Lactose synthesis

Sources:

#	Name	Source	Genes
1	Lactose synthesis	Reactome	B4GALT1 LALBA SLC2A1
2	Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	Reactome	SLC2A1
3	Defective B4GALT1 causes CDG-2d	Reactome	B4GALT1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	2
2	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	2
3	LALBA	Lactalbumin Alpha	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Early infantile epileptic encephalopathy	Direct
2	Immunodeficiency 47	Direct
3	Congenital disorder of glycosylation, type iid	Enrichment	B4GALT1	3.66
4	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	3.66
5	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	3.66
6	Combined low ldl and fibrinogen	Enrichment	B4GALT1	3.66
7	Epilepsy with myoclonic absences	Enrichment	SLC2A1	3.66
8	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	3.66
9	Dystonia 9	Enrichment	SLC2A1	3.35
10	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	3.35
11	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	3.35
12	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	3.18
13	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	3.18
14	Paroxysmal dystonia	Enrichment	SLC2A1	2.81
15	Alternating hemiplegia of childhood	Enrichment	SLC2A1	2.75
16	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	2.70
17	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	2.26
18	Strabismus	Enrichment	SLC2A1	2.22
19	Epilepsy	Enrichment	SLC2A1	2.05
20	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	2.04
21	Centralopathic epilepsy	Enrichment	SLC2A1	2.02
22	West syndrome	Enrichment	SLC2A1	2.01
23	Microcephaly	Enrichment	SLC2A1	1.57

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Lactose synthesis