Lung fibrosis

No Pathway Network information available for Lung fibrosis

Pathways in the Lung fibrosis SuperPath

#	Name	Source	Genes
1	Lung fibrosis	WikiPathways	ATP11A BMP7 CALCA CCL11 CCL2 CCL3 CCL4 CCL5 CCN2 CCR2 CCR3 CEBPB CMA1 CSF2 CSF3 CXCL2 CXCL8 CYSLTR2 DPP9 DSP EDN1 EGF ELMOD2 ELN FAM13A FGF1 FGF2 FGF7 GREM1 HGF HMOX1 IGF1 IL12B IL13 IL1B IL4 IL5 IL6 MECP2 MMP2 MMP9 MT2A MUC5B NFE2L2 PARN PDGFA PDGFB PLAU PTX3 RTEL1 SERPINA1 SFTPA1 SFTPA2 SFTPC SKIL SMAD7 SPP1 STN1 TERT TGFA TGFB1 TIMP1 TNF (see all 63) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SFTPA1	Surfactant Protein A1	Protein Coding	1
2	DPP9	Dipeptidyl Peptidase 9	Protein Coding	1
3	STN1	STN1 Subunit Of CST Complex	Protein Coding	1
4	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	1
5	SFTPA2	Surfactant Protein A2	Protein Coding	1
6	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	1
7	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	1
8	TNF	Tumor Necrosis Factor	Protein Coding	1
9	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	1
10	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
11	TGFA	Transforming Growth Factor Alpha	Protein Coding	1
12	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
13	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
14	BMP7	Bone Morphogenetic Protein 7	Protein Coding	1
15	SKIL	SKI Like Proto-Oncogene	Protein Coding	1
16	SFTPC	Surfactant Protein C	Protein Coding	1
17	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	1
18	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	1
19	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	1
20	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	1
21	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
22	PTX3	Pentraxin 3	Protein Coding	1
23	CYSLTR2	Cysteinyl Leukotriene Receptor 2	Protein Coding	1
24	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
25	SERPINA1	Serpin Family A Member 1	Protein Coding	1
26	RTEL1	Regulator Of Telomere Elongation Helicase 1	Protein Coding	1
27	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
28	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
29	PARN	Poly(A)-Specific Ribonuclease	Protein Coding	1
30	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
31	MT2A	Metallothionein 2A	Protein Coding	1
32	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
33	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
34	MECP2	Methyl-CpG Binding Protein 2	Protein Coding	1
35	SMAD7	SMAD Family Member 7	Protein Coding	1
36	IL13	Interleukin 13	Protein Coding	1
37	IL12B	Interleukin 12B	Protein Coding	1
38	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
39	IL6	Interleukin 6	Protein Coding	1
40	IL5	Interleukin 5	Protein Coding	1
41	IL4	Interleukin 4	Protein Coding	1
42	IL1B	Interleukin 1 Beta	Protein Coding	1
43	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
44	HMOX1	Heme Oxygenase 1	Protein Coding	1
45	HGF	Hepatocyte Growth Factor	Protein Coding	1
46	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	1
47	GREM1	Gremlin 1, DAN Family BMP Antagonist	Protein Coding	1
48	ATP11A	ATPase Phospholipid Transporting 11A	Protein Coding	1
49	FGF7	Fibroblast Growth Factor 7	Protein Coding	1
50	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
51	FGF1	Fibroblast Growth Factor 1	Protein Coding	1
52	ELN	Elastin	Protein Coding	1
53	EGF	Epidermal Growth Factor	Protein Coding	1
54	EDN1	Endothelin 1	Protein Coding	1
55	DSP	Desmoplakin	Protein Coding	1
56	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
57	CSF3	Colony Stimulating Factor 3	Protein Coding	1
58	CSF2	Colony Stimulating Factor 2	Protein Coding	1
59	CCR3	C-C Motif Chemokine Receptor 3	Protein Coding	1
60	CMA1	Chymase 1	Protein Coding	1
61	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
62	FAM13A	Family With Sequence Similarity 13 Member A	Protein Coding	1
63	ELMOD2	ELMO Domain Containing 2	Protein Coding	1

Disorders associated with Lung fibrosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Interstitial lung disease 2	Enrichment	ATP11A, DPP9, DSP, FAM13A, MUC5B, PARN, RTEL1, SFTPA1, SFTPA2, SFTPC, STN1, TERT	16.00
2	Pulmonary fibrosis	Enrichment	MUC5B, PARN, RTEL1, TERT	8.20
3	Human immunodeficiency virus type 1	Enrichment	CCL11, CCL2, CCL3, CCL5, CCR2	7.82
4	Hoyeraal-hreidarsson syndrome	Enrichment	PARN, RTEL1, TERT	5.72
5	Asthma	Enrichment	CCL11, IL13, TNF	4.81
6	Dyskeratosis congenita	Enrichment	PARN, RTEL1, TERT	4.06
7	Cystic fibrosis	Enrichment	HMOX1, SERPINA1, TGFB1	3.37
8	Systemic lupus erythematosus	Enrichment	MECP2, SPP1, TNF	3.11
9	Meningioma	Enrichment	PDGFB, TERT	2.87
10	Pulmonary disease, chronic obstructive	Enrichment	HMOX1, SERPINA1	2.80
11	Hypomagnesemia 4, renal	Enrichment	EGF	2.33
12	Facial hypertrichosis	Enrichment	MECP2	2.33
13	Deafness, autosomal recessive 39	Enrichment	HGF	2.33
14	Surfactant metabolism dysfunction, pulmonary, 2	Enrichment	SFTPC	2.33
15	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.33
16	Polycystic lung disease	Enrichment	CCR2	2.33
17	Dyskeratosis congenita, autosomal recessive 6	Enrichment	PARN	2.33
18	Interstitial lung disease 1	Enrichment	SFTPA1	2.33
19	Auriculocondylar syndrome 3	Enrichment	EDN1	2.33
20	Intellectual developmental disorder, x-linked, syndromic, lubs type	Enrichment	MECP2	2.33
21	Autism x-linked 3	Enrichment	MECP2	2.33
22	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.33
23	Deafness, autosomal dominant 33	Enrichment	ATP11A	2.33
24	Allergic rhinitis	Enrichment	IL13	2.33
25	Leukodystrophy, hypomyelinating, 24	Enrichment	ATP11A	2.33
26	Question mark ears, isolated	Enrichment	EDN1	2.33
27	Immunodeficiency 29	Enrichment	IL12B	2.33
28	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4	Enrichment	PARN	2.33
29	Syndromic x-linked intellectual disability lubs type	Enrichment	MECP2	2.33
30	Alpha-1-antitrypsin deficiency	Enrichment	SERPINA1	2.33
31	Colorectal cancer 3	Enrichment	SMAD7	2.33
32	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.33
33	Chronic respiratory distress with surfactant metabolism deficiency	Enrichment	SFTPC	2.33
34	Cerebroretinal microangiopathy with calcifications and cysts 2	Enrichment	STN1	2.33
35	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.33
36	Auditory neuropathy, autosomal dominant 2	Enrichment	ATP11A	2.33
37	Skin fragility-woolly hair-palmoplantar keratoderma syndrome	Enrichment	DSP	2.33
38	Hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation	Enrichment	SERPINA1	2.33
39	Extrinsic allergic alveolitis	Enrichment	MUC5B	2.33
40	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.33
41	Severe covid-19	Enrichment	DPP9, MUC5B	2.10
42	Cutis laxa, autosomal dominant 1	Enrichment	ELN	2.03
43	Camurati-engelmann disease 1	Enrichment	TGFB1	2.03
44	Kyphomelic dysplasia	Enrichment	CCN2	2.03
45	Encephalopathy, neonatal severe, due to mecp2 mutations	Enrichment	MECP2	2.03
46	Arrhythmogenic right ventricular dysplasia, familial, 8	Enrichment	DSP	2.03
47	Quebec platelet disorder	Enrichment	PLAU	2.03
48	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.03
49	Panbronchiolitis, diffuse	Enrichment	MUC5B	2.03
50	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	2.03
51	Dyskeratosis congenita, autosomal recessive 5	Enrichment	RTEL1	2.03
52	Keratosis palmoplantaris striata ii	Enrichment	DSP	2.03
53	Supravalvular aortic stenosis	Enrichment	ELN	2.03
54	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.03
55	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis	Enrichment	DSP	2.03
56	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.03
