Keratan sulfate biosynthesis

Pathway network for the Keratan sulfate biosynthesis SuperPath

Sources:

Reactome

Pathways in the Keratan sulfate biosynthesis SuperPath

#	Name	Source	Genes
1	Keratan sulfate biosynthesis	Reactome	ACAN B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GAT1 CHST1 CHST2 CHST3 CHST5 CHST6 FMOD KERA LUM OGN OMD PRELP SLC35D2 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 (see all 29) (see less)
2	Keratan sulfate/keratin metabolism	Reactome	ACAN B3GNT2 B3GNT3 B3GNT4 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GAT1 CHST1 CHST2 CHST3 CHST5 CHST6 FMOD GALNS GLB1 GLB1L GLB1L2 GLB1L3 GNS HEXA HEXB KERA LUM OGN OMD PRELP SLC35D2 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL6 (see all 37) (see less)
3	Keratan sulfate degradation	Reactome	ACAN FMOD GALNS GLB1 GLB1L GLB1L2 GLB1L3 GNS HEXA HEXB KERA LUM OGN OMD PRELP (see all 15) (see less)
4	Defective ST3GAL3 causes MCT12 and EIEE15	Reactome	ACAN FMOD KERA LUM OGN OMD PRELP ST3GAL3 (see all 8) (see less)
5	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Reactome	ACAN B4GALT1 FMOD KERA LUM OGN OMD PRELP (see all 8) (see less)
6	Defective CHST6 causes MCDC1	Reactome	ACAN CHST6 FMOD KERA LUM OGN OMD PRELP (see all 8) (see less)

Gene overlap in member pathways for Keratan sulfate biosynthesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KERA	Keratocan	Protein Coding	6
2	ACAN	Aggrecan	Protein Coding	6
3	FMOD	Fibromodulin	Protein Coding	6
4	LUM	Lumican	Protein Coding	6
5	OMD	Osteomodulin	Protein Coding	6
6	OGN	Osteoglycin	Protein Coding	6
7	PRELP	Proline And Arginine Rich End Leucine Rich Repeat Protein	Protein Coding	6
8	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	3
9	CHST6	Carbohydrate Sulfotransferase 6	Protein Coding	3
10	ST3GAL3	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3	Protein Coding	3
11	B3GNT3	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 3	Protein Coding	2
12	ST3GAL6	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6	Protein Coding	2
13	B3GNT2	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2	Protein Coding	2
14	B4GAT1	Beta-1,4-Glucuronyltransferase 1	Protein Coding	2
15	SLC35D2	Solute Carrier Family 35 Member D2	Protein Coding	2
16	CHST5	Carbohydrate Sulfotransferase 5	Protein Coding	2
17	ST3GAL1	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 1	Protein Coding	2
18	ST3GAL2	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 2	Protein Coding	2
19	ST3GAL4	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4	Protein Coding	2
20	B3GNT4	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4	Protein Coding	2
21	CHST1	Carbohydrate Sulfotransferase 1	Protein Coding	2
22	B4GALT4	Beta-1,4-Galactosyltransferase 4	Protein Coding	2
23	B4GALT3	Beta-1,4-Galactosyltransferase 3	Protein Coding	2
24	B4GALT2	Beta-1,4-Galactosyltransferase 2	Protein Coding	2
25	B3GNT7	UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 7	Protein Coding	2
26	B4GALT6	Beta-1,4-Galactosyltransferase 6	Protein Coding	2
27	B4GALT5	Beta-1,4-Galactosyltransferase 5	Protein Coding	2
28	CHST2	Carbohydrate Sulfotransferase 2	Protein Coding	2
29	CHST3	Carbohydrate Sulfotransferase 3	Protein Coding	2
30	GLB1L3	Galactosidase Beta 1 Like 3	Protein Coding	2
31	GALNS	Galactosamine (N-Acetyl)-6-Sulfatase	Protein Coding	2
32	GLB1	Galactosidase Beta 1	Protein Coding	2
33	GNS	Glucosamine (N-Acetyl)-6-Sulfatase	Protein Coding	2
34	HEXA	Hexosaminidase Subunit Alpha	Protein Coding	2
35	HEXB	Hexosaminidase Subunit Beta	Protein Coding	2
36	GLB1L	Galactosidase Beta 1 Like	Protein Coding	2
37	GLB1L2	Galactosidase Beta 1 Like 2	Protein Coding	2

Disorders associated with Keratan sulfate biosynthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immunodeficiency 47	Direct
2	Macular dystrophy, corneal	Direct
3	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	ACAN, CHST3, GLB1	6.43
4	Short stature and advanced bone age with or without early-onset osteoarthritis and/or osteochondritis dissecans	Enrichment	ACAN	3.23
5	Intellectual developmental disorder, autosomal recessive 12	Enrichment	ST3GAL3	3.23
6	Cornea plana 2, autosomal recessive	Enrichment	KERA	3.23
7	Spondyloepimetaphyseal dysplasia, aggrecan type	Enrichment	ACAN	3.23
8	Spondyloepiphyseal dysplasia, kimberley type	Enrichment	ACAN	3.23
9	Osteochondritis dissecans	Enrichment	ACAN	3.23
10	St3gal3-cdg	Enrichment	ST3GAL3	3.23
11	Short stature-advanced bone age-early-onset osteoarthritis syndrome	Enrichment	ACAN	3.23
12	Mucopolysaccharidosis, type iiid	Enrichment	GNS	2.96
13	Sandhoff disease	Enrichment	HEXB	2.96
14	Glb1-related disorders	Enrichment	GLB1	2.96
15	Developmental and epileptic encephalopathy 15	Enrichment	ST3GAL3	2.93
16	Congenital cornea plana	Enrichment	KERA	2.75
17	Congenital disorder of glycosylation, type iid	Enrichment	B4GALT1	2.67
18	Muscular dystrophy-dystroglycanopathy , type a, 13	Enrichment	B4GAT1	2.67
19	Combined low ldl and fibrinogen	Enrichment	B4GALT1	2.67
20	Gm2-gangliosidosis, ab variant	Enrichment	HEXA	2.66
21	Gm1-gangliosidosis, type i	Enrichment	GLB1	2.48
22	Mucopolysaccharidosis, type ivb	Enrichment	GLB1	2.48
23	Gm1-gangliosidosis, type ii	Enrichment	GLB1	2.48
24	Gm1-gangliosidosis, type iii	Enrichment	GLB1	2.48
25	Tay-sachs disease	Enrichment	HEXA	2.48
26	Gm1 gangliosidosis	Enrichment	GLB1	2.48
27	Deafness, autosomal dominant 64	Enrichment	B3GNT4	2.37
28	Mucopolysaccharidosis iv	Enrichment	GALNS	2.35
29	Mucopolysaccharidosis, type iva	Enrichment	GALNS	2.26
30	Larsen syndrome	Enrichment	CHST3	2.19
31	Multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects	Enrichment	CHST3	2.19
32	Larsen-like syndrome b3gat3 type	Enrichment	CHST3	2.19
33	Mucopolysaccharidosis iii	Enrichment	GNS	2.18
34	Progressive familial intrahepatic cholestasis	Enrichment	GLB1	2.11
35	Muscular dystrophy-dystroglycanopathy , type a, 1	Enrichment	B4GAT1	1.97
36	Variegate porphyria	Enrichment	B4GALT3	1.97
37	Primary bone dysplasia	Enrichment	GALNS	1.96
38	Osteochondrodysplasia	Enrichment	GALNS	1.92
39	Developmental and epileptic encephalopathy	Enrichment	ST3GAL3	1.68
40	Leukodystrophy	Enrichment	HEXA	1.66
41	Walker-warburg syndrome	Enrichment	B4GAT1	1.53
42	Spastic ataxia	Enrichment	GLB1	1.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Keratan sulfate biosynthesis

Pathway Network for Keratan sulfate biosynthesis

Pathway network for the Keratan sulfate biosynthesis SuperPath

Member Pathways for Keratan sulfate biosynthesis

Pathways in the Keratan sulfate biosynthesis SuperPath

Gene overlap in member pathways for Keratan sulfate biosynthesis SuperPath

Associated Genes for Keratan sulfate biosynthesis

Associated Disorders for Keratan sulfate biosynthesis

Disorders associated with Keratan sulfate biosynthesis SuperPath

STRING Interaction Network for Keratan sulfate biosynthesis

Sources for Keratan sulfate biosynthesis