB4A RAB4B RAB7A RABAC1 SBF2 SH3TC2 (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAB4A	RAB4A, Member RAS Oncogene Family	Protein Coding	1
2	MFN2	Mitofusin 2	Protein Coding	1
3	FIG4	FIG4 Phosphoinositide 5-Phosphatase	Protein Coding	1
4	LITAF	Lipopolysaccharide Induced TNF Factor	Protein Coding	1
5	RAB11B	RAB11B, Member RAS Oncogene Family	Protein Coding	1
6	LRSAM1	Leucine Rich Repeat And Sterile Alpha Motif Containing 1	Protein Coding	1
7	MTMR2	Myotubularin Related Protein 2	Protein Coding	1
8	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	1
9	SBF2	SET Binding Factor 2	Protein Coding	1
10	SH3TC2	SH3 Domain And Tetratricopeptide Repeats 2	Protein Coding	1
11	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	1
12	RAB3A	RAB3A, Member RAS Oncogene Family	Protein Coding	1
13	GDAP1	Ganglioside Induced Differentiation Associated Protein 1	Protein Coding	1
14	RAB4B	RAB4B, Member RAS Oncogene Family	Protein Coding	1
15	PMP22	Peripheral Myelin Protein 22	Protein Coding	1
16	NEFL	Neurofilament Light Chain	Protein Coding	1
17	MPZ	Myelin Protein Zero	Protein Coding	1
18	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
19	HSPB8	Heat Shock Protein Family B (Small) Member 8	Protein Coding	1
20	KIF1B	Kinesin Family Member 1B	Protein Coding	1
21	EGR2	Early Growth Response 2	Protein Coding	1
22	DNM2	Dynamin 2	Protein Coding	1
23	FGD4	FYVE, RhoGEF And PH Domain Containing 4	Protein Coding	1
24	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	1
25	RABAC1	Rab Acceptor 1	Protein Coding	1
26	RAB3B	RAB3B, Member RAS Oncogene Family	Protein Coding	1
27	RAB25	RAB25, Member RAS Oncogene Family	Protein Coding	1

Disorders associated with Intracellular trafficking proteins involved in CMT neuropathy SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Charcot-marie-tooth disease	Enrichment	DNM2, FIG4, GDAP1, HSPB1, LITAF, LRSAM1, MFN2, MPZ, NDRG1, NEFL, PMP22, SBF2, SH3TC2	11.23
2	Charcot-marie-tooth disease type 4	Enrichment	EGR2, FGD4, FIG4, MPZ, MTMR2, NDRG1, SBF2, SH3TC2	10.79
3	Peripheral nervous system disease	Enrichment	GDAP1, MFN2, MPZ, NEFL, PMP22, SH3TC2	10.35
4	Neuropathy	Enrichment	GDAP1, MFN2, MPZ, NEFL, PMP22, SH3TC2	10.35
5	Charcot-marie-tooth disease type 1	Enrichment	EGR2, MPZ, PMP22	8.15
6	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2, MPZ, PMP22	7.15
7	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1, HSPB8, MPZ	7.15
8	Genetic motor neuron disease	Enrichment	MFN2, MPZ, SH3TC2	7.15
9	Charcot-marie-tooth disease, demyelinating, type 1b	Enrichment	MPZ, SH3TC2	5.42
10	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2, MPZ	5.42
11	Roussy-levy hereditary areflexic dystasia	Enrichment	MPZ, PMP22	5.42
12	Charcot-marie-tooth disease type 1b	Enrichment	MPZ, SH3TC2	5.42
13	Axonal neuropathy	Enrichment	GDAP1, MFN2	5.42
14	Sensory peripheral neuropathy	Enrichment	GDAP1, MPZ	4.42
15	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MFN2, NEFL	3.19
16	Auditory neuropathy	Enrichment	MFN2, NEFL	2.92
17	Charcot-marie-tooth disease and deafness	Enrichment	PMP22	2.70
18	Charcot-marie-tooth disease, axonal, type 2a1	Enrichment	KIF1B	2.70
19	Guillain-barre syndrome, familial	Enrichment	PMP22	2.70
20	Charcot-marie-tooth disease, demyelinating, type 4c	Enrichment	SH3TC2	2.70
21	Charcot-marie-tooth disease, demyelinating, type 1c	Enrichment	LITAF	2.70
22	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.70
23	Polymicrogyria, bilateral temporooccipital	Enrichment	FIG4	2.70
24	Charcot-marie-tooth disease, axonal, type 2j	Enrichment	MPZ	2.70
25	Neuropathy, hereditary, with liability to pressure palsies	Enrichment	PMP22	2.70
26	Charcot-marie-tooth disease, axonal, type 2p	Enrichment	LRSAM1	2.70
27	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.70
28	Charcot-marie-tooth disease, demyelinating, type 1f	Enrichment	NEFL	2.70
29	Charcot-marie-tooth disease, demyelinating, type 4h	Enrichment	FGD4	2.70
30	Neuroblastoma 1	Enrichment	KIF1B	2.70
31	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	2.70
32	Charcot-marie-tooth disease, dominant intermediate g	Enrichment	NEFL	2.70
33	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	2.70
34	Charcot-marie-tooth disease type 4b1	Enrichment	MTMR2	2.70
35	Charcot-marie-tooth disease, demyelinating, type 4b1	Enrichment	MTMR2	2.70
36	Charcot-marie-tooth disease type 4c	Enrichment	SH3TC2	2.70
37	Amyotrophic lateral sclerosis 11	Enrichment	FIG4	2.70
38	Charcot-marie-tooth disease type 4h	Enrichment	FGD4	2.70
39	Charcot-marie-tooth disease, axonal, type 2l	Enrichment	HSPB8	2.70
40	Multiple symmetric lipomatosis	Enrichment	MFN2	2.70
41	Charcot-marie-tooth disease, demyelinating, type 4j	Enrichment	FIG4	2.70
42	Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter	Enrichment	RAB11B	2.70
43	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.70
44	Charcot-marie-tooth disease, axonal, autosomal dominant, type 2a2a	Enrichment	MFN2	2.70
45	Charcot-marie-tooth disease, dominant intermediate d	Enrichment	MPZ	2.70
46	Charcot-marie-tooth disease, axonal, type 2i	Enrichment	MPZ	2.70
47	Charcot-marie-tooth disease type 1f	Enrichment	NEFL	2.70
48	Charcot-marie-tooth disease type 2a1	Enrichment	KIF1B	2.70
49	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.70
50	Myopathy, myofibrillar, 13, with rimmed vacuoles	Enrichment	HSPB8	2.70
51	Charcot-marie-tooth disease, axonal, autosomal recessive, type 2a2b	Enrichment	MFN2	2.70
52	Charcot-marie-tooth disease type 4j	Enrichment	FIG4	2.70
53	Autosomal dominant intermediate charcot-marie-tooth disease with neuropathic pain	Enrichment	MPZ	2.70
54	Charcot-marie-tooth disease type 2i	Enrichment	MPZ	2.70
55	Charcot-marie-tooth disease type 1c	Enrichment	LITAF	2.70
56	Charcot-marie-tooth disease type 5	Enrichment	MFN2	2.70
57	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.70
58	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.70
59	Charcot-marie-tooth disease type 2b5	Enrichment	NEFL	2.70
60	Charcot-marie-tooth disease type 2a2b	Enrichment	MFN2	2.70
61	Charcot-marie-tooth disease type 2j	Enrichment	MPZ	2.70
62	Autosomal dominant distal axonal motor neuropathy-myofibrillar myopathy syndrome	Enrichment	HSPB8	2.70
63	Charcot-marie-tooth disease, demyelinating, type 1a	Enrichment	PMP22	2.40
64	Charcot-marie-tooth disease, demyelinating, type 4a	Enrichment	GDAP1	2.40
65	Yunis-varon syndrome	Enrichment	FIG4	2.40
66	Charcot-marie-tooth disease, axonal, with vocal cord paresis, autosomal recessive	Enrichment	GDAP1	2.40
67	Charcot-marie-tooth disease, recessive intermediate a	Enrichment	GDAP1	2.40
68	Keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy	Enrichment	MPZ	2.40
69	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	MFN2	2.40
70	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.40
71	Mononeuropathy of the median nerve, mild	Enrichment	SH3TC2	2.40
72	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	2.40
73	Neuropathy, congenital hypomyelinating, 2	Enrichment	MPZ	2.40
74	Charcot-marie-tooth disease type 1a	Enrichment	PMP22	2.40
75	Charcot-marie-tooth disease, axonal, type 2h	Enrichment	GDAP1	2.40
76	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	2.40
77	Charcot-marie-tooth disease type 4a	Enrichment	GDAP1	2.40
78	Multiple system atrophy, cerebellar type	Enrichment	MFN2	2.40
79	Myopathy, centronuclear, x-linked	Enrichment	DNM2	2.22
80	Neuropathy, hereditary motor and sensory, type via, with optic atrophy	Enrichment	MFN2	2.22
81	Charcot-marie-tooth disease, axonal, type 2k	Enrichment	GDAP1	2.22
82	Distal myopathy	Enrichment	HSPB8	2.22
83	Hyperpigmentation of the skin	Enrichment	MFN2	2.22
84	Charcot-marie-tooth disease, demyelinating, type 4b2	Enrichment	SBF2	2.10
85	Myopathy, autophagic vacuolar, infantile-onset	Enrichment	HSPB8	2.10
86	Charcot-marie-tooth disease type 4b2	Enrichment	SBF2	2.10
87	Multiple endocrine neoplasia, type iia	Enrichment	KIF1B	2.00
88	Pseudovaginal perineoscrotal hypospadias	Enrichment	FIG4	2.00
89	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	NEFL	2.00
90	Polyneuropathy	Enrichment	GDAP1	2.00
91	Myopathy, centronuclear, 1	Enrichment	DNM2	1.92
92	Motor neuron disease	Enrichment	MPZ	1.86
93	Neuroblastoma	Enrichment	KIF1B	1.80
94	Creatine phosphokinase, elevated serum	Enrichment	GDAP1	1.50
95	Isolated elevated serum creatine phosphokinase levels	Enrichment	GDAP1	1.50
96	Isolated congenital microcephaly	Enrichment	RAB11A	1.50
97	Beckwith-wiedemann syndrome	Enrichment	MFN2	1.45
98	Centronuclear myopathy	Enrichment	DNM2	1.39
99	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	KIF1B	1.39
100	Cerebral palsy	Enrichment	MFN2	1.13
101	Myopathy	Enrichment	DNM2	1.12
102	Hereditary spastic paraplegia	Enrichment	SH3TC2	1.09
103	Sensorineural hearing loss	Enrichment	NEFL	1.04
104	Autosomal dominant non-syndromic intellectual disability	Enrichment	RAB11A	1.02
105	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	FIG4	0.96
106	Ovarian cancer	Enrichment	KIF1B	0.74
107	Microcephaly	Enrichment	MFN2	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Intracellular trafficking proteins involved in CMT neuropathy

Pathway Network for Intracellular trafficking proteins involved in CMT neuropathy

Member Pathways for Intracellular trafficking proteins involved in CMT neuropathy

Pathways in the Intracellular trafficking proteins involved in CMT neuropathy SuperPath

Associated Genes for Intracellular trafficking proteins involved in CMT neuropathy

Associated Disorders for Intracellular trafficking proteins involved in CMT neuropathy

Disorders associated with Intracellular trafficking proteins involved in CMT neuropathy SuperPath

STRING Interaction Network for Intracellular trafficking proteins involved in CMT neuropathy

Sources for Intracellular trafficking proteins involved in CMT neuropathy