LPA receptor mediated events

No Pathway Network information available for LPA receptor mediated events

Pathways in the LPA receptor mediated events SuperPath

#	Name	Source	Genes
1	LPA receptor mediated events	PubChem	ADRA1B AKT1 ARHGEF1 BCAR1 CASP3 CRK CXCL8 EGFR FOS GAB1 GNA12 GNA13 GNB1 GNG2 GSK3B HBEGF HRAS JUN LPAR1 LPAR2 LPAR3 LPAR4 LYN MAPT MMP2 MMP9 NFKB1 NFKBIA NHERF2 PIK3CB PIK3R1 PLCB3 PLCG1 PLD2 PRKCD PRKCE PRKD1 PRRT2 PTK2 PTK2B PXN RAC1 RELA RHOA SRC TIAM1 TRIP6 (see all 47) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TRIP6	Thyroid Hormone Receptor Interactor 6	Protein Coding	1
2	ADRA1B	Adrenoceptor Alpha 1B	Protein Coding	1
3	NHERF2	NHERF Family PDZ Scaffold Protein 2	Protein Coding	1
4	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
5	PRKD1	Protein Kinase D1	Protein Coding	1
6	LPAR3	Lysophosphatidic Acid Receptor 3	Protein Coding	1
7	LPAR2	Lysophosphatidic Acid Receptor 2	Protein Coding	1
8	LPAR1	Lysophosphatidic Acid Receptor 1	Protein Coding	1
9	PLD2	Phospholipase D2	Protein Coding	1
10	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
11	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
12	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
13	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	1
14	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
15	LPAR4	Lysophosphatidic Acid Receptor 4	Protein Coding	1
16	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
17	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
18	PRKCD	Protein Kinase C Delta	Protein Coding	1
19	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
20	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
21	PLCB3	Phospholipase C Beta 3	Protein Coding	1
22	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
23	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
24	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
25	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
26	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
27	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
28	PXN	Paxillin	Protein Coding	1
29	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
30	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
31	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
32	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
33	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
34	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
35	RHOA	Ras Homolog Family Member A	Protein Coding	1
36	RAC1	Rac Family Small GTPase 1	Protein Coding	1
37	GNB1	G Protein Subunit Beta 1	Protein Coding	1
38	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
39	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
40	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
41	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
42	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
43	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
44	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
45	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
46	CASP3	Caspase 3	Protein Coding	1
47	MMP9	Matrix Metallopeptidase 9	Protein Coding	1

