Male infertility

No Pathway Network information available for Male infertility

Pathways in the Male infertility SuperPath

#	Name	Source	Genes
1	Male infertility	WikiPathways	AGO2 BRDT CCNA1 CCNK CCNT1 CCNT2 CDK9 CLU CREBBP CTCFL CXXC1 DAZ1 DAZ2 DAZ3 DAZ4 DAZL DDX20 DDX4 DND1 EP300 EPPIN H2BW1 H3-4 H4C1 HMGA1 HORMAD1 HORMAD2 IHO1 KDM3A LTF MMP2 MMP9 MOV10L1 NANOS1 PIWIL1 PIWIL2 PIWIL3 PIWIL4 POLB PRDM9 PRM1 PRM2 PRM3 PRMT6 PUM2 SEMG1 SLC46A1 SPO11 THBS1 TRIP13 VCX YBX2 (see all 52) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TRIP13	Thyroid Hormone Receptor Interactor 13	Protein Coding	1
2	PIWIL1	Piwi Like RNA-Mediated Gene Silencing 1	Protein Coding	1
3	CCNA1	Cyclin A1	Protein Coding	1
4	H4C1	H4 Clustered Histone 1	Protein Coding	1
5	H3-4	H3.4 Histone, Cluster Member	Protein Coding	1
6	THBS1	Thrombospondin 1	Protein Coding	1
7	DAZ2	Deleted In Azoospermia 2	Protein Coding	1
8	DAZ3	Deleted In Azoospermia 3	Protein Coding	1
9	PRMT6	Protein Arginine Methyltransferase 6	Protein Coding	1
10	PIWIL2	Piwi Like RNA-Mediated Gene Silencing 2	Protein Coding	1
11	POLB	DNA Polymerase Beta	Protein Coding	1
12	PIWIL3	Piwi Like RNA-Mediated Gene Silencing 3	Protein Coding	1
13	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
14	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
15	LTF	Lactotransferrin	Protein Coding	1
16	NANOS1	Nanos C2HC-Type Zinc Finger 1	Protein Coding	1
17	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	1
18	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	1
19	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
20	DAZL	Deleted In Azoospermia Like	Protein Coding	1
21	DAZ1	Deleted In Azoospermia 1	Protein Coding	1
22	PIWIL4	Piwi Like RNA-Mediated Gene Silencing 4	Protein Coding	1
23	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
24	CLU	Clusterin	Protein Coding	1
25	SLC46A1	Solute Carrier Family 46 Member 1	Protein Coding	1
26	CDK9	Cyclin Dependent Kinase 9	Protein Coding	1
27	H2BW1	H2B.W Histone 1	Protein Coding	1
28	HORMAD2	HORMA Domain Containing 2	Protein Coding	1
29	CCNT2	Cyclin T2	Protein Coding	1
30	CCNT1	Cyclin T1	Protein Coding	1
31	CCNK	Cyclin K	Protein Coding	1
32	HORMAD1	HORMA Domain Containing 1	Protein Coding	1
33	CTCFL	CCCTC-Binding Factor Like	Protein Coding	1
34	DDX20	DEAD-Box Helicase 20	Protein Coding	1
35	BRDT	Bromodomain Testis Associated	Protein Coding	1
36	SEMG1	Semenogelin 1	Protein Coding	1
37	PRM3	Protamine 3	Protein Coding	1
38	DAZ4	Deleted In Azoospermia 4	Protein Coding	1
39	EPPIN	Epididymal Peptidase Inhibitor	Protein Coding	1
40	PRDM9	PR/SET Domain 9	Protein Coding	1
41	PRM2	Protamine 2	Protein Coding	1
42	PRM1	Protamine 1	Protein Coding	1
43	KDM3A	Lysine Demethylase 3A	Protein Coding	1
44	DDX4	DEAD-Box Helicase 4	Protein Coding	1
45	MOV10L1	Mov10 Like RNA Helicase 1	Protein Coding	1
46	YBX2	Y-Box Binding Protein 2	Protein Coding	1
47	DND1	DND MicroRNA-Mediated Repression Inhibitor 1	Protein Coding	1
48	IHO1	Interactor Of HORMAD1 1	Protein Coding	1
49	CXXC1	CXXC Finger Protein 1	Protein Coding	1
50	VCX	Variable Charge X-Linked	Protein Coding	1
51	SPO11	SPO11 Initiator Of Meiotic Double Strand Breaks	Protein Coding	1
52	PUM2	Pumilio RNA Binding Family Member 2	Protein Coding	1

Disorders associated with Male infertility SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chromosome y microdeletion syndrome	Enrichment	DAZ1, DAZ2, DAZ3, DAZ4	7.88
2	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.67
3	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.67
4	Male infertility	Enrichment	HORMAD1, MOV10L1, PIWIL1	3.53
5	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.83
6	Spermatogenic failure 21	Enrichment	BRDT	2.42
7	Spermatogenic failure 73	Enrichment	MOV10L1	2.42
8	Mosaic variegated aneuploidy syndrome 3	Enrichment	TRIP13	2.42
9	Oocyte/zygote/embryo maturation arrest 9	Enrichment	TRIP13	2.42
10	Intellectual developmental disorder with hypertelorism and distinctive facies	Enrichment	CCNK	2.42
11	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.42
12	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.42
13	Menke-hennekam syndrome	Enrichment	CREBBP	2.42
14	Thumb deformity	Enrichment	CREBBP	2.12
15	Premature ovarian failure 3	Enrichment	AGO2	2.12
16	Spermatogenic failure 12	Enrichment	NANOS1	2.12
17	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1	2.12
18	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1	2.12
19	Menke-hennekam syndrome 2	Enrichment	EP300	2.12
20	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.12
21	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.12
22	Metaphyseal anadysplasia	Enrichment	MMP9	2.12
23	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.94
24	Folate malabsorption, hereditary	Enrichment	SLC46A1	1.94
25	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H4C1	1.94
26	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1	1.94
27	Tethered spinal cord syndrome	Enrichment	CREBBP	1.94
28	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.94
29	Lessel-kreienkamp syndrome	Enrichment	AGO2	1.94
30	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.72
31	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	MOV10L1, NANOS1	1.71
32	Primary ovarian insufficiency	Enrichment	BRDT, THBS1	1.67
33	Hypertrichosis	Enrichment	CREBBP	1.64
34	Mosaic variegated aneuploidy syndrome	Enrichment	TRIP13	1.52
35	Charge syndrome	Enrichment	EP300	1.47
36	Heart disease	Enrichment	CREBBP	1.28
37	Polydactyly, postaxial, type a1	Enrichment	EP300	1.25
38	Wilms tumor 1	Enrichment	TRIP13	1.25
39	Corpus callosum, agenesis of	Enrichment	CREBBP	1.25
40	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.25
41	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.25
42	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.15
43	Azoospermia	Enrichment	MOV10L1	1.13
44	Scoliosis	Enrichment	CREBBP	1.05
45	Type 2 diabetes mellitus	Enrichment	HMGA1	0.83
46	Myeloma, multiple	Enrichment	CREBBP	0.71
47	Autism	Enrichment	CREBBP	0.62
48	Colorectal cancer	Enrichment	EP300	0.55
49	Congenital nervous system abnormality	Enrichment	CREBBP	0.47
50	Nervous system disease	Enrichment	CREBBP	0.47
51	Microcephaly	Enrichment	EP300	0.42
52	Complex neurodevelopmental disorder	Enrichment	AGO2	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Male infertility

Member Pathways for Male infertility

Pathways in the Male infertility SuperPath

Associated Genes for Male infertility

Associated Disorders for Male infertility

Disorders associated with Male infertility SuperPath

STRING Interaction Network for Male infertility

Sources for Male infertility