LKB1 signaling events

No Pathway Network information available for LKB1 signaling events

Pathways in the LKB1 signaling events SuperPath

#	Name	Source	Genes
1	LKB1 signaling events	PubChem	AKT1S1 BRSK1 BRSK2 CAB39 CDC37 CREB1 CRTC2 CTSD ESR1 ETV4 EZR GSK3B HSP90AA1 LOC102724428 MAP2 MAPT MARK2 MARK4 MLST8 MTOR MYC PRKACA PSEN2 RPTOR SFN SIK1 SIK2 SIK3 SMAD4 SMARCD3 STK11 STK11IP STK26 STRADA TP53 TSC1 TSC2 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CAB39	Calcium Binding Protein 39	Protein Coding	1
2	STK11IP	Serine/Threonine Kinase 11 Interacting Protein	Protein Coding	1
3	SIK3	SIK Family Kinase 3	Protein Coding	1
4	SIK2	Salt Inducible Kinase 2	Protein Coding	1
5	BRSK1	BR Serine/Threonine Kinase 1	Protein Coding	1
6	BRSK2	BR Serine/Threonine Kinase 2	Protein Coding	1
7	STRADA	STE20 Related Adaptor Alpha	Protein Coding	1
8	PSEN2	Presenilin 2	Protein Coding	1
9	SIK1	Salt Inducible Kinase 1	Protein Coding	1
10	LOC102724428	Salt Inducible Kinase 1B (Putative)	Protein Coding	1
11	MAP2	Microtubule Associated Protein 2	Protein Coding	1
12	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	1
13	MARK2	Microtubule Affinity Regulating Kinase 2	Protein Coding	1
14	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
15	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
16	AKT1S1	AKT1 Substrate 1	Protein Coding	1
17	ETV4	ETS Variant Transcription Factor 4	Protein Coding	1
18	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
19	CTSD	Cathepsin D	Protein Coding	1
20	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	1
21	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
22	STK26	Serine/Threonine Kinase 26	Protein Coding	1
23	SMAD4	SMAD Family Member 4	Protein Coding	1
24	EZR	Ezrin	Protein Coding	1
25	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
26	MARK4	Microtubule Affinity Regulating Kinase 4	Protein Coding	1
27	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
28	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
29	TSC1	TSC Complex Subunit 1	Protein Coding	1
30	TSC2	TSC Complex Subunit 2	Protein Coding	1
31	SFN	Stratifin	Protein Coding	1
32	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
33	CRTC2	CREB Regulated Transcription Coactivator 2	Protein Coding	1
34	STK11	Serine/Threonine Kinase 11	Protein Coding	1
35	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
36	TP53	Tumor Protein P53	Protein Coding	1
37	ESR1	Estrogen Receptor 1	Protein Coding	1

