Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling

No Pathway Network information available for Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling

#	Name	Source	Genes
1	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	Reactome	CUL1 FBXW7 NOTCH1 RBX1 SKP1
2	FBXW7 Mutants and NOTCH1 in Cancer	Reactome	CUL1 FBXW7 NOTCH1 RBX1 SKP1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOTCH1	Notch Receptor 1	Protein Coding	2
2	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	2
3	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	2
4	CUL1	Cullin 1	Protein Coding	2
5	RBX1	Ring-Box 1	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	3.43
2	Adams-oliver syndrome 5	Enrichment	NOTCH1	3.13
3	Keratoacanthoma	Enrichment	NOTCH1	2.96
4	Pervasive developmental disorder	Enrichment	FBXW7	2.73
5	Rare pervasive developmental disorder	Enrichment	FBXW7	2.73
6	Adams-oliver syndrome	Enrichment	NOTCH1	2.59
7	Hypoplastic left heart syndrome	Enrichment	NOTCH1	2.53
8	Aortic valve disease 1	Enrichment	NOTCH1	2.32
9	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	2.29
10	Tetralogy of fallot	Enrichment	NOTCH1	2.02
11	Connective tissue disease	Enrichment	NOTCH1	1.93
12	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	1.79
13	Colorectal cancer	Enrichment	FBXW7	1.50

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling