MAP3K1 role in promoting and blocking gonadal determination

No Pathway Network information available for MAP3K1 role in promoting and blocking gonadal determination

Pathways in the MAP3K1 role in promoting and blocking gonadal determination SuperPath

#	Name	Source	Genes
1	MAP3K1 role in promoting and blocking gonadal determination	WikiPathways	AXIN1 FGF9 FGFR2 FOXL2 FRAT1 GADD45G GSK3B MAP3K1 MAP3K4 MAPK1 MAPK11 RHOA ROCK1 SOX9 SRY WNT4 (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AXIN1	Axin 1	Protein Coding	1
2	SRY	Sex Determining Region Y	Protein Coding	1
3	FOXL2	Forkhead Box L2	Protein Coding	1
4	SOX9	SRY-Box Transcription Factor 9	Protein Coding	1
5	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
6	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
7	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
8	WNT4	Wnt Family Member 4	Protein Coding	1
9	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
10	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
11	RHOA	Ras Homolog Family Member A	Protein Coding	1
12	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
13	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
14	FGF9	Fibroblast Growth Factor 9	Protein Coding	1
15	GADD45G	Growth Arrest And DNA Damage Inducible Gamma	Protein Coding	1
16	FRAT1	FRAT Regulator Of Wnt Signaling Pathway 1	Protein Coding	1

Disorders associated with MAP3K1 role in promoting and blocking gonadal determination SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1, SOX9, SRY	6.66
2	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOX9, SRY	6.31
3	46,xx sex reversal 1	Enrichment	SOX9, SRY	5.41
4	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SOX9, SRY	4.89
5	Blepharophimosis, ptosis, and epicanthus inversus	Enrichment	FOXL2	2.93
6	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.93
7	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.93
8	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.93
9	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.93
10	Apert syndrome	Enrichment	FGFR2	2.93
11	Caudal duplication anomaly	Enrichment	AXIN1	2.93
12	46,xy sex reversal 6	Enrichment	MAP3K1	2.93
13	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.93
14	Noonan syndrome 13	Enrichment	MAPK1	2.93
15	46,xy sex reversal 10	Enrichment	SOX9	2.93
16	46,xx sex reversal 2	Enrichment	SOX9	2.93
17	Multiple synostoses syndrome 3	Enrichment	FGF9	2.93
18	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.93
19	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.93
20	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.93
21	45,x/46,xy mixed gonadal dysgenesis	Enrichment	SRY	2.93
22	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.93
23	Campomelic dysplasia	Enrichment	SOX9	2.63
24	Premature ovarian failure 3	Enrichment	FOXL2	2.63
25	Aural atresia, congenital	Enrichment	FGFR2	2.63
26	Pfeiffer syndrome	Enrichment	FGFR2	2.63
27	Jackson-weiss syndrome	Enrichment	FGFR2	2.63
28	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.63
29	46,xy sex reversal 1	Enrichment	SRY	2.63
30	Split hand-foot malformation	Enrichment	FGFR2	2.63
31	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.63
32	Malignant granulosa cell tumor of the ovary	Enrichment	FOXL2	2.63
33	Campomelic dysplasia and related disorders	Enrichment	SOX9	2.63
34	Crouzon syndrome	Enrichment	FGFR2	2.45
35	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2	2.45
36	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	2.45
37	Colorectal cancer	Enrichment	FGFR2, SOX9	2.34
38	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.33
39	Saethre-chotzen syndrome	Enrichment	FGFR2	2.33
40	Blepharophimosis	Enrichment	FOXL2	2.33
41	Multiple synostoses syndrome	Enrichment	FGF9	2.33
42	Glioma	Enrichment	FGFR2	2.33
43	Hemifacial hyperplasia	Enrichment	FGFR2	2.23
44	Split-hand/foot malformation 1	Enrichment	FGFR2	2.15
45	Hemihyperplasia, isolated	Enrichment	RHOA	2.15
46	Pierre robin syndrome	Enrichment	SOX9	2.15
47	46,xy disorder of sex development	Enrichment	SRY	2.15
48	Adult hepatocellular carcinoma	Enrichment	AXIN1	1.98
49	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.93
50	Specific learning disability	Enrichment	MAPK1	1.89
51	Hydrocephalus	Enrichment	FGFR2	1.76
52	Heart, malformation of	Enrichment	MAPK1	1.68
53	Craniosynostosis	Enrichment	FGFR2	1.63
54	Endometrial cancer	Enrichment	FGFR2	1.61
55	Hepatocellular carcinoma	Enrichment	AXIN1	1.59
56	Connective tissue disease	Enrichment	SOX9	1.43
57	Gastric cancer	Enrichment	FGFR2	1.30
58	Hypertelorism	Enrichment	FGFR2	1.22
59	Ovarian cancer	Enrichment	MAP3K1	0.95
60	Microcephaly	Enrichment	MAPK1	0.87

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MAP3K1 role in promoting and blocking gonadal determination

Pathway Network for MAP3K1 role in promoting and blocking gonadal determination

Member Pathways for MAP3K1 role in promoting and blocking gonadal determination

Pathways in the MAP3K1 role in promoting and blocking gonadal determination SuperPath

Associated Genes for MAP3K1 role in promoting and blocking gonadal determination

Associated Disorders for MAP3K1 role in promoting and blocking gonadal determination

Disorders associated with MAP3K1 role in promoting and blocking gonadal determination SuperPath

STRING Interaction Network for MAP3K1 role in promoting and blocking gonadal determination

Sources for MAP3K1 role in promoting and blocking gonadal determination