LT-BetaR Pathway

No Pathway Network information available for LT-BetaR Pathway

Pathways in the LT-BetaR Pathway SuperPath

#	Name	Source	Genes
1	LT-BetaR Pathway	QIAGEN	AKT1 AKT2 AKT3 APAF1 BIRC2 CASP3 CASP7 CASP9 CCL19 CCL21 CHUK CREBBP CXCL12 CXCL13 CYCS DIABLO EP300 IKBKB IKBKE IKBKG LTA LTB LTBR MAP3K14 MAPK1 MAPK3 NFKB1 NFKB2 NFKBIA PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 RELA RELB TNFSF14 TRAF2 TRAF3 TRAF4 TRAF5 (see all 42) (see less)
2	Apoptosis and survival Lymphotoxin-beta receptor signaling	GeneGo (Thomson Reuters)	APAF1 BAX BIRC2 CASP3 CASP7 CASP9 CCL19 CCL21 CHUK CXCL12 CXCL13 CXCL8 CYCS DIABLO IKBKB IKBKG IL2 JUN LTA LTB LTBR MAP2K4 MAP2K7 MAP3K1 MAP3K14 MAP3K5 MAPK10 MAPK8 MAPK9 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE RELA RELB TNFSF14 TRAF2 TRAF3 TRAF5 VCAM1 (see all 41) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	2
2	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	2
3	CASP3	Caspase 3	Protein Coding	2
4	CASP7	Caspase 7	Protein Coding	2
5	CASP9	Caspase 9	Protein Coding	2
6	CCL19	C-C Motif Chemokine Ligand 19	Protein Coding	2
7	CCL21	C-C Motif Chemokine Ligand 21	Protein Coding	2
8	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
9	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	2
10	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	2
11	CYCS	Cytochrome C, Somatic	Protein Coding	2
12	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
13	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
14	LTA	Lymphotoxin Alpha	Protein Coding	2
15	LTB	Lymphotoxin Beta	Protein Coding	2
16	LTBR	Lymphotoxin Beta Receptor	Protein Coding	2
17	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	2
18	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
19	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
20	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
21	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
22	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	2
23	DIABLO	Diablo IAP-Binding Mitochondrial Protein	Protein Coding	2
24	TNFSF14	TNF Superfamily Member 14	Protein Coding	2
25	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	2
26	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	2
27	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	2
28	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
29	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
30	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
31	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
32	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
33	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
34	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
35	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
36	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
37	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
38	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
39	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
40	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
41	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
42	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	1
43	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
44	IL2	Interleukin 2	Protein Coding	1
45	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
46	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
47	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
48	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
49	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
50	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
51	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
52	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
53	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
54	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
55	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
56	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1

Disorders associated with LT-BetaR Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.05
2	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	4.25
3	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.25
4	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.86
5	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.86
6	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.73
7	Myeloma, multiple	Enrichment	CREBBP, PIK3R2, TRAF5	3.17
8	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.02
9	Colorectal cancer	Enrichment	AKT1, EP300, PIK3R1	2.61
10	Incontinentia pigmenti	Enrichment	IKBKG	2.52
11	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.52
12	Leprosy 4	Enrichment	LTA	2.52
13	Fetal encasement syndrome	Enrichment	CHUK	2.52
14	46,xy sex reversal 6	Enrichment	MAP3K1	2.52
15	Immunodeficiency 15b	Enrichment	IKBKB	2.52
16	Immunodeficiency 15a	Enrichment	IKBKB	2.52
17	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.52
18	Immunodeficiency 132a	Enrichment	TRAF3	2.52
19	Immunodeficiency 132b	Enrichment	TRAF3	2.52
20	Thrombocytopenia 4	Enrichment	CYCS	2.52
21	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.52
22	Immunodeficiency 53	Enrichment	RELB	2.52
23	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.52
24	Immunodeficiency 112	Enrichment	MAP3K14	2.52
25	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.52
26	Nik deficiency	Enrichment	MAP3K14	2.52
27	Proteus syndrome	Enrichment	AKT1	2.51
28	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.51
29	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.51
30	Noonan syndrome 13	Enrichment	MAPK1	2.51
31	Short syndrome	Enrichment	PIK3R1	2.51
32	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.51
33	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.51
34	Cowden syndrome 6	Enrichment	AKT1	2.51
35	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.51
36	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.51
37	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.51
38	Capillary hemangioma	Enrichment	AKT3	2.51
39	Menke-hennekam syndrome	Enrichment	CREBBP	2.51
40	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.51
41	Immunodeficiency 33	Enrichment	IKBKG	2.22
42	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.22
43	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.22
44	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.22
45	Deafness, autosomal dominant 64	Enrichment	DIABLO	2.22
46	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.22
47	Rela fusion-positive ependymoma	Enrichment	RELA	2.22
48	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.22
49	Common variable immunodeficiency 12	Enrichment	NFKB1	2.22
50	Thumb deformity	Enrichment	CREBBP	2.21
51	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.21
52	Menke-hennekam syndrome 2	Enrichment	EP300	2.21
53	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.21
54	Senior-loken syndrome 7	Enrichment	AKT3	2.21
55	Bardet-biedl syndrome 16	Enrichment	AKT3	2.21
56	Psoriatic arthritis	Enrichment	LTA	2.04
57	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.04
58	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.04
59	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.03
60	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.03
61	Tethered spinal cord syndrome	Enrichment	CREBBP	2.03
62	Immunodeficiency 14	Enrichment	PIK3R1	2.03
63	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.03
64	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.92
65	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.91
66	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.82
67	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.82
68	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.82
69	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.81
70	Hemimegalencephaly	Enrichment	AKT3	1.81
71	Breast adenocarcinoma	Enrichment	AKT1	1.73
72	Hypertrichosis	Enrichment	CREBBP	1.73
73	Megacolon	Enrichment	AKT3	1.67
74	Overgrowth syndrome	Enrichment	PIK3R1	1.67
75	Breast cancer	Enrichment	IL2, JUN	1.67
76	Lennox-gastaut syndrome	Enrichment	MAPK10	1.62
77	Coronary heart disease 5	Enrichment	IKBKG	1.57
78	Charge syndrome	Enrichment	EP300	1.56
79	Cowden syndrome	Enrichment	AKT1	1.56
80	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.53
81	Polymicrogyria	Enrichment	AKT3	1.52
82	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.52
83	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.48
84	Specific learning disability	Enrichment	MAPK1	1.47
85	Meningioma	Enrichment	AKT1	1.44
86	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.38
87	Heart disease	Enrichment	CREBBP	1.37
88	Polydactyly, postaxial, type a1	Enrichment	EP300	1.34
89	Corpus callosum, agenesis of	Enrichment	CREBBP	1.34
90	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.34
91	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.34
92	Gliosarcoma	Enrichment	NFKBIA	1.33
93	Giant cell glioblastoma	Enrichment	NFKBIA	1.30
94	Human immunodeficiency virus type 1	Enrichment	CXCL12	1.28
95	Heart, malformation of	Enrichment	MAPK1	1.27
96	Microcephaly	Enrichment	EP300, MAPK1	1.26
97	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.24
98	Myocardial infarction	Enrichment	LTA	1.19
99	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.19
100	Malaria	Enrichment	IKBKG	1.17
101	Scoliosis	Enrichment	CREBBP	1.14
102	Severe combined immunodeficiency	Enrichment	IKBKB	1.02
103	Type 2 diabetes mellitus	Enrichment	AKT2	0.91
104	Hereditary breast carcinoma	Enrichment	AKT1	0.89
105	Thrombocytopenia	Enrichment	CYCS	0.87
106	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIABLO	0.84
107	Autism	Enrichment	CREBBP	0.70
108	Ovarian cancer	Enrichment	MAP3K1	0.58
109	Congenital nervous system abnormality	Enrichment	CREBBP	0.55
110	Nervous system disease	Enrichment	CREBBP	0.55

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for LT-BetaR Pathway

Member Pathways for LT-BetaR Pathway

Pathways in the LT-BetaR Pathway SuperPath

Associated Genes for LT-BetaR Pathway

Associated Disorders for LT-BetaR Pathway

Disorders associated with LT-BetaR Pathway SuperPath

STRING Interaction Network for LT-BetaR Pathway

Sources for LT-BetaR Pathway