Kisspeptin/kisspeptin receptor system in the ovary

No Pathway Network information available for Kisspeptin/kisspeptin receptor system in the ovary

Pathways in the Kisspeptin/kisspeptin receptor system in the ovary SuperPath

#	Name	Source	Genes
1	Kisspeptin/kisspeptin receptor system in the ovary	WikiPathways	AKT1 AKT2 AMH ARRB1 ARRB2 BMP15 CYP11A1 FSHR GDF9 HRAS HSD3B1 KISS1 KISS1R KRAS LOC105372522 MAP2K1 MAP2K2 MAPK1 MAPK3 MMP9 NFKB1 NRAS PDK1 PIK3CA PIK3CB PIK3CD PIK3CG PLCB2 PLCB3 PLCB4 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ RAF1 STAR (see all 39) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLCB3	Phospholipase C Beta 3	Protein Coding	1
2	PLCB2	Phospholipase C Beta 2	Protein Coding	1
3	BMP15	Bone Morphogenetic Protein 15	Protein Coding	1
4	KISS1R	KISS1 Receptor	Protein Coding	1
5	STAR	Steroidogenic Acute Regulatory Protein	Protein Coding	1
6	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
7	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
8	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
9	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
10	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
11	PRKCQ	Protein Kinase C Theta	Protein Coding	1
12	PRKCH	Protein Kinase C Eta	Protein Coding	1
13	PRKCG	Protein Kinase C Gamma	Protein Coding	1
14	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
15	PRKCD	Protein Kinase C Delta	Protein Coding	1
16	PRKCB	Protein Kinase C Beta	Protein Coding	1
17	PRKCA	Protein Kinase C Alpha	Protein Coding	1
18	PLCB4	Phospholipase C Beta 4	Protein Coding	1
19	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
20	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
21	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
22	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
23	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
24	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
25	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
26	ARRB2	Arrestin Beta 2	Protein Coding	1
27	ARRB1	Arrestin Beta 1	Protein Coding	1
28	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
29	KISS1	KiSS-1 Metastasis Suppressor	Protein Coding	1
30	HSD3B1	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1	Protein Coding	1
31	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
32	AMH	Anti-Mullerian Hormone	Protein Coding	1
33	GDF9	Growth Differentiation Factor 9	Protein Coding	1
34	FSHR	Follicle Stimulating Hormone Receptor	Protein Coding	1
35	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
36	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
37	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	1
38	LOC105372522	Uncharacterized LOC105372522	RNA Gene	1
39	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1

Disorders associated with Kisspeptin/kisspeptin receptor system in the ovary SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	10.75
2	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	10.38
3	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	10.19
4	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, MAP2K1, NRAS, PIK3CA	10.15
5	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.69
6	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.06
7	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	7.06
8	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	7.06
9	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	6.36
10	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	6.12
11	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	6.12
12	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	5.91
13	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.74
14	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	5.58
15	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.09
16	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	4.62
17	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.62
18	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.32
19	Genetic central precocious puberty in male	Enrichment	KISS1, KISS1R	4.32
20	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	4.12
21	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.12
22	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	3.92
23	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.78
24	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.78
25	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.78
26	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	3.78
27	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.78
28	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	3.57
29	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.54
30	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.28
31	Meningioma	Enrichment	AKT1, PIK3CA	3.28
32	46 xx gonadal dysgenesis	Enrichment	BMP15, FSHR	3.28
33	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.28
34	Lipoid congenital adrenal hyperplasia	Enrichment	CYP11A1, STAR	3.14
35	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.08
36	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	KISS1, KISS1R	2.92
37	Breast cancer	Enrichment	AKT1, KRAS, PIK3CA	2.89
38	Colorectal cancer	Enrichment	AKT1, NRAS, PIK3CA	2.71
39	Precocious puberty, central, 1	Enrichment	KISS1R	2.54
40	Macrodactyly	Enrichment	PIK3CA	2.54
41	Proteus syndrome	Enrichment	AKT1	2.54
42	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.54
43	Oculoectodermal syndrome	Enrichment	KRAS	2.54
44	Noonan syndrome 5	Enrichment	RAF1	2.54
45	Melorheostosis, isolated	Enrichment	MAP2K1	2.54
46	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.54
47	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.54
48	Cowden syndrome 5	Enrichment	PIK3CA	2.54
49	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.54
50	Melanosis, neurocutaneous	Enrichment	NRAS	2.54
51	Hypogonadotropic hypogonadism 8 with or without anosmia	Enrichment	KISS1R	2.54
52	Noonan syndrome 6	Enrichment	NRAS	2.54
53	Adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	Enrichment	CYP11A1	2.54
54	Ovarian dysgenesis 1	Enrichment	FSHR	2.54
55	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.54
56	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.54
57	Noonan syndrome 13	Enrichment	MAPK1	2.54
58	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.54
59	Twinning, dizygotic	Enrichment	FSHR	2.54
60	Ovarian dysgenesis 2	Enrichment	BMP15	2.54
61	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.54
62	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.54
63	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.54
64	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.54
65	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.54
66	Ovarian hyperstimulation syndrome	Enrichment	FSHR	2.54
67	Melorheostosis	Enrichment	MAP2K1	2.54
68	Leopard syndrome 2	Enrichment	RAF1	2.54
69	Hypogonadotropic hypogonadism 13 with or without anosmia	Enrichment	KISS1	2.54
70	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.54
71	Cowden syndrome 6	Enrichment	AKT1	2.54
72	Amenorrhea	Enrichment	FSHR	2.54
73	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.54
74	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.54
75	Premature ovarian failure 14	Enrichment	GDF9	2.54
76	Trigonitis	Enrichment	RAF1	2.54
77	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.54
78	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.54
79	Immature teratoma of ovary	Enrichment	BMP15	2.54
80	Hypospadias	Enrichment	PIK3CA	2.54
81	Inherited isolated adrenal insufficiency due to partial cyp11a1 deficiency	Enrichment	CYP11A1	2.54
82	Congenital pulmonary airway malformation	Enrichment	KRAS	2.54
83	Rare venous malformation	Enrichment	PIK3CA	2.54
84	Diaphragmatic eventration	Enrichment	PIK3CA	2.54
85	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.54
86	Non-classic congenital lipoid adrenal hyperplasia due to star deficency	Enrichment	STAR	2.54
87	Rare combined vascular malformation	Enrichment	PIK3CA	2.54
88	Cavernous lymphangioma	Enrichment	PIK3CA	2.54
89	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.54
90	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.54
91	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.54
92	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.54
93	Macrodactyly of toe	Enrichment	PIK3CA	2.54
94	Neurocutaneous melanocytosis	Enrichment	NRAS	2.54
