Lissencephaly gene (LIS1) in neuronal migration and development

No Pathway Network information available for Lissencephaly gene (LIS1) in neuronal migration and development

Pathways in the Lissencephaly gene (LIS1) in neuronal migration and development SuperPath

#	Name	Source	Genes
1	Lissencephaly gene (LIS1) in neuronal migration and development	PubChem	ABL1 CDC42 CDK5 CDK5R1 CDK5R2 CLIP1 CSNK2A1 DAB1 DCX DYNC1H1 DYNLT1 IQGAP1 KATNA1 LRP8 LRPAP1 MAP1B NDEL1 NUDC PAFAH1B1 PAFAH1B2 PAFAH1B3 PLA2G7 PPP2R5D RAC1 RELN RHOA VLDLR YWHAE (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDK5R2	Cyclin Dependent Kinase 5 Regulatory Subunit 2	Protein Coding	1
2	KATNA1	Katanin Catalytic Subunit A1	Protein Coding	1
3	PAFAH1B3	Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 3	Protein Coding	1
4	PAFAH1B2	Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 2	Protein Coding	1
5	LRPAP1	LDL Receptor Related Protein Associated Protein 1	Protein Coding	1
6	DYNLT1	Dynein Light Chain Tctex-Type 1	Protein Coding	1
7	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
8	MAP1B	Microtubule Associated Protein 1B	Protein Coding	1
9	PLA2G7	Phospholipase A2 Group VII	Protein Coding	1
10	NUDC	Nuclear Distribution C, Dynein Complex Regulator	Protein Coding	1
11	NDEL1	NudE Neurodevelopment Protein 1 Like 1	Protein Coding	1
12	CLIP1	CAP-Gly Domain Containing Linker Protein 1	Protein Coding	1
13	LRP8	LDL Receptor Related Protein 8	Protein Coding	1
14	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
15	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
16	DAB1	DAB Adaptor Protein 1	Protein Coding	1
17	RELN	Reelin	Protein Coding	1
18	DCX	Doublecortin	Protein Coding	1
19	CDC42	Cell Division Cycle 42	Protein Coding	1
20	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
21	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
22	RHOA	Ras Homolog Family Member A	Protein Coding	1
23	DYNC1H1	Dynein Cytoplasmic 1 Heavy Chain 1	Protein Coding	1
24	RAC1	Rac Family Small GTPase 1	Protein Coding	1
25	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
26	PAFAH1B1	Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1	Protein Coding	1
27	VLDLR	Very Low Density Lipoprotein Receptor	Protein Coding	1
28	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1

Disorders associated with Lissencephaly gene (LIS1) in neuronal migration and development SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly	Enrichment	DCX, DYNC1H1, PAFAH1B1, RELN	7.07
2	Band heterotopia	Enrichment	DCX, PAFAH1B1	4.91
3	Miller-dieker lissencephaly syndrome	Enrichment	PAFAH1B1, YWHAE	4.91
4	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	PAFAH1B1, YWHAE	4.91
5	Congenital nervous system abnormality	Enrichment	DCX, DYNC1H1, VLDLR	2.88
6	Nervous system disease	Enrichment	DCX, DYNC1H1, VLDLR	2.88
7	Autism spectrum disorder	Enrichment	CSNK2A1, DYNC1H1, MAP1B	2.85
8	Arthritis, sacroiliac	Enrichment	RELN	2.69
9	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.69
10	Lissencephaly, x-linked, 1	Enrichment	DCX	2.69
11	Deafness, autosomal dominant 83	Enrichment	MAP1B	2.69
12	Spinocerebellar ataxia 37	Enrichment	DAB1	2.69
13	Synovitis	Enrichment	RELN	2.69
14	Platelet-activating factor acetylhydrolase deficiency	Enrichment	PLA2G7	2.69
15	Dync1h1-related disorders	Enrichment	DYNC1H1	2.69
16	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.69
17	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.69
18	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.69
19	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.69
20	Cerebellar hypoplasia	Enrichment	VLDLR	2.69
21	Dcx-related disorders	Enrichment	DCX	2.69
22	Nocarh syndrome	Enrichment	CDC42	2.69
23	Lissencephaly due to lis1 mutation	Enrichment	PAFAH1B1	2.69
24	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.69
25	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.69
26	Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant	Enrichment	DYNC1H1	2.38
27	Lissencephaly 1	Enrichment	PAFAH1B1	2.38
28	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.38
29	Cortical dysplasia, complex, with other brain malformations 13	Enrichment	DYNC1H1	2.38
30	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.38
31	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.38
32	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome	Enrichment	VLDLR	2.38
33	Periventricular nodular heterotopia 9	Enrichment	MAP1B	2.38
34	Spinal muscular atrophy with lower extremity predominant	Enrichment	DYNC1H1	2.38
35	Charcot-marie-tooth disease, axonal, type 2o	Enrichment	DYNC1H1	2.38
36	Immune system disease	Enrichment	CDC42	2.38
37	Intellectual developmental disorder, autosomal dominant 45	Enrichment	PAFAH1B3	2.38
38	Arthritis	Enrichment	RELN	2.38
39	Chromosome 5q14.3 deletion syndrome, distal	Enrichment	MAP1B	2.21
40	Epilepsy, familial temporal lobe, 7	Enrichment	RELN	2.21
41	Myopia 23, autosomal recessive	Enrichment	LRPAP1	2.21
42	Pyloric stenosis	Enrichment	MAP1B	2.21
43	Kyphosis	Enrichment	RELN	2.21
44	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.21
45	Epilepsy with auditory features	Enrichment	RELN	2.21
46	Fucosidosis	Enrichment	DCX	2.08
47	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.08
48	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.08
49	Chromosome 15q11.2 deletion syndrome	Enrichment	PAFAH1B1	1.99
50	Lissencephaly 2	Enrichment	RELN	1.99
51	Spinal muscular atrophy	Enrichment	DYNC1H1	1.99
52	Rare isolated myopia	Enrichment	LRPAP1	1.99
53	Endometrial stromal sarcoma	Enrichment	YWHAE	1.99
54	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	VLDLR	1.91
55	Hemihyperplasia, isolated	Enrichment	RHOA	1.91
56	Kidney clear cell sarcoma	Enrichment	YWHAE	1.91
57	Leukemia, chronic myeloid	Enrichment	ABL1	1.84
58	Moyamoya angiopathy	Enrichment	ABL1	1.84
59	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.84
60	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.73
61	Polymicrogyria	Enrichment	DYNC1H1	1.69
62	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	DYNC1H1	1.61
63	Lip and oral cavity carcinoma	Enrichment	ABL1	1.61
64	Microcephaly	Enrichment	ABL1, DYNC1H1	1.58
65	Periventricular nodular heterotopia	Enrichment	MAP1B	1.54
66	Heart disease	Enrichment	ABL1	1.54
67	Charcot-marie-tooth disease type 4	Enrichment	DYNC1H1	1.44
68	Attention deficit-hyperactivity disorder	Enrichment	MAP1B	1.35
69	Myocardial infarction	Enrichment	LRP8	1.35
70	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.33
71	Scoliosis	Enrichment	RELN	1.31
72	Peripheral nervous system disease	Enrichment	DYNC1H1	1.19
73	Neuropathy	Enrichment	DYNC1H1	1.19
74	Myopathy	Enrichment	DYNC1H1	1.10
75	Charcot-marie-tooth disease	Enrichment	DYNC1H1	1.09
76	Benign epilepsy with centrotemporal spikes	Enrichment	RELN	1.09
77	Centralopathic epilepsy	Enrichment	RELN	1.07
78	Body mass index quantitative trait locus 11	Enrichment	NUDC	1.01
79	Autosomal dominant non-syndromic intellectual disability	Enrichment	DYNC1H1	1.01
80	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MAP1B	0.99
81	Spastic ataxia	Enrichment	DAB1	0.98
82	Autosomal recessive non-syndromic intellectual disability	Enrichment	CLIP1	0.95
83	Schizophrenia	Enrichment	RELN	0.94
84	Complex neurodevelopmental disorder	Enrichment	CSNK2A1	0.64

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Lissencephaly gene (LIS1) in neuronal migration and development

Pathway Network for Lissencephaly gene (LIS1) in neuronal migration and development

Member Pathways for Lissencephaly gene (LIS1) in neuronal migration and development

Pathways in the Lissencephaly gene (LIS1) in neuronal migration and development SuperPath

Associated Genes for Lissencephaly gene (LIS1) in neuronal migration and development

Associated Disorders for Lissencephaly gene (LIS1) in neuronal migration and development

Disorders associated with Lissencephaly gene (LIS1) in neuronal migration and development SuperPath

STRING Interaction Network for Lissencephaly gene (LIS1) in neuronal migration and development

Sources for Lissencephaly gene (LIS1) in neuronal migration and development