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Intrinsic Pathway for Apoptosis SuperPath

Pathway network for Intrinsic Pathway for Apoptosis SuperPath
14 Pathways in the Intrinsic Pathway for Apoptosis SuperPath
Intrinsic Pathway for Apoptosis Activation, myristolyation of BID and translocation to mitochondria
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Apoptotic factor-mediated response Activation of PUMA and translocation to mitochondria
Activation of BMF and translocation to mitochondria Cytochrome c-mediated apoptotic response
Activation of NOXA and translocation to mitochondria Activation of BAD and translocation to mitochondria
Release of apoptotic factors from the mitochondria Activation of BH3-only proteins
Activation of BIM and translocation to mitochondria SMAC, XIAP-regulated apoptotic response
55 Genes in the Intrinsic Pathway for Apoptosis SuperPath
CYCS DIABLO BID BCL2L11 E2F1 BBC3 APAF1 XIAP PMAIP1 SEPTIN4 MAPK8 BAD
BCL2 TFDP1 TFDP2 TP53 CASP3 CASP7 CASP9 BMF AKT3 CDKN2A YWHAQ DYNLL2
GSDME AKT1 AKT2 CARD8 PPP1R13B SFN APIP UACA PPP3CC PPP3R1 MAPK1 MAPK3
AVEN BAK1 BAX C1QBP TP53BP2 TP73 YWHAB YWHAE YWHAG YWHAH YWHAZ GSDMD
TP63 DYNLL1 GZMB NMT1 BCL2L1 STAT3 CASP8
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network for Intrinsic Pathway for Apoptosis SuperPath