Leukotriene modifiers pathway, Pharmacodynamics
Pathways in the Leukotriene modifiers pathway, Pharmacodynamics SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Leukotriene modifiers pathway, Pharmacodynamics | PharmGKB |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | ALOX5 | Arachidonate 5-Lipoxygenase | Protein Coding | 1 |
| 2 | ALOX5AP | Arachidonate 5-Lipoxygenase Activating Protein | Protein Coding | 1 |
| 3 | LTA4H | Leukotriene A4 Hydrolase | Protein Coding | 1 |
| 4 | LTC4S | Leukotriene C4 Synthase | Protein Coding | 1 |
| 5 | PLA2G4A | Phospholipase A2 Group IVA | Protein Coding | 1 |
| 6 | LTB4R | Leukotriene B4 Receptor | Protein Coding | 1 |
| 7 | GGT1 | Gamma-Glutamyltransferase 1 | Protein Coding | 1 |
| 8 | CYSLTR1 | Cysteinyl Leukotriene Receptor 1 | Protein Coding | 1 |
Disorders associated with Leukotriene modifiers pathway, Pharmacodynamics SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Glutathionuria | Enrichment | GGT1 | 3.23 |
| 2 | Leukotriene c4 synthase deficiency | Enrichment | LTC4S | 3.23 |
| 3 | Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder | Enrichment | PLA2G4A | 3.23 |
| 4 | Gastrointestinal ulceration, recurrent, with dysfunctional platelets | Enrichment | PLA2G4A | 3.23 |
| 5 | Atherosclerosis | Enrichment | ALOX5 | 3.23 |
| 6 | Cryptogenic multifocal ulcerous stenosing enteritis | Enrichment | PLA2G4A | 3.23 |
| 7 | Stroke, ischemic | Enrichment | ALOX5AP | 2.23 |
| 8 | Asthma | Enrichment | ALOX5 | 2.19 |