Disorders associated with LKB1 signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC1, TSC2	7.13
2	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC1, TSC2	7.13
3	Adult hepatocellular carcinoma	Enrichment	TP53, TSC1, TSC2	5.81
4	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	5.14
5	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	4.66
6	Hamartoma	Enrichment	TSC1, TSC2	4.66
7	Inherited cancer-predisposing syndrome	Enrichment	SMAD4, STK11, TP53, TSC1, TSC2	4.56
8	Pancreatic cancer	Enrichment	SMAD4, STK11, TP53	4.38
9	Tuberous sclerosis	Enrichment	TSC1, TSC2	4.36
10	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4, STK11	4.14
11	Gallbladder cancer	Enrichment	SMAD4, TP53	3.82
12	Gastric cancer	Enrichment	SMAD4, STK11, TP53	3.67
13	Lip and oral cavity carcinoma	Enrichment	STK11, TP53	3.33
14	Ceroid lipofuscinosis, neuronal, 10	Enrichment	CTSD	2.56
15	Bone marrow failure syndrome 5	Enrichment	TP53	2.56
16	Papilloma of choroid plexus	Enrichment	TP53	2.56
17	Parkinson-dementia syndrome	Enrichment	MAPT	2.56
18	Basal cell carcinoma 7	Enrichment	TP53	2.56
19	Anaplastic thyroid carcinoma	Enrichment	TP53	2.56
20	Intellectual developmental disorder, autosomal dominant 76	Enrichment	MARK2	2.56
21	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.56
22	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.56
23	Progressive supranuclear palsy	Enrichment	MAPT	2.56
24	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.56
25	Ductal carcinoma in situ	Enrichment	TP53	2.56
26	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.56
27	Spondyloepimetaphyseal dysplasia, krakow type	Enrichment	SIK3	2.56
28	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.56
29	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.56
30	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.56
31	Heritable thoracic aortic disease	Enrichment	SMAD4	2.56
32	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.56
33	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.56
34	Choroid plexus cancer	Enrichment	TP53	2.56
35	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.56
36	Huntington's disease-like	Enrichment	PSEN2	2.56
37	Intestinal polyposis syndrome	Enrichment	STK11	2.56
38	Language disorder	Enrichment	SIK1	2.56
39	Bladder cancer	Enrichment	TP53, TSC1	2.55
40	Peutz-jeghers syndrome	Enrichment	STK11	2.26
41	Burkitt lymphoma	Enrichment	MYC	2.26
42	Myhre syndrome	Enrichment	SMAD4	2.26
43	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.26
44	Cervical cancer	Enrichment	TP53	2.26
45	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.26
46	Pick disease of brain	Enrichment	MAPT	2.26
47	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.26
48	Lymphoma, hodgkin, classic	Enrichment	TP53	2.26
49	Cebalid syndrome	Enrichment	MTOR	2.26
50	Polyhydramnios, megalencephaly, and symptomatic epilepsy	Enrichment	STRADA	2.26
51	Developmental and epileptic encephalopathy 30	Enrichment	SIK1	2.26
52	Congenital fibrosarcoma	Enrichment	TP53	2.26
53	Li-fraumeni syndrome 1	Enrichment	TP53	2.26
54	Sarcoma	Enrichment	TP53	2.26
55	Fibrolamellar carcinoma	Enrichment	PRKACA	2.26
56	Cervix carcinoma	Enrichment	TP53	2.26
57	Hodgkin's lymphoma	Enrichment	TP53	2.26
58	Smith-kingsmore syndrome	Enrichment	MTOR	2.26
59	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.26
60	Benign epilepsy with centrotemporal spikes	Enrichment	LOC102724428, STRADA	2.26
61	Centralopathic epilepsy	Enrichment	LOC102724428, STRADA	2.22
62	West syndrome	Enrichment	SIK1, TSC2	2.20
63	Hereditary breast carcinoma	Enrichment	ESR1, TP53	2.20
64	Juvenile polyposis syndrome	Enrichment	SMAD4	2.09
65	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	2.09
66	Osteogenic sarcoma	Enrichment	TP53	2.09
67	Alzheimer disease 4	Enrichment	PSEN2	2.09
68	Nasopharyngeal carcinoma	Enrichment	TP53	2.09
69	Estrogen resistance	Enrichment	ESR1	2.09
70	Tuberous sclerosis 2	Enrichment	TSC2	2.09
71	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.09
72	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.09
73	Testicular germ cell cancer	Enrichment	STK11	2.09
74	Anaplastic astrocytoma	Enrichment	TP53	2.09
75	Xanthinuria, type ii	Enrichment	TSC2	2.09
76	Squamous cell carcinoma	Enrichment	TP53	2.09
77	Adenocarcinoma	Enrichment	TP53	2.09
78	Migraine without aura	Enrichment	ESR1	2.09
79	Bone osteosarcoma	Enrichment	TP53	2.09
80	Melanoma of soft tissue	Enrichment	CREB1	2.09
81	Testicular cancer	Enrichment	STK11	2.09
82	Apc-associated polyposis conditions	Enrichment	STK11	2.09
83	Small cell cancer of the lung	Enrichment	TP53	1.96
84	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.96
85	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.96
86	Lung sarcomatoid carcinoma	Enrichment	TP53	1.96
87	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.96
88	Rhabdomyosarcoma 2	Enrichment	TP53	1.87
89	Familial adenomatous polyposis 1	Enrichment	STK11	1.87
90	Lymphoma	Enrichment	TP53	1.87
91	Acute megakaryocytic leukemia	Enrichment	TP53	1.87
92	Hemimegalencephaly	Enrichment	MTOR	1.87
93	Dementia	Enrichment	MAPT	1.87
94	Li-fraumeni syndrome	Enrichment	TP53	1.79
95	Testicular germ cell tumor	Enrichment	STK11	1.79
96	Keratoconus	Enrichment	TSC1	1.79
97	Adrenocortical carcinoma	Enrichment	TP53	1.79
98	Breast adenocarcinoma	Enrichment	TP53	1.79
99	Breast cancer	Enrichment	ESR1, TP53	1.75
100	Esophageal cancer	Enrichment	TP53	1.72
101	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.72
102	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.72
103	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.72
104	Semantic dementia	Enrichment	MAPT	1.72
105	Polycystic kidney disease 1	Enrichment	TSC2	1.72
106	Essential thrombocythemia	Enrichment	TP53	1.72
107	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.72
108	Overgrowth syndrome	Enrichment	MTOR	1.72
109	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN2	1.72
110	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.72
111	Glioma susceptibility 1	Enrichment	TP53	1.67
112	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.67
113	Ewing sarcoma	Enrichment	ETV4	1.67
114	Colorectal cancer	Enrichment	SMAD4, TP53	1.63
115	Ellis-van creveld syndrome	Enrichment	PRKACA	1.61
116	Progressive non-fluent aphasia	Enrichment	MAPT	1.61
117	Primary hyperaldosteronism	Enrichment	TP53	1.61
118	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.61
119	Leukemia, chronic lymphocytic	Enrichment	TP53	1.57
120	Melanoma	Enrichment	STK11	1.57
121	Familial colorectal cancer	Enrichment	TP53	1.57
122	Migraine with or without aura 1	Enrichment	ESR1	1.53
123	Frontotemporal dementia 1	Enrichment	MAPT	1.53
124	Myelodysplastic syndrome	Enrichment	TP53	1.53
125	Ovarian cancer	Enrichment	TP53, TSC2	1.51
126	Alzheimer's disease	Enrichment	MAPT	1.46
127	Autism spectrum disorder	Enrichment	MARK2, TSC2	1.45
128	Lung cancer susceptibility 3	Enrichment	TP53	1.43
129	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.40
130	Neuronal ceroid lipofuscinosis	Enrichment	CTSD	1.40
131	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.40
132	Kidney disease	Enrichment	TSC1	1.40
133	Rare genetic intellectual disability	Enrichment	MTOR	1.40
134	Rhabdomyosarcoma	Enrichment	TP53	1.37
135	Gliosarcoma	Enrichment	TP53	1.37
136	Alzheimer disease, familial, 1	Enrichment	MAPT	1.34
137	Melanoma, cutaneous malignant 1	Enrichment	STK11	1.34
138	Giant cell glioblastoma	Enrichment	TP53	1.34
139	Early infantile developmental and epileptic encephalopathy	Enrichment	SIK1	1.32
140	Diffuse large b-cell lymphoma	Enrichment	TP53	1.30
141	Hepatoblastoma	Enrichment	TP53	1.25
142	Hepatocellular carcinoma	Enrichment	TP53	1.23
143	Myocardial infarction	Enrichment	ESR1	1.23
144	Diamond-blackfan anemia 1	Enrichment	TP53	1.22
145	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.22
146	Parkinson disease, late-onset	Enrichment	MAPT	1.20
147	Prostate cancer	Enrichment	TP53	1.12
148	Cakut	Enrichment	ETV4	1.05
149	Diamond-blackfan anemia	Enrichment	TP53	1.03
150	Leukemia, acute myeloid	Enrichment	TP53	0.98
151	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD4	0.95
152	Thrombocytopenia	Enrichment	SMAD4	0.91
153	Autosomal dominant non-syndromic intellectual disability	Enrichment	BRSK2	0.89
154	Familial isolated dilated cardiomyopathy	Enrichment	PSEN2	0.87
155	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.85
156	Myeloma, multiple	Enrichment	TP53	0.85
157	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT	0.83
158	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.83
159	Congenital nervous system abnormality	Enrichment	TSC2	0.60
160	Nervous system disease	Enrichment	TSC2	0.60

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

LKB1 signaling events

Pathway Network for LKB1 signaling events

Member Pathways for LKB1 signaling events

Pathways in the LKB1 signaling events SuperPath

Associated Genes for LKB1 signaling events

Associated Disorders for LKB1 signaling events

Disorders associated with LKB1 signaling events SuperPath

STRING Interaction Network for LKB1 signaling events

Sources for LKB1 signaling events