Keratinization

No Pathway Network information available for Keratinization

Pathways in the Keratinization SuperPath

#	Name	Source	Genes
1	Keratinization	Reactome	CAPN1 CAPNS1 CASP14 CDSN CELA2A CSTA DSC1 DSC2 DSC3 DSG3 DSG4 EVPL FLG FURIN IVL JUP KAZN KLK12 KLK13 KLK14 KLK5 KLK8 KRT1 KRT10 KRT12 KRT13 KRT14 KRT15 KRT16 KRT17 KRT18 KRT19 KRT2 KRT20 KRT23 KRT24 KRT25 KRT26 KRT27 KRT28 KRT3 KRT31 KRT32 KRT33A KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT4 KRT40 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT84 KRT85 KRT86 KRT9 KRTAP1-1 KRTAP1-3 KRTAP1-4 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP10-2 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP15-1 KRTAP16-1 KRTAP17-1 KRTAP19-1 KRTAP19-2 KRTAP19-3 KRTAP19-4 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP19-8 KRTAP2-1 KRTAP2-2 KRTAP2-3 KRTAP2-4 KRTAP20-1 KRTAP20-2 KRTAP21-1 KRTAP21-2 KRTAP21-3 KRTAP22-1 KRTAP23-1 KRTAP24-1 KRTAP25-1 KRTAP26-1 KRTAP27-1 KRTAP29-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-2 KRTAP4-3 KRTAP4-4 KRTAP4-5 KRTAP4-6 KRTAP4-7 KRTAP4-8 KRTAP4-9 KRTAP5-1 KRTAP5-10 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-5 KRTAP5-6 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP8-1 KRTAP9-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-6 KRTAP9-7 KRTAP9-8 KRTAP9-9 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LCE6A LELP1 LIPJ LIPK LIPM LIPN LORICRIN PCSK6 PERP PI3 PKP2 PKP3 PKP4 PPL PRSS8 RPTN SPINK5 SPINK6 SPINK9 SPRR1A SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G SPRR3 ST14 TCHH TGM1 TGM5 (see all 212) (see less)
2	Formation of the cornified envelope	Reactome	CAPN1 CAPNS1 CASP14 CDSN CELA2A CSTA DSC1 DSC2 DSC3 DSG3 DSG4 EVPL FLG FURIN IVL JUP KAZN KLK12 KLK13 KLK14 KLK5 KLK8 KRT1 KRT10 KRT12 KRT13 KRT14 KRT15 KRT16 KRT17 KRT18 KRT19 KRT2 KRT20 KRT23 KRT24 KRT25 KRT26 KRT27 KRT28 KRT3 KRT31 KRT32 KRT33A KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT4 KRT40 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT84 KRT85 KRT86 KRT9 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LCE6A LELP1 LIPJ LIPK LIPM LIPN LORICRIN PCSK6 PERP PI3 PKP2 PKP3 PKP4 PPL PRSS8 RPTN SPINK5 SPINK6 SPINK9 SPRR1A SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G SPRR3 ST14 TCHH TGM1 TGM5 (see all 125) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDSN	Corneodesmosin	Protein Coding	2
2	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	2
3	PKP3	Plakophilin 3	Protein Coding	2
4	KLK8	Kallikrein Related Peptidase 8	Protein Coding	2
5	KRT71	Keratin 71	Protein Coding	2
6	KRT74	Keratin 74	Protein Coding	2
7	KRT40	Keratin 40	Protein Coding	2
8	RPTN	Repetin	Protein Coding	2
9	KRT72	Keratin 72	Protein Coding	2
10	LIPJ	Lipase Family Member J	Protein Coding	2
11	KRT80	Keratin 80	Protein Coding	2
12	KRT25	Keratin 25	Protein Coding	2
13	DSG4	Desmoglein 4	Protein Coding	2
14	CSTA	Cystatin A	Protein Coding	2
15	LELP1	Late Cornified Envelope Like Proline Rich 1	Protein Coding	2
16	KRT28	Keratin 28	Protein Coding	2
17	DSC1	Desmocollin 1	Protein Coding	2
18	DSC2	Desmocollin 2	Protein Coding	2
19	DSC3	Desmocollin 3	Protein Coding	2
