Inwardly rectifying K+ channels

Pathway network for the Inwardly rectifying K+ channels SuperPath

Sources:

Reactome

Pathways in the Inwardly rectifying K+ channels SuperPath

#	Name	Source	Genes
1	Inwardly rectifying K+ channels	Reactome	ABCC8 ABCC9 GABBR1 GABBR2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ1 KCNJ10 KCNJ11 KCNJ12 KCNJ14 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ8 KCNJ9 (see all 35) (see less)
2	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Reactome	GABBR1 GABBR2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 (see all 29) (see less)
3	G protein gated Potassium channels	Reactome	GABBR1 GABBR2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 (see all 29) (see less)
4	Activation of G protein gated Potassium channels	Reactome	GABBR1 GABBR2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KCNJ10 KCNJ12 KCNJ15 KCNJ16 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ9 (see all 29) (see less)
5	ATP sensitive Potassium channels	Reactome	ABCC8 ABCC9 KCNJ11 KCNJ8
6	Potassium transport channels	Reactome	KCNJ1 KCNJ10 KCNJ16
7	Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome	Reactome	ABCC9 KCNJ11
8	Defective ABCC8 can cause hypo- and hyper-glycemias	Reactome	ABCC8 KCNJ11

Gene overlap in member pathways for Inwardly rectifying K+ channels SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KCNJ10	Potassium Inwardly Rectifying Channel Subfamily J Member 10	Protein Coding	5
2	KCNJ16	Potassium Inwardly Rectifying Channel Subfamily J Member 16	Protein Coding	5
3	GNB5	G Protein Subunit Beta 5	Protein Coding	4
4	GABBR1	Gamma-Aminobutyric Acid Type B Receptor Subunit 1	Protein Coding	4
5	GNB1	G Protein Subunit Beta 1	Protein Coding	4
6	GNB2	G Protein Subunit Beta 2	Protein Coding	4
7	GNB3	G Protein Subunit Beta 3	Protein Coding	4
8	GNG3	G Protein Subunit Gamma 3	Protein Coding	4
9	GNG4	G Protein Subunit Gamma 4	Protein Coding	4
10	GNG5	G Protein Subunit Gamma 5	Protein Coding	4
11	GNG7	G Protein Subunit Gamma 7	Protein Coding	4
12	GNG10	G Protein Subunit Gamma 10	Protein Coding	4
13	GNG11	G Protein Subunit Gamma 11	Protein Coding	4
14	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	4
15	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	4
16	KCNJ2	Potassium Inwardly Rectifying Channel Subfamily J Member 2	Protein Coding	4
17	KCNJ3	Potassium Inwardly Rectifying Channel Subfamily J Member 3	Protein Coding	4
18	KCNJ4	Potassium Inwardly Rectifying Channel Subfamily J Member 4	Protein Coding	4
19	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	4
20	KCNJ6	Potassium Inwardly Rectifying Channel Subfamily J Member 6	Protein Coding	4
21	KCNJ9	Potassium Inwardly Rectifying Channel Subfamily J Member 9	Protein Coding	4
22	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	4
23	KCNJ12	Potassium Inwardly Rectifying Channel Subfamily J Member 12	Protein Coding	4
24	KCNJ15	Potassium Inwardly Rectifying Channel Subfamily J Member 15	Protein Coding	4
25	GNG13	G Protein Subunit Gamma 13	Protein Coding	4
26	GNG2	G Protein Subunit Gamma 2	Protein Coding	4
27	GNG12	G Protein Subunit Gamma 12	Protein Coding	4
28	GNB4	G Protein Subunit Beta 4	Protein Coding	4
29	GNG8	G Protein Subunit Gamma 8	Protein Coding	4
30	GABBR2	Gamma-Aminobutyric Acid Type B Receptor Subunit 2	Protein Coding	4
31	ABCC9	ATP Binding Cassette Subfamily C Member 9	Protein Coding	3
32	ABCC8	ATP Binding Cassette Subfamily C Member 8	Protein Coding	3
33	KCNJ1	Potassium Inwardly Rectifying Channel Subfamily J Member 1	Protein Coding	2
34	KCNJ8	Potassium Inwardly Rectifying Channel Subfamily J Member 8	Protein Coding	2
35	KCNJ14	Potassium Inwardly Rectifying Channel Subfamily J Member 14	Protein Coding	1

Disorders associated with Inwardly rectifying K+ channels SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Dilated cardiomyopathy	Direct
2	Familial atrial fibrillation	Direct
3	Osteochondrodysplasia	Direct
4	Hypertrichosis	Direct
5	Neonatal diabetes mellitus	Direct
6	Hyperinsulinemic hypoglycemia	Direct
7	Hypoglycemia	Direct
8	Cantu syndrome	Enrichment	ABCC9, KCNJ8	6.71
9	Dend syndrome	Enrichment	ABCC8, KCNJ11	6.71
10	Transient neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	6.19
11	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	ABCC8, KCNJ11	6.01
12	Nonsyndromic genetic hyperinsulinism	Enrichment	ABCC8, KCNJ11	6.01
13	Permanent neonatal diabetes mellitus	Enrichment	ABCC8, KCNJ11	5.74
14	Andersen cardiodysrhythmic periodic paralysis	Enrichment	KCNJ2, KCNJ5	5.36
15	Maturity-onset diabetes of the young	Enrichment	ABCC8, KCNJ11	4.91
16	Brugada syndrome	Enrichment	ABCC9, KCNJ8	4.67
17	Type 2 diabetes mellitus	Enrichment	ABCC8, KCNJ11	4.25
18	Bartter syndrome, type 2, antenatal	Enrichment	KCNJ1	3.66
19	Hypokalemic tubulopathy and deafness	Enrichment	KCNJ16	3.66
20	Seizures, sensorineural deafness, ataxia, impaired intellectual development, and electrolyte imbalance	Enrichment	KCNJ10	3.66
21	Rare renal tubular disease	Enrichment	KCNJ10	3.66
22	Hyperinsulinemic hypoglycemia, familial, 2	Enrichment	KCNJ11	3.53
23	Intellectual disability and myopathy syndrome	Enrichment	ABCC9	3.53
24	Maturity-onset diabetes of the young, type 12	Enrichment	ABCC8	3.53
25	Diabetes mellitus, transient neonatal, 3	Enrichment	KCNJ11	3.53
26	Diabetes mellitus, permanent neonatal, 2	Enrichment	KCNJ11	3.53
27	Maturity-onset diabetes of the young, type 13	Enrichment	KCNJ11	3.53
28	Autosomal dominant hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	3.53
29	Diazoxide-resistant focal hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	3.53
30	Congestive heart failure	Enrichment	ABCC8	3.53
31	Intermediate dend syndrome	Enrichment	KCNJ11	3.53
32	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	3.53
33	Autosomal recessive hyperinsulinism due to sur1 deficiency	Enrichment	ABCC8	3.53
34	Autosomal dominant hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	3.53
35	Autosomal recessive hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	3.53
36	Cardiomyopathy, dilated, 1o	Enrichment	ABCC9	3.23
37	Diabetes mellitus, permanent neonatal, 1	Enrichment	KCNJ11	3.23
38	Hypoglycemia, leucine-induced	Enrichment	ABCC8	3.23
39	Atrial fibrillation, familial, 12	Enrichment	ABCC9	3.23
40	Diabetes mellitus, transient neonatal, 2	Enrichment	ABCC8	3.23
41	Diabetes mellitus, permanent neonatal, 3	Enrichment	ABCC8	3.23
42	Hyperinsulinism	Enrichment	KCNJ11	3.23
43	Episodic kinesigenic dyskinesia 1	Enrichment	KCNJ10	3.05
44	Deafness, autosomal recessive 4, with enlarged vestibular aqueduct	Enrichment	KCNJ10	2.96
45	Spastic diplegia	Enrichment	KCNJ10	2.96
46	Dermatitis, atopic	Enrichment	KCNJ11	2.93
47	Newborn respiratory distress syndrome	Enrichment	ABCC8	2.93
48	Pendred syndrome	Enrichment	KCNJ10	2.88
49	Polyhydramnios	Enrichment	ABCC8	2.83
50	Bartter disease	Enrichment	KCNJ1	2.81
51	Kleefstra syndrome 1	Enrichment	ABCC9	2.75
52	Patent ductus arteriosus	Enrichment	ABCC9	2.75
53	Long qt syndrome 13	Enrichment	KCNJ5	2.67
54	Short qt syndrome 3	Enrichment	KCNJ2	2.67
55	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.67
56	Neurodevelopmental disorder with poor language and loss of hand skills	Enrichment	GABBR2	2.67
57	Developmental and epileptic encephalopathy 59	Enrichment	GABBR2	2.67
58	Hyperaldosteronism, familial, type iii	Enrichment	KCNJ5	2.67
59	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.67
60	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.67
61	Atrial fibrillation, familial, 9	Enrichment	KCNJ2	2.67
62	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.67
63	Sick sinus syndrome 4	Enrichment	GNB2	2.67
64	Neurodevelopmental disorder with language delay and variable cognitive abnormalities	Enrichment	GABBR1	2.67
65	Gastroesophageal reflux	Enrichment	ABCC8	2.63
66	Fanconi anemia, complementation group c	Enrichment	ABCC9	2.63
67	Atrial heart septal defect	Enrichment	ABCC8	2.49
68	Diabetes mellitus	Enrichment	KCNJ11	2.49
69	Interatrial communication	Enrichment	ABCC8	2.49
70	Epicanthus	Enrichment	ABCC9	2.45
71	Keppen-lubinsky syndrome	Enrichment	KCNJ6	2.37
72	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.37
73	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.37
74	Cerebral visual impairment	Enrichment	GNB1	2.37
75	Wolff-parkinson-white syndrome	Enrichment	ABCC9	2.33
76	Sudden infant death syndrome	Enrichment	KCNJ8	2.30
77	Autosomal dominant non-syndromic intellectual disability	Enrichment	GABBR1, GNB1	2.29
78	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	2.07
79	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	2.07
80	Tobacco addiction	Enrichment	GABBR2	2.07
81	Familial sick sinus syndrome	Enrichment	GNB2	2.07
82	Congenital short qt syndrome	Enrichment	KCNJ2	1.97
83	Rett syndrome	Enrichment	GABBR2	1.83
84	Familial isolated dilated cardiomyopathy	Enrichment	ABCC9	1.81
85	Rett syndrome, congenital variant	Enrichment	GABBR2	1.77
86	Hypothyroidism	Enrichment	GNB1	1.77
87	Neurofibromatosis, type i	Enrichment	GABBR1	1.72
88	Congenital nervous system abnormality	Enrichment	GNB5, KCNJ10	1.67
89	Nervous system disease	Enrichment	GNB5, KCNJ10	1.67
90	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.63
91	Myelodysplastic syndrome	Enrichment	GNB1	1.63
92	Microcephaly	Enrichment	KCNJ10	1.57
93	Hypertension, essential	Enrichment	GNB3	1.45
94	Cleft palate, isolated	Enrichment	GNB1	1.45
95	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.34
96	Congenital stationary night blindness	Enrichment	GNB3	1.32
97	Strabismus	Enrichment	GNB1	1.25
98	Long qt syndrome 1	Enrichment	KCNJ5	1.21
99	Long qt syndrome	Enrichment	KCNJ5	1.19
100	Dystonia	Enrichment	GNB1	1.14
101	Cerebral palsy	Enrichment	GNB1	1.10
102	Undetermined early-onset epileptic encephalopathy	Enrichment	GABBR2	0.95
103	Breast cancer	Enrichment	GNG3	0.83
104	Autism spectrum disorder	Enrichment	GNB1	0.68
105	Complex neurodevelopmental disorder	Enrichment	GNB2	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Inwardly rectifying K+ channels

Pathway Network for Inwardly rectifying K+ channels

Pathway network for the Inwardly rectifying K+ channels SuperPath

Member Pathways for Inwardly rectifying K+ channels

Pathways in the Inwardly rectifying K+ channels SuperPath

Gene overlap in member pathways for Inwardly rectifying K+ channels SuperPath

Associated Genes for Inwardly rectifying K+ channels

Associated Disorders for Inwardly rectifying K+ channels

Disorders associated with Inwardly rectifying K+ channels SuperPath

STRING Interaction Network for Inwardly rectifying K+ channels

Sources for Inwardly rectifying K+ channels