Involvement of -secretase in neurodegenerative diseases

No Pathway Network information available for Involvement of -secretase in neurodegenerative diseases

Pathways in the Involvement of -secretase in neurodegenerative diseases SuperPath

#	Name	Source	Genes
1	Involvement of -secretase in neurodegenerative diseases	WikiPathways	AKT1 AKT2 AKT3 APP BDNF CEBPB LGMN MAOB MAPT NTRK2 PPP2CB SET SNCA SRPK2 STAT1 TARDBP (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TARDBP	TAR DNA Binding Protein	Protein Coding	1
2	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
3	SRPK2	SRSF Protein Kinase 2	Protein Coding	1
4	SNCA	Synuclein Alpha	Protein Coding	1
5	SET	SET Nuclear Proto-Oncogene	Protein Coding	1
6	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
7	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
8	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
9	MAOB	Monoamine Oxidase B	Protein Coding	1
10	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
11	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
12	APP	Amyloid Beta Precursor Protein	Protein Coding	1
13	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
14	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
15	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
16	LGMN	Legumain	Protein Coding	1

Disorders associated with Involvement of -secretase in neurodegenerative diseases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alzheimer's disease	Enrichment	APP, MAPT	4.00
2	Alzheimer disease, familial, 1	Enrichment	APP, MAPT	3.76
3	Parkinson disease, late-onset	Enrichment	MAPT, SNCA	3.45
4	Proteus syndrome	Enrichment	AKT1	2.93
5	Parkinson disease 1, autosomal dominant	Enrichment	SNCA	2.93
6	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.93
7	Parkinson disease 4, autosomal dominant	Enrichment	SNCA	2.93
8	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.93
9	Parkinson-dementia syndrome	Enrichment	MAPT	2.93
10	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.93
11	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.93
12	Progressive supranuclear palsy	Enrichment	MAPT	2.93
13	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.93
14	Immunodeficiency 31a	Enrichment	STAT1	2.93
15	Cowden syndrome 6	Enrichment	AKT1	2.93
16	Immunodeficiency 31b	Enrichment	STAT1	2.93
17	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.93
18	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.93
19	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.93
20	Capillary hemangioma	Enrichment	AKT3	2.93
21	Tardbp-related predominantly upper-limb distal myopathy	Enrichment	TARDBP	2.93
22	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.93
23	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT, TARDBP	2.68
24	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	2.63
25	Pick disease of brain	Enrichment	MAPT	2.63
26	Immunodeficiency 31c	Enrichment	STAT1	2.63
27	Parkinson disease 15, autosomal recessive early-onset	Enrichment	SNCA	2.63
28	Senior-loken syndrome 7	Enrichment	AKT3	2.63
29	Bardet-biedl syndrome 16	Enrichment	AKT3	2.63
30	Intellectual developmental disorder, autosomal dominant 58	Enrichment	SET	2.63
31	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.33
32	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.33
33	Dementia, lewy body	Enrichment	SNCA	2.23
34	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	TARDBP	2.23
35	Hemimegalencephaly	Enrichment	AKT3	2.23
36	Dementia	Enrichment	MAPT	2.23
37	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	2.15
38	Chronic mucocutaneous candidiasis	Enrichment	STAT1	2.15
39	Breast adenocarcinoma	Enrichment	AKT1	2.15
40	Semantic dementia	Enrichment	MAPT	2.08
41	Alzheimer's disease 1	Enrichment	APP	2.08
42	Motor neuron disease	Enrichment	TARDBP	2.08
43	Pilomyxoid astrocytoma	Enrichment	NTRK2	2.08
44	Megacolon	Enrichment	AKT3	2.08
45	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	2.08
46	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.98
47	Progressive non-fluent aphasia	Enrichment	MAPT	1.98
48	Cowden syndrome	Enrichment	AKT1	1.98
49	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.98
50	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TARDBP	1.93
51	Polymicrogyria	Enrichment	AKT3	1.93
52	Frontotemporal dementia 1	Enrichment	MAPT	1.89
53	Early-onset parkinson's disease	Enrichment	SNCA	1.85
54	Meningioma	Enrichment	AKT1	1.85
55	Precursor t-cell acute lymphoblastic leukemia	Enrichment	SET	1.57
56	Type 2 diabetes mellitus	Enrichment	AKT2	1.31
57	West syndrome	Enrichment	NTRK2	1.30
58	Hereditary breast carcinoma	Enrichment	AKT1	1.30
59	Body mass index quantitative trait locus 11	Enrichment	BDNF	1.24
60	Autosomal dominant non-syndromic intellectual disability	Enrichment	SET	1.24
61	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	1.19
62	Breast cancer	Enrichment	AKT1	1.07
63	Colorectal cancer	Enrichment	AKT1	1.01
64	Ovarian cancer	Enrichment	AKT1	0.95

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Involvement of -secretase in neurodegenerative diseases

Pathway Network for Involvement of -secretase in neurodegenerative diseases

Member Pathways for Involvement of -secretase in neurodegenerative diseases

Pathways in the Involvement of -secretase in neurodegenerative diseases SuperPath

Associated Genes for Involvement of -secretase in neurodegenerative diseases

Associated Disorders for Involvement of -secretase in neurodegenerative diseases

Disorders associated with Involvement of -secretase in neurodegenerative diseases SuperPath

STRING Interaction Network for Involvement of -secretase in neurodegenerative diseases

Sources for Involvement of -secretase in neurodegenerative diseases