IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Pathway network for the IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation SuperPath

Sources:

Reactome

Pathways in the IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation SuperPath

#	Name	Source	Genes
1	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Reactome	CHUK IKBKB IKBKG IRAK1 PELI1 PELI2 PELI3 RPS27A TRAF6 UBA52 UBB UBC UBE2N UBE2V1 (see all 14) (see less)
2	IKK complex recruitment mediated by RIP1	Reactome	BIRC2 BIRC3 CD14 CHUK IKBKB IKBKG LY96 RIPK1 RIPK3 RPS27A SARM1 TICAM1 TICAM2 TLR4 TMED7-TICAM2 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UBE2V1 (see all 24) (see less)
3	IRAK1 recruits IKK complex	Reactome	CHUK IKBKB IKBKG IRAK1 PELI1 PELI2 PELI3 RPS27A TRAF6 UBA52 UBB UBC UBE2N UBE2V1 (see all 14) (see less)

Gene overlap in member pathways for IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
2	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
3	RPS27A	Ribosomal Protein S27a	Protein Coding	3
4	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	3
5	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
6	UBB	Ubiquitin B	Protein Coding	3
7	UBC	Ubiquitin C	Protein Coding	3
8	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	3
9	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	3
10	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
11	PELI3	Pellino E3 Ubiquitin Protein Ligase Family Member 3	Protein Coding	2
12	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	2
13	PELI2	Pellino E3 Ubiquitin Protein Ligase Family Member 2	Protein Coding	2
14	PELI1	Pellino E3 Ubiquitin Protein Ligase 1	Protein Coding	2
15	TMED7-TICAM2	TMED7-TICAM2 Readthrough	Protein Coding	1
16	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
17	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	1
18	SARM1	Sterile Alpha And TIR Motif Containing 1	Protein Coding	1
19	LY96	Lymphocyte Antigen 96	Protein Coding	1
20	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
21	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
22	TICAM2	TIR Domain Containing Adaptor Molecule 2	Protein Coding	1
23	TLR4	Toll Like Receptor 4	Protein Coding	1
24	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
25	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	1
26	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	1
27	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
28	CD14	CD14 Molecule	Protein Coding	1

Disorders associated with IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Incontinentia pigmenti	Enrichment	IKBKG	2.99
2	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.99
3	Fetal encasement syndrome	Enrichment	CHUK	2.99
4	Immunodeficiency 15b	Enrichment	IKBKB	2.99
5	Immunodeficiency 15a	Enrichment	IKBKB	2.99
6	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.99
7	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.99
8	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.99
9	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	2.75
10	Macular degeneration, age-related, 10	Enrichment	TLR4	2.75
11	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.75
12	Immunodeficiency 33	Enrichment	IKBKG	2.69
13	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.69
14	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.69
15	Submucosal cleft palate	Enrichment	UBB	2.69
16	Cleft hard palate	Enrichment	UBB	2.69
17	Uvula, bifid	Enrichment	UBB	2.51
18	Cleft soft palate	Enrichment	UBB	2.51
19	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.45
20	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.38
21	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.29
22	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.29
23	Folate malabsorption, hereditary	Enrichment	SARM1	2.28
24	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	2.05
25	Herpes simplex virus encephalitis	Enrichment	TICAM1	2.05
26	Coronary heart disease 5	Enrichment	IKBKG	2.03
27	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.98
28	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.98
29	Immune deficiency disease	Enrichment	RIPK1	1.71
30	Malaria	Enrichment	IKBKG	1.63
31	Behcet syndrome	Enrichment	TLR4	1.48
32	Severe combined immunodeficiency	Enrichment	IKBKB	1.47
33	Systemic lupus erythematosus	Enrichment	IRAK1	1.40
34	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.03

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Pathway Network for IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Pathway network for the IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation SuperPath

Member Pathways for IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Pathways in the IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation SuperPath

Gene overlap in member pathways for IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation SuperPath

Associated Genes for IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Associated Disorders for IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Disorders associated with IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation SuperPath

STRING Interaction Network for IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Sources for IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation