Loss of Nlp from mitotic centrosomes

Pathway network for the Loss of Nlp from mitotic centrosomes SuperPath

Sources:

Reactome

Pathways in the Loss of Nlp from mitotic centrosomes SuperPath

#	Name	Source	Genes
1	Loss of Nlp from mitotic centrosomes	Reactome	ACTR1A AKAP9 ALMS1 CCP110 CDK1 CDK5RAP2 CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 YWHAE YWHAG (see all 69) (see less)
2	Mitotic G2-G2/M phases	Reactome	ACTR1A ADRM1 AJUBA AKAP9 ALMS1 AURKA BORA BTRC CCNA1 CCNA2 CCNB1 CCNB2 CCNH CCP110 CDC25A CDC25B CDC25C CDK1 CDK11A CDK11B CDK2 CDK5RAP2 CDK7 CDKN1A CENPF CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E CUL1 DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 E2F1 E2F3 EP300 FBXL18 FBXL7 FBXW11 FKBPL FOXM1 FZR1 GTSE1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HJURP HMMR HSP90AA1 HSP90AB1 LCMT1 LIN37 LIN52 LIN54 LIN9 MAPRE1 MIS18BP1 MNAT1 MYBL2 MZT1 MZT2A MZT2B NDE1 NEDD1 NEK2 NINL NME7 OBI1 ODF2 OFD1 OPTN PAFAH1B1 PCM1 PCNT PHLDA1 PKMYT1 PLK1 PLK4 PPME1 PPP1CB PPP1R12A PPP1R12B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PRKACA PRKAR2B PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RAB8A RBBP4 RBX1 RPS27A SDCCAG8 SEM1 SFI1 SGO1 SKP1 SSNA1 TICRR TP53 TPX2 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 UBA52 UBB UBC WEE1 XPO1 YWHAE YWHAG (see all 193) (see less)
3	G2/M Transition	Reactome	ACTR1A ADRM1 AJUBA AKAP9 ALMS1 AURKA BORA BTRC CCNA1 CCNA2 CCNB1 CCNB2 CCNH CCP110 CDC25A CDC25B CDC25C CDK1 CDK11A CDK11B CDK2 CDK5RAP2 CDK7 CDKN1A CENPF CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E CUL1 DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 EP300 FBXL18 FBXL7 FBXW11 FKBPL FOXM1 FZR1 GTSE1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HJURP HMMR HSP90AA1 HSP90AB1 LCMT1 LIN37 LIN52 LIN54 LIN9 MAPRE1 MIS18BP1 MNAT1 MYBL2 MZT1 MZT2A MZT2B NDE1 NEDD1 NEK2 NINL NME7 OBI1 ODF2 OFD1 OPTN PAFAH1B1 PCM1 PCNT PHLDA1 PKMYT1 PLK1 PLK4 PPME1 PPP1CB PPP1R12A PPP1R12B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PRKACA PRKAR2B PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RAB8A RBBP4 RBX1 RPS27A SDCCAG8 SEM1 SFI1 SGO1 SKP1 SSNA1 TICRR TP53 TPX2 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 UBA52 UBB UBC WEE1 XPO1 YWHAE YWHAG (see all 191) (see less)
4	Anchoring of the basal body to the plasma membrane	Reactome	ACTR1A AHI1 AKAP9 ALMS1 B9D1 B9D2 C2CD3 CC2D2A CCP110 CDK1 CDK5RAP2 CEP131 CEP135 CEP152 CEP162 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CEP83 CEP89 CEP97 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FBF1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HSP90AA1 IQCB1 KIF24 MAPRE1 MARK4 MKS1 NDE1 NEDD1 NEK2 NINL NPHP1 NPHP4 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B RAB11A RAB3IP RAB8A RPGRIP1L SCLT1 SDCCAG8 SEPTIN2 SFI1 SSNA1 TCTN1 TCTN2 TCTN3 TMEM216 TMEM67 TTBK2 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 YWHAE YWHAG (see all 97) (see less)
5	Recruitment of NuMA to mitotic centrosomes	Reactome	ACTR1A AKAP9 ALMS1 CCP110 CDK1 CDK5RAP2 CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HSP90AA1 MAPRE1 MZT1 MZT2A MZT2B NDE1 NEDD1 NEK2 NINL NME7 NUMA1 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 YWHAE YWHAG (see all 95) (see less)
6	Regulation of PLK1 Activity at G2/M Transition	Reactome	ACTR1A AJUBA AKAP9 ALMS1 AURKA BORA BTRC CCNB1 CCNB2 CCP110 CDK1 CDK5RAP2 CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E CUL1 DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 FBXW11 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL ODF2 OFD1 OPTN PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP1CB PPP1R12A PPP1R12B PPP2R1A PRKACA PRKAR2B RAB8A RPS27A SDCCAG8 SFI1 SKP1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 UBA52 UBB UBC YWHAE YWHAG (see all 87) (see less)
7	Centrosome maturation	Reactome	ACTR1A AKAP9 ALMS1 CCP110 CDK1 CDK11A CDK11B CDK5RAP2 CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HSP90AA1 MAPRE1 MZT1 MZT2A MZT2B NDE1 NEDD1 NEK2 NINL NME7 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 YWHAE YWHAG (see all 81) (see less)
8	Recruitment of mitotic centrosome proteins and complexes	Reactome	ACTR1A AKAP9 ALMS1 CCP110 CDK1 CDK11A CDK11B CDK5RAP2 CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HSP90AA1 MAPRE1 MZT1 MZT2A MZT2B NDE1 NEDD1 NEK2 NINL NME7 ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 YWHAE YWHAG (see all 81) (see less)
9	AURKA Activation by TPX2	Reactome	ACTR1A AKAP9 ALMS1 AURKA CCP110 CDK1 CDK5RAP2 CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HMMR HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TPX2 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 YWHAE YWHAG (see all 72) (see less)
10	Loss of proteins required for interphase microtubule organization from the centrosome	Reactome	ACTR1A AKAP9 ALMS1 CCP110 CDK1 CDK5RAP2 CEP131 CEP135 CEP152 CEP164 CEP192 CEP250 CEP290 CEP41 CEP43 CEP57 CEP63 CEP70 CEP72 CEP76 CEP78 CETN2 CKAP5 CLASP1 CNTRL CPAP CSNK1D CSNK1E DCTN1 DCTN2 DCTN3 DYNC1H1 DYNC1I2 DYNLL1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HSP90AA1 MAPRE1 NDE1 NEDD1 NEK2 NINL ODF2 OFD1 PAFAH1B1 PCM1 PCNT PLK1 PLK4 PPP2R1A PRKACA PRKAR2B SDCCAG8 SFI1 SSNA1 TUBA1A TUBA4A TUBB TUBB4A TUBB4B TUBG1 YWHAE YWHAG (see all 69) (see less)
11	Polo-like kinase mediated events	Reactome	CCNB1 CCNB2 CDC25A CDC25C CENPF EP300 FOXM1 LIN37 LIN52 LIN54 LIN9 MYBL2 PKMYT1 PLK1 RBBP4 WEE1 (see all 16) (see less)
12	Interaction between PHLDA1 and AURKA	Reactome	AURKA PHLDA1

Gene overlap in member pathways for Loss of Nlp from mitotic centrosomes SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLK1	Polo Like Kinase 1	Protein Coding	11
2	ACTR1A	Actin Related Protein 1A	Protein Coding	10
3	AKAP9	A-Kinase Anchoring Protein 9	Protein Coding	10
4	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	10
5	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	10
6	DCTN2	Dynactin Subunit 2	Protein Coding	10
7	CETN2	Centrin 2	Protein Coding	10
8	PLK4	Polo Like Kinase 4	Protein Coding	10
9	SDCCAG8	SHH Signaling And Ciliogenesis Regulator SDCCAG8	Protein Coding	10
10	CNTRL	Centriolin	Protein Coding	10
11	CEP43	Centrosomal Protein 43	Protein Coding	10
12	CEP250	Centrosomal Protein 250	Protein Coding	10
13	DCTN3	Dynactin Subunit 3	Protein Coding	10
14	HAUS1	HAUS Augmin Like Complex Subunit 1	Protein Coding	10
15	NEDD1	NEDD1 Gamma-Tubulin Ring Complex Targeting Factor	Protein Coding	10
16	CSNK1D	Casein Kinase 1 Delta	Protein Coding	10
17	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	10
18	DCTN1	Dynactin Subunit 1	Protein Coding	10
19	DYNC1H1	Dynein Cytoplasmic 1 Heavy Chain 1	Protein Coding	10
20	DYNC1I2	Dynein Cytoplasmic 1 Intermediate Chain 2	Protein Coding	10
21	TUBB	Tubulin Beta Class I	Protein Coding	10
22	CEP164	Centrosomal Protein 164	Protein Coding	10
23	MAPRE1	Microtubule Associated Protein RP/EB Family Member 1	Protein Coding	10
24	NINL	Ninein Like	Protein Coding	10
25	CEP131	Centrosomal Protein 131	Protein Coding	10
26	CEP152	Centrosomal Protein 152	Protein Coding	10
27	CLASP1	Cytoplasmic Linker Associated Protein 1	Protein Coding	10
28	HAUS5	HAUS Augmin Like Complex Subunit 5	Protein Coding	10
29	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	10
30	NEK2	NIMA Related Kinase 2	Protein Coding	10
31	ODF2	Outer Dense Fiber Of Sperm Tails 2	Protein Coding	10
32	PAFAH1B1	Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1	Protein Coding	10
33	PCM1	Pericentriolar Material 1	Protein Coding	10
34	PCNT	Pericentrin	Protein Coding	10
35	HAUS6	HAUS Augmin Like Complex Subunit 6	Protein Coding	10
36	NDE1	NudE Neurodevelopment Protein 1	Protein Coding	10
37	HAUS4	HAUS Augmin Like Complex Subunit 4	Protein Coding	10
38	CEP192	Centrosomal Protein 192	Protein Coding	10
39	HAUS2	HAUS Augmin Like Complex Subunit 2	Protein Coding	10
40	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	10
41	HAUS7	HAUS Augmin Like Complex Subunit 7	Protein Coding	10
42	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	10
43	CEP72	Centrosomal Protein 72	Protein Coding	10
44	CDK5RAP2	CDK5 Regulatory Subunit Associated Protein 2	Protein Coding	10
45	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	10
46	CPAP	Centrosome Assembly And Centriole Elongation Protein	Protein Coding	10
47	TUBA4A	Tubulin Alpha 4a	Protein Coding	10
48	TUBG1	Tubulin Gamma 1	Protein Coding	10
49	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	10
50	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	10
51	ALMS1	ALMS1 Centrosome And Basal Body Associated Protein	Protein Coding	10
52	TUBA1A	Tubulin Alpha 1a	Protein Coding	10
53	HAUS3	HAUS Augmin Like Complex Subunit 3	Protein Coding	10
54	CEP76	Centrosomal Protein 76	Protein Coding	10
55	CEP290	Centrosomal Protein 290	Protein Coding	10
56	CEP63	Centrosomal Protein 63	Protein Coding	10
57	CEP70	Centrosomal Protein 70	Protein Coding	10
58	CEP78	Centrosomal Protein 78	Protein Coding	10
59	OFD1	OFD1 Centriole And Centriolar Satellite Protein	Protein Coding	10
60	SSNA1	SS Nuclear Autoantigen 1	Protein Coding	10
61	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	10
62	HAUS8	HAUS Augmin Like Complex Subunit 8	Protein Coding	10
63	CEP41	Centrosomal Protein 41	Protein Coding	10
64	CEP135	Centrosomal Protein 135	Protein Coding	10
65	CEP57	Centrosomal Protein 57	Protein Coding	10
66	CCP110	Centriolar Coiled-Coil Protein 110	Protein Coding	10
67	CKAP5	Cytoskeleton Associated Protein 5	Protein Coding	10
68	SFI1	SFI1 Centrin Binding Protein	Protein Coding	10
69	CDK1	Cyclin Dependent Kinase 1	Protein Coding	10
70	TUBGCP3	Tubulin Gamma Complex Component 3	Protein Coding	5
71	TUBGCP2	Tubulin Gamma Complex Component 2	Protein Coding	5
72	TUBGCP5	Tubulin Gamma Complex Component 5	Protein Coding	5
73	TUBG2	Tubulin Gamma 2	Protein Coding	5
74	TUBGCP4	Tubulin Gamma Complex Component 4	Protein Coding	5
75	NME7	NME/NM23 Family Member 7	Protein Coding	5
76	MZT1	Mitotic Spindle Organizing Protein 1	Protein Coding	5
77	MZT2A	Mitotic Spindle Organizing Protein 2A	Protein Coding	5
78	AURKA	Aurora Kinase A	Protein Coding	5
79	MZT2B	Mitotic Spindle Organizing Protein 2B	Protein Coding	5
80	TUBGCP6	Tubulin Gamma Complex Component 6	Protein Coding	5
81	RAB8A	RAB8A, Member RAS Oncogene Family	Protein Coding	4
82	CDK11A	Cyclin Dependent Kinase 11A	Protein Coding	4
83	CCNB1	Cyclin B1	Protein Coding	4
84	CCNB2	Cyclin B2	Protein Coding	4
85	CDK11B	Cyclin Dependent Kinase 11B	Protein Coding	4
86	OPTN	Optineurin	Protein Coding	3
87	TUBA1B	Tubulin Alpha 1b	Protein Coding	3
88	TUBB3	Tubulin Beta 3 Class III	Protein Coding	3
89	CENPF	Centromere Protein F	Protein Coding	3
90	TUBA3E	Tubulin Alpha 3e	Protein Coding	3
91	TUBA3D	Tubulin Alpha 3d	Protein Coding	3
92	LIN54	Lin-54 DREAM MuvB Core Complex Component	Protein Coding	3
93	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
94	PHLDA1	Pleckstrin Homology Like Domain Family A Member 1	Protein Coding	3
95	TPX2	TPX2 Microtubule Nucleation Factor	Protein Coding	3
96	FOXM1	Forkhead Box M1	Protein Coding	3
97	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	3
98	TUBB8B	Tubulin Beta 8B	Protein Coding	3
99	LIN9	Lin-9 DREAM MuvB Core Complex Component	Protein Coding	3
100	HMMR	Hyaluronan Mediated Motility Receptor	Protein Coding	3
101	TUBB8	Tubulin Beta 8 Class VIII	Protein Coding	3
102	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	3
103	MYBL2	MYB Proto-Oncogene Like 2	Protein Coding	3
104	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	3
105	PPP1R12B	Protein Phosphatase 1 Regulatory Subunit 12B	Protein Coding	3
106	TUBA8	Tubulin Alpha 8	Protein Coding	3
107	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	3
108	LIN37	Lin-37 DREAM MuvB Core Complex Component	Protein Coding	3
109	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	3