95	Classic congenital lipoid adrenal hyperplasia due to star deficency	Enrichment	STAR	2.54
96	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.54
97	Ovarian cancer	Enrichment	AKT1, KRAS, PIK3CA	2.52
98	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.45
99	Lung cancer	Enrichment	KRAS, PIK3CA	2.42
100	Costello syndrome	Enrichment	HRAS	2.24
101	Toe syndactyly, telecanthus, and anogenital and renal malformations	Enrichment	STAR	2.24
102	Keratosis, seborrheic	Enrichment	PIK3CA	2.24
103	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.24
104	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.24
105	Noonan syndrome 8	Enrichment	PIK3CA	2.24
106	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.24
107	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.24
108	Central precocious puberty	Enrichment	KISS1R	2.24
109	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.24
110	Ocular melanoma	Enrichment	PLCB4	2.24
111	Immune system disease	Enrichment	PIK3CD	2.24
112	Metaphyseal anadysplasia	Enrichment	MMP9	2.24
113	Common variable immunodeficiency 12	Enrichment	NFKB1	2.24
114	Tafro syndrome	Enrichment	MAP2K2	2.24
115	Wooly hair nevus	Enrichment	HRAS	2.24
116	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.23
117	Gastric cancer	Enrichment	KRAS, PIK3CA	2.17
118	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.07
119	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.07
120	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	2.07
121	Precocious puberty, central, 2	Enrichment	KISS1R	2.07
122	Immunodeficiency 14	Enrichment	PIK3CD	2.07
123	Gonadal dysgenesis	Enrichment	FSHR	2.07
124	Spermatocytoma	Enrichment	HRAS	2.07
125	Keratoacanthoma	Enrichment	PIK3CA	2.07
126	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.94
127	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.94
128	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.94
129	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.94
130	Persistent mullerian duct syndrome, types i and ii	Enrichment	AMH	1.94
131	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.94
132	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.94
133	Hereditary ataxia	Enrichment	PRKCG	1.94
134	Cerebrovascular disease	Enrichment	PIK3CA	1.94
135	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.94
136	Pilocytic astrocytoma	Enrichment	KRAS	1.94
137	Epidermolytic nevus	Enrichment	HRAS	1.94
138	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.94
139	Persistent mullerian duct syndrome	Enrichment	AMH	1.94
140	Capillary malformations, congenital	Enrichment	PIK3CA	1.84
141	Hemimegalencephaly	Enrichment	PIK3CA	1.84
142	Familial glucocorticoid deficiency	Enrichment	STAR	1.84
143	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.77
144	Melanoma, uveal	Enrichment	PLCB4	1.77
145	Cowden syndrome 1	Enrichment	PIK3CA	1.77
146	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	Enrichment	CYP11A1	1.77
147	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.77
148	21-hydroxylase-deficient congenital adrenal hyperplasia	Enrichment	CYP11A1	1.77
149	Common variable immunodeficiency	Enrichment	NFKB1	1.70
150	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.59
151	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.59
152	Hypogonadotropic hypogonadism	Enrichment	KISS1R	1.59
153	Stroke, ischemic	Enrichment	PRKCH	1.55
154	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.55
155	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.55
156	Specific learning disability	Enrichment	MAPK1	1.51
157	Protein-deficiency anemia	Enrichment	NRAS	1.43
158	Nk-cell enteropathy	Enrichment	PIK3CB	1.43
159	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	KISS1R	1.40
160	Lung cancer susceptibility 3	Enrichment	KRAS	1.40
161	Pituitary stalk interruption syndrome	Enrichment	KISS1R	1.40
162	Perrault syndrome 1	Enrichment	FSHR	1.35
163	Rhabdomyosarcoma	Enrichment	HRAS	1.35
164	Heart, malformation of	Enrichment	MAPK1	1.30
165	Arteriovenous malformations of the brain	Enrichment	KRAS	1.27
166	Endometrial cancer	Enrichment	PIK3CA	1.23
167	Hepatocellular carcinoma	Enrichment	PIK3CA	1.21
168	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.18
169	Pancreatic cancer	Enrichment	KRAS	1.16
170	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.14
171	Prostate cancer	Enrichment	PIK3CA	1.10
172	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.04
173	Left ventricular noncompaction	Enrichment	RAF1	1.02
174	Type 2 diabetes mellitus	Enrichment	AKT2	0.94
175	Hypertelorism	Enrichment	PIK3CA	0.86
176	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.85
177	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.83
178	Myeloma, multiple	Enrichment	KRAS	0.83
179	Dilated cardiomyopathy	Enrichment	RAF1	0.69
180	Autism spectrum disorder	Enrichment	MAP2K1	0.57
181	Microcephaly	Enrichment	MAPK1	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Kisspeptin/kisspeptin receptor system in the ovary

Pathway Network for Kisspeptin/kisspeptin receptor system in the ovary

Member Pathways for Kisspeptin/kisspeptin receptor system in the ovary

Pathways in the Kisspeptin/kisspeptin receptor system in the ovary SuperPath

Associated Genes for Kisspeptin/kisspeptin receptor system in the ovary

Associated Disorders for Kisspeptin/kisspeptin receptor system in the ovary

Disorders associated with Kisspeptin/kisspeptin receptor system in the ovary SuperPath

STRING Interaction Network for Kisspeptin/kisspeptin receptor system in the ovary

Sources for Kisspeptin/kisspeptin receptor system in the ovary