L-methionine degradation I (to L-homocysteine)

Sources:

#	Name	Source	Genes
1	L-methionine degradation I (to L-homocysteine)	PubChem	AHCY MAT1A MAT2A MAT2B
2	Methylation pathways	WikiPathways	COMT HNMT INMT MAT1A MAT2A MAT2B NNMT PNMT TPMT (see all 9) (see less)
3	cysteine biosynthesis	PubChem	AHCY CBS LOC102724560 MAT1A MAT2A MAT2B (see all 6) (see less)
4	superpathway of L-cysteine biosynthesis (mammalian)	PubChem	AHCY CBS LOC102724560 MAT1A MAT2A MAT2B (see all 6) (see less)
5	methionine degradation	PubChem	AHCY MAT1A MAT2A MAT2B
6	Defective MAT1A causes MATD	Reactome	MAT1A
7	Methylation of MeSeH for excretion	Reactome	INMT
8	Defective AHCY causes HMAHCHD	Reactome	AHCY

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	6
2	MAT2B	Methionine Adenosyltransferase 2 Non-Catalytic Beta Subunit	Protein Coding	5
3	AHCY	Adenosylhomocysteinase	Protein Coding	5
4	MAT2A	Methionine Adenosyltransferase 2A	Protein Coding	5
5	INMT	Indolethylamine N-Methyltransferase	Protein Coding	2
6	CBS	Cystathionine Beta-Synthase	Protein Coding	2
7	LOC102724560	Cystathionine Beta-Synthase Like	Protein Coding	2
8	TPMT	Thiopurine S-Methyltransferase	Protein Coding	1
9	NNMT	Nicotinamide N-Methyltransferase	Protein Coding	1
10	HNMT	Histamine N-Methyltransferase	Protein Coding	1
11	COMT	Catechol-O-Methyltransferase	Protein Coding	1
12	PNMT	Phenylethanolamine N-Methyltransferase	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypermethioninemia	Direct
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	CBS, MAT2A	3.82
3	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	3.53
4	Hyperhomocysteinemia	Enrichment	CBS	3.35
5	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	3.23
6	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	3.23
7	Thiopurines, poor metabolism of, 1	Enrichment	TPMT	3.18
8	Intellectual developmental disorder, autosomal recessive 51	Enrichment	HNMT	3.18
9	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	3.18
10	Homocystinuria due to cystathionine beta-synthase deficiency	Enrichment	CBS	2.88
11	Homocystinuria	Enrichment	CBS	2.88
12	Asthma	Enrichment	HNMT	2.14
13	Digeorge syndrome	Enrichment	COMT	2.10
14	Connective tissue disease	Enrichment	CBS	1.85
15	Bardet-biedl syndrome	Enrichment	COMT	1.56
16	Autosomal recessive non-syndromic intellectual disability	Enrichment	HNMT	1.42
17	Schizophrenia	Enrichment	COMT	1.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for L-methionine degradation I (to L-homocysteine)