Jak-Stat Signaling Pathway

No Pathway Network information available for Jak-Stat Signaling Pathway

Pathways in the Jak-Stat Signaling Pathway SuperPath

#	Name	Source	Genes
1	Jak-Stat Signaling Pathway	Sino Biological	ABL1 AKT1 AKT2 AKT3 BLK CCR1 CCR2 CCR5 CSF1R CSF3R CXCR4 EGF EGFR FYN HRAS IFNL2 IGF1R IKBKE IL10RA IL10RB IL11RA IL12RB1 IL12RB2 IL13RA1 IL15 IL15RA IL20RB IL21 IL21R IL23R IL27RA IL2RA IL2RB IL3RA IL4R IL5RA IL6R IL6ST IL7R IL9R JAK1 JAK2 JAK3 KRAS LCK LYN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK15 MAPK3 MAPK6 MAPK7 MTOR NRAS PIAS1 PIAS2 PIAS3 PIK3CA PIK3R1 PIK3R2 PTPN11 PTPN6 PTPRA PTPRC RAF1 SHC1 SHC4 SHCBP1 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOCS6 SRC STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 YES1 (see all 88) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
2	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
3	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
4	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
5	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
6	CCR1	C-C Motif Chemokine Receptor 1	Protein Coding	1
7	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	1
8	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	1
9	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
10	CSF3R	Colony Stimulating Factor 3 Receptor	Protein Coding	1
11	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
12	EGF	Epidermal Growth Factor	Protein Coding	1
13	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
14	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
15	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
16	IFNL2	Interferon Lambda 2	Protein Coding	1
17	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
18	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
19	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	1
20	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	1
21	IL11RA	Interleukin 11 Receptor Subunit Alpha	Protein Coding	1
22	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	1
23	IL12RB2	Interleukin 12 Receptor Subunit Beta 2	Protein Coding	1
24	IL13RA1	Interleukin 13 Receptor Subunit Alpha 1	Protein Coding	1
25	IL15	Interleukin 15	Protein Coding	1
26	IL15RA	Interleukin 15 Receptor Subunit Alpha	Protein Coding	1
27	IL20RB	Interleukin 20 Receptor Subunit Beta	Protein Coding	1
28	IL21	Interleukin 21	Protein Coding	1
29	IL21R	Interleukin 21 Receptor	Protein Coding	1
30	IL23R	Interleukin 23 Receptor	Protein Coding	1
31	IL27RA	Interleukin 27 Receptor Subunit Alpha	Protein Coding	1
32	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
33	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
34	IL3RA	Interleukin 3 Receptor Subunit Alpha	Protein Coding	1
35	IL4R	Interleukin 4 Receptor	Protein Coding	1
36	IL5RA	Interleukin 5 Receptor Subunit Alpha	Protein Coding	1
37	IL6R	Interleukin 6 Receptor	Protein Coding	1
38	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
39	IL7R	Interleukin 7 Receptor	Protein Coding	1
40	IL9R	Interleukin 9 Receptor	Protein Coding	1
41	JAK1	Janus Kinase 1	Protein Coding	1
42	JAK2	Janus Kinase 2	Protein Coding	1
43	JAK3	Janus Kinase 3	Protein Coding	1
44	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
45	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
46	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
47	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
48	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
49	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
50	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
51	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
52	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
53	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
54	MAPK15	Mitogen-Activated Protein Kinase 15	Protein Coding	1
55	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
56	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
57	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
58	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
59	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
60	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
61	PIAS2	Protein Inhibitor Of Activated STAT 2	Protein Coding	1
62	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
63	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
64	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
65	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
66	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
67	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
68	PTPRA	Protein Tyrosine Phosphatase Receptor Type A	Protein Coding	1
69	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
70	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
71	SHC1	SHC Adaptor Protein 1	Protein Coding	1
72	SHC4	SHC Adaptor Protein 4	Protein Coding	1
73	SHCBP1	SHC Binding And Spindle Associated 1	Protein Coding	1
74	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
75	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	1
76	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
77	SOCS4	Suppressor Of Cytokine Signaling 4	Protein Coding	1
78	SOCS5	Suppressor Of Cytokine Signaling 5	Protein Coding	1
79	SOCS6	Suppressor Of Cytokine Signaling 6	Protein Coding	1
80	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
81	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
82	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
83	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
84	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
85	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
86	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
87	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
88	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1

Disorders associated with Jak-Stat Signaling Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1	10.92
2	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	10.38
3	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1	9.98
4	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1	9.64
5	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	7.24
6	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, RAF1	7.24
7	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	6.58
8	Lip and oral cavity carcinoma	Enrichment	ABL1, EGFR, HRAS, PIK3CA	6.10
9	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.98
10	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	5.98
11	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.98
12	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	5.98
13	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1, KRAS, NRAS	5.98
14	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA	5.58
15	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	5.28
16	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS, PIK3CA	5.28
17	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	5.04
18	Leukemia, chronic myeloid	Enrichment	ABL1, KRAS, NRAS	5.04
19	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.04
20	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, STAT4	5.04
21	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	4.84
22	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	4.67
23	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	4.51
24	Bladder cancer	Enrichment	EGFR, HRAS, KRAS, PIK3CA	4.46
25	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.38
26	Immunodeficiency 31c	Enrichment	IL21R, STAT1	4.38
27	Immunodeficiency 104, severe combined	Enrichment	IL7R, PTPRC	4.38
28	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, PTPN11	4.25
29	Severe combined immunodeficiency	Enrichment	IL7R, JAK3, LCK, PTPRC	4.23
30	Breast cancer	Enrichment	AKT1, IL7R, KRAS, PIK3CA, SHC1	3.91
31	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	3.91
32	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.91
33	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.91
34	Behcet syndrome	Enrichment	CCR1, IL23R, STAT4	3.63
35	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.61
36	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	3.61
37	Colorectal cancer	Enrichment	AKT1, NRAS, PIK3CA, PIK3R1, SRC	3.60
38	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.21
39	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10RA, IL10RB	3.21
40	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.07
41	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.07
42	Myelofibrosis	Enrichment	JAK2, SRC	3.07
43	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.07
44	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	3.07
45	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.07
46	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.07
47	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	2.98
48	Lung cancer	Enrichment	EGFR, KRAS, PIK3CA	2.94
49	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	2.84
50	Cowden syndrome	Enrichment	AKT1, PIK3CA	2.84
51	Systemic lupus erythematosus	Enrichment	BLK, SOCS1, STAT4	2.69
52	Leukemia, acute myeloid	Enrichment	JAK2, KRAS, NRAS	2.66
53	Specific learning disability	Enrichment	MAPK1, PTPN11	2.66
54	Meningioma	Enrichment	AKT1, PIK3CA	2.58
55	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	2.54
56	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	2.51
57	Nk-cell enteropathy	Enrichment	IGF1R, JAK3	2.51
58	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	2.44
59	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.38
60	Ovarian cancer	Enrichment	AKT1, EGFR, KRAS, PIK3CA	2.38
61	Myeloma, multiple	Enrichment	IL7R, KRAS, PIK3R2	2.24
62	Human immunodeficiency virus type 1	Enrichment	CCR2, CCR5	2.23
63	Macrodactyly	Enrichment	PIK3CA	2.19
64	Proteus syndrome	Enrichment	AKT1	2.19
65	Metachondromatosis	Enrichment	PTPN11	2.19
66	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.19
67	Oculoectodermal syndrome	Enrichment	KRAS	2.19
68	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.19
69	Noonan syndrome 5	Enrichment	RAF1	2.19
70	Hypomagnesemia 4, renal	Enrichment	EGF	2.19
71	Melorheostosis, isolated	Enrichment	MAP2K1	2.19
72	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.19
73	Immunodeficiency 30	Enrichment	IL12RB1	2.19
74	Dermatitis, atopic, 4	Enrichment	SOCS3	2.19
75	Leopard syndrome 1	Enrichment	PTPN11	2.19
76	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.19
77	Cowden syndrome 5	Enrichment	PIK3CA	2.19
78	Polycystic lung disease	Enrichment	CCR2	2.19
79	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.19
80	Melanosis, neurocutaneous	Enrichment	NRAS	2.19
81	Noonan syndrome 6	Enrichment	NRAS	2.19
82	Whim syndrome 1	Enrichment	CXCR4	2.19
83	Craniosynostosis and dental anomalies	Enrichment	IL11RA	2.19
84	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.19
85	Pseudo-torch syndrome 3	Enrichment	STAT2	2.19
86	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.19
87	Noonan syndrome 13	Enrichment	MAPK1	2.19
88	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.19
89	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.19
90	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.19
91	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.19
92	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.19
93	Short syndrome	Enrichment	PIK3R1	2.19
94	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.19
95	Systemic lupus erythematosus 11	Enrichment	STAT4	2.19
96	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.19
97	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.19
98	Psoriasis 7	Enrichment	IL23R	2.19
99	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.19
100	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.19
101	Melorheostosis	Enrichment	MAP2K1	2.19
102	Leopard syndrome 2	Enrichment	RAF1	2.19
103	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.19
104	Immunodeficiency 31a	Enrichment	STAT1	2.19
105	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.19
106	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.19
107	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.19
108	Cowden syndrome 6	Enrichment	AKT1	2.19
109	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.19
110	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.19
111	Inflammatory bowel disease 17	Enrichment	IL23R	2.19
112	Immunodeficiency 31b	Enrichment	STAT1	2.19
113	Type 1 diabetes mellitus 22	Enrichment	CCR5	2.19
114	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.19
115	Immunodeficiency 22	Enrichment	LCK	2.19
116	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.19
117	Thrombocytopenia 6	Enrichment	SRC	2.19
118	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.19
119	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.19
120	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.19
121	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.19
122	Cd45 deficiency	Enrichment	PTPRC	2.19
123	Trigonitis	Enrichment	RAF1	2.19
124	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.19
125	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.19
126	Csf1r-related disorder	Enrichment	CSF1R	2.19
127	Hypospadias	Enrichment	PIK3CA	2.19
128	Capillary hemangioma	Enrichment	AKT3	2.19
129	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.19
130	Congenital pulmonary airway malformation	Enrichment	KRAS	2.19
131	Rare venous malformation	Enrichment	PIK3CA	2.19
132	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.19
133	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.19
134	Diaphragmatic eventration	Enrichment	PIK3CA	2.19
135	Chronic neutrophilic leukemia	Enrichment	CSF3R	2.19
136	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.19
137	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.19
138	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.19
139	Rare combined vascular malformation	Enrichment	PIK3CA	2.19
140	Cavernous lymphangioma	Enrichment	PIK3CA	2.19
141	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.19
142	T-b+ severe combined immunodeficiency due to il-7ralpha deficiency	Enrichment	IL7R	2.19
143	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.19
144	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.19
145	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.19
146	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.19
147	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.19
148	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.19