Disorders associated with LPA receptor mediated events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS	3.20
2	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS	3.12
3	Gliosarcoma	Enrichment	EGFR, NFKBIA	2.86
4	Giant cell glioblastoma	Enrichment	EGFR, NFKBIA	2.81
5	Colorectal cancer	Enrichment	AKT1, PIK3R1, SRC	2.47
6	Proteus syndrome	Enrichment	AKT1	2.46
7	Deafness, autosomal recessive 26	Enrichment	GAB1	2.46
8	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.46
9	Immunodeficiency 62	Enrichment	ARHGEF1	2.46
10	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.46
11	Short syndrome	Enrichment	PIK3R1	2.46
12	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.46
13	Parkinson-dementia syndrome	Enrichment	MAPT	2.46
14	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.46
15	Progressive supranuclear palsy	Enrichment	MAPT	2.46
16	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.46
17	Cowden syndrome 6	Enrichment	AKT1	2.46
18	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.46
19	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.46
20	Thrombocytopenia 6	Enrichment	SRC	2.46
21	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.46
22	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.46
23	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.46
24	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.46
25	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.46
26	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.46
27	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.46
28	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.46
29	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.46
30	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.46
31	Bladder cancer	Enrichment	EGFR, HRAS	2.35
32	Differentiated thyroid carcinoma	Enrichment	HRAS, LPAR4	2.35
33	Costello syndrome	Enrichment	HRAS	2.16
34	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.16
35	Pick disease of brain	Enrichment	MAPT	2.16
36	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.16
37	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.16
38	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.16
39	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.16
40	Rela fusion-positive ependymoma	Enrichment	RELA	2.16
41	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.16
42	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.16
43	Metaphyseal anadysplasia	Enrichment	MMP9	2.16
44	Common variable immunodeficiency 12	Enrichment	NFKB1	2.16
45	Prrt2-related disorder	Enrichment	PRRT2	2.16
46	Cerebral visual impairment	Enrichment	GNB1	2.16
47	Wooly hair nevus	Enrichment	HRAS	2.16
48	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.98
49	Glut1 deficiency syndrome 2	Enrichment	PRRT2	1.98
50	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.98
51	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.98
52	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.98
53	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.98
54	Large congenital melanocytic nevus	Enrichment	HRAS	1.98
55	Immunodeficiency 14	Enrichment	PIK3R1	1.98
56	Spermatocytoma	Enrichment	HRAS	1.98
57	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.98
58	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	1.86
59	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.86
60	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	1.86
61	Congenital generalized lipodystrophy	Enrichment	FOS	1.86
62	Epidermolytic nevus	Enrichment	HRAS	1.86
63	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	1.86
64	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	1.86
65	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	1.76
66	Histiocytoid hemangioma	Enrichment	FOS	1.76
67	Dementia	Enrichment	MAPT	1.76
68	Self-limited infantile epilepsy	Enrichment	PRRT2	1.76
69	Cowden syndrome 1	Enrichment	EGFR	1.69
70	Hemihyperplasia, isolated	Enrichment	RHOA	1.69
71	Breast adenocarcinoma	Enrichment	AKT1	1.69
72	Lung squamous cell carcinoma	Enrichment	EGFR	1.69
73	Nevus, epidermal	Enrichment	HRAS	1.62
74	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.62
75	Myelofibrosis	Enrichment	SRC	1.62
76	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.62
77	Noonan syndrome 3	Enrichment	HRAS	1.62
78	Semantic dementia	Enrichment	MAPT	1.62
79	Common variable immunodeficiency	Enrichment	NFKB1	1.62
80	Follicular thyroid carcinoma	Enrichment	HRAS	1.62
81	Overgrowth syndrome	Enrichment	PIK3R1	1.62
82	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.56
83	Hypothyroidism	Enrichment	GNB1	1.56
84	Breast cancer	Enrichment	AKT1, JUN	1.56
85	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.51
86	Arteriovenous malformation	Enrichment	HRAS	1.51
87	Progressive non-fluent aphasia	Enrichment	MAPT	1.51
88	Cowden syndrome	Enrichment	AKT1	1.51
89	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.51
90	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.47
91	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.47
92	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.47
93	Frontotemporal dementia 1	Enrichment	MAPT	1.43
94	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.43
95	Myelodysplastic syndrome	Enrichment	GNB1	1.43
96	Meningioma	Enrichment	AKT1	1.39
97	Alzheimer's disease	Enrichment	MAPT	1.36
98	Nk-cell enteropathy	Enrichment	PIK3CB	1.36
99	Osteoporosis	Enrichment	SRC	1.32
100	Lung cancer susceptibility 3	Enrichment	EGFR	1.32
101	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.32
102	Ovarian cancer	Enrichment	AKT1, EGFR	1.32
103	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.29
104	Rhabdomyosarcoma	Enrichment	HRAS	1.27
105	Alzheimer disease, familial, 1	Enrichment	MAPT	1.24
106	Cleft palate, isolated	Enrichment	GNB1	1.24
107	Arteriovenous malformations of the brain	Enrichment	EGFR	1.19
108	Noonan syndrome 1	Enrichment	HRAS	1.11
109	Parkinson disease, late-onset	Enrichment	MAPT	1.10
110	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.06
111	Rasopathy	Enrichment	HRAS	1.06
112	Strabismus	Enrichment	GNB1	1.05
113	Non-immune hydrops fetalis	Enrichment	HRAS	0.99
114	Lung cancer	Enrichment	EGFR	0.98
115	Dystonia	Enrichment	GNB1	0.94
116	Cerebral palsy	Enrichment	GNB1	0.90
117	Hereditary breast carcinoma	Enrichment	AKT1	0.85
118	Thrombocytopenia	Enrichment	SRC	0.81
119	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.80
120	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.76
121	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT	0.74
122	Autism spectrum disorder	Enrichment	GNB1	0.50
123	Microcephaly	Enrichment	GNB1	0.46
124	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.45
125	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.43

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

LPA receptor mediated events

Pathway Network for LPA receptor mediated events

Member Pathways for LPA receptor mediated events

Pathways in the LPA receptor mediated events SuperPath

Associated Genes for LPA receptor mediated events

Associated Disorders for LPA receptor mediated events

Disorders associated with LPA receptor mediated events SuperPath

STRING Interaction Network for LPA receptor mediated events

Sources for LPA receptor mediated events