Intrinsic Pathway for Apoptosis

Pathway network for the Intrinsic Pathway for Apoptosis SuperPath

Sources:

Reactome

Pathways in the Intrinsic Pathway for Apoptosis SuperPath

#	Name	Source	Genes
1	Intrinsic Pathway for Apoptosis	Reactome	AKT1 AKT2 AKT3 BAD BBC3 BCL2 BCL2L1 BCL2L11 BMF C1QBP CASP8 CASP9 CDKN2A DYNLL1 DYNLL2 E2F1 GSDMD GSDME MAPK1 MAPK3 MAPK8 PMAIP1 PPP3CC PPP3R1 SEPTIN4 SFN STAT3 TFDP1 TFDP2 TP53 UACA YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 37) (see less)
2	Activation of BH3-only proteins	Reactome	AKT1 AKT2 AKT3 BAD BBC3 BCL2 BCL2L11 BMF DYNLL1 DYNLL2 E2F1 MAPK8 PMAIP1 PPP3CC PPP3R1 SFN TFDP1 TFDP2 TP53 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 25) (see less)
3	Activation of BAD and translocation to mitochondria	Reactome	AKT1 AKT2 AKT3 BAD BCL2 PPP3CC PPP3R1 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 14) (see less)
4	Apoptotic factor-mediated response	Reactome	C1QBP CASP9 CDKN2A GSDMD GSDME MAPK1 MAPK3 SEPTIN4 UACA (see all 9) (see less)
5	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	Reactome	BAD BBC3 BCL2 BCL2L1 BCL2L11 BMF PMAIP1 STAT3 (see all 8) (see less)
6	Activation of PUMA and translocation to mitochondria	Reactome	BBC3 E2F1 TFDP1 TFDP2 TP53
7	Activation of NOXA and translocation to mitochondria	Reactome	E2F1 PMAIP1 TFDP1 TFDP2 TP53
8	Activation of BIM and translocation to mitochondria	Reactome	BCL2L11 DYNLL1 MAPK8
9	Release of apoptotic factors from the mitochondria	Reactome	GSDMD GSDME SEPTIN4
10	Activation of BMF and translocation to mitochondria	Reactome	BMF DYNLL2 MAPK8
11	Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function	Reactome	C1QBP CDKN2A
12	SMAC, XIAP-regulated apoptotic response	Reactome	CASP9 SEPTIN4

Gene overlap in member pathways for Intrinsic Pathway for Apoptosis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BCL2L11	BCL2 Like 11	Protein Coding	4
2	E2F1	E2F Transcription Factor 1	Protein Coding	4
3	BBC3	BCL2 Binding Component 3	Protein Coding	4
4	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	4
5	SEPTIN4	Septin 4	Protein Coding	4
6	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	4
7	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	4
8	BCL2	BCL2 Apoptosis Regulator	Protein Coding	4
9	TFDP1	Transcription Factor Dp-1	Protein Coding	4
10	TFDP2	Transcription Factor Dp-2	Protein Coding	4
11	TP53	Tumor Protein P53	Protein Coding	4
12	BMF	Bcl2 Modifying Factor	Protein Coding	4
13	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
14	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3
15	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	3
16	DYNLL2	Dynein Light Chain LC8-Type 2	Protein Coding	3
17	GSDME	Gasdermin E	Protein Coding	3
18	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
19	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
20	SFN	Stratifin	Protein Coding	3
21	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	3
22	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	3
23	C1QBP	Complement C1q Binding Protein	Protein Coding	3
24	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	3
25	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	3
26	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	3
27	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	3
28	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	3
29	GSDMD	Gasdermin D	Protein Coding	3
30	CASP9	Caspase 9	Protein Coding	3
31	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	3
32	UACA	Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats	Protein Coding	2
33	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
34	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
35	BCL2L1	BCL2 Like 1	Protein Coding	2
36	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
37	CASP8	Caspase 8	Protein Coding	1

