Loss of Function of SMAD4 in Cancer

Sources:

#	Name	Source	Genes
1	Loss of Function of SMAD4 in Cancer	Reactome	SMAD2 SMAD3 SMAD4
2	SMAD2/3 MH2 Domain Mutants in Cancer	Reactome	SMAD2 SMAD3 SMAD4
3	SMAD4 MH2 Domain Mutants in Cancer	Reactome	SMAD2 SMAD3 SMAD4

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SMAD2	SMAD Family Member 2	Protein Coding	3
2	SMAD3	SMAD Family Member 3	Protein Coding	3
3	SMAD4	SMAD Family Member 4	Protein Coding	3

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4	7.50
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3	5.93
3	Loeys-dietz syndrome 6	Enrichment	SMAD2	3.66
4	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	3.66
5	Heritable thoracic aortic disease	Enrichment	SMAD4	3.66
6	Myhre syndrome	Enrichment	SMAD4	3.35
7	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	3.35
8	Loeys-dietz syndrome 3	Enrichment	SMAD3	3.35
9	Juvenile polyposis syndrome	Enrichment	SMAD4	3.18
10	Loeys-dietz syndrome 1	Enrichment	SMAD2	3.18
11	Aortic aneurysm	Enrichment	SMAD3	3.05
12	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.96
13	Gallbladder cancer	Enrichment	SMAD4	2.81
14	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	2.81
15	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	2.70
16	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	2.51
17	Ehlers-danlos syndrome	Enrichment	SMAD3	2.38
18	Pancreatic cancer	Enrichment	SMAD4	2.26
19	Connective tissue disease	Enrichment	SMAD3	2.15
20	Gastric cancer	Enrichment	SMAD4	2.02
21	Thrombocytopenia	Enrichment	SMAD4	1.98
22	Colorectal cancer	Enrichment	SMAD4	1.72
23	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	1.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Loss of Function of SMAD4 in Cancer