110	RPS27A	Ribosomal Protein S27a	Protein Coding	3
111	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	3
112	TUBA3C	Tubulin Alpha 3c	Protein Coding	3
113	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	3
114	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
115	UBB	Ubiquitin B	Protein Coding	3
116	UBC	Ubiquitin C	Protein Coding	3
117	WEE1	WEE1 G2 Checkpoint Kinase	Protein Coding	3
118	TUBAL3	Tubulin Alpha Like 3	Protein Coding	3
119	BORA	BORA Aurora Kinase A Activator	Protein Coding	3
120	TUBA4B	Tubulin Alpha 4b	Protein Coding	3
121	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	3
122	CUL1	Cullin 1	Protein Coding	3
123	TUBB6	Tubulin Beta 6 Class V	Protein Coding	3
124	TUBA1C	Tubulin Alpha 1c	Protein Coding	3
125	AJUBA	Ajuba LIM Protein	Protein Coding	3
126	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	3
127	PKMYT1	Protein Kinase, Membrane Associated Tyrosine/Threonine 1	Protein Coding	3
128	LIN52	Lin-52 DREAM MuvB Core Complex Component	Protein Coding	3
129	CDC25A	Cell Division Cycle 25A	Protein Coding	3
130	CDC25C	Cell Division Cycle 25C	Protein Coding	3
131	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
132	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	2
133	CDK7	Cyclin Dependent Kinase 7	Protein Coding	2
134	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
135	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	2
136	SGO1	Shugoshin 1	Protein Coding	2
137	FBXL7	F-Box And Leucine Rich Repeat Protein 7	Protein Coding	2
138	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	2
139	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	2
140	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	2
141	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	2
142	PPME1	Protein Phosphatase Methylesterase 1	Protein Coding	2
143	LCMT1	Leucine Carboxyl Methyltransferase 1	Protein Coding	2
144	GTSE1	G2 And S-Phase Expressed 1	Protein Coding	2
145	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
146	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
147	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
148	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	2
149	MIS18BP1	MIS18 Binding Protein 1	Protein Coding	2
150	HJURP	Holliday Junction Recognition Protein	Protein Coding	2
151	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
152	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
153	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
154	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
155	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
156	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
157	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
158	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
159	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
160	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
161	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
162	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
163	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
164	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
165	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	2
166	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	2
167	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	2
168	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	2
169	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	2
170	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	2
171	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	2
172	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	2
173	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	2
174	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	2
175	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	2
176	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	2
177	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	2
178	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	2
179	FKBPL	FKBP Prolyl Isomerase Like	Protein Coding	2
180	TP53	Tumor Protein P53	Protein Coding	2
181	XPO1	Exportin 1	Protein Coding	2
182	OBI1	ORC Ubiquitin Ligase 1	Protein Coding	2
183	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	2
184	FBXL18	F-Box And Leucine Rich Repeat Protein 18	Protein Coding	2
185	CCNA2	Cyclin A2	Protein Coding	2
186	CCNA1	Cyclin A1	Protein Coding	2
187	CCNH	Cyclin H	Protein Coding	2
188	TICRR	TOPBP1 Interacting Checkpoint And Replication Regulator	Protein Coding	2
189	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	2
190	CDC25B	Cell Division Cycle 25B	Protein Coding	2
191	RBX1	Ring-Box 1	Protein Coding	2
192	E2F1	E2F Transcription Factor 1	Protein Coding	1
193	E2F3	E2F Transcription Factor 3	Protein Coding	1
194	RAB3IP	RAB3A Interacting Protein	Protein Coding	1
195	SCLT1	Sodium Channel And Clathrin Linker 1	Protein Coding	1
196	TTBK2	Tau Tubulin Kinase 2	Protein Coding	1
197	CEP162	Centrosomal Protein 162	Protein Coding	1
198	RPGRIP1L	RPGRIP1 Like	Protein Coding	1
199	C2CD3	C2 Domain Containing 3 Centriole Elongation Regulator	Protein Coding	1
200	TCTN3	Tectonic Family Member 3	Protein Coding	1
201	NPHP4	Nephrocystin 4	Protein Coding	1
202	B9D1	B9 Domain Containing 1	Protein Coding	1
203	KIF24	Kinesin Family Member 24	Protein Coding	1
204	SEPTIN2	Septin 2	Protein Coding	1
205	NPHP1	Nephrocystin 1	Protein Coding	1
206	CEP83	Centrosomal Protein 83	Protein Coding	1
207	TMEM216	Transmembrane Protein 216	Protein Coding	1
208	AHI1	Abelson Helper Integration Site 1	Protein Coding	1
209	MKS1	MKS Transition Zone Complex Subunit 1	Protein Coding	1
210	CC2D2A	Coiled-Coil And C2 Domain Containing 2A	Protein Coding	1
211	MARK4	Microtubule Affinity Regulating Kinase 4	Protein Coding	1
212	CEP97	Centrosomal Protein 97	Protein Coding	1
213	TCTN1	Tectonic Family Member 1	Protein Coding	1
214	TCTN2	Tectonic Family Member 2	Protein Coding	1
215	B9D2	B9 Domain Containing 2	Protein Coding	1
216	CEP89	Centrosomal Protein 89	Protein Coding	1
217	FBF1	Fas Binding Factor 1	Protein Coding	1
218	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	1
219	TMEM67	Transmembrane Protein 67	Protein Coding	1
220	IQCB1	IQ Motif Containing B1	Protein Coding	1
221	NUMA1	Nuclear Mitotic Apparatus Protein 1	Protein Coding	1

Disorders associated with Loss of Nlp from mitotic centrosomes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lissencephaly	Enrichment	CPAP, DYNC1H1, MZT2B, PAFAH1B1, TUBA1A, TUBA3E, TUBB, TUBB2B, TUBB3, TUBG1	16.00
2	Meckel syndrome, type 1	Enrichment	B9D1, B9D2, CC2D2A, CEP290, MKS1, RPGRIP1L, TCTN1, TCTN2, TCTN3, TMEM216, TMEM67	16.00
3	Isolated joubert syndrome	Enrichment	AHI1, B9D1, B9D2, CEP41, MKS1, OFD1, TCTN1, TCTN2, TCTN3, TMEM67	10.91
4	Bardet-biedl syndrome	Enrichment	ALMS1, CEP290, IQCB1, MKS1, NPHP1, NPHP4, RPGRIP1L, SCLT1, SDCCAG8, TMEM67	10.75
5	Joubert syndrome 1	Enrichment	AHI1, B9D1, B9D2, C2CD3, CC2D2A, CEP290, MKS1, NPHP1, NPHP4, OFD1, RPGRIP1L, TCTN1, TCTN2, TCTN3, TMEM216, TMEM67	10.63
6	Senior-loken syndrome 1	Enrichment	CEP164, CEP290, IQCB1, NPHP1, NPHP4, SDCCAG8	9.68
7	Coach syndrome 1	Enrichment	CC2D2A, OFD1, RPGRIP1L, TMEM67	7.91
8	Hereditary retinal dystrophy	Enrichment	AHI1, ALMS1, CC2D2A, CEP164, CEP250, CEP290, CEP78, IQCB1, NEK2, NPHP1, NPHP4, OFD1, SDCCAG8	6.86
9	Fundus dystrophy	Enrichment	AHI1, ALMS1, CC2D2A, CEP164, CEP250, CEP290, CEP78, IQCB1, NEK2, NPHP1, NPHP4, OFD1, SDCCAG8	6.86
10	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	6.48
11	Meckel syndrome, type 6	Enrichment	CC2D2A, CEP290, TCTN2	6.45
12	Primary autosomal recessive microcephaly	Enrichment	CDK5RAP2, CEP135, CEP152, CEP63, CPAP	6.27
13	Seckel syndrome	Enrichment	CEP152, CPAP, PCNT, PLK4	6.23
14	Ciliopathy	Enrichment	CC2D2A, CEP83, RPGRIP1L, TCTN3	6.11
15	Autosomal recessive chorioretinopathy-microcephaly syndrome	Enrichment	PLK4, TUBGCP4, TUBGCP6	6.09
16	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	5.88
17	Retinitis pigmentosa	Enrichment	AHI1, ALMS1, CC2D2A, CEP290, IQCB1, MKS1, NEK2, NPHP4, OFD1, TMEM216	5.57
18	Nephronophthisis	Enrichment	AHI1, CEP290, IQCB1, NPHP1, NPHP4	5.47
19	Joubert syndrome with ocular defect	Enrichment	AHI1, CEP41, MKS1	5.45
20	Leber plus disease	Enrichment	AHI1, ALMS1, CC2D2A, CEP290, IQCB1, RPGRIP1L, TUBB4B	5.29
21	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	5.18
22	Arima syndrome	Enrichment	CC2D2A, CEP290, TMEM216	4.92
23	Lissencephaly 3	Enrichment	CPAP, TUBA1A	4.59
24	Keratoconus 9	Enrichment	MZT2A, TUBA3D	4.31
25	Joubert syndrome 10	Enrichment	CC2D2A, OFD1	4.30
26	Orofaciodigital syndrome vi	Enrichment	OFD1, TCTN3, TMEM216	4.25
27	Seckel syndrome 5	Enrichment	CEP152, CPAP	4.12
28	Miller-dieker lissencephaly syndrome	Enrichment	PAFAH1B1, YWHAE	4.12
29	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	PAFAH1B1, YWHAE	4.12
30	Congenital nervous system abnormality	Enrichment	CEP290, DYNC1H1, TMEM216, TMEM67, TUBA1A, TUBB4A	3.96
31	Nervous system disease	Enrichment	CEP290, DYNC1H1, TMEM216, TMEM67, TUBA1A, TUBB4A	3.96
32	Isolated congenital microcephaly	Enrichment	CPAP, MZT2B, TUBA3E	3.76
33	Microcephaly	Enrichment	CC2D2A, CDK5RAP2, CPAP, DYNC1H1, TUBB4A, YWHAG	3.61
34	Chromosome 15q11.2 deletion syndrome	Enrichment	PAFAH1B1, TUBG1	3.60
35	Joubert syndrome 4	Enrichment	NPHP1, RPGRIP1L	3.52
36	Bardet-biedl syndrome 14	Enrichment	CEP290, TMEM67	3.52
37	Oligohydramnios	Enrichment	CC2D2A, TMEM67	3.52
38	Polymicrogyria	Enrichment	DYNC1H1, OFD1, PSMC3	3.51
39	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.00
40	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	2.77
41	Polydactyly	Enrichment	CC2D2A, MKS1	2.75
42	Cystic kidney disease	Enrichment	CC2D2A, TMEM67	2.75
43	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	2.68
44	Stromme syndrome	Enrichment	CENPF	2.63
45	Menke-hennekam syndrome 2	Enrichment	EP300	2.63
46	Corpus callosum, agenesis of	Enrichment	CDK5RAP2, TUBA1A	2.59
47	Isolated corpus callosum agenesis	Enrichment	CDK5RAP2, TUBA1A	2.59
48	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDK5RAP2, TUBA1A	2.59
49	Hydrocephalus, congenital, 1	Enrichment	OFD1, TUBB	2.53
50	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	DYNC1H1, KIF24	2.50
51	Cystinuria	Enrichment	CENPF	2.33
52	Ciliary dyskinesia, primary, 29	Enrichment	CENPF	2.33
53	Cone-rod dystrophy 2	Enrichment	ALMS1, CEP290, CEP78	2.30
54	Kidney disease	Enrichment	CEP290, NPHP4	2.30
55	Skin creases, congenital symmetric circumferential, 1	Enrichment	TUBB	2.29
56	Perry syndrome	Enrichment	DCTN1	2.29
57	Retinitis pigmentosa 23	Enrichment	OFD1	2.29
58	Simpson-golabi-behmel syndrome, type 2	Enrichment	OFD1	2.29
59	Microcephaly 3, primary, autosomal recessive	Enrichment	CDK5RAP2	2.29
60	Microcephaly 9, primary, autosomal recessive	Enrichment	CEP152	2.29
61	Microcephaly and chorioretinopathy, autosomal recessive, 2	Enrichment	PLK4	2.29
62	Microcephaly 8, primary, autosomal recessive	Enrichment	CEP135	2.29
63	Cortical dysplasia, complex, with other brain malformations 6	Enrichment	TUBB	2.29
