JNK signaling in the CD4+ TCR pathway
Pathways in the JNK signaling in the CD4+ TCR pathway SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | JNK signaling in the CD4+ TCR pathway | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | MAP4K1 | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 | Protein Coding | 1 |
| 2 | MAP3K8 | Mitogen-Activated Protein Kinase Kinase Kinase 8 | Protein Coding | 1 |
| 3 | GRAP2 | GRB2 Related Adaptor Protein 2 | Protein Coding | 1 |
| 4 | MAP2K4 | Mitogen-Activated Protein Kinase Kinase 4 | Protein Coding | 1 |
| 5 | MAP3K7 | Mitogen-Activated Protein Kinase Kinase Kinase 7 | Protein Coding | 1 |
| 6 | MAPK8 | Mitogen-Activated Protein Kinase 8 | Protein Coding | 1 |
| 7 | DBNL | Drebrin Like | Protein Coding | 1 |
| 8 | LAT | Linker For Activation Of T Cells | Protein Coding | 1 |
| 9 | LCP2 | Lymphocyte Cytosolic Protein 2 | Protein Coding | 1 |
| 10 | JUN | Jun Proto-Oncogene, AP-1 Transcription Factor Subunit | Protein Coding | 1 |
| 11 | PRKCB | Protein Kinase C Beta | Protein Coding | 1 |
| 12 | MAP3K1 | Mitogen-Activated Protein Kinase Kinase Kinase 1 | Protein Coding | 1 |
Disorders associated with JNK signaling in the CD4+ TCR pathway SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Cardiospondylocarpofacial syndrome | Enrichment | MAP3K7 | 3.05 |
| 2 | 46,xy sex reversal 6 | Enrichment | MAP3K1 | 3.05 |
| 3 | Frontometaphyseal dysplasia 2 | Enrichment | MAP3K7 | 3.05 |
| 4 | Immunodeficiency 81 | Enrichment | LCP2 | 3.05 |
| 5 | Immunodeficiency 52 | Enrichment | LAT | 2.75 |
| 6 | Frontometaphyseal dysplasia | Enrichment | MAP3K7 | 2.58 |
| 7 | Glycogen storage disease x | Enrichment | DBNL | 2.45 |
| 8 | 46,xy complete gonadal dysgenesis | Enrichment | MAP3K1 | 2.01 |
| 9 | 46,xy partial gonadal dysgenesis | Enrichment | MAP3K1 | 1.91 |
| 10 | Lung cancer | Enrichment | MAP3K8 | 1.55 |
| 11 | Breast cancer | Enrichment | JUN | 1.19 |
| 12 | Ovarian cancer | Enrichment | MAP3K1 | 1.07 |
