Kynurenine pathway and links to cell senescence

No Pathway Network information available for Kynurenine pathway and links to cell senescence

Pathways in the Kynurenine pathway and links to cell senescence SuperPath

#	Name	Source	Genes
1	Kynurenine pathway and links to cell senescence	WikiPathways	AADAT ACMSD AFMID AHR CDKN1A EIF2AK1 EIF2AK4 FOXO1 HAAO IDO1 IDO2 IFNB1 IFNG IL1R2 KLF5 KMO KYNU QPRT TDO2 TLR4 TNF TP53 (see all 22) (see less)
2	Tryptophan catabolism	Reactome	AADAT ACMSD AFMID HAAO IDO1 IDO2 KMO KYAT1 KYAT3 KYNU SLC36A4 SLC3A2 SLC7A5 TDO2 (see all 14) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AFMID	Arylformamidase	Protein Coding	2
2	TDO2	Tryptophan 2,3-Dioxygenase	Protein Coding	2
3	IDO1	Indoleamine 2,3-Dioxygenase 1	Protein Coding	2
4	ACMSD	Aminocarboxymuconate Semialdehyde Decarboxylase	Protein Coding	2
5	IDO2	Indoleamine 2,3-Dioxygenase 2	Protein Coding	2
6	KYNU	Kynureninase	Protein Coding	2
7	HAAO	3-Hydroxyanthranilate 3,4-Dioxygenase	Protein Coding	2
8	KMO	Kynurenine 3-Monooxygenase	Protein Coding	2
9	AADAT	Aminoadipate Aminotransferase	Protein Coding	2
10	EIF2AK1	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1	Protein Coding	1
11	EIF2AK4	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4	Protein Coding	1
12	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	1
13	TLR4	Toll Like Receptor 4	Protein Coding	1
14	IFNG	Interferon Gamma	Protein Coding	1
15	IFNB1	Interferon Beta 1	Protein Coding	1
16	AHR	Aryl Hydrocarbon Receptor	Protein Coding	1
17	TNF	Tumor Necrosis Factor	Protein Coding	1
18	TP53	Tumor Protein P53	Protein Coding	1
19	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
20	QPRT	Quinolinate Phosphoribosyltransferase	Protein Coding	1
21	KLF5	KLF Transcription Factor 5	Protein Coding	1
22	FOXO1	Forkhead Box O1	Protein Coding	1
23	SLC36A4	Solute Carrier Family 36 Member 4	Protein Coding	1
24	KYAT3	Kynurenine Aminotransferase 3	Protein Coding	1
25	SLC3A2	Solute Carrier Family 3 Member 2	Protein Coding	1
26	SLC7A5	Solute Carrier Family 7 Member 5	Protein Coding	1
27	KYAT1	Kynurenine Aminotransferase 1	Protein Coding	1

Disorders associated with Kynurenine pathway and links to cell senescence SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital nad deficiency disorder	Enrichment	HAAO, KYNU	5.23
2	Rhabdomyosarcoma 2	Enrichment	FOXO1, TP53	4.60
3	Diffuse large b-cell lymphoma	Enrichment	FOXO1, TP53	3.37
4	Bladder cancer	Enrichment	CDKN1A, TP53	3.00
5	Hydroxykynureninuria	Enrichment	KYNU	2.99
6	Vertebral, cardiac, renal, and limb defects syndrome 2	Enrichment	KYNU	2.99
7	Hypertryptophanemia	Enrichment	TDO2	2.99
8	Retinitis pigmentosa 85	Enrichment	AHR	2.79
9	Immunodeficiency 69	Enrichment	IFNG	2.79
10	Bone marrow failure syndrome 5	Enrichment	TP53	2.79
11	Papilloma of choroid plexus	Enrichment	TP53	2.79
12	Basal cell carcinoma 7	Enrichment	TP53	2.79
13	Foveal hypoplasia 3	Enrichment	AHR	2.79
14	Leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome	Enrichment	EIF2AK1	2.79
15	Anaplastic thyroid carcinoma	Enrichment	TP53	2.79
16	Macular degeneration, age-related, 10	Enrichment	TLR4	2.79
17	Ductal carcinoma in situ	Enrichment	TP53	2.79
18	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.79
19	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.79
20	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.79
21	Choroid plexus cancer	Enrichment	TP53	2.79
22	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.79
23	Vertebral, cardiac, renal, and limb defects syndrome 1	Enrichment	HAAO	2.69
24	Catel-manzke syndrome	Enrichment	KYNU	2.69
25	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.49
26	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	EIF2AK4	2.49
27	Cervical cancer	Enrichment	TP53	2.49
28	Pulmonary venoocclusive disease 2, autosomal recessive	Enrichment	EIF2AK4	2.49
29	Lymphoma, hodgkin, classic	Enrichment	TP53	2.49
30	Cardiomyopathy, dilated, 1ff	Enrichment	KLF5	2.49
31	Pulmonary venoocclusive disease 1	Enrichment	EIF2AK4	2.49
32	Pulmonary venoocclusive disease 2	Enrichment	EIF2AK4	2.49
33	Leukodystrophy, hypomyelinating, 17	Enrichment	EIF2AK1	2.49
34	Immunodeficiency 127	Enrichment	TNF	2.49
35	Congenital fibrosarcoma	Enrichment	TP53	2.49
36	Li-fraumeni syndrome 1	Enrichment	TP53	2.49
37	Sarcoma	Enrichment	TP53	2.49
38	Cervix carcinoma	Enrichment	TP53	2.49
39	Hodgkin's lymphoma	Enrichment	TP53	2.49
40	Pulmonary venoocclusive disease	Enrichment	EIF2AK4	2.49
41	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.49
42	Tuberous sclerosis 1	Enrichment	IFNG	2.31
43	Osteogenic sarcoma	Enrichment	TP53	2.31
44	Psoriatic arthritis	Enrichment	TNF	2.31
45	Hepatitis c virus	Enrichment	IFNG	2.31
46	Nasopharyngeal carcinoma	Enrichment	TP53	2.31
47	Tuberous sclerosis 2	Enrichment	IFNG	2.31
48	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.31
49	Anaplastic astrocytoma	Enrichment	TP53	2.31
50	Squamous cell carcinoma	Enrichment	TP53	2.31
51	Adenocarcinoma	Enrichment	TP53	2.31
52	Migraine without aura	Enrichment	TNF	2.31
53	Bone osteosarcoma	Enrichment	TP53	2.31
54	Small cell cancer of the lung	Enrichment	TP53	2.19
55	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.19
56	Lung sarcomatoid carcinoma	Enrichment	TP53	2.19
57	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.19
58	Cerebral malaria	Enrichment	TNF	2.19
59	Lymphoma	Enrichment	TP53	2.09
60	Vascular dementia	Enrichment	TNF	2.09
61	Acute megakaryocytic leukemia	Enrichment	TP53	2.09
62	Idiopathic aplastic anemia	Enrichment	IFNG	2.09
63	Li-fraumeni syndrome	Enrichment	TP53	2.01
64	Adrenocortical carcinoma	Enrichment	TP53	2.01
65	Breast adenocarcinoma	Enrichment	TP53	2.01
66	Esophageal cancer	Enrichment	TP53	1.95
67	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.95
68	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.95
69	Essential thrombocythemia	Enrichment	TP53	1.95
70	Gallbladder cancer	Enrichment	TP53	1.95
71	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.95
72	Glioma susceptibility 1	Enrichment	TP53	1.89
73	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.89
74	Adult hepatocellular carcinoma	Enrichment	TP53	1.84
75	Primary hyperaldosteronism	Enrichment	TP53	1.84
76	Leukemia, chronic lymphocytic	Enrichment	TP53	1.79
77	Aplastic anemia	Enrichment	IFNG	1.79
78	Familial colorectal cancer	Enrichment	TP53	1.79
79	Asthma	Enrichment	TNF	1.75
80	Myelodysplastic syndrome	Enrichment	TP53	1.75
81	Heritable pulmonary arterial hypertension	Enrichment	EIF2AK4	1.75
82	Lip and oral cavity carcinoma	Enrichment	TP53	1.71
83	Pulmonary hypertension, primary, 1	Enrichment	EIF2AK4	1.68
84	Alzheimer's disease	Enrichment	TNF	1.68
85	Lung cancer susceptibility 3	Enrichment	TP53	1.65
86	Rhabdomyosarcoma	Enrichment	TP53	1.59
87	Gliosarcoma	Enrichment	TP53	1.59
88	Giant cell glioblastoma	Enrichment	TP53	1.56
89	Human immunodeficiency virus type 1	Enrichment	IFNG	1.54
90	Behcet syndrome	Enrichment	TLR4	1.52
91	Hepatoblastoma	Enrichment	TP53	1.47
92	Hepatocellular carcinoma	Enrichment	TP53	1.45
93	Multisystem inflammatory syndrome in children	Enrichment	IFNB1	1.45
94	Diamond-blackfan anemia 1	Enrichment	TP53	1.44
95	Malaria	Enrichment	TNF	1.44
96	Pancreatic cancer	Enrichment	TP53	1.40
97	Prostate cancer	Enrichment	TP53	1.34
98	Diamond-blackfan anemia	Enrichment	TP53	1.25
99	Systemic lupus erythematosus	Enrichment	TNF	1.21
100	Leukemia, acute myeloid	Enrichment	TP53	1.20
101	Gastric cancer	Enrichment	TP53	1.17
102	Hereditary breast carcinoma	Enrichment	TP53	1.16
103	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.07
104	Myeloma, multiple	Enrichment	TP53	1.06
105	Breast cancer	Enrichment	TP53	0.94
106	Colorectal cancer	Enrichment	TP53	0.88
107	Ovarian cancer	Enrichment	TP53	0.82
108	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.71
109	Retinitis pigmentosa	Enrichment	AHR	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Kynurenine pathway and links to cell senescence

Pathway Network for Kynurenine pathway and links to cell senescence

Member Pathways for Kynurenine pathway and links to cell senescence

Pathways in the Kynurenine pathway and links to cell senescence SuperPath

Associated Genes for Kynurenine pathway and links to cell senescence

Associated Disorders for Kynurenine pathway and links to cell senescence

Disorders associated with Kynurenine pathway and links to cell senescence SuperPath

STRING Interaction Network for Kynurenine pathway and links to cell senescence

Sources for Kynurenine pathway and links to cell senescence