64	Advanced sleep phase syndrome, familial, 2	Enrichment	CSNK1D	2.29
65	Cone-rod dystrophy and hearing loss 1	Enrichment	CEP78	2.29
66	Microcephalic osteodysplastic primordial dwarfism, type ii	Enrichment	PCNT	2.29
67	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.29
68	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.29
69	Long qt syndrome 11	Enrichment	AKAP9	2.29
70	Microhydranencephaly	Enrichment	NDE1	2.29
71	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	2.29
72	Joubert syndrome 15	Enrichment	CEP41	2.29
73	Nephronophthisis 15	Enrichment	CEP164	2.29
74	Lissencephaly 4 with microcephaly	Enrichment	NDE1	2.29
75	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.29
76	Retinitis pigmentosa 67	Enrichment	NEK2	2.29
77	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.29
78	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.29
79	Seckel syndrome 6	Enrichment	CEP63	2.29
80	Microcephaly and chorioretinopathy 2	Enrichment	PLK4	2.29
81	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.29
82	Dync1h1-related disorders	Enrichment	DYNC1H1	2.29
83	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.29
84	Neurodevelopmental disorder with microcephaly and structural brain anomalies	Enrichment	DYNC1I2	2.29
85	Hydranencephaly	Enrichment	NDE1	2.29
86	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.29
87	Nde1-related microhydranencephaly	Enrichment	NDE1	2.29
88	Congenital myopathy 26	Enrichment	TUBA4A	2.29
89	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.29
90	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.29
91	Lissencephaly due to lis1 mutation	Enrichment	PAFAH1B1	2.29
92	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.29
93	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.29
94	Dandy-walker syndrome	Enrichment	PPP1CB, TUBA1A	2.28
95	Isolated split hand-split foot malformation	Enrichment	BTRC, SEM1	2.28
96	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.23
97	Spastic ataxia	Enrichment	CEP290, MKS1, TMEM67	2.19
98	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.19
99	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.19
100	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.15
101	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.15
102	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.15
103	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.15
104	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.15
105	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.15
106	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.15
107	Rubinstein-taybi syndrome 1	Enrichment	EP300	2.15
108	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	2.15
109	Joubert syndrome 7	Enrichment	RPGRIP1L	2.15
110	Joubert syndrome 2	Enrichment	TMEM216	2.15
111	Joubert syndrome 3	Enrichment	AHI1	2.15
112	Senior-loken syndrome 5	Enrichment	IQCB1	2.15
113	Orofaciodigital syndrome xiv	Enrichment	C2CD3	2.15
114	Meckel syndrome, type 3	Enrichment	TMEM67	2.15
115	Joubert syndrome 6	Enrichment	TMEM67	2.15
116	Retinitis pigmentosa 98	Enrichment	TMEM216	2.15
117	Rhyns syndrome	Enrichment	TMEM67	2.15
118	Retinitis pigmentosa 93	Enrichment	CC2D2A	2.15
119	Meckel syndrome, type 9	Enrichment	B9D1	2.15
120	Joubert syndrome 9	Enrichment	CC2D2A	2.15
121	Spinocerebellar ataxia 11	Enrichment	TTBK2	2.15
122	Coach syndrome 2	Enrichment	CC2D2A	2.15
123	Coach syndrome 3	Enrichment	RPGRIP1L	2.15
124	Meckel syndrome, type 2	Enrichment	TMEM216	2.15
125	Senior-loken syndrome 4	Enrichment	NPHP4	2.15
126	Meckel syndrome, type 5	Enrichment	RPGRIP1L	2.15
127	Nephronophthisis 11	Enrichment	TMEM67	2.15
128	Peritonitis	Enrichment	TMEM67	2.15
129	Meckel syndrome, type 10	Enrichment	B9D2	2.15
130	Joubert syndrome 27	Enrichment	B9D1	2.15
131	Meckel syndrome, type 8	Enrichment	TCTN2	2.15
132	Joubert syndrome 13	Enrichment	TCTN1	2.15
133	Joubert syndrome 24	Enrichment	TCTN2	2.15
134	Nephronophthisis 18	Enrichment	CEP83	2.15
135	Pancreatitis	Enrichment	TMEM67	2.15
136	Polycystic kidney disease	Enrichment	CC2D2A, CEP290	2.14
137	Auditory neuropathy	Enrichment	CEP135, TUBB4A	2.12
138	Myeloma, multiple	Enrichment	AURKA	2.08
139	Aortic aneurysm, familial thoracic 4	Enrichment	NDE1	1.99
140	Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant	Enrichment	DYNC1H1	1.99
141	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	1.99
142	Microcephalic osteodysplastic primordial dwarfism, type i	Enrichment	CLASP1	1.99
143	Lowry-wood syndrome	Enrichment	CLASP1	1.99
144	Spondyloepiphyseal dysplasia tarda, x-linked	Enrichment	OFD1	1.99
145	Orofaciodigital syndrome i	Enrichment	OFD1	1.99
146	Microcephaly 6, primary, autosomal recessive	Enrichment	CPAP	1.99
147	Seckel syndrome 4	Enrichment	CPAP	1.99
148	Lissencephaly 1	Enrichment	PAFAH1B1	1.99
