Leptin-insulin signaling overlap

No Pathway Network information available for Leptin-insulin signaling overlap

Pathways in the Leptin-insulin signaling overlap SuperPath

#	Name	Source	Genes
1	Leptin-insulin signaling overlap	WikiPathways	AKT1 DGKZ INS INSR IRS1 IRS2 IRS4 JAK2 LEP LEPR PDPK1 PIK3CG PIK3R3 SOCS1 SOCS2 SOCS3 STAT3 (see all 17) (see less)
2	Signaling by Leptin	Reactome	IRS1 IRS2 JAK2 LEP LEPR PTPN11 SH2B1 SOCS3 STAT3 STAT5A STAT5B (see all 11) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	2
2	IRS2	Insulin Receptor Substrate 2	Protein Coding	2
3	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
4	LEPR	Leptin Receptor	Protein Coding	2
5	LEP	Leptin	Protein Coding	2
6	JAK2	Janus Kinase 2	Protein Coding	2
7	IRS1	Insulin Receptor Substrate 1	Protein Coding	2
8	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	1
9	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
10	DGKZ	Diacylglycerol Kinase Zeta	Protein Coding	1
11	IRS4	Insulin Receptor Substrate 4	Protein Coding	1
12	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
13	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
14	INSR	Insulin Receptor	Protein Coding	1
15	INS	Insulin	Protein Coding	1
16	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
17	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
18	SH2B1	SH2B Adaptor Protein 1	Protein Coding	1
19	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
20	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
21	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1

Disorders associated with Leptin-insulin signaling overlap SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	5.75
2	Leptin deficiency or dysfunction	Enrichment	LEP, LEPR	5.45
3	Type 2 diabetes mellitus	Enrichment	INSR, IRS1, IRS2	4.74
4	Permanent neonatal diabetes mellitus	Enrichment	INS, STAT3	4.39
5	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	4.33
6	Diffuse large b-cell lymphoma	Enrichment	SOCS1, STAT3	3.60
7	Metachondromatosis	Enrichment	PTPN11	3.09
8	Dermatitis, atopic, 4	Enrichment	SOCS3	3.09
9	Leopard syndrome 1	Enrichment	PTPN11	3.09
10	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	3.09
11	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.09
12	Leptin receptor deficiency	Enrichment	LEPR	3.09
13	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.09
14	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.09
15	Severe early-onset obesity-insulin resistance syndrome due to sh2b1 deficiency	Enrichment	SH2B1	3.09
16	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.09
17	Malignant astrocytoma	Enrichment	PTPN11	3.09
18	Primary ovarian insufficiency	Enrichment	JAK2, SH2B1	3.00
19	Proteus syndrome	Enrichment	AKT1	2.90
20	Donohue syndrome	Enrichment	INSR	2.90
21	Hypothyroidism, congenital, nongoitrous, 9	Enrichment	IRS4	2.90
22	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.90
23	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.90
24	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.90
25	Cowden syndrome 6	Enrichment	AKT1	2.90
26	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.90
27	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.79
28	Chromosome 16p11.2 deletion syndrome, 220-kb	Enrichment	SH2B1	2.79
29	Thrombocythemia 3	Enrichment	JAK2	2.79
30	Werner syndrome	Enrichment	PTPN11	2.79
31	Chromosome 16p11.2 deletion syndrome, 593-kb	Enrichment	SH2B1	2.79
32	Polycythemia	Enrichment	JAK2	2.79
33	Hypereosinophilic syndrome	Enrichment	JAK2	2.79
34	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.79
35	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.61
36	Polycythemia vera	Enrichment	JAK2	2.61
37	Hyper ige syndrome	Enrichment	STAT3	2.61
38	Tricuspid valve insufficiency	Enrichment	PTPN11	2.61
39	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.60
40	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.60
41	Hyperproinsulinemia	Enrichment	INS	2.60
42	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.60
43	Erythrocytosis, familial, 1	Enrichment	JAK2	2.49
44	Budd-chiari syndrome	Enrichment	JAK2	2.49
45	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.49
46	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.49
47	Type 1 diabetes mellitus 2	Enrichment	INS	2.43
48	Immune thrombocytopenia	Enrichment	SOCS1	2.43
49	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.43
50	Lymphoma	Enrichment	PTPN11	2.39
51	Myeloproliferative neoplasm	Enrichment	JAK2	2.39
52	Patent ductus arteriosus	Enrichment	PTPN11	2.31
53	Anemia, autoimmune hemolytic	Enrichment	SOCS1	2.30
54	Neonatal diabetes mellitus	Enrichment	INS	2.30
55	Myelofibrosis	Enrichment	JAK2	2.25
56	Noonan syndrome 3	Enrichment	PTPN11	2.25
57	Essential thrombocythemia	Enrichment	JAK2	2.25
58	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	2.14
59	Type 1 diabetes mellitus	Enrichment	INS	2.13
60	Breast adenocarcinoma	Enrichment	AKT1	2.13
61	46,xy disorder of sex development	Enrichment	INSR	2.13
62	Pectus excavatum	Enrichment	PTPN11	2.05
63	Specific learning disability	Enrichment	PTPN11	2.05
64	Epicanthus	Enrichment	PTPN11	2.01
65	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.01
66	Congenital long qt syndrome	Enrichment	PTPN11	2.01
67	Cowden syndrome	Enrichment	AKT1	1.95
68	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.92
69	Diabetes mellitus	Enrichment	INS	1.86
70	Patent foramen ovale	Enrichment	PTPN11	1.84
71	Meningioma	Enrichment	AKT1	1.83
72	Noonan syndrome 1	Enrichment	PTPN11	1.73
73	Scoliosis	Enrichment	PTPN11	1.71
74	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.68
75	Rasopathy	Enrichment	PTPN11	1.68
76	Strabismus	Enrichment	PTPN11	1.66
77	Long qt syndrome 1	Enrichment	PTPN11	1.62
78	Maturity-onset diabetes of the young	Enrichment	INS	1.61
79	Non-immune hydrops fetalis	Enrichment	PTPN11	1.60
80	Leukemia, acute myeloid	Enrichment	JAK2	1.50
81	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.46
82	Thrombocytopenia	Enrichment	PTPN11	1.42
83	Body mass index quantitative trait locus 11	Enrichment	LEPR	1.40
84	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.35
85	Systemic lupus erythematosus	Enrichment	SOCS1	1.32
86	Hereditary breast carcinoma	Enrichment	AKT1	1.27
87	Autism spectrum disorder	Enrichment	PTPN11	1.07
88	Breast cancer	Enrichment	AKT1	1.05
89	Microcephaly	Enrichment	PTPN11	1.02
90	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.99
91	Colorectal cancer	Enrichment	AKT1	0.98
92	Ovarian cancer	Enrichment	AKT1	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Leptin-insulin signaling overlap

Pathway Network for Leptin-insulin signaling overlap

Member Pathways for Leptin-insulin signaling overlap

Pathways in the Leptin-insulin signaling overlap SuperPath

Associated Genes for Leptin-insulin signaling overlap

Associated Disorders for Leptin-insulin signaling overlap

Disorders associated with Leptin-insulin signaling overlap SuperPath

STRING Interaction Network for Leptin-insulin signaling overlap

Sources for Leptin-insulin signaling overlap