MAP kinase activation

Pathway network for the MAP kinase activation SuperPath

Sources:

Reactome

Pathways in the MAP kinase activation SuperPath

#	Name	Source	Genes
1	MAP kinase activation	Reactome	ATF1 ATF2 BTRC CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FOS IKBKB IKBKG IRAK1 IRAK2 JUN MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C NFKB1 NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 SKP1 TAB1 TAB2 TAB3 TNIP2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 VRK3 (see all 63) (see less)
2	Interleukin-17 signaling	Reactome	ATF1 ATF2 BTRC CHUK CREB1 CUL1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FBXW11 FOS IKBKB IKBKG IL17A IL17C IL17F IL17RA IL17RB IL17RC IL17RE IL25 IRAK1 IRAK2 JUN MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K7 MAP3K8 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MEF2A MEF2C NFKB1 NOD1 NOD2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RIPK2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 SKP1 TAB1 TAB2 TAB3 TNIP2 TRAF6 UBA52 UBB UBC UBE2N UBE2V1 VRK3 (see all 71) (see less)
3	MAP3K8 (TPL2)-dependent MAPK1/3 activation	Reactome	BTRC CHUK CUL1 FBXW11 IKBKB IKBKG MAP2K1 MAP2K4 MAP3K8 NFKB1 RPS27A SKP1 TNIP2 UBA52 UBB UBC (see all 16) (see less)

Gene overlap in member pathways for MAP kinase activation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
2	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	3
3	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	3
4	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
5	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
6	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
7	RPS27A	Ribosomal Protein S27a	Protein Coding	3
8	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
9	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	3
10	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
11	UBB	Ubiquitin B	Protein Coding	3
12	UBC	Ubiquitin C	Protein Coding	3
13	TNIP2	TNFAIP3 Interacting Protein 2	Protein Coding	3
14	CUL1	Cullin 1	Protein Coding	3
15	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
16	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	3
17	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	2
18	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	2
19	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
20	ATF2	Activating Transcription Factor 2	Protein Coding	2
21	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
22	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	2
23	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	2
24	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	2
25	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	2
26	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
27	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	2
28	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
29	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	2
30	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	2
31	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	2
32	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
33	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	2
34	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	2
35	ATF1	Activating Transcription Factor 1	Protein Coding	2
36	VRK3	VRK Serine/Threonine Kinase 3	Protein Coding	2
37	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
38	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
39	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
40	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
41	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	2
42	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
43	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
44	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	2
45	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
46	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
47	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
48	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
49	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
50	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
51	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	2
52	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	2
53	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	2
54	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	2
55	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	2
56	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
57	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
58	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	2
59	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	2
60	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	2
61	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	2
62	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	2
63	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	2
64	IL17F	Interleukin 17F	Protein Coding	1
65	IL17RE	Interleukin 17 Receptor E	Protein Coding	1
66	IL17RA	Interleukin 17 Receptor A	Protein Coding	1
67	IL17C	Interleukin 17C	Protein Coding	1
68	IL17A	Interleukin 17A	Protein Coding	1
69	IL17RB	Interleukin 17 Receptor B	Protein Coding	1
70	IL25	Interleukin 25	Protein Coding	1
71	IL17RC	Interleukin 17 Receptor C	Protein Coding	1

Disorders associated with MAP kinase activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic mucocutaneous candidiasis	Enrichment	IL17F, IL17RA, IL17RC	5.57
2	Melanoma of soft tissue	Enrichment	ATF1, CREB1	4.20
3	Specific learning disability	Enrichment	MAPK1, RPS6KA3	2.94
4	Incontinentia pigmenti	Enrichment	IKBKG	2.93
5	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.93
6	Melorheostosis, isolated	Enrichment	MAP2K1	2.93
7	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.93
8	Fetal encasement syndrome	Enrichment	CHUK	2.93
9	Immunodeficiency 15b	Enrichment	IKBKB	2.93
10	Immunodeficiency 15a	Enrichment	IKBKB	2.93
11	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.93
12	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.93
13	Melorheostosis	Enrichment	MAP2K1	2.93
14	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.93
15	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.93
16	Immunodeficiency 33	Enrichment	IKBKG	2.63
17	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.63
18	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.63
19	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.63
20	Common variable immunodeficiency 12	Enrichment	NFKB1	2.63
21	Submucosal cleft palate	Enrichment	UBB	2.63
22	Cleft hard palate	Enrichment	UBB	2.63
23	Uvula, bifid	Enrichment	UBB	2.45
24	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.45
25	Cleft soft palate	Enrichment	UBB	2.45
26	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.33
27	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.33
28	Blau syndrome	Enrichment	NOD2	2.33
29	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.33
30	Noonan syndrome 13	Enrichment	MAPK1	2.33
31	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.33
32	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.33
33	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.33
34	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.33
35	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.33
36	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.33
37	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.33
38	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.33
39	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.33
40	Mef2c-related disorder	Enrichment	MEF2C	2.33
41	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.33
42	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.33
43	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.33
44	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.33
45	Malaria	Enrichment	IKBKG, MAPKAPK3	2.30
46	Candidiasis, familial, 6	Enrichment	IL17F	2.28
47	Candidiasis, familial, 9	Enrichment	IL17RC	2.28
48	Psoriasis	Enrichment	IL17RA	2.28
49	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.23
50	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	2.08
51	Common variable immunodeficiency	Enrichment	NFKB1	2.08
52	Scoliosis, isolated 1	Enrichment	MAPK7	2.03
53	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.03
54	Yao syndrome	Enrichment	NOD2	2.03
55	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.03
56	Congenital heart defects, multiple types, 2	Enrichment	TAB2	2.03
57	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.03
58	Crohn's disease	Enrichment	NOD2	2.03
59	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	2.03
60	Isolated split hand-split foot malformation	Enrichment	BTRC	2.03
61	Lung cancer	Enrichment	MAP3K8, PPP2R1B	2.02
62	Immunodeficiency 51	Enrichment	IL17RA	1.98
63	Coronary heart disease 5	Enrichment	IKBKG	1.98
64	Arteriovenous malformation	Enrichment	MAP2K1	1.98
65	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.93
66	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.93
67	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.89
68	Pelvic organ prolapse	Enrichment	TAB2	1.86
69	Bacteremia 2	Enrichment	MAPKAPK3	1.86
70	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.86
71	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1	1.76
72	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.73
73	Congenital generalized lipodystrophy	Enrichment	FOS	1.73
74	Tuberculosis	Enrichment	MAPKAPK3	1.73
75	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.73
76	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.64
77	Histiocytoid hemangioma	Enrichment	FOS	1.64
78	Noonan syndrome 1	Enrichment	MAP2K1	1.57
79	Rasopathy	Enrichment	MAP2K1	1.52
80	Gastroesophageal reflux	Enrichment	RPS6KA3	1.44
81	Orthostatic intolerance	Enrichment	RPS6KA3	1.44
82	Lennox-gastaut syndrome	Enrichment	MAPK10	1.44
83	Severe combined immunodeficiency	Enrichment	IKBKB	1.42
84	Inflammatory bowel disease 1	Enrichment	NOD2	1.39
85	Ventricular septal defect	Enrichment	RPS6KA3	1.39
86	Migraine with or without aura 1	Enrichment	TAB2	1.30
87	Aortic valve disease 1	Enrichment	TAB2	1.23
88	Heart, malformation of	Enrichment	MAPK1	1.09
89	Patent foramen ovale	Enrichment	TAB2	1.09
90	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	1.09
91	Behcet syndrome	Enrichment	NOD2	1.07
92	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C	1.04
93	Kallmann syndrome	Enrichment	DUSP6	0.99
94	Autoinflammatory disease	Enrichment	NOD2	0.98
95	Complex neurodevelopmental disorder	Enrichment	FBXW11, PPP2CA	0.95
96	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.81
97	Systemic lupus erythematosus	Enrichment	IRAK1	0.78
98	Hypertelorism	Enrichment	RPS6KA3	0.67
99	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.63
100	Breast cancer	Enrichment	JUN	0.53
101	Dilated cardiomyopathy	Enrichment	TAB2	0.51
102	Microcephaly	Enrichment	MAPK1	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MAP kinase activation

Pathway Network for MAP kinase activation

Pathway network for the MAP kinase activation SuperPath

Member Pathways for MAP kinase activation

Pathways in the MAP kinase activation SuperPath

Gene overlap in member pathways for MAP kinase activation SuperPath

Associated Genes for MAP kinase activation

Associated Disorders for MAP kinase activation

Disorders associated with MAP kinase activation SuperPath

STRING Interaction Network for MAP kinase activation

Sources for MAP kinase activation