LGI-ADAM interactions

No Pathway Network information available for LGI-ADAM interactions

Pathways in the LGI-ADAM interactions SuperPath

#	Name	Source	Genes
1	LGI-ADAM interactions	Reactome	ADAM11 ADAM22 ADAM23 CACNG2 CACNG3 CACNG4 CACNG8 DLG4 LGI1 LGI2 LGI3 LGI4 STX1A STX1B (see all 14) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CACNG3	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3	Protein Coding	1
2	CACNG2	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2	Protein Coding	1
3	STX1B	Syntaxin 1B	Protein Coding	1
4	LGI4	Leucine Rich Repeat LGI Family Member 4	Protein Coding	1
5	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	1
6	LGI3	Leucine Rich Repeat LGI Family Member 3	Protein Coding	1
7	CACNG4	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4	Protein Coding	1
8	ADAM11	ADAM Metallopeptidase Domain 11	Protein Coding	1
9	ADAM22	ADAM Metallopeptidase Domain 22	Protein Coding	1
10	LGI2	Leucine Rich Repeat LGI Family Member 2	Protein Coding	1
11	CACNG8	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8	Protein Coding	1
12	STX1A	Syntaxin 1A	Protein Coding	1
13	ADAM23	ADAM Metallopeptidase Domain 23	Protein Coding	1
14	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	1

Disorders associated with LGI-ADAM interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect	Enrichment	LGI4	2.99
2	Intellectual developmental disorder, autosomal dominant 10	Enrichment	CACNG2	2.99
3	Developmental and epileptic encephalopathy 61	Enrichment	ADAM22	2.99
4	Intellectual developmental disorder with muscle tone abnormalities and distal skeletal defects	Enrichment	LGI3	2.99
5	Generalized epilepsy with febrile seizures plus, type 9	Enrichment	STX1B	2.99
6	Autosomal dominant epilepsy with auditory features	Enrichment	LGI1	2.99
7	Genitopatellar syndrome	Enrichment	LGI1	2.69
8	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.69
9	Epilepsy, familial temporal lobe, 1	Enrichment	LGI1	2.51
10	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.51
11	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.51
12	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.51
13	Dlg4-related synaptopathy	Enrichment	DLG4	2.51
14	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	LGI4	2.51
15	Epilepsy with auditory features	Enrichment	LGI1	2.51
16	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	2.38
17	Arthrogryposis multiplex congenita 2, neurogenic type	Enrichment	LGI4	2.38
18	Generalized epilepsy	Enrichment	STX1B	2.38
19	Episodic ataxia	Enrichment	LGI3	2.38
20	Generalized epilepsy with febrile seizures plus	Enrichment	STX1B	1.84
21	Williams-beuren syndrome	Enrichment	STX1A	1.69
22	Cystic fibrosis	Enrichment	STX1A	1.49
23	Fetal akinesia deformation sequence 1	Enrichment	LGI4	1.43
24	Distal arthrogryposis	Enrichment	LGI4	1.37
25	Autosomal dominant non-syndromic intellectual disability	Enrichment	CACNG2	1.30
26	Autism	Enrichment	STX1A	1.14
27	Complex neurodevelopmental disorder	Enrichment	DLG4	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

LGI-ADAM interactions

Pathway Network for LGI-ADAM interactions

Member Pathways for LGI-ADAM interactions

Pathways in the LGI-ADAM interactions SuperPath

Associated Genes for LGI-ADAM interactions

Associated Disorders for LGI-ADAM interactions

Disorders associated with LGI-ADAM interactions SuperPath

STRING Interaction Network for LGI-ADAM interactions

Sources for LGI-ADAM interactions