Intraflagellar transport

No Pathway Network information available for Intraflagellar transport

Pathways in the Intraflagellar transport SuperPath

#	Name	Source	Genes
1	Intraflagellar transport	Reactome	CLUAP1 DYNC2H1 DYNC2I1 DYNC2I2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT2 DYNLT2B DYNLT5 IFT122 IFT140 IFT172 IFT20 IFT22 IFT25 IFT27 IFT43 IFT46 IFT52 IFT56 IFT57 IFT70A IFT70B IFT74 IFT80 IFT81 IFT88 KIF17 KIF3A KIF3B KIF3C KIFAP3 TNPO1 TRAF3IP1 TRIP11 TTC21B TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 WDR19 WDR35 (see all 54) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TUBA1B	Tubulin Alpha 1b	Protein Coding	1
2	TUBB3	Tubulin Beta 3 Class III	Protein Coding	1
3	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	1
4	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	1
5	IFT27	Intraflagellar Transport 27	Protein Coding	1
6	KIF3A	Kinesin Family Member 3A	Protein Coding	1
7	IFT43	Intraflagellar Transport 43	Protein Coding	1
8	TUBA3D	Tubulin Alpha 3d	Protein Coding	1
9	DYNLL2	Dynein Light Chain LC8-Type 2	Protein Coding	1
10	IFT70B	Intraflagellar Transport 70B	Protein Coding	1
11	DYNLT5	Dynein Light Chain Tctex-Type Family Member 5	Protein Coding	1
12	KIFAP3	Kinesin Associated Protein 3	Protein Coding	1
13	CLUAP1	Clusterin Associated Protein 1	Protein Coding	1
14	DYNLT2B	Dynein Light Chain Tctex-Type 2B	Protein Coding	1
15	TRAF3IP1	TRAF3 Interacting Protein 1	Protein Coding	1
16	IFT172	Intraflagellar Transport 172	Protein Coding	1
17	IFT81	Intraflagellar Transport 81	Protein Coding	1
18	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	1
19	KIF3C	Kinesin Family Member 3C	Protein Coding	1
20	TNPO1	Transportin 1	Protein Coding	1
21	IFT52	Intraflagellar Transport 52	Protein Coding	1
22	DYNC2LI1	Dynein Cytoplasmic 2 Light Intermediate Chain 1	Protein Coding	1
23	IFT25	Intraflagellar Transport 25	Protein Coding	1
24	IFT57	Intraflagellar Transport 57	Protein Coding	1
25	DYNC2I1	Dynein 2 Intermediate Chain 1	Protein Coding	1
26	IFT122	Intraflagellar Transport 122	Protein Coding	1
27	IFT46	Intraflagellar Transport 46	Protein Coding	1
28	WDR35	WD Repeat Domain 35	Protein Coding	1
29	IFT80	Intraflagellar Transport 80	Protein Coding	1
30	KIF17	Kinesin Family Member 17	Protein Coding	1
31	WDR19	WD Repeat Domain 19	Protein Coding	1
32	IFT22	Intraflagellar Transport 22	Protein Coding	1
33	DYNLT2	Dynein Light Chain Tctex-Type 2	Protein Coding	1
34	TUBA4A	Tubulin Alpha 4a	Protein Coding	1
35	TUBA3C	Tubulin Alpha 3c	Protein Coding	1
36	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	1
37	TUBA1A	Tubulin Alpha 1a	Protein Coding	1
38	DYNC2H1	Dynein Cytoplasmic 2 Heavy Chain 1	Protein Coding	1
39	TTC21B	Tetratricopeptide Repeat Domain 21B	Protein Coding	1
40	IFT56	Intraflagellar Transport 56	Protein Coding	1
41	IFT74	Intraflagellar Transport 74	Protein Coding	1
42	IFT88	Intraflagellar Transport 88	Protein Coding	1
43	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	1
44	DYNLRB2	Dynein Light Chain Roadblock-Type 2	Protein Coding	1
45	DYNLRB1	Dynein Light Chain Roadblock-Type 1	Protein Coding	1
46	TUBB6	Tubulin Beta 6 Class V	Protein Coding	1
47	TUBA1C	Tubulin Alpha 1c	Protein Coding	1
48	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	1
49	DYNC2I2	Dynein 2 Intermediate Chain 2	Protein Coding	1
50	IFT20	Intraflagellar Transport 20	Protein Coding	1
51	IFT70A	Intraflagellar Transport 70A	Protein Coding	1
52	TRIP11	Thyroid Hormone Receptor Interactor 11	Protein Coding	1
53	KIF3B	Kinesin Family Member 3B	Protein Coding	1
54	IFT140	Intraflagellar Transport 140	Protein Coding	1

Disorders associated with Intraflagellar transport SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Asphyxiating thoracic dystrophy	Enrichment	DYNC2H1, DYNC2I1, DYNC2I2, IFT140, IFT27, IFT74, IFT80, IFT81, TRAF3IP1, TTC21B, WDR19, WDR35	16.00
2	Jeune thoracic dystrophy	Enrichment	DYNC2H1, DYNC2I1, DYNC2I2, IFT140, IFT27, IFT74, IFT80, IFT81, TRAF3IP1, TTC21B, WDR19, WDR35	16.00
3	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	DYNC2H1, DYNC2I1, DYNC2I2, DYNC2LI1, IFT140, IFT172, IFT27, IFT74, IFT80, IFT81, TRAF3IP1, TTC21B, WDR19, WDR35	10.97
4	Short rib-polydactyly syndrome, verma-naumoff type	Enrichment	DYNC2H1, DYNC2I1, DYNC2I2, IFT80, WDR35	10.95
5	Short rib-polydactyly syndrome	Enrichment	DYNC2H1, IFT43, IFT52, IFT81, WDR35	10.65
6	Cranioectodermal dysplasia	Enrichment	IFT122, IFT140, IFT43, IFT52, WDR19, WDR35	10.54
7	Short-rib thoracic dysplasia 12	Enrichment	DYNC2H1, IFT122, IFT80, TTC21B, WDR19	10.21
8	Short-rib thoracic dysplasia 6 with or without polydactyly	Enrichment	DYNC2H1, IFT172, IFT80, TRAF3IP1, TTC21B	9.19
9	Cranioectodermal dysplasia 1	Enrichment	IFT122, IFT140, WDR19, WDR35	8.11
10	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	7.22
11	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	DYNC2H1, DYNC2I1, DYNC2I2, DYNLT2B	6.96
12	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	6.62
13	Short-rib thoracic dysplasia 9 with or without polydactyly	Enrichment	IFT140, IFT172, WDR19	6.23
14	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	5.93
15	Bardet-biedl syndrome 22	Enrichment	IFT172, IFT74	4.81
16	Senior-loken syndrome 1	Enrichment	TRAF3IP1, TTC21B, WDR19	4.78
17	Lissencephaly	Enrichment	TUBA1A, TUBB2B, TUBB3	4.12
18	Retinitis pigmentosa	Enrichment	IFT122, IFT140, IFT172, IFT43, IFT81, IFT88	3.73
19	Connective tissue disease	Enrichment	TRIP11, TTC21B, WDR19	3.56
20	Nephronophthisis	Enrichment	IFT140, TTC21B, WDR19	3.52
21	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.49
22	Leber plus disease	Enrichment	CLUAP1, IFT140, TUBB4B, WDR19	3.26
23	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	3.26
24	Bardet-biedl syndrome	Enrichment	IFT172, IFT27, IFT74	3.21
25	Hereditary retinal dystrophy	Enrichment	DYNC2H1, IFT140, IFT172, IFT81, TTC21B, WDR19	3.00
26	Fundus dystrophy	Enrichment	DYNC2H1, IFT140, IFT172, IFT81, TTC21B, WDR19	3.00
27	Achondrogenesis, type ia	Enrichment	TRIP11	2.40
28	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.40
29	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.40
30	Odontochondrodysplasia 1	Enrichment	TRIP11	2.40
31	Senior-loken syndrome 8	Enrichment	WDR19	2.40
32	Cranioectodermal dysplasia 4	Enrichment	WDR19	2.40
33	Orofaciodigital syndrome xviii	Enrichment	IFT57	2.40
34	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.40
35	Short-rib thoracic dysplasia 18 with polydactyly	Enrichment	IFT43	2.40
36	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.40
37	Biliary, renal, neurologic, and skeletal syndrome	Enrichment	IFT56	2.40
38	Spermatogenic failure 72	Enrichment	WDR19	2.40
39	Short-rib thoracic dysplasia 5 with or without polydactyly	Enrichment	WDR19	2.40
40	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.40
41	Cranioectodermal dysplasia 3	Enrichment	IFT43	2.40
42	Retinitis pigmentosa 89	Enrichment	KIF3B	2.40
43	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.40
44	Nephronophthisis 13	Enrichment	WDR19	2.40
45	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.40
46	Retinitis pigmentosa 81	Enrichment	IFT43	2.40
47	Short-rib thoracic dysplasia 8 with or without polydactyly	Enrichment	DYNC2I1	2.40
48	Senior-loken syndrome 9	Enrichment	TRAF3IP1	2.40
49	Short-rib thoracic dysplasia 16 with or without polydactyly	Enrichment	IFT52	2.40
50	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.40
51	Short-rib thoracic dysplasia 19 with or without polydactyly	Enrichment	IFT81	2.40
52	Joubert syndrome 40	Enrichment	IFT74	2.40
53	Spermatogenic failure 58	Enrichment	IFT74	2.40
54	Lung disease	Enrichment	DYNC2H1	2.40
55	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.40
56	Congenital myopathy 26	Enrichment	TUBA4A	2.40
57	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.40
58	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.40
59	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	2.10
60	Short-rib thoracic dysplasia 2 with or without polydactyly	Enrichment	IFT80	2.10
61	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	2.10
62	Short-rib thoracic dysplasia 17 with or without polydactyly	Enrichment	DYNLT2B	2.10
63	Nephronophthisis 12	Enrichment	TTC21B	2.10
64	Cranioectodermal dysplasia 2	Enrichment	WDR35	2.10
65	Short-rib thoracic dysplasia 4 with or without polydactyly	Enrichment	TTC21B	2.10
66	Polycystic kidney disease 9	Enrichment	IFT140	2.10
67	Sitosterolemia 2	Enrichment	DYNC2LI1	2.10
68	Keratoconus 9	Enrichment	TUBA3D	2.10
69	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	2.10
70	Cranioectodermal dysplasia 5	Enrichment	IFT140	2.10
71	Lissencephaly 3	Enrichment	TUBA1A	2.10
72	Short-rib thoracic dysplasia 15 with polydactyly	Enrichment	DYNC2LI1	2.10
73	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	2.10
74	Short-rib thoracic dysplasia 7 with or without polydactyly	Enrichment	WDR35	2.10
75	Torsion dystonia 4	Enrichment	TUBB4A	2.10
76	Continuous spikes and waves during sleep	Enrichment	TUBA1A	2.10
77	Retinal ciliopathy due to mutation in the retinitis pigmentosa-1 gene	Enrichment	IFT140	2.10
78	Cerebral palsy	Enrichment	TUBA1A, TUBB4A	1.98
79	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.92
80	Caroli disease, isolated	Enrichment	IFT56	1.92
81	Nephronophthisis 2	Enrichment	TTC21B	1.92
82	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	1.92
83	Sitosterolemia 1	Enrichment	DYNC2LI1	1.92
84	Bardet-biedl syndrome 19	Enrichment	IFT27	1.92
85	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	DYNC2I2	1.92
86	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.92
87	Caroli disease	Enrichment	IFT56	1.92
88	Sitosterolemia	Enrichment	DYNC2LI1	1.92
89	Retinitis pigmentosa 80	Enrichment	IFT140	1.92
90	Orofaciodigital syndrome iii	Enrichment	IFT140	1.80
91	Short-rib thoracic dysplasia 10 with or without polydactyly	Enrichment	IFT172	1.80
92	Retinitis pigmentosa 71	Enrichment	IFT172	1.80
93	Bardet-biedl syndrome 20	Enrichment	IFT172	1.80
94	Newborn respiratory distress syndrome	Enrichment	DYNC2H1	1.80
95	Joubert syndrome 1	Enrichment	CLUAP1, IFT172	1.77
96	Joubert syndrome with jeune asphyxiating thoracic dystrophy	Enrichment	IFT140	1.70
97	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.63
98	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.63
99	Spermatogenic failure 5	Enrichment	IFT74	1.50
100	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	DYNC2H1	1.50
101	Cryptorchidism	Enrichment	TUBA1A	1.50
102	Infantile nephronophthisis	Enrichment	TTC21B	1.50
103	Nephrotic syndrome, type 1	Enrichment	TTC21B	1.45
104	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.45
105	Ellis-van creveld syndrome	Enrichment	DYNC2LI1	1.45
106	Cystic kidney disease	Enrichment	IFT140	1.45
107	Autosomal dominant macrothrombocytopenia	Enrichment	TUBB1	1.41
108	Primary bone dysplasia	Enrichment	DYNC2H1	1.41
109	Osteochondrodysplasia	Enrichment	DYNC2H1	1.37
110	Congenital hypothyroidism	Enrichment	TUBB1	1.33
111	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.24
112	Hydrocephalus	Enrichment	IFT56	1.24
113	Autosomal dominant polycystic kidney disease	Enrichment	IFT140	1.24
114	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.24
115	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.24
116	Dandy-walker syndrome	Enrichment	TUBA1A	1.18
117	Congenital nervous system abnormality	Enrichment	TUBA1A, TUBB4A	1.18
118	Nervous system disease	Enrichment	TUBA1A, TUBB4A	1.18
119	Heart, malformation of	Enrichment	DYNC2H1	1.16
120	Polycystic kidney disease	Enrichment	IFT140	1.16
121	Cone dystrophy	Enrichment	WDR19	1.04
122	Auditory neuropathy	Enrichment	TUBB4A	1.01
123	Isolated joubert syndrome	Enrichment	IFT74	0.95
124	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.86
125	Epilepsy	Enrichment	TTC21B	0.83
126	Nephrotic syndrome	Enrichment	TTC21B	0.80
127	Optic atrophy plus syndrome	Enrichment	TUBB6	0.79
128	West syndrome	Enrichment	TUBA1A	0.79
129	Thrombocytopenia	Enrichment	TUBB1	0.76
130	Spastic ataxia	Enrichment	TUBB3	0.72
131	Cone-rod dystrophy 2	Enrichment	IFT81	0.62
132	Microcephaly	Enrichment	TUBB4A	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Intraflagellar transport

Pathway Network for Intraflagellar transport

Member Pathways for Intraflagellar transport

Pathways in the Intraflagellar transport SuperPath

Associated Genes for Intraflagellar transport

Associated Disorders for Intraflagellar transport

Disorders associated with Intraflagellar transport SuperPath

STRING Interaction Network for Intraflagellar transport

Sources for Intraflagellar transport