20	DSG3	Desmoglein 3	Protein Coding	2
21	KRT24	Keratin 24	Protein Coding	2
22	KRT78	Keratin 78	Protein Coding	2
23	LCE4A	Late Cornified Envelope 4A	Protein Coding	2
24	EVPL	Envoplakin	Protein Coding	2
25	FLG	Filaggrin	Protein Coding	2
26	KAZN	Kazrin, Periplakin Interacting Protein	Protein Coding	2
27	CASP14	Caspase 14	Protein Coding	2
28	LCE5A	Late Cornified Envelope 5A	Protein Coding	2
29	KLK5	Kallikrein Related Peptidase 5	Protein Coding	2
30	KRT23	Keratin 23	Protein Coding	2
31	KLK13	Kallikrein Related Peptidase 13	Protein Coding	2
32	LCE2B	Late Cornified Envelope 2B	Protein Coding	2
33	KRT6C	Keratin 6C	Protein Coding	2
34	KRT73	Keratin 73	Protein Coding	2
35	KRT79	Keratin 79	Protein Coding	2
36	LIPM	Lipase Family Member M	Protein Coding	2
37	KRT27	Keratin 27	Protein Coding	2
38	LCE1A	Late Cornified Envelope 1A	Protein Coding	2
39	LCE1B	Late Cornified Envelope 1B	Protein Coding	2
40	LCE1C	Late Cornified Envelope 1C	Protein Coding	2
41	LCE1D	Late Cornified Envelope 1D	Protein Coding	2
42	LCE1E	Late Cornified Envelope 1E	Protein Coding	2
43	LCE1F	Late Cornified Envelope 1F	Protein Coding	2
44	LCE2A	Late Cornified Envelope 2A	Protein Coding	2
45	LCE2C	Late Cornified Envelope 2C	Protein Coding	2
46	LCE2D	Late Cornified Envelope 2D	Protein Coding	2
47	LCE3A	Late Cornified Envelope 3A	Protein Coding	2
48	LCE3B	Late Cornified Envelope 3B	Protein Coding	2
49	LCE3C	Late Cornified Envelope 3C	Protein Coding	2
50	LCE3E	Late Cornified Envelope 3E	Protein Coding	2
51	KRT26	Keratin 26	Protein Coding	2
52	IVL	Involucrin	Protein Coding	2
53	JUP	Junction Plakoglobin	Protein Coding	2
54	KRT77	Keratin 77	Protein Coding	2
55	KRT1	Keratin 1	Protein Coding	2
56	KRT2	Keratin 2	Protein Coding	2
57	KRT3	Keratin 3	Protein Coding	2
58	KRT4	Keratin 4	Protein Coding	2
59	KRT5	Keratin 5	Protein Coding	2
60	KRT6A	Keratin 6A	Protein Coding	2
61	KRT6B	Keratin 6B	Protein Coding	2
62	KRT7	Keratin 7	Protein Coding	2
63	KRT8	Keratin 8	Protein Coding	2
64	KRT9	Keratin 9	Protein Coding	2
65	KRT10	Keratin 10	Protein Coding	2
66	KRT12	Keratin 12	Protein Coding	2
67	KRT13	Keratin 13	Protein Coding	2
68	KRT14	Keratin 14	Protein Coding	2
69	KRT15	Keratin 15	Protein Coding	2
70	KRT16	Keratin 16	Protein Coding	2
71	KRT17	Keratin 17	Protein Coding	2
72	KRT18	Keratin 18	Protein Coding	2
73	KRT19	Keratin 19	Protein Coding	2
74	KRT31	Keratin 31	Protein Coding	2
75	KRT32	Keratin 32	Protein Coding	2
76	KRT33A	Keratin 33A	Protein Coding	2
77	KRT33B	Keratin 33B	Protein Coding	2
78	KRT34	Keratin 34	Protein Coding	2
79	KRT35	Keratin 35	Protein Coding	2
80	KRT81	Keratin 81	Protein Coding	2
81	KRT82	Keratin 82	Protein Coding	2
82	KRT83	Keratin 83	Protein Coding	2
83	KRT84	Keratin 84	Protein Coding	2
84	KRT85	Keratin 85	Protein Coding	2
85	KRT86	Keratin 86	Protein Coding	2
86	KRT39	Keratin 39	Protein Coding	2
87	LORICRIN	Loricrin Cornified Envelope Precursor Protein	Protein Coding	2
88	SPINK6	Serine Peptidase Inhibitor Kazal Type 6	Protein Coding	2
89	KLK14	Kallikrein Related Peptidase 14	Protein Coding	2
90	KLK12	Kallikrein Related Peptidase 12	Protein Coding	2
91	LCE6A	Late Cornified Envelope 6A	Protein Coding	2
92	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	2
93	PCSK6	Proprotein Convertase Subtilisin/Kexin Type 6	Protein Coding	2
94	KRT76	Keratin 76	Protein Coding	2
95	PI3	Peptidase Inhibitor 3	Protein Coding	2
96	PKP2	Plakophilin 2	Protein Coding	2
97	KRT20	Keratin 20	Protein Coding	2
98	PPL	Periplakin	Protein Coding	2
99	PRSS8	Serine Protease 8	Protein Coding	2
100	CELA2A	Chymotrypsin Like Elastase 2A	Protein Coding	2
101	PERP	P53 Apoptosis Effector Related To PMP22	Protein Coding	2
102	SPINK9	Serine Peptidase Inhibitor Kazal Type 9	Protein Coding	2
103	LIPK	Lipase Family Member K	Protein Coding	2
104	LIPN	Lipase Family Member N	Protein Coding	2
105	SPRR1A	Small Proline Rich Protein 1A	Protein Coding	2
106	SPRR1B	Small Proline Rich Protein 1B	Protein Coding	2
107	SPRR2A	Small Proline Rich Protein 2A	Protein Coding	2
108	SPRR2B	Small Proline Rich Protein 2B	Protein Coding	2
109	SPRR2D	Small Proline Rich Protein 2D	Protein Coding	2
110	SPRR2E	Small Proline Rich Protein 2E	Protein Coding	2
111	SPRR2F	Small Proline Rich Protein 2F	Protein Coding	2
112	SPRR2G	Small Proline Rich Protein 2G	Protein Coding	2
113	SPRR3	Small Proline Rich Protein 3	Protein Coding	2
114	ST14	ST14 Transmembrane Serine Protease Matriptase	Protein Coding	2
115	TGM1	Transglutaminase 1	Protein Coding	2
116	TCHH	Trichohyalin	Protein Coding	2
117	CAPN1	Calpain 1	Protein Coding	2
118	CAPNS1	Calpain Small Subunit 1	Protein Coding	2
119	LCE3D	Late Cornified Envelope 3D	Protein Coding	2
120	PKP4	Plakophilin 4	Protein Coding	2
121	KRT38	Keratin 38	Protein Coding	2
122	KRT37	Keratin 37	Protein Coding	2
123	KRT36	Keratin 36	Protein Coding	2
124	KRT75	Keratin 75	Protein Coding	2
125	TGM5	Transglutaminase 5	Protein Coding	2
126	KRTAP25-1	Keratin Associated Protein 25-1	Protein Coding	1
127	KRTAP4-9	Keratin Associated Protein 4-9	Protein Coding	1
128	KRTAP4-7	Keratin Associated Protein 4-7	Protein Coding	1
129	KRTAP21-3	Keratin Associated Protein 21-3	Protein Coding	1
130	KRTAP9-7	Keratin Associated Protein 9-7	Protein Coding	1
131	KRTAP16-1	Keratin Associated Protein 16-1	Protein Coding	1
132	KRTAP9-6	Keratin Associated Protein 9-6	Protein Coding	1
133	KRTAP29-1	Keratin Associated Like Protein 29-1	Protein Coding	1
134	KRTAP13-1	Keratin Associated Protein 13-1	Protein Coding	1
135	KRTAP15-1	Keratin Associated Protein 15-1	Protein Coding	1
136	KRTAP13-4	Keratin Associated Protein 13-4	Protein Coding	1
137	KRTAP8-1	Keratin Associated Protein 8-1	Protein Coding	1
138	KRTAP11-1	Keratin Associated Protein 11-1	Protein Coding	1
139	KRTAP19-1	Keratin Associated Protein 19-1	Protein Coding	1
140	KRTAP13-2	Keratin Associated Protein 13-2	Protein Coding	1
141	KRTAP13-3	Keratin Associated Protein 13-3	Protein Coding	1
142	KRTAP23-1	Keratin Associated Protein 23-1	Protein Coding	1
143	KRTAP6-1	Keratin Associated Protein 6-1	Protein Coding	1
144	KRTAP6-2	Keratin Associated Protein 6-2	Protein Coding	1
145	KRTAP19-2	Keratin Associated Protein 19-2	Protein Coding	1
146	KRTAP19-3	Keratin Associated Protein 19-3	Protein Coding	1
147	KRTAP19-4	Keratin Associated Protein 19-4	Protein Coding	1
148	KRTAP19-5	Keratin Associated Protein 19-5	Protein Coding	1