149	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	1.99
150	Mosaic variegated aneuploidy syndrome 2	Enrichment	CEP57	1.99
151	Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies	Enrichment	DYNC1I2	1.99
152	Roifman syndrome	Enrichment	CLASP1	1.99
153	Cortical dysplasia, complex, with other brain malformations 13	Enrichment	DYNC1H1	1.99
154	Cone-rod dystrophy and hearing loss 2	Enrichment	CEP250	1.99
155	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	NDE1	1.99
156	Cortical dysplasia, complex, with other brain malformations 4	Enrichment	TUBG1	1.99
157	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	1.99
158	Spinal muscular atrophy with lower extremity predominant	Enrichment	DYNC1H1	1.99
159	Senior-loken syndrome 7	Enrichment	SDCCAG8	1.99
160	Spondyloepiphyseal dysplasia tarda	Enrichment	OFD1	1.99
161	Fibrolamellar carcinoma	Enrichment	PRKACA	1.99
162	Charcot-marie-tooth disease, axonal, type 2o	Enrichment	DYNC1H1	1.99
163	Visceral myopathy 2	Enrichment	NDE1	1.99
164	Bardet-biedl syndrome 16	Enrichment	SDCCAG8	1.99
165	Rnu4atac-opathy	Enrichment	CLASP1	1.99
166	Torsion dystonia 4	Enrichment	TUBB4A	1.99
167	Multiple benign circumferential skin creases on limbs	Enrichment	TUBB	1.99
168	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	1.99
169	Continuous spikes and waves during sleep	Enrichment	TUBA1A	1.99
170	Charge syndrome	Enrichment	EP300	1.98
171	Microcephaly and chorioretinopathy, autosomal recessive, 1	Enrichment	TUBGCP6	1.92
172	Cortical dysplasia, complex, with other brain malformations 15	Enrichment	TUBGCP2	1.92
173	Microcephaly and chorioretinopathy 1	Enrichment	TUBGCP6	1.92
174	Microcephaly and chorioretinopathy, autosomal recessive, 3	Enrichment	TUBGCP4	1.92
175	Microcephaly and chorioretinopathy 3	Enrichment	TUBGCP4	1.92
176	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.89
177	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	1.89
178	Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia	Enrichment	OPTN	1.89
179	Amyotrophic lateral sclerosis type 12	Enrichment	OPTN	1.89
180	Submucosal cleft palate	Enrichment	UBB	1.89
181	Cleft hard palate	Enrichment	UBB	1.89
182	Colorectal cancer	Enrichment	AURKA	1.89
183	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	1.86
184	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	1.85
185	Bone marrow failure syndrome 5	Enrichment	TP53	1.85
186	Stankiewicz-isidor syndrome	Enrichment	PSMD12	1.85
187	Papilloma of choroid plexus	Enrichment	TP53	1.85
188	Basal cell carcinoma 7	Enrichment	TP53	1.85
189	Anaplastic thyroid carcinoma	Enrichment	TP53	1.85
190	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	1.85
191	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	1.85
192	Ductal carcinoma in situ	Enrichment	TP53	1.85
193	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.85
194	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.85
195	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.85
196	Choroid plexus cancer	Enrichment	TP53	1.85
197	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.85
198	Pallister-hall-like syndrome	Enrichment	SCLT1	1.85
199	Nephronophthisis 1	Enrichment	NPHP1	1.85
200	Nephronophthisis 4	Enrichment	NPHP4	1.85
201	Joubert syndrome 18	Enrichment	TCTN3	1.85
202	Leber congenital amaurosis 6	Enrichment	MKS1	1.85
203	Orofaciodigital syndrome iv	Enrichment	TCTN3	1.85
204	Bardet-biedl syndrome 13	Enrichment	MKS1	1.85
205	Joubert syndrome 28	Enrichment	MKS1	1.85
206	Cerebellar malformation	Enrichment	TMEM67	1.85
207	Senior-boichis syndrome	Enrichment	TMEM67	1.85
208	Spondyloepiphyseal dysplasia congenita	Enrichment	CLASP1	1.82
209	Alstrom syndrome	Enrichment	ALMS1	1.82
210	Simpson-golabi-behmel syndrome, type 1	Enrichment	OFD1	1.82
211	Band heterotopia	Enrichment	PAFAH1B1	1.82
212	Senior-loken syndrome 6	Enrichment	CEP290	1.82
213	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	1.82
214	Joubert syndrome 5	Enrichment	CEP290	1.82
215	Myopathy, myofibrillar, 7	Enrichment	CEP63	1.82
216	End stage renal disease	Enrichment	ALMS1	1.82
217	Cog7-congenital disorder of glycosylation	Enrichment	CEP290	1.82
218	Occipital encephalocele	Enrichment	CEP290	1.82
219	Advanced sleep phase syndrome	Enrichment	CSNK1D	1.82
220	Tricuspid valve insufficiency	Enrichment	NDE1	1.82
221	Cerebral palsy	Enrichment	TUBA1A, TUBB4A	1.78
222	Polydactyly, postaxial, type a1	Enrichment	EP300	1.76
223	Rare genetic intellectual disability	Enrichment	EP300	1.76
224	Charcot-marie-tooth disease	Enrichment	DCTN1, DYNC1H1	1.74
225	Uvula, bifid	Enrichment	UBB	1.72
226	Cleft soft palate	Enrichment	UBB	1.72
227	Glaucoma, normal tension	Enrichment	OPTN	1.72
228	Polycystic liver disease	Enrichment	CDC25A	1.70
229	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.70
230	Meckel syndrome, type 4	Enrichment	CEP290	1.69
231	Orofaciodigital syndrome iii	Enrichment	OFD1	1.69
232	Mitral valve insufficiency	Enrichment	NDE1	1.69
233	Orofaciodigital syndrome	Enrichment	OFD1	1.69
234	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.68
235	Oocyte/zygote/embryo maturation arrest 2	Enrichment	TUBB8	1.68
236	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.68
237	West syndrome	Enrichment	CSNK1E, TUBA1A	1.68
238	Cakut	Enrichment	NPHP1, NPHP4	1.61
239	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	CPAP	1.60
240	Microcephaly 1, primary, autosomal recessive	Enrichment	CPAP	1.60
241	Mosaic variegated aneuploidy syndrome 1	Enrichment	CEP57	1.60
242	Leber congenital amaurosis 10	Enrichment	CEP290	1.60
243	Lissencephaly 2	Enrichment	NDE1	1.60
244	Night blindness	Enrichment	CEP290	1.60
245	Spinal muscular atrophy	Enrichment	DYNC1H1	1.60
246	Genetic motor neuron disease	Enrichment	DCTN1	1.60
247	Endometrial stromal sarcoma	Enrichment	YWHAE	1.60
248	Eye disease	Enrichment	AHI1, ALMS1	1.59
249	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.55
250	Cervical cancer	Enrichment	TP53	1.55
251	Lymphoma, hodgkin, classic	Enrichment	TP53	1.55
252	Birk-aharoni syndrome	Enrichment	PSMC1	1.55
253	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.55
254	Congenital fibrosarcoma	Enrichment	TP53	1.55
255	Li-fraumeni syndrome 1	Enrichment	TP53	1.55
256	Sarcoma	Enrichment	TP53	1.55
257	Cervix carcinoma	Enrichment	TP53	1.55
258	Hodgkin's lymphoma	Enrichment	TP53	1.55
259	Chronic atrial and intestinal dysrhythmia	Enrichment	SGO1	1.55
260	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.55
261	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.55
262	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	1.55
263	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.55
264	Astigmatism	Enrichment	SCLT1	1.55
265	Anencephaly	Enrichment	CC2D2A	1.55
266	Renal dysplasia, cystic	Enrichment	CEP290	1.52
267	Intestinal pseudo-obstruction	Enrichment	NDE1	1.52
268	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.52
269	Kidney clear cell sarcoma	Enrichment	YWHAE	1.52
270	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	OPTN	1.50
271	Severe covid-19	Enrichment	CENPF	1.47
272	Female infertility due to oocyte meiotic arrest	Enrichment	TUBB8	1.46
273	Usher syndrome, type iiia	Enrichment	CEP78	1.45
274	Moyamoya angiopathy	Enrichment	CEP78	1.45
275	Farsightedness	Enrichment	SCLT1	1.45
276	Glaucoma, primary open angle	Enrichment	OPTN	1.42
277	Spastic paraplegia 4, autosomal dominant	Enrichment	OFD1	1.40
278	Immunodeficiency 47	Enrichment	CEP290	1.40
279	Cryptorchidism	Enrichment	TUBA1A	1.40
280	Mosaic variegated aneuploidy syndrome	Enrichment	CEP57	1.40
281	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.38
282	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.38
283	Osteogenic sarcoma	Enrichment	TP53	1.38
284	Nasopharyngeal carcinoma	Enrichment	TP53	1.38
285	Wieacker-wolff syndrome	Enrichment	CCNH	1.38
286	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.38
287	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.38
288	Anaplastic astrocytoma	Enrichment	TP53	1.38
289	Squamous cell carcinoma	Enrichment	TP53	1.38
290	Adenocarcinoma	Enrichment	TP53	1.38
291	Bone osteosarcoma	Enrichment	TP53	1.38
292	Thyroid hemiagenesis	Enrichment	PSMD3	1.38
293	Infertility	Enrichment	NPHP4	1.38
294	Motor neuron disease	Enrichment	OPTN	1.36
295	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.35
296	Ellis-van creveld syndrome	Enrichment	PRKACA	1.35
297	Autosomal dominant non-syndromic intellectual disability	Enrichment	DYNC1H1, RAB11A	1.30
298	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1	1.30
299	Stickler syndrome	Enrichment	ALMS1	1.30
300	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	DCTN1, OPTN	1.27
301	Frontotemporal dementia 1	Enrichment	DCTN1	1.26
302	Specific learning disability	Enrichment	YWHAG	1.26
303	Small cell cancer of the lung	Enrichment	TP53	1.26
304	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.26
305	Lung sarcomatoid carcinoma	Enrichment	TP53	1.26
306	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.26
307	Infantile nephronophthisis	Enrichment	CEP83	1.25
308	Bladder cancer	Enrichment	CDKN1A, TP53	1.20
309	Capillary malformations, congenital	Enrichment	CCNH	1.16
310	Rhabdomyosarcoma 2	Enrichment	TP53	1.16
311	Lymphoma	Enrichment	TP53	1.16
312	Acute megakaryocytic leukemia	Enrichment	TP53	1.16
313	Osteoporosis	Enrichment	OFD1	1.16
314	Cat eye syndrome	Enrichment	TMEM67	1.16
315	Myopia	Enrichment	NDE1	1.13
316	Congenital hypothyroidism	Enrichment	TUBB1	1.09
317	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.09
318	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	1.09
319	Li-fraumeni syndrome	Enrichment	TP53	1.09
320	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	1.09
321	Hemangioma, capillary infantile	Enrichment	CCNH	1.09
322	Basal cell carcinoma 1	Enrichment	CCNH	1.09
323	Patent ductus arteriosus	Enrichment	PSMC3	1.09
324	Adrenocortical carcinoma	Enrichment	TP53	1.09
325	Breast adenocarcinoma	Enrichment	TP53	1.09
326	Acute promyelocytic leukemia	Enrichment	NUMA1	1.06
327	Charcot-marie-tooth disease type 4	Enrichment	DYNC1H1	1.06
328	Microphthalmia/coloboma 12	Enrichment	TMEM67	1.05
329	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	CC2D2A	1.05
330	Clubfoot	Enrichment	CC2D2A	1.05
331	Chronic kidney disease	Enrichment	MKS1	1.05
332	Esophageal cancer	Enrichment	TP53	1.02
333	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.02
334	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.02
335	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	1.02
336	Essential thrombocythemia	Enrichment	TP53	1.02
337	Gallbladder cancer	Enrichment	TP53	1.02
338	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	1.02
339	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.02
340	Leukodystrophy	Enrichment	ALMS1	1.01
341	Focal segmental glomerulosclerosis	Enrichment	SDCCAG8	1.01
342	Coloboma of macula	Enrichment	TMEM67	0.99
343	Glioma susceptibility 1	Enrichment	TP53	0.97
344	Lymphoma, non-hodgkin, familial	Enrichment	TP53	0.97
345	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E	0.92
346	Arteriovenous malformation	Enrichment	CCNH	0.92
347	Adult hepatocellular carcinoma	Enrichment	TP53	0.92
348	Primary hyperaldosteronism	Enrichment	TP53	0.92
349	Brugada syndrome	Enrichment	AKAP9	0.91
350	Leukemia, chronic lymphocytic	Enrichment	TP53	0.88
351	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	0.88
352	Familial colorectal cancer	Enrichment	TP53	0.88
353	Differentiated thyroid carcinoma	Enrichment	PCM1	0.86
354	Noonan syndrome 1	Enrichment	PPP1CB	0.86
355	Long qt syndrome 1	Enrichment	AKAP9	0.85
356	Stargardt disease 1	Enrichment	ALMS1	0.85
357	Myelodysplastic syndrome	Enrichment	TP53	0.84
358	Long qt syndrome	Enrichment	AKAP9	0.83
359	Connective tissue disease	Enrichment	OFD1	0.82
360	Peripheral nervous system disease	Enrichment	DYNC1H1	0.82
361	Neuropathy	Enrichment	DYNC1H1	0.82
362	Rasopathy	Enrichment	PPP1CB	0.81
363	Usher syndrome	Enrichment	CEP250	0.81
364	Lip and oral cavity carcinoma	Enrichment	TP53	0.81
365	Visceral heterotaxy 5	Enrichment	NME7	0.77
366	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.76
367	Lung cancer susceptibility 3	Enrichment	TP53	0.74
368	Myopathy	Enrichment	DYNC1H1	0.73
369	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1, YWHAG	0.73
370	Hereditary spastic paraplegia	Enrichment	CEP63	0.71
371	Rhabdomyosarcoma	Enrichment	TP53	0.69
372	Gliosarcoma	Enrichment	TP53	0.69
373	Giant cell glioblastoma	Enrichment	TP53	0.67
374	Sensorineural hearing loss	Enrichment	CEP78	0.66
375	Patent foramen ovale	Enrichment	PSMC3	0.65
376	Diffuse large b-cell lymphoma	Enrichment	TP53	0.63
377	Complex neurodevelopmental disorder	Enrichment	FBXW11, PPP2CA, PSMD12	0.59
378	Hepatoblastoma	Enrichment	TP53	0.59
379	Optic atrophy plus syndrome	Enrichment	TUBB6	0.57
380	Hepatocellular carcinoma	Enrichment	TP53	0.57
381	Myocardial infarction	Enrichment	PSMA6	0.57
382	Diamond-blackfan anemia 1	Enrichment	TP53	0.56
383	Breast cancer	Enrichment	HMMR, TP53	0.55
384	Thrombocytopenia	Enrichment	TUBB1	0.54
385	Pancreatic cancer	Enrichment	TP53	0.52
386	Primary ciliary dyskinesia	Enrichment	OFD1	0.49
387	Prostate cancer	Enrichment	TP53	0.47
388	Lung cancer	Enrichment	PPP2R1B	0.44
389	Diamond-blackfan anemia	Enrichment	TP53	0.40
390	Ovarian cancer	Enrichment	HMMR	0.38
391	Autism spectrum disorder	Enrichment	DYNC1H1	0.37
392	Leukemia, acute myeloid	Enrichment	TP53	0.36
393	Gastric cancer	Enrichment	TP53	0.34
394	Hereditary breast carcinoma	Enrichment	TP53	0.33
395	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.27
396	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Loss of Nlp from mitotic centrosomes

Pathway Network for Loss of Nlp from mitotic centrosomes

Pathway network for the Loss of Nlp from mitotic centrosomes SuperPath

Member Pathways for Loss of Nlp from mitotic centrosomes

Pathways in the Loss of Nlp from mitotic centrosomes SuperPath

Gene overlap in member pathways for Loss of Nlp from mitotic centrosomes SuperPath

Associated Genes for Loss of Nlp from mitotic centrosomes

Associated Disorders for Loss of Nlp from mitotic centrosomes

Disorders associated with Loss of Nlp from mitotic centrosomes SuperPath

STRING Interaction Network for Loss of Nlp from mitotic centrosomes

Sources for Loss of Nlp from mitotic centrosomes