Disorders associated with Intrinsic Pathway for Apoptosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast adenocarcinoma	Enrichment	AKT1, TP53	4.31
2	Li-fraumeni syndrome	Enrichment	CDKN2A, TP53	3.97
3	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	3.97
4	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	3.83
5	Cdkn2a cancer predisposition	Enrichment	CDKN2A	3.83
6	Spermatogenic failure 99	Enrichment	SEPTIN4	3.83
7	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	3.82
8	Deafness, autosomal dominant 5	Enrichment	GSDME	3.66
9	Adult hepatocellular carcinoma	Enrichment	CASP8, TP53	3.59
10	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	3.53
11	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	3.53
12	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	3.53
13	Bone marrow failure syndrome 5	Enrichment	TP53	3.43
14	Papilloma of choroid plexus	Enrichment	TP53	3.43
15	Basal cell carcinoma 7	Enrichment	TP53	3.43
16	Anaplastic thyroid carcinoma	Enrichment	TP53	3.43
17	Ductal carcinoma in situ	Enrichment	TP53	3.43
18	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.43
19	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.43
20	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.43
21	Choroid plexus cancer	Enrichment	TP53	3.43
22	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.43
23	Specific learning disability	Enrichment	MAPK1, YWHAG	3.41
24	Lip and oral cavity carcinoma	Enrichment	CDKN2A, TP53	3.33
25	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.23
26	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.23
27	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.23
28	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.23
29	Noonan syndrome 13	Enrichment	MAPK1	3.18
30	Adrenocortical carcinoma, hereditary	Enrichment	TP53	3.13
31	Cervical cancer	Enrichment	TP53	3.13
32	Lymphoma, hodgkin, classic	Enrichment	TP53	3.13
33	Congenital fibrosarcoma	Enrichment	TP53	3.13
34	Li-fraumeni syndrome 1	Enrichment	TP53	3.13
35	Sarcoma	Enrichment	TP53	3.13
36	Cervix carcinoma	Enrichment	TP53	3.13
37	Hodgkin's lymphoma	Enrichment	TP53	3.13
38	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	3.13
39	Lung squamous cell carcinoma	Enrichment	CDKN2A	3.05
40	Proteus syndrome	Enrichment	AKT1	2.99
41	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.99
42	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.99
43	Cowden syndrome 6	Enrichment	AKT1	2.99
44	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.99
45	Capillary hemangioma	Enrichment	AKT3	2.99
46	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.99
47	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.99
48	Breast cancer	Enrichment	AKT1, CASP8, TP53	2.96
49	Osteogenic sarcoma	Enrichment	TP53	2.96
50	Nasopharyngeal carcinoma	Enrichment	TP53	2.96
51	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.96
52	Anaplastic astrocytoma	Enrichment	TP53	2.96
53	Squamous cell carcinoma	Enrichment	TP53	2.96
54	Adenocarcinoma	Enrichment	TP53	2.96
55	Bone osteosarcoma	Enrichment	TP53	2.96
56	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.93
57	Male infertility due to globozoospermia	Enrichment	SEPTIN4	2.93
58	Diffuse large b-cell lymphoma	Enrichment	STAT3, TP53	2.92
59	Small cell cancer of the lung	Enrichment	TP53	2.83
60	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.83
61	Lung sarcomatoid carcinoma	Enrichment	TP53	2.83
62	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.83
63	Melanoma	Enrichment	CDKN2A	2.83
64	Hepatocellular carcinoma	Enrichment	CASP8, TP53	2.79
65	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	2.79
66	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.75
67	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.75
68	Hyper ige syndrome	Enrichment	STAT3	2.75
69	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.75
70	Rhabdomyosarcoma 2	Enrichment	TP53	2.73
71	Lymphoma	Enrichment	TP53	2.73
72	Acute megakaryocytic leukemia	Enrichment	TP53	2.73
73	Senior-loken syndrome 7	Enrichment	AKT3	2.69
74	Bardet-biedl syndrome 16	Enrichment	AKT3	2.69
75	Pancreatic cancer	Enrichment	CDKN2A, TP53	2.68
76	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	2.60
77	Esophageal cancer	Enrichment	TP53	2.59
78	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.59
79	Essential thrombocythemia	Enrichment	TP53	2.59
80	Gallbladder cancer	Enrichment	TP53	2.59
81	Ovarian cancer	Enrichment	AKT1, CDKN2A, TP53	2.59
82	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.58
83	Caspase 8 deficiency	Enrichment	CASP8	2.56
84	Bladder cancer	Enrichment	CDKN2A, TP53	2.55
85	Hereditary breast carcinoma	Enrichment	AKT1, TP53	2.53
86	Follicular lymphoma	Enrichment	BCL2	2.53
87	Glioma susceptibility 1	Enrichment	TP53	2.53
88	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.53
89	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	2.51
90	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	2.51
91	Primary hyperaldosteronism	Enrichment	TP53	2.48
92	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	2.47
93	Leukemia, chronic lymphocytic	Enrichment	TP53	2.43
94	Familial colorectal cancer	Enrichment	TP53	2.43
95	Myelodysplastic syndrome	Enrichment	TP53	2.39
96	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.38
97	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.38
98	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	2.38
99	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.33
100	Hemimegalencephaly	Enrichment	AKT3	2.29
101	Endometrial stromal sarcoma	Enrichment	YWHAE	2.29
102	Lung cancer susceptibility 3	Enrichment	TP53	2.29
103	Rhabdomyosarcoma	Enrichment	TP53	2.23
104	Gliosarcoma	Enrichment	TP53	2.23
105	Gastric cancer	Enrichment	CDKN2A, TP53	2.22
106	Kidney clear cell sarcoma	Enrichment	YWHAE	2.21
107	Giant cell glioblastoma	Enrichment	TP53	2.20
108	Megacolon	Enrichment	AKT3	2.14
109	Acute promyelocytic leukemia	Enrichment	STAT3	2.12
110	Hepatoblastoma	Enrichment	TP53	2.11
111	Diamond-blackfan anemia 1	Enrichment	TP53	2.07
112	Cowden syndrome	Enrichment	AKT1	2.03
113	Polymicrogyria	Enrichment	AKT3	1.99
114	Prostate cancer	Enrichment	TP53	1.97
115	Colorectal cancer	Enrichment	AKT1, TP53	1.96
116	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GSDME	1.94
117	Heart, malformation of	Enrichment	MAPK1	1.93
118	Meningioma	Enrichment	AKT1	1.91
119	Mitochondrial disease	Enrichment	C1QBP	1.89
120	Diamond-blackfan anemia	Enrichment	TP53	1.88
121	Leukemia, acute myeloid	Enrichment	TP53	1.83
122	Rare genetic deafness	Enrichment	GSDME	1.76
123	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A	1.71
124	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.70
125	Myeloma, multiple	Enrichment	TP53	1.69
126	Type 2 diabetes mellitus	Enrichment	AKT2	1.37
127	Microcephaly	Enrichment	MAPK1, YWHAG	1.35
128	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	1.30
129	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	1.25
130	Lung cancer	Enrichment	CASP8	1.08

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Intrinsic Pathway for Apoptosis

Pathway Network for Intrinsic Pathway for Apoptosis

Pathway network for the Intrinsic Pathway for Apoptosis SuperPath

Member Pathways for Intrinsic Pathway for Apoptosis

Pathways in the Intrinsic Pathway for Apoptosis SuperPath

Gene overlap in member pathways for Intrinsic Pathway for Apoptosis SuperPath

Associated Genes for Intrinsic Pathway for Apoptosis

Associated Disorders for Intrinsic Pathway for Apoptosis

Disorders associated with Intrinsic Pathway for Apoptosis SuperPath

STRING Interaction Network for Intrinsic Pathway for Apoptosis

Sources for Intrinsic Pathway for Apoptosis