149	KRTAP19-6	Keratin Associated Protein 19-6	Protein Coding	1
150	KRTAP19-7	Keratin Associated Protein 19-7	Protein Coding	1
151	KRTAP20-1	Keratin Associated Protein 20-1	Protein Coding	1
152	KRTAP20-2	Keratin Associated Protein 20-2	Protein Coding	1
153	KRTAP21-1	Keratin Associated Protein 21-1	Protein Coding	1
154	KRTAP21-2	Keratin Associated Protein 21-2	Protein Coding	1
155	KRTAP22-1	Keratin Associated Protein 22-1	Protein Coding	1
156	KRTAP12-2	Keratin Associated Protein 12-2	Protein Coding	1
157	KRTAP12-1	Keratin Associated Protein 12-1	Protein Coding	1
158	KRTAP10-10	Keratin Associated Protein 10-10	Protein Coding	1
159	KRTAP5-9	Keratin Associated Protein 5-9	Protein Coding	1
160	KRTAP10-4	Keratin Associated Protein 10-4	Protein Coding	1
161	KRTAP10-6	Keratin Associated Protein 10-6	Protein Coding	1
162	KRTAP10-7	Keratin Associated Protein 10-7	Protein Coding	1
163	KRTAP10-9	Keratin Associated Protein 10-9	Protein Coding	1
164	KRTAP10-1	Keratin Associated Protein 10-1	Protein Coding	1
165	KRTAP10-11	Keratin Associated Protein 10-11	Protein Coding	1
166	KRTAP10-2	Keratin Associated Protein 10-2	Protein Coding	1
167	KRTAP10-5	Keratin Associated Protein 10-5	Protein Coding	1
168	KRTAP10-8	Keratin Associated Protein 10-8	Protein Coding	1
169	KRTAP10-3	Keratin Associated Protein 10-3	Protein Coding	1
170	KRTAP12-3	Keratin Associated Protein 12-3	Protein Coding	1
171	KRTAP12-4	Keratin Associated Protein 12-4	Protein Coding	1
172	KRTAP10-12	Keratin Associated Protein 10-12	Protein Coding	1
173	KRTAP5-1	Keratin Associated Protein 5-1	Protein Coding	1
174	KRTAP5-3	Keratin Associated Protein 5-3	Protein Coding	1
175	KRTAP5-4	Keratin Associated Protein 5-4	Protein Coding	1
176	KRTAP5-10	Keratin Associated Protein 5-10	Protein Coding	1
177	KRTAP26-1	Keratin Associated Protein 26-1	Protein Coding	1
178	KRTAP5-5	Keratin Associated Protein 5-5	Protein Coding	1
179	KRTAP5-2	Keratin Associated Protein 5-2	Protein Coding	1
180	KRTAP5-6	Keratin Associated Protein 5-6	Protein Coding	1
181	KRTAP5-7	Keratin Associated Protein 5-7	Protein Coding	1
182	KRTAP5-11	Keratin Associated Protein 5-11	Protein Coding	1
183	KRTAP5-8	Keratin Associated Protein 5-8	Protein Coding	1
184	KRTAP24-1	Keratin Associated Protein 24-1	Protein Coding	1
185	KRTAP27-1	Keratin Associated Protein 27-1	Protein Coding	1
186	KRTAP4-11	Keratin Associated Protein 4-11	Protein Coding	1
187	KRTAP4-8	Keratin Associated Protein 4-8	Protein Coding	1
188	KRTAP1-4	Keratin Associated Protein 1-4	Protein Coding	1
189	KRTAP2-2	Keratin Associated Protein 2-2	Protein Coding	1
190	KRTAP19-8	Keratin Associated Protein 19-8	Protein Coding	1
191	KRTAP9-1	Keratin Associated Protein 9-1	Protein Coding	1
192	KRTAP2-3	Keratin Associated Protein 2-3	Protein Coding	1
193	KRTAP1-3	Keratin Associated Protein 1-3	Protein Coding	1
194	KRTAP1-1	Keratin Associated Protein 1-1	Protein Coding	1
195	KRTAP9-9	Keratin Associated Protein 9-9	Protein Coding	1
196	KRTAP4-6	Keratin Associated Protein 4-6	Protein Coding	1
197	KRTAP2-1	Keratin Associated Protein 2-1	Protein Coding	1
198	KRTAP1-5	Keratin Associated Protein 1-5	Protein Coding	1
199	KRTAP3-1	Keratin Associated Protein 3-1	Protein Coding	1
200	KRTAP3-2	Keratin Associated Protein 3-2	Protein Coding	1
201	KRTAP9-2	Keratin Associated Protein 9-2	Protein Coding	1
202	KRTAP9-3	Keratin Associated Protein 9-3	Protein Coding	1
203	KRTAP9-8	Keratin Associated Protein 9-8	Protein Coding	1
204	KRTAP17-1	Keratin Associated Protein 17-1	Protein Coding	1
205	KRTAP4-4	Keratin Associated Protein 4-4	Protein Coding	1
206	KRTAP9-4	Keratin Associated Protein 9-4	Protein Coding	1
207	KRTAP4-1	Keratin Associated Protein 4-1	Protein Coding	1
208	KRTAP4-5	Keratin Associated Protein 4-5	Protein Coding	1
209	KRTAP4-3	Keratin Associated Protein 4-3	Protein Coding	1
210	KRTAP4-2	Keratin Associated Protein 4-2	Protein Coding	1
211	KRTAP3-3	Keratin Associated Protein 3-3	Protein Coding	1
212	KRTAP2-4	Keratin Associated Protein 2-4	Protein Coding	1

Disorders associated with Keratinization SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pachyonychia congenita 1	Enrichment	KRT16, KRT17, KRT6A, KRT6B	8.16
2	Monilethrix	Enrichment	DSG4, KRT81, KRT83, KRT86	8.16
3	Monilethrix 1	Enrichment	KRT81, KRT83, KRT86	6.12
4	Palmoplantar keratoderma, epidermolytic, 1	Enrichment	KRT1, KRT16, KRT9	6.12
5	Epidermolytic hyperkeratosis 1	Enrichment	KRT1, KRT10, KRT2	5.12
6	Familial woolly hair syndrome	Enrichment	KRT25, KRT71, KRT74	5.12
7	Skin disease	Enrichment	FLG, KRT14, KRT17, TGM1	4.35
8	Epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT14, KRT5	4.07
9	Peeling skin syndrome 2	Enrichment	CSTA, TGM5	4.07
10	Corneal dystrophy, meesmann, 1	Enrichment	KRT12, KRT3	4.07
11	Hypotrichosis simplex of the scalp	Enrichment	CDSN, KRT74	4.07
12	White sponge nevus	Enrichment	KRT13, KRT4	4.07
13	Monilethrix 2	Enrichment	KRT81, KRT86	4.07
14	Ichthyosis	Enrichment	FLG, ST14, TGM1	3.92
15	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	DSC2, JUP, PKP2	3.80
16	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	DSC2, JUP, PKP2	3.80
17	Ectodermal dysplasia 4, hair/nail type	Enrichment	KRT74, KRT85	3.60
18	Peeling skin syndrome 4	Enrichment	CSTA, KRT2	3.60
19	Ichthyosis with confetti	Enrichment	KRT1, KRT10	3.60
20	Ichthyosis, annular epidermolytic, 1	Enrichment	KRT1, KRT10	3.60
21	Peeling skin syndrome 1	Enrichment	CDSN, TGM5	3.60
22	Cryptogenic cirrhosis	Enrichment	KRT18, KRT8	3.60
23	Annular epidermolytic ichthyosis	Enrichment	KRT1, KRT10	3.60
24	Autosomal dominant epidermolytic ichthyosis	Enrichment	KRT1, KRT10	3.60
25	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	DSC2, JUP, PKP2	3.59
26	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DSC2, JUP, PKP2	3.41
27	Epidermolysis bullosa simplex 1b, generalized intermediate	Enrichment	KRT14, KRT5	3.30
28	Epidermolysis bullosa simplex generalized type	Enrichment	KRT14, KRT5	3.30
29	Epidermolytic hyperkeratosis	Enrichment	KRT1, KRT10	3.30
30	Epidermolysis bullosa simplex 2f, with mottled pigmentation	Enrichment	KRT14, KRT5	3.08
31	Epidermolysis bullosa simplex 1a, generalized severe	Enrichment	KRT14, KRT5	3.08
32	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	DSC2, PKP2	3.08
33	Epidermolysis bullosa simplex 1c, localized	Enrichment	KRT14, KRT5	3.08
34	Arrhythmogenic right ventricular dysplasia 1	Enrichment	DSC2, PKP2	3.08
35	Epidermolysis bullosa simplex	Enrichment	KRT14, KRT5	2.77
36	Erythrokeratodermia variabilis et progressiva 1	Enrichment	KRT83, LORICRIN	2.64
37	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSC2, PKP2	2.54
38	Autosomal recessive congenital ichthyosis	Enrichment	LIPN, TGM1	2.09
39	Ichthyosis hystrix, curth-macklin type	Enrichment	KRT1	2.04
40	Dermatopathia pigmentosa reticularis	Enrichment	KRT14	2.04
41	Pachyonychia congenita 2	Enrichment	KRT17	2.04
42	Woolly hair, autosomal dominant	Enrichment	KRT74	2.04
43	Ichthyosis, congenital, autosomal recessive 11	Enrichment	ST14	2.04
44	Loose anagen hair syndrome	Enrichment	KRT75	2.04
45	Palmoplantar keratoderma, nonepidermolytic	Enrichment	KRT1	2.04
46	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.04
47	Vohwinkel syndrome, variant form	Enrichment	LORICRIN	2.04
48	Ichthyosis bullosa of siemens	Enrichment	KRT2	2.04
49	Naegeli-franceschetti-jadassohn syndrome	Enrichment	KRT14	2.04
50	Pachyonychia congenita 3	Enrichment	KRT6A	2.04
51	Ichthyosis, congenital, autosomal recessive 12	Enrichment	CASP14	2.04
52	Pseudofolliculitis barbae	Enrichment	KRT75	2.04
53	Steatocystoma multiplex	Enrichment	KRT17	2.04
54	White sponge nevus 1	Enrichment	KRT4	2.04
55	Naxos disease	Enrichment	JUP	2.04
56	Abdominal obesity-metabolic syndrome 4	Enrichment	CELA2A	2.04
57	Uncombable hair syndrome 3	Enrichment	TCHH	2.04
58	Ichthyosis, annular epidermolytic, 2	Enrichment	KRT1	2.04
59	Pulmonary hypertension, primary, 6	Enrichment	CAPNS1	2.04
60	Erythrokeratodermia variabilis et progressiva 5	Enrichment	KRT83	2.04
61	Palmoplantar keratoderma, nonepidermolytic, focal or diffuse	Enrichment	KRT6C	2.04
62	Netherton syndrome	Enrichment	SPINK5	2.04
63	Keratosis palmoplantaris striata iii	Enrichment	KRT1	2.04
64	White sponge nevus 2	Enrichment	KRT13	2.04
65	Hypotrichosis and recurrent skin vesicles	Enrichment	DSC3	2.04
66	Hypotrichosis 3	Enrichment	KRT74	2.04
67	Ichthyosis, congenital, autosomal recessive 8	Enrichment	LIPN	2.04
68	Monilethrix 3	Enrichment	KRT83	2.04
69	Pachyonychia congenita 4	Enrichment	KRT6B	2.04
70	Olmsted syndrome 2	Enrichment	PERP	2.04
71	Hypotrichosis 13	Enrichment	KRT71	2.04
72	Ectodermal dysplasia 7, hair/nail type	Enrichment	KRT74	2.04
73	Erythrokeratodermia variabilis et progressiva 7	Enrichment	PERP	2.04
74	Blistering, acantholytic, of oral and laryngeal mucosa	Enrichment	DSG3	2.04
75	Hereditary hypotrichosis with recurrent skin vesicles	Enrichment	DSC3	2.04
76	Palmoplantar keratoderma, epidermolytic, 2	Enrichment	KRT1	2.04
77	Ichthyosis linearis circumflexa	Enrichment	SPINK5	2.04
78	Focal palmoplantar keratoderma	Enrichment	KRT6C	2.04
79	Autosomal recessive epidermolytic ichthyosis	Enrichment	KRT10	2.04
80	Acral self-healing collodion baby	Enrichment	TGM1	2.04
81	Hypotrichosis 2	Enrichment	CDSN	1.74
82	Ichthyosis hystrix, lambert type	Enrichment	KRT10	1.74
83	Ichthyosis vulgaris	Enrichment	FLG	1.74
84	Arrhythmogenic right ventricular dysplasia, familial, 11	Enrichment	DSC2	1.74
85	Keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy	Enrichment	KRT1	1.74
86	Epidermolysis bullosa simplex 2e, with migratory circinate erythema	Enrichment	KRT5	1.74
87	Dermatitis, atopic, 2	Enrichment	FLG	1.74
88	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	1.74
89	Palmoplantar keratoderma, nonepidermolytic, focal 1	Enrichment	KRT16	1.74
90	Epidermolysis bullosa simplex 2d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT5	1.74
91	Sjogren-larsson syndrome	Enrichment	KRT14	1.74
92	Epidermolytic hyperkeratosis 2a, autosomal dominant	Enrichment	KRT10	1.74
93	Corneal dystrophy, meesmann, 2	Enrichment	KRT3	1.74
94	Ichthyosis, x-linked	Enrichment	FLG	1.74
95	Hypotrichosis 6	Enrichment	DSG4	1.74
96	Dermatitis	Enrichment	FLG	1.74
97	Epidermolytic acanthoma	Enrichment	KRT10	1.74
98	Epidermolysis bullosa simplex 2a, generalized severe	Enrichment	KRT5	1.74
99	Ichthyosis, congenital, autosomal recessive 1	Enrichment	TGM1	1.56
100	Nail disorder, nonsyndromic congenital, 4	Enrichment	KRT17	1.56
101	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.56
102	Woolly hair, autosomal recessive 3	Enrichment	KRT25	1.56
103	Epidermolysis bullosa simplex 2b, generalized intermediate	Enrichment	KRT5	1.56
104	Epidermolytic hyperkeratosis 2b, autosomal recessive	Enrichment	KRT10	1.56
105	Hypotrichosis 8	Enrichment	KRT25	1.56
106	Keratosis palmoplantaris striata	Enrichment	KRT1	1.56
107	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	PERP	1.56
108	Epidermolysis bullosa simplex 2c, localized	Enrichment	KRT5	1.56
109	Palmoplantar keratosis	Enrichment	KRT9	1.56
110	Self-improving collodion baby	Enrichment	TGM1	1.56
111	Otitis media	Enrichment	SPINK5	1.44
112	Dowling-degos disease 1	Enrichment	KRT5	1.44
113	Dermatitis, atopic	Enrichment	FLG	1.44
114	Dowling-degos disease	Enrichment	KRT5	1.44
115	Epidermolytic nevus	Enrichment	KRT10	1.44
116	Coronary artery anomaly	Enrichment	CELA2A	1.44
117	Epidermolysis bullosa	Enrichment	KRT5	1.34
118	Inherited arrhythmogenic cardiomyopathy	Enrichment	PKP2	1.27
119	Paroxysmal dystonia	Enrichment	FLG	1.20
120	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	PKP2	1.10
121	Hypotrichosis simplex	Enrichment	DSG4	1.10
122	Congenital nonbullous ichthyosiform erythroderma	Enrichment	TGM1	1.05
123	Diabetes mellitus	Enrichment	CELA2A	1.01
124	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	FLG	0.86
125	Wolff-parkinson-white syndrome	Enrichment	JUP	0.86
126	Hypertension	Enrichment	CELA2A	0.86
127	Cardiomyopathy, dilated, 1e	Enrichment	PKP2	0.84
128	Cardiomyopathy, dilated, 1a	Enrichment	DSC2	0.75
129	Brugada syndrome	Enrichment	PKP2	0.67
130	Long qt syndrome 1	Enrichment	PKP2	0.61
131	Left ventricular noncompaction	Enrichment	PKP2	0.56
132	Hypertrophic cardiomyopathy	Enrichment	PKP2	0.48
133	Dilated cardiomyopathy	Enrichment	JUP	0.28
134	Microcephaly	Enrichment	FLG	0.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Keratinization

Pathway Network for Keratinization

Member Pathways for Keratinization

Pathways in the Keratinization SuperPath

Associated Genes for Keratinization

Associated Disorders for Keratinization

Disorders associated with Keratinization SuperPath

STRING Interaction Network for Keratinization

Sources for Keratinization