57	Intellectual developmental disorder, x-linked, syndromic 13	Enrichment	MECP2	2.03
58	Immunodeficiency 127	Enrichment	TNF	2.03
59	Autosomal dominant dyskeratosis congenita 4	Enrichment	RTEL1	2.03
60	Progressive familial heart block	Enrichment	DSP	2.03
61	X-linked intellectual disability-psychosis-macroorchidism syndrome	Enrichment	MECP2	2.03
62	Camurati-engelmann disease	Enrichment	TGFB1	2.03
63	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.03
64	Cardiomyopathy, dilated, with woolly hair and keratoderma	Enrichment	DSP	2.03
65	Melanoma, cutaneous malignant 9	Enrichment	TERT	2.03
66	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 3	Enrichment	RTEL1	2.03
67	Deafness, autosomal dominant 84	Enrichment	ATP11A	2.03
68	Idiopathic interstitial pneumonia	Enrichment	TERT	2.03
69	Hereditary mixed polyposis syndrome	Enrichment	GREM1	2.03
70	Hatipoglu immunodeficiency syndrome	Enrichment	DPP9	2.03
71	Metaphyseal anadysplasia	Enrichment	MMP9	2.03
72	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.03
73	Progressive bulbar palsy	Enrichment	MECP2	2.03
74	Bruxism	Enrichment	MECP2	2.03
75	Laryngomalacia	Enrichment	MECP2	1.86
76	Alagille syndrome 1	Enrichment	FAM13A	1.86
77	Takayasu arteritis	Enrichment	IL12B	1.86
78	Intellectual developmental disorder, x-linked 109	Enrichment	SERPINA1	1.86
79	Dyskeratosis congenita, x-linked	Enrichment	RTEL1	1.86
80	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.86
81	Psoriatic arthritis	Enrichment	TNF	1.86
82	Epidermolysis bullosa, lethal acantholytic	Enrichment	DSP	1.86
83	Polycystic kidney disease 2 with or without polycystic liver disease	Enrichment	FAM13A	1.86
84	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige	Enrichment	DSP	1.86
85	Woolly hair-skin fragility syndrome	Enrichment	DSP	1.86
86	Polycystic kidney disease 2	Enrichment	FAM13A	1.86
87	Keratosis palmoplantaris striata	Enrichment	DSP	1.86
88	Cerebroretinal microangiopathy with calcifications and cysts 1	Enrichment	STN1	1.86
89	Autosomal dominant cutis laxa	Enrichment	ELN	1.86
90	Interstitial lung disease	Enrichment	TERT	1.86
91	Squamous cell carcinoma	Enrichment	FAM13A	1.86
92	Macrocytic anemia	Enrichment	TERT	1.86
93	Migraine without aura	Enrichment	TNF	1.86
94	Pediatric acute respiratory distress syndrome	Enrichment	SFTPC	1.86
95	Leukemia, acute myeloid	Enrichment	RTEL1, TERT	1.83
96	Kaposi sarcoma	Enrichment	IL6	1.73
97	Epilepsy, progressive myoclonic, 4, with or without renal failure	Enrichment	RTEL1	1.73
98	Polyposis syndrome, hereditary mixed, 1	Enrichment	GREM1	1.73
99	Auriculocondylar syndrome 1	Enrichment	EDN1	1.73
100	Lung sarcomatoid carcinoma	Enrichment	TERT	1.73
101	Combined oxidative phosphorylation deficiency 24	Enrichment	RTEL1	1.73
102	Sick sinus syndrome	Enrichment	MECP2	1.73
103	Cerebral malaria	Enrichment	TNF	1.73
104	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.73
105	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.73
106	Alzheimer disease 2	Enrichment	PLAU	1.64
107	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.64
108	Insulin-like growth factor i	Enrichment	IGF1	1.64
109	Ventricular septal defect 1	Enrichment	BMP7	1.64
110	Congenital heart defects, multiple types, 4	Enrichment	BMP7	1.64
111	Cardiac arrest	Enrichment	DSP	1.64
112	Vascular dementia	Enrichment	TNF	1.64
113	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	1.64
114	Hereditary pulmonary alveolar proteinosis	Enrichment	SFTPC	1.64
115	Idiopathic aplastic anemia	Enrichment	TERT	1.64
116	Angelman syndrome	Enrichment	MECP2	1.56
117	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT	1.56
118	Melanoma, uveal	Enrichment	CYSLTR2	1.56
119	Type 1 diabetes mellitus	Enrichment	IL6	1.56
120	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.56
121	Adrenocortical carcinoma	Enrichment	TERT	1.56
122	Limited scleroderma	Enrichment	CCN2	1.56
123	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.56
124	Inherited arrhythmogenic cardiomyopathy	Enrichment	DSP	1.56
125	Kidney clear cell sarcoma	Enrichment	TERT	1.56
126	Rett syndrome	Enrichment	MECP2	1.49
127	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT	1.49
128	Focal epilepsy	Enrichment	MECP2	1.49
129	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB	1.44
130	Rett syndrome, congenital variant	Enrichment	MECP2	1.44
131	Myocarditis	Enrichment	DSP	1.44
132	Inflammatory bowel disease 1	Enrichment	IL6	1.39
133	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	DSP	1.39
134	Adult hepatocellular carcinoma	Enrichment	EGF	1.39
135	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSP	1.39
136	Aplastic anemia	Enrichment	TERT	1.34
137	Familial colorectal cancer	Enrichment	GREM1	1.34
138	Meningioma, familial	Enrichment	PDGFB	1.30
139	Cardiac conduction defect	Enrichment	DSP	1.26
140	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	DSP	1.26
141	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	DSP	1.26
142	Aortic valve disease 1	Enrichment	DSP	1.23
143	Alzheimer's disease	Enrichment	TNF	1.23
144	Stereotypic movement disorder	Enrichment	MECP2	1.23
145	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	DSP	1.20
146	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DSP	1.14
147	Alzheimer disease, familial, 1	Enrichment	PLAU	1.12
148	Melanoma, cutaneous malignant 1	Enrichment	TERT	1.12
149	Arteriovenous malformations of the brain	Enrichment	IL6	1.07
150	Williams-beuren syndrome	Enrichment	ELN	1.05
151	Cardiomyopathy, dilated, 1a	Enrichment	DSP	1.03
152	Hepatoblastoma	Enrichment	TERT	1.03
153	Hepatocellular carcinoma	Enrichment	TERT	1.01
154	Attention deficit-hyperactivity disorder	Enrichment	MECP2	1.01
155	Cardiomyopathy, dilated, 1g	Enrichment	DSP	1.01
156	Tooth agenesis	Enrichment	TGFA	1.01
157	Malaria	Enrichment	TNF	0.99
158	Bladder cancer	Enrichment	TERT	0.90
159	Differentiated thyroid carcinoma	Enrichment	TERT	0.90
160	Long qt syndrome 1	Enrichment	DSP	0.88
161	Long qt syndrome	Enrichment	DSP	0.87
162	Lung cancer	Enrichment	NFE2L2	0.86
163	Left ventricular noncompaction	Enrichment	DSP	0.82
164	Dystonia	Enrichment	MECP2	0.82
165	Non-syndromic x-linked intellectual disability	Enrichment	MECP2	0.81
166	Epilepsy	Enrichment	MECP2	0.77
167	Type 2 diabetes mellitus	Enrichment	IL6	0.75
168	Gastric cancer	Enrichment	IL1B	0.74
169	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ELN	0.73
170	Sensorineural hearing loss	Enrichment	HGF	0.70
171	Hypertelorism	Enrichment	ELN	0.67
172	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ATP11A	0.67
173	Familial isolated dilated cardiomyopathy	Enrichment	DSP	0.66
174	Autism	Enrichment	MECP2	0.54
175	Dilated cardiomyopathy	Enrichment	DSP	0.51
176	Colorectal cancer	Enrichment	NFE2L2	0.48
177	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF	0.47
178	Congenital nervous system abnormality	Enrichment	MECP2	0.41
179	Nervous system disease	Enrichment	MECP2	0.41
180	Autism spectrum disorder	Enrichment	MECP2	0.40
181	Microcephaly	Enrichment	MECP2	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Lung fibrosis

Pathway Network for Lung fibrosis

Member Pathways for Lung fibrosis

Pathways in the Lung fibrosis SuperPath

Associated Genes for Lung fibrosis

Associated Disorders for Lung fibrosis

Disorders associated with Lung fibrosis SuperPath

STRING Interaction Network for Lung fibrosis

Sources for Lung fibrosis