Iron metabolism disorders

No Pathway Network information available for Iron metabolism disorders

Pathways in the Iron metabolism disorders SuperPath

#	Name	Source	Genes
1	Iron metabolism disorders	WikiPathways	BCS1L CP CYBRD1 FTH1 FTL HAMP HEPH HFE HJV PANK2 SLC11A2 SLC40A1 STEAP3 TF TFR2 TFRC UQCRFS1 (see all 17) (see less)
2	Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	Reactome	HEPH SLC40A1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HEPH	Hephaestin	Protein Coding	2
2	SLC40A1	Solute Carrier Family 40 Member 1	Protein Coding	2
3	PANK2	Pantothenate Kinase 2	Protein Coding	1
4	UQCRFS1	Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1	Protein Coding	1
5	TFRC	Transferrin Receptor	Protein Coding	1
6	TFR2	Transferrin Receptor 2	Protein Coding	1
7	TF	Transferrin	Protein Coding	1
8	BCS1L	BCS1 Ubiquinol-Cytochrome C Reductase Complex Chaperone	Protein Coding	1
9	HAMP	Hepcidin Antimicrobial Peptide	Protein Coding	1
10	STEAP3	STEAP3 Metalloreductase	Protein Coding	1
11	SLC11A2	Solute Carrier Family 11 Member 2	Protein Coding	1
12	HFE	Homeostatic Iron Regulator	Protein Coding	1
13	FTL	Ferritin Light Chain	Protein Coding	1
14	FTH1	Ferritin Heavy Chain 1	Protein Coding	1
15	HJV	Hemojuvelin BMP Co-Receptor	Protein Coding	1
16	CP	Ceruloplasmin	Protein Coding	1
17	CYBRD1	Cytochrome B Reductase 1	Protein Coding	1

Disorders associated with Iron metabolism disorders SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemochromatosis, type 1	Direct
2	Digenic hemochromatosis	Enrichment	HAMP, HFE, HJV, TFR2	11.14
3	Hemochromatosis type 2	Enrichment	HFE, HJV	5.83
4	Hjv or hamp-related hemochromatosis	Enrichment	HAMP, HJV	5.83
5	Isolated complex iii deficiency	Enrichment	BCS1L, UQCRFS1	4.09
6	Aceruloplasminemia	Enrichment	CP	2.90
7	Neurodegeneration with brain iron accumulation 3	Enrichment	FTL	2.90
8	Anemia, hypochromic microcytic, with iron overload 1	Enrichment	SLC11A2	2.90
9	Atransferrinemia	Enrichment	TF	2.90
10	Bjornstad syndrome	Enrichment	BCS1L	2.90
11	Hemochromatosis, type 2a	Enrichment	HJV	2.90
12	Hemochromatosis, type 4	Enrichment	SLC40A1	2.90
13	Gracile syndrome	Enrichment	BCS1L	2.90
14	Mitochondrial complex iii deficiency, nuclear type 10	Enrichment	UQCRFS1	2.90
15	Immunodeficiency 46	Enrichment	TFRC	2.90
16	L-ferritin deficiency	Enrichment	FTL	2.90
17	Hemochromatosis, type 2b	Enrichment	HAMP	2.90
18	Genetic hyperferritinemia without iron overload	Enrichment	FTL	2.90
19	Renal tubulopathy-encephalopathy-liver failure syndrome	Enrichment	BCS1L	2.90
20	Vitreoretinochoroidopathy	Enrichment	FTH1	2.60
21	Porphyria cutanea tarda, type i	Enrichment	HFE	2.60
22	Retinitis pigmentosa 50	Enrichment	FTH1	2.60
23	Anemia, hypochromic microcytic, with iron overload 2	Enrichment	STEAP3	2.60
24	Hermansky-pudlak syndrome 3	Enrichment	CP	2.60
25	Hyperferritinemia with or without cataract	Enrichment	FTL	2.60
26	Hemochromatosis, type 5	Enrichment	FTH1	2.60
27	Neurodegeneration with brain iron accumulation 9	Enrichment	FTH1	2.60
28	Mitochondrial complex iii deficiency, nuclear type 1	Enrichment	BCS1L	2.43
29	Hemochromatosis, type 3	Enrichment	TFR2	2.43
30	Microvascular complications of diabetes 7	Enrichment	HFE	2.43
31	Transferrin serum level quantitative trait locus 2	Enrichment	HFE	2.43
32	Familial porphyria cutanea tarda	Enrichment	HFE	2.43
33	Porphyria cutanea tarda	Enrichment	HFE	2.30
34	Neurodegeneration with brain iron accumulation 1	Enrichment	PANK2	2.30
35	Propionic acidemia	Enrichment	UQCRFS1	2.30
36	Bestrophinopathy, autosomal recessive	Enrichment	FTH1	2.30
37	Macular dystrophy, vitelliform, 2	Enrichment	FTH1	2.20
38	Variegate porphyria	Enrichment	HFE	2.20
39	Rubinstein-taybi syndrome 2	Enrichment	PANK2	2.20
40	Pain disorder	Enrichment	HFE	2.13
41	Alzheimer's disease 1	Enrichment	HFE	2.06
42	Neurodegeneration with brain iron accumulation	Enrichment	CP	1.90
43	Combined immunodeficiency	Enrichment	TFRC	1.86
44	Movement disease	Enrichment	BCS1L	1.86
45	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.86
46	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.86
47	Lactic acidosis	Enrichment	UQCRFS1	1.83
48	Alzheimer's disease	Enrichment	HFE	1.79
49	Hermansky-pudlak syndrome	Enrichment	CP	1.73
50	Hermansky-pudlak syndrome 1	Enrichment	CP	1.70
51	Alzheimer disease, familial, 1	Enrichment	HFE	1.68
52	Cystic fibrosis	Enrichment	HFE	1.40
53	Peripheral nervous system disease	Enrichment	HFE	1.40
54	Neuropathy	Enrichment	HFE	1.40
55	Dystonia	Enrichment	PANK2	1.37
56	Hereditary retinal dystrophy	Enrichment	FTH1, PANK2	1.30
57	Fundus dystrophy	Enrichment	FTH1, PANK2	1.30
58	Cone-rod dystrophy 2	Enrichment	PANK2	1.09
59	Leigh syndrome, nuclear	Enrichment	BCS1L	1.08
60	Leigh disease	Enrichment	BCS1L	1.04
61	Congenital nervous system abnormality	Enrichment	HFE	0.90
62	Nervous system disease	Enrichment	HFE	0.90
63	Microcephaly	Enrichment	BCS1L	0.84
64	Inherited cancer-predisposing syndrome	Enrichment	HFE	0.81
65	Retinitis pigmentosa	Enrichment	PANK2	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Iron metabolism disorders

Pathway Network for Iron metabolism disorders

Member Pathways for Iron metabolism disorders

Pathways in the Iron metabolism disorders SuperPath

Associated Genes for Iron metabolism disorders

Associated Disorders for Iron metabolism disorders

Disorders associated with Iron metabolism disorders SuperPath

STRING Interaction Network for Iron metabolism disorders

Sources for Iron metabolism disorders