Krebs cycle disorders

No Pathway Network information available for Krebs cycle disorders

#	Name	Source	Genes
1	Krebs cycle disorders	WikiPathways	DHTKD1 DLST FH GPT LDHA LDHB LDHC MPC1 PDHX SUCLA2 SUCLG1 SUCLG2 (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SUCLA2	Succinate-CoA Ligase ADP-Forming Subunit Beta	Protein Coding	1
2	PDHX	Pyruvate Dehydrogenase Complex Component X	Protein Coding	1
3	LDHC	Lactate Dehydrogenase C	Protein Coding	1
4	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	1
5	LDHB	Lactate Dehydrogenase B	Protein Coding	1
6	LDHA	Lactate Dehydrogenase A	Protein Coding	1
7	DHTKD1	Dehydrogenase E1 And Transketolase Domain Containing 1	Protein Coding	1
8	SUCLG2	Succinate-CoA Ligase GDP-Forming Subunit Beta	Protein Coding	1
9	SUCLG1	Succinate-CoA Ligase GDP/ADP-Forming Subunit Alpha	Protein Coding	1
10	DLST	Dihydrolipoamide S-Succinyltransferase	Protein Coding	1
11	MPC1	Mitochondrial Pyruvate Carrier 1	Protein Coding	1
12	FH	Fumarate Hydratase	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	DLST, FH	3.83
2	Hereditary leiomyomatosis and renal cell cancer	Enrichment	FH	3.05
3	Mitochondrial dna depletion syndrome 9	Enrichment	SUCLG1	3.05
4	Fumarase deficiency	Enrichment	FH	3.05
5	Alpha-aminoadipic and alpha-ketoadipic aciduria	Enrichment	DHTKD1	3.05
6	Pheochromocytoma/paraganglioma syndrome 7	Enrichment	DLST	3.05
7	Mitochondrial dna depletion syndrome 5	Enrichment	SUCLA2	3.05
8	Leiomyoma cutis	Enrichment	FH	3.05
9	Lactate dehydrogenase b deficiency	Enrichment	LDHB	3.05
10	Charcot-marie-tooth disease, axonal, type 2q	Enrichment	DHTKD1	3.05
11	Mitochondrial pyruvate carrier deficiency	Enrichment	MPC1	3.05
12	Fumarate hydratase deficiency	Enrichment	FH	3.05
13	Suclg1-related mitochondrial dna depletion syndrome, encephalomyopathic form with methylmalonic aciduria	Enrichment	SUCLG1	3.05
14	Leiomyoma, uterine	Enrichment	FH	2.75
15	Fanconi-bickel syndrome	Enrichment	LDHA	2.75
16	Pyruvate dehydrogenase e3-binding protein deficiency	Enrichment	PDHX	2.75
17	Spinocerebellar ataxia 45	Enrichment	FH	2.75
18	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHX	2.45
19	Hepatocellular carcinoma	Enrichment	FH	1.71
20	Mitochondrial disease	Enrichment	PDHX	1.13
21	Ovarian cancer	Enrichment	FH	1.07
22	Inherited cancer-predisposing syndrome	Enrichment	FH	0.96

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Krebs cycle disorders