lysine degradation I (saccharopine pathway)

Pathway network for the lysine degradation I (saccharopine pathway) SuperPath

Sources:

PubChem
Reactome

Pathways in the lysine degradation I (saccharopine pathway) SuperPath

#	Name	Source	Genes
1	lysine degradation I (saccharopine pathway)	PubChem	AADAT AASS ALDH7A1 DHTKD1
2	Lysine catabolism	Reactome	AADAT AASS ALDH7A1 CRYM DHTKD1 DLD DLST GCDH HYKK PHYKPL PIPOX SLC25A21 (see all 12) (see less)
3	superpathway of L-lysine degradation	PubChem	AADAT AASS ACADS ACAT1 ACAT2 ALDH7A1 CRYM DHTKD1 SUGCT (see all 9) (see less)
4	lysine degradation II (pipecolate pathway)	PubChem	AADAT CRYM DHTKD1 PIPOX PYCR1
5	L-lysine degradation XI (mammalian)	PubChem	AADAT AASS ALDH7A1 DHTKD1
6	L-lysine degradation II (L-pipecolate pathway)	PubChem	AADAT CRYM DHTKD1 PYCR1
7	OADH complex synthesizes glutaryl-CoA from 2-OA	Reactome	DHTKD1 DLD DLST

Gene overlap in member pathways for lysine degradation I (saccharopine pathway) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DHTKD1	Dehydrogenase E1 And Transketolase Domain Containing 1	Protein Coding	7
2	AADAT	Aminoadipate Aminotransferase	Protein Coding	6
3	ALDH7A1	Aldehyde Dehydrogenase 7 Family Member A1	Protein Coding	4
4	AASS	Aminoadipate-Semialdehyde Synthase	Protein Coding	4
5	CRYM	Crystallin Mu	Protein Coding	4
6	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	2
7	DLST	Dihydrolipoamide S-Succinyltransferase	Protein Coding	2
8	PIPOX	Pipecolic Acid And Sarcosine Oxidase	Protein Coding	2
9	PYCR1	Pyrroline-5-Carboxylate Reductase 1	Protein Coding	2
10	HYKK	Hydroxylysine Kinase	Protein Coding	1
11	GCDH	Glutaryl-CoA Dehydrogenase	Protein Coding	1
12	PHYKPL	5-Phosphohydroxy-L-Lysine Phospho-Lyase	Protein Coding	1
13	SLC25A21	Solute Carrier Family 25 Member 21	Protein Coding	1
14	SUGCT	Succinyl-CoA:Glutarate-CoA Transferase	Protein Coding	1
15	ACAT1	Acetyl-CoA Acetyltransferase 1	Protein Coding	1
16	ACAT2	Acetyl-CoA Acetyltransferase 2	Protein Coding	1
17	ACADS	Acyl-CoA Dehydrogenase Short Chain	Protein Coding	1

Disorders associated with lysine degradation I (saccharopine pathway) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alpha-methylacetoacetic aciduria	Enrichment	ACAT1, ACAT2	6.41
2	Alpha-aminoadipic and alpha-ketoadipic aciduria	Enrichment	DHTKD1	3.66
3	Pheochromocytoma/paraganglioma syndrome 7	Enrichment	DLST	3.66
4	Charcot-marie-tooth disease, axonal, type 2q	Enrichment	DHTKD1	3.66
5	Hyperlysinemia, type i	Enrichment	AASS	3.53
6	Epilepsy, early-onset, 4, vitamin b6-dependent	Enrichment	ALDH7A1	3.53
7	Saccharopinuria	Enrichment	AASS	3.53
8	Hyperlysinemia	Enrichment	AASS	3.53
9	Cutis laxa, autosomal recessive, type iiib	Enrichment	PYCR1	3.53
10	Deafness, autosomal dominant 40	Enrichment	CRYM	3.53
11	Cutis laxa, autosomal recessive, type iib	Enrichment	PYCR1	3.53
12	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	3.35
13	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	3.35
14	Pyridoxine-dependent-developmental and epileptic encephalopathy	Enrichment	ALDH7A1	3.23
15	Acetyl-coa acetyltransferase-2 deficiency	Enrichment	ACAT2	3.18
16	Developmental and epileptic encephalopathy 13	Enrichment	ALDH7A1	3.05
17	Geroderma osteodysplasticum	Enrichment	PYCR1	3.05
18	Phosphohydroxylysinuria	Enrichment	PHYKPL	3.05
19	Mitochondrial dna depletion syndrome 18	Enrichment	SLC25A21	3.05
20	Acyl-coa dehydrogenase, short-chain, deficiency of	Enrichment	ACADS	2.88
21	Glutaric aciduria iii	Enrichment	SUGCT	2.88
22	Leukodystrophy, hypomyelinating, 2	Enrichment	GCDH	2.58
23	Lactic acidosis	Enrichment	DLD	2.58
24	Anemia, congenital dyserythropoietic, type iva	Enrichment	GCDH	2.45
25	Fetal hemoglobin quantitative trait locus 6	Enrichment	GCDH	2.45
26	Ciliary dyskinesia, primary, 29	Enrichment	GCDH	2.45
27	Cutis laxa	Enrichment	PYCR1	2.45
28	Glutaric acidemia i	Enrichment	GCDH	2.35
29	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	DLST	2.33
30	Hydrocephalus, congenital, 1	Enrichment	ALDH7A1	2.33
31	Connective tissue disease	Enrichment	PYCR1	2.03
32	Pulmonary disease, chronic obstructive	Enrichment	HYKK	1.94
33	Epilepsy	Enrichment	ALDH7A1	1.93
34	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	CRYM	1.82
35	Congenital nervous system abnormality	Enrichment	ALDH7A1	1.51
36	Nervous system disease	Enrichment	ALDH7A1	1.51

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

lysine degradation I (saccharopine pathway)

Pathway Network for lysine degradation I (saccharopine pathway)

Pathway network for the lysine degradation I (saccharopine pathway) SuperPath

Member Pathways for lysine degradation I (saccharopine pathway)

Pathways in the lysine degradation I (saccharopine pathway) SuperPath

Gene overlap in member pathways for lysine degradation I (saccharopine pathway) SuperPath

Associated Genes for lysine degradation I (saccharopine pathway)

Associated Disorders for lysine degradation I (saccharopine pathway)

Disorders associated with lysine degradation I (saccharopine pathway) SuperPath

STRING Interaction Network for lysine degradation I (saccharopine pathway)

Sources for lysine degradation I (saccharopine pathway)