149	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.19
150	Macrodactyly of toe	Enrichment	PIK3CA	2.19
151	Neurocutaneous melanocytosis	Enrichment	NRAS	2.19
152	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.19
153	Malignant astrocytoma	Enrichment	PTPN11	2.19
154	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.18
155	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	2.18
156	Microcephaly	Enrichment	ABL1, IGF1R, MAPK1, PTPN11	2.08
157	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	1.91
158	Scoliosis, isolated 1	Enrichment	MAPK7	1.89
159	Costello syndrome	Enrichment	HRAS	1.89
160	Hemangiopericytoma, malignant	Enrichment	STAT6	1.89
161	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	1.89
162	West nile virus	Enrichment	CCR5	1.89
163	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	1.89
164	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	1.89
165	Keratosis, seborrheic	Enrichment	PIK3CA	1.89
166	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.89
167	Neutrophilia, hereditary	Enrichment	CSF3R	1.89
168	Maturity-onset diabetes of the young, type 11	Enrichment	BLK	1.89
169	Noonan syndrome 8	Enrichment	PIK3CA	1.89
170	Thrombocythemia 3	Enrichment	JAK2	1.89
171	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	CSF3R	1.89
172	Dystonia 30	Enrichment	PTPRA	1.89
173	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.89
174	Werner syndrome	Enrichment	PTPN11	1.89
175	Cebalid syndrome	Enrichment	MTOR	1.89
176	Immunodeficiency 56	Enrichment	IL21R	1.89
177	Senior-loken syndrome 7	Enrichment	AKT3	1.89
178	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.89
179	Inflammatory bowel disease 28	Enrichment	IL10RA	1.89
180	Severe congenital neutropenia 7	Enrichment	CSF3R	1.89
181	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.89
182	Multiple sclerosis 3	Enrichment	IL7R	1.89
183	Bardet-biedl syndrome 16	Enrichment	AKT3	1.89
184	Smith-kingsmore syndrome	Enrichment	MTOR	1.89
185	Polycythemia	Enrichment	JAK2	1.89
186	Hypereosinophilic syndrome	Enrichment	JAK2	1.89
187	Tafro syndrome	Enrichment	MAP2K2	1.89
188	Laron syndrome with immunodeficiency	Enrichment	STAT5B	1.89
189	Wooly hair nevus	Enrichment	HRAS	1.89
190	Severe covid-19	Enrichment	IL10RB, JAK3	1.82
191	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.71
192	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.71
193	Immune thrombocytopenia	Enrichment	SOCS1	1.71
194	Polycythemia vera	Enrichment	JAK2	1.71
195	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.71
196	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.71
197	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	1.71
198	Hepatitis c virus	Enrichment	CCR5	1.71
199	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.71
200	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.71
201	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.71
202	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.71
203	Hyper ige syndrome	Enrichment	STAT3	1.71
204	Inflammatory bowel disease 25	Enrichment	IL10RB	1.71
205	Immunodeficiency 14	Enrichment	PIK3R1	1.71
206	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.71
207	Immunodeficiency 44	Enrichment	STAT2	1.71
208	Immunodeficiency, common variable, 11	Enrichment	IL21	1.71
209	Spermatocytoma	Enrichment	HRAS	1.71
210	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.71
211	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.71
212	Tricuspid valve insufficiency	Enrichment	PTPN11	1.71
213	Stüve-wiedemann syndrome	Enrichment	IL6ST	1.71
214	Keratoacanthoma	Enrichment	PIK3CA	1.71
215	Erythrocytosis, familial, 1	Enrichment	JAK2	1.59
216	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.59
217	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.59
218	Budd-chiari syndrome	Enrichment	JAK2	1.59
219	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.59
220	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.59
221	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.59
222	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.59
223	Hepatitis b	Enrichment	IL10RB	1.59
224	Cerebrovascular disease	Enrichment	PIK3CA	1.59
225	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.59
226	Pilocytic astrocytoma	Enrichment	KRAS	1.59
227	Epidermolytic nevus	Enrichment	HRAS	1.59
228	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.59
229	Adenosine deaminase deficiency	Enrichment	JAK3	1.59
230	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.59
231	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.59
232	Gastric cancer	Enrichment	KRAS, PIK3CA	1.50
233	Capillary malformations, congenital	Enrichment	PIK3CA	1.49
234	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.49
235	Insulin-like growth factor i	Enrichment	IGF1R	1.49
236	Lymphoma	Enrichment	PTPN11	1.49
237	Myeloproliferative neoplasm	Enrichment	JAK2	1.49
238	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.42
239	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.42
240	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB	1.42
241	Patent ductus arteriosus	Enrichment	PTPN11	1.42
242	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.42
243	Thrombocytopenia	Enrichment	PTPN11, SRC	1.41
244	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.35
245	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.35
246	Essential thrombocythemia	Enrichment	JAK2	1.35
247	Megacolon	Enrichment	AKT3	1.35
248	Moyamoya angiopathy	Enrichment	ABL1	1.35
249	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.35
250	Severe congenital neutropenia	Enrichment	CSF3R	1.29
251	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.29
252	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.24
253	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	CSF3R	1.24
254	Primary biliary cholangitis	Enrichment	IL12RB1	1.24
255	Omenn syndrome	Enrichment	IL7R	1.20
256	Polymicrogyria	Enrichment	AKT3	1.20
257	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.20
258	Pectus excavatum	Enrichment	PTPN11	1.16
259	Frontotemporal dementia 1	Enrichment	CSF1R	1.16
260	Ichthyosis	Enrichment	IL2RB	1.16
261	Epicanthus	Enrichment	PTPN11	1.12
262	Congenital long qt syndrome	Enrichment	PTPN11	1.12
263	Alzheimer's disease	Enrichment	CSF1R	1.09
264	Protein-deficiency anemia	Enrichment	NRAS	1.09
265	Osteoporosis	Enrichment	SRC	1.06
266	Heart disease	Enrichment	ABL1	1.06
267	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.03
268	Rare genetic intellectual disability	Enrichment	MTOR	1.03
269	Rhabdomyosarcoma	Enrichment	HRAS	1.00
270	Gliosarcoma	Enrichment	EGFR	1.00
271	Alzheimer disease, familial, 1	Enrichment	CSF1R	0.98
272	Giant cell glioblastoma	Enrichment	EGFR	0.98
273	Heart, malformation of	Enrichment	MAPK1	0.96
274	Patent foramen ovale	Enrichment	PTPN11	0.96
275	Maturity-onset diabetes of the young	Enrichment	BLK	0.91
276	Craniosynostosis	Enrichment	IL11RA	0.91
277	Endometrial cancer	Enrichment	PIK3CA	0.89
278	Hepatocellular carcinoma	Enrichment	PIK3CA	0.87
279	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	0.86
280	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.84
281	Scoliosis	Enrichment	PTPN11	0.84
282	Pancreatic cancer	Enrichment	KRAS	0.82
283	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	0.80
284	Strabismus	Enrichment	PTPN11	0.79
285	Prostate cancer	Enrichment	PIK3CA	0.76
286	Long qt syndrome 1	Enrichment	PTPN11	0.75
287	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.71
288	Nephronophthisis	Enrichment	PIAS1	0.71
289	Left ventricular noncompaction	Enrichment	RAF1	0.69
290	Inherited cancer-predisposing syndrome	Enrichment	EGFR, PTPN11	0.68
291	Type 2 diabetes mellitus	Enrichment	AKT2	0.62
292	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.61
293	Hypertelorism	Enrichment	PIK3CA	0.54
294	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.53
295	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.52
296	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.51
297	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.50
298	Primary ovarian insufficiency	Enrichment	JAK2	0.50
299	Dilated cardiomyopathy	Enrichment	RAF1	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Jak-Stat Signaling Pathway

Pathway Network for Jak-Stat Signaling Pathway

Member Pathways for Jak-Stat Signaling Pathway

Pathways in the Jak-Stat Signaling Pathway SuperPath

Associated Genes for Jak-Stat Signaling Pathway

Associated Disorders for Jak-Stat Signaling Pathway

Disorders associated with Jak-Stat Signaling Pathway SuperPath

STRING Interaction Network for Jak-Stat Signaling Pathway

Sources for Jak-Stat Signaling Pathway