KW2449-resistant FLT3 mutants
Pathways in the KW2449-resistant FLT3 mutants SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | KW2449-resistant FLT3 mutants | Reactome | |
| 2 | tamatinib-resistant FLT3 mutants | Reactome | |
| 3 | linifanib-resistant FLT3 mutants | Reactome | |
| 4 | Drug resistance of FLT3 mutants | Reactome | |
| 5 | semaxanib-resistant FLT3 mutants | Reactome | |
| 6 | ponatinib-resistant FLT3 mutants | Reactome | |
| 7 | gilteritinib-resistant FLT3 mutants | Reactome | |
| 8 | midostaurin-resistant FLT3 mutants | Reactome | |
| 9 | crenolanib-resistant FLT3 mutants | Reactome | |
| 10 | pexidartinib-resistant FLT3 mutants | Reactome | |
| 11 | tandutinib-resistant FLT3 mutants | Reactome | |
| 12 | FLT3 mutants bind TKIs | Reactome | |
| 13 | quizartinib-resistant FLT3 mutants | Reactome | |
| 14 | lestaurtinib-resistant FLT3 mutants | Reactome | |
| 15 | sunitinib-resistant FLT3 mutants | Reactome | |
| 16 | sorafenib-resistant FLT3 mutants | Reactome |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | FLT3 | Fms Related Receptor Tyrosine Kinase 3 | Protein Coding | 16 |
Disorders associated with KW2449-resistant FLT3 mutants SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Acute myeloid leukemia with minimal differentiation | Enrichment | FLT3 | 4.13 |
| 2 | Acute myeloid leukemia without maturation | Enrichment | FLT3 | 3.83 |
| 3 | Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) | Enrichment | FLT3 | 3.83 |
| 4 | Mixed phenotype acute leukemia with t | Enrichment | FLT3 | 3.66 |
| 5 | Chronic myelomonocytic leukemia | Enrichment | FLT3 | 3.53 |
| 6 | Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) | Enrichment | FLT3 | 3.53 |
| 7 | Acute myeloid leukemia with maturation | Enrichment | FLT3 | 3.43 |
| 8 | Acute myeloid leukemia with t(8;21)(q22;q22) translocation | Enrichment | FLT3 | 3.43 |
| 9 | B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) | Enrichment | FLT3 | 3.29 |
| 10 | Atypical chronic myeloid leukemia, bcr-abl1 negative | Enrichment | FLT3 | 3.18 |
| 11 | Leukemia, acute lymphoblastic | Enrichment | FLT3 | 3.09 |
| 12 | Precursor t-cell acute lymphoblastic leukemia | Enrichment | FLT3 | 2.77 |
| 13 | Leukemia, acute myeloid | Enrichment | FLT3 | 2.53 |
| 14 | Myeloma, multiple | Enrichment | FLT3 | 2.38 |
