Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics

No Pathway Network information available for Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics

#	Name	Source	Genes
1	Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics	PharmGKB	ABCB1 ABCC1 ABCC2 ABCC3 ABCC4 ABCG2 CYP2A6 CYP2D6 ESR1 NR1I2 NR1I3 SLC22A1 UGT1A3 UGT1A4 UGT2B7 (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	1
2	SLC22A1	Solute Carrier Family 22 Member 1	Protein Coding	1
3	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	1
4	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	1
5	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1
6	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	1
7	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	1
8	ESR1	Estrogen Receptor 1	Protein Coding	1
9	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	1
10	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
11	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	1
12	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	1
13	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	1
14	NR1I3	Nuclear Receptor Subfamily 1 Group I Member 3	Protein Coding	1
15	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Crigler-najjar syndrome, type i	Enrichment	UGT1A3, UGT1A4	4.29
2	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A3, UGT1A4	4.29
3	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A3, UGT1A4	4.29
4	Crigler-najjar syndrome, type ii	Enrichment	UGT1A3, UGT1A4	4.29
5	Gilbert syndrome	Enrichment	UGT1A3, UGT1A4	4.20
6	Bilirubin metabolic disorder	Enrichment	UGT1A3, UGT1A4	4.20
7	Colchicine resistance	Enrichment	ABCB1	2.96
8	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.96
9	Encephalopathy, acute transient	Enrichment	ABCB1	2.96
10	Deafness, autosomal dominant 77	Enrichment	ABCC1	2.96
11	Inflammatory bowel disease 13	Enrichment	ABCB1	2.96
12	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	2.96
13	Blood group, junior system	Enrichment	ABCG2	2.96
14	Letrozole toxicity	Enrichment	CYP2A6	2.96
15	Dubin-johnson syndrome	Enrichment	ABCC2	2.48
16	Estrogen resistance	Enrichment	ESR1	2.48
17	Coumarin resistance	Enrichment	CYP2A6	2.48
18	Migraine without aura	Enrichment	ESR1	2.48
19	Tobacco addiction	Enrichment	CYP2A6	2.35
20	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.35
21	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.18
22	Migraine with or without aura 1	Enrichment	ESR1	1.92
23	Epilepsy, idiopathic generalized	Enrichment	ABCB1	1.92
24	Myocardial infarction	Enrichment	ESR1	1.62
25	Lung cancer	Enrichment	CYP2A6	1.46
26	Hereditary breast carcinoma	Enrichment	ESR1	1.32
27	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.25
28	Breast cancer	Enrichment	ESR1	1.10

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics