Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

No Pathway Network information available for Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

Pathways in the Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) SuperPath

#	Name	Source	Genes
1	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)	WikiPathways	ATP2C2 BCL2L1 CAV1 CCND1 CEBPA CEBPB CHUK CSN2 EGFR EIF4E ELF5 ERBB2 ERBB3 ERBB4 ESR1 ESR2 GAL GJB2 JAK2 MYC NR3C1 PGR PNCK PRL PRLR PTPN1 TNFRSF11A TNFSF11 TPM3 TTC9 USF2 YY1 (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	1
2	TNFSF11	TNF Superfamily Member 11	Protein Coding	1
3	CAV1	Caveolin 1	Protein Coding	1
4	YY1	YY1 Transcription Factor	Protein Coding	1
5	TPM3	Tropomyosin 3	Protein Coding	1
6	BCL2L1	BCL2 Like 1	Protein Coding	1
7	CCND1	Cyclin D1	Protein Coding	1
8	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
9	PRLR	Prolactin Receptor	Protein Coding	1
10	PRL	Prolactin	Protein Coding	1
11	PGR	Progesterone Receptor	Protein Coding	1
12	GAL	Galanin And GMAP Prepropeptide	Protein Coding	1
13	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
14	JAK2	Janus Kinase 2	Protein Coding	1
15	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
16	GJB2	Gap Junction Protein Beta 2	Protein Coding	1
17	TTC9	Tetratricopeptide Repeat Domain 9	Protein Coding	1
18	ESR2	Estrogen Receptor 2	Protein Coding	1
19	ESR1	Estrogen Receptor 1	Protein Coding	1
20	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	1
21	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
22	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
23	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
24	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
25	CSN2	Casein Beta	Protein Coding	1
26	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
27	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
28	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
29	PNCK	Pregnancy Up-Regulated Nonubiquitous CaM Kinase	Protein Coding	1
30	USF2	Upstream Transcription Factor 2, C-Fos Interacting	Protein Coding	1
31	ATP2C2	ATPase Secretory Pathway Ca2+ Transporting 2	Protein Coding	1
32	ELF5	E74 Like ETS Transcription Factor 5	Protein Coding	1

Disorders associated with Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3	4.38
2	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2	3.53
3	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2	3.32
4	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3	2.68
5	Erythroleukemia, familial	Enrichment	ERBB3	2.63
6	Bart-pumphrey syndrome	Enrichment	GJB2	2.63
7	Paget disease, extramammary	Enrichment	ERBB2	2.63
8	Vohwinkel syndrome	Enrichment	GJB2	2.63
9	Deafness, autosomal dominant 3a	Enrichment	GJB2	2.63
10	Osteopetrosis, autosomal recessive 7	Enrichment	TNFRSF11A	2.63
11	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.63
12	Keratitis-ichthyosis-deafness syndrome, autosomal dominant	Enrichment	GJB2	2.63
13	Congenital myopathy 4b, autosomal recessive	Enrichment	TPM3	2.63
14	Multiple fibroadenomas of the breast	Enrichment	PRLR	2.63
15	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.63
16	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.63
17	Fetal encasement syndrome	Enrichment	CHUK	2.63
18	Epilepsy, familial temporal lobe, 8	Enrichment	GAL	2.63
19	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.63
20	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.63
21	Progesterone resistance	Enrichment	PGR	2.63
22	Autism 19	Enrichment	EIF4E	2.63
23	Hyperprolactinemia	Enrichment	PRLR	2.63
24	Ichthyosis, hystrix-like, with deafness	Enrichment	GJB2	2.63
25	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.63
26	Ovarian dysgenesis 8	Enrichment	ESR2	2.63
27	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	2.63
28	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.63
29	Familial hyperprolactinemia	Enrichment	PRLR	2.63
30	Porokeratotic eccrine ostial and dermal duct nevus	Enrichment	GJB2	2.63
31	Autosomal dominant nonsyndromic hearing loss 3a	Enrichment	GJB2	2.63
32	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.63
33	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.63
34	Congenital generalized hypercontractile muscle stiffness syndrome	Enrichment	TPM3	2.63
35	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.63
36	Lung cancer	Enrichment	EGFR, ERBB2	2.59
37	Leukemia, acute myeloid	Enrichment	CEBPA, JAK2	2.40
38	Burkitt lymphoma	Enrichment	MYC	2.33
39	Familial expansile osteolysis	Enrichment	TNFRSF11A	2.33
40	Paget disease of bone 5, juvenile-onset	Enrichment	TNFRSF11A	2.33
41	Galactosemia ii	Enrichment	NR3C1	2.33
42	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.33
43	Thrombocythemia 3	Enrichment	JAK2	2.33
44	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	2.33
45	Deafness, autosomal recessive 104	Enrichment	GJB2	2.33
46	Gabriele-de vries syndrome	Enrichment	YY1	2.33
47	Deafness, autosomal recessive 1b	Enrichment	GJB2	2.33
48	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.33
49	Insulinoma	Enrichment	YY1	2.33
50	Polycythemia	Enrichment	JAK2	2.33
51	Keratitis ichthyosis and deafness syndrome	Enrichment	GJB2	2.33
52	Hypereosinophilic syndrome	Enrichment	JAK2	2.33
53	Hereditary palmoplantar keratoderma	Enrichment	GJB2	2.33
54	Thyroid carcinoma, familial medullary	Enrichment	ESR2	2.15
55	Keratoderma, palmoplantar, with deafness	Enrichment	GJB2	2.15
56	Dysosteosclerosis	Enrichment	TNFRSF11A	2.15
57	Polycythemia vera	Enrichment	JAK2	2.15
58	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	GJB2	2.15
59	Estrogen resistance	Enrichment	ESR1	2.15
60	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.15
61	Deafness, x-linked 2	Enrichment	GJB2	2.15
62	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.15
63	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.15
64	Migraine without aura	Enrichment	ESR1	2.15
65	X-linked mixed hearing loss with perilymphatic gusher	Enrichment	GJB2	2.15
66	Adult-onset myasthenia gravis	Enrichment	TNFRSF11A	2.15
67	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.15
68	Cap myopathy	Enrichment	TPM3	2.15
69	Primary ovarian insufficiency	Enrichment	JAK2, PRLR	2.07
70	Erythrocytosis, familial, 1	Enrichment	JAK2	2.03
71	Deafness, autosomal recessive 1a	Enrichment	GJB2	2.03
72	Budd-chiari syndrome	Enrichment	JAK2	2.03
73	Paget disease of bone 2, early-onset	Enrichment	TNFRSF11A	2.03
74	Barrett esophagus	Enrichment	ERBB2	2.03
75	Mantle cell lymphoma	Enrichment	CCND1	2.03
76	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.03
77	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	2.03
78	Gjb2-related autosomal recessive nonsyndromic hearing loss	Enrichment	GJB2	2.03
79	Paget's disease of bone 2	Enrichment	TNFRSF11A	2.03
80	Intermediate nemaline myopathy	Enrichment	TPM3	2.03
81	Von hippel-lindau syndrome	Enrichment	CCND1	1.93
82	Myeloproliferative neoplasm	Enrichment	JAK2	1.93
83	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.93
84	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.93
85	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.93
86	Cowden syndrome 1	Enrichment	EGFR	1.85
87	Deafness, autosomal recessive 12	Enrichment	GJB2	1.85
88	Inflammatory myofibroblastic tumor	Enrichment	TPM3	1.85
89	Limited scleroderma	Enrichment	CAV1	1.85
90	Lung squamous cell carcinoma	Enrichment	EGFR	1.85
91	Myelofibrosis	Enrichment	JAK2	1.79
92	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.79
93	Essential thrombocythemia	Enrichment	JAK2	1.79
94	Childhood-onset nemaline myopathy	Enrichment	TPM3	1.79
95	Colorectal cancer	Enrichment	CCND1, ERBB2	1.75
96	Glioma susceptibility 1	Enrichment	ERBB2	1.73
97	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.68
98	Primary hyperaldosteronism	Enrichment	NR3C1	1.68
99	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.63
100	Nemaline myopathy	Enrichment	TPM3	1.63
101	Ovarian cancer	Enrichment	EGFR, ERBB2	1.63
102	Migraine with or without aura 1	Enrichment	ESR1	1.59
103	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.59
104	Lip and oral cavity carcinoma	Enrichment	EGFR	1.55
105	Nk-cell enteropathy	Enrichment	ERBB4	1.52
106	Congenital myopathy 4a, autosomal dominant	Enrichment	TPM3	1.46
107	Gliosarcoma	Enrichment	EGFR	1.43
108	Inherited cancer-predisposing syndrome	Enrichment	CEBPA, EGFR	1.41
109	Giant cell glioblastoma	Enrichment	EGFR	1.40
110	Arteriovenous malformations of the brain	Enrichment	EGFR	1.36
111	Centronuclear myopathy	Enrichment	TPM3	1.31
112	Myocardial infarction	Enrichment	ESR1	1.30
113	Noonan syndrome 1	Enrichment	GJB2	1.28
114	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.28
115	Ear malformation	Enrichment	GJB2	1.26
116	Non-syndromic genetic deafness	Enrichment	GJB2	1.09
117	Myopathy	Enrichment	TPM3	1.04
118	Type 2 diabetes mellitus	Enrichment	PTPN1	1.02
119	Nonsyndromic hearing loss	Enrichment	GJB2	1.02
120	Gastric cancer	Enrichment	ERBB2	1.01
121	Hereditary breast carcinoma	Enrichment	ESR1	1.01
122	Sensorineural hearing loss	Enrichment	GJB2	0.97
123	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4	0.95
124	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GJB2	0.94
125	Myeloma, multiple	Enrichment	CCND1	0.91
126	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4	0.89
127	Deafness, autosomal recessive	Enrichment	GJB2	0.86
128	Autosomal recessive nonsyndromic deafness	Enrichment	GJB2	0.85
129	Breast cancer	Enrichment	ESR1	0.79
130	Rare genetic deafness	Enrichment	GJB2	0.77
131	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJB2	0.72
132	Autism spectrum disorder	Enrichment	GJB2	0.64

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

Pathway Network for Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

Member Pathways for Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

Pathways in the Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) SuperPath

Associated Genes for Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

Associated Disorders for Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

Disorders associated with Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) SuperPath

STRING Interaction Network for Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

